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Medicine

Ebola Lurked In Cured Patient's Eye 65

An anonymous reader writes: During the Ebola outbreak last year, Dr. Ian Crozier was infected. He was eventually airlifted to Emory University for treatment, and a couple months later he was cured of the disease — or so physicians thought. Not long after he was released, his left eye began bothering him. His sight faded, and he felt intense pressure and pain in his eye. Examination of the eye found it teeming with Ebola. His doctors were surprised. Cured patients frequently deal with health issues long after the virus is gone, but this adds a new dimension to the course of the disease.

Doctors say Crozier posed no threat to others through casual contact; the virus did not exist in his tears or on the surface of his eye. But in addition to the new symptoms, his eye turned from blue to green. And doctors had to rush to disinfect the exam area used for what they thought was an Ebola-free patient. Research is ongoing to determine whether and how to protect from this lingering ebola infection. One theory suggests the virus survived, but was damaged somehow. Crozier was treated with antiviral drugs, and his eye improved, but doctors aren't sure whether the drug actually helped. Either way, it's made the medical community realize this is a longer battle than they had thought.
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Ebola Lurked In Cured Patient's Eye

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  • by turkeydance ( 1266624 ) on Friday May 08, 2015 @04:36PM (#49650321)
    28 Days
  • by tomhath ( 637240 ) on Friday May 08, 2015 @04:42PM (#49650351)
    All the research related to HIV taught us a lot, but this kind of thing makes it obvious that we don't know nearly as much about viruses as we thought.
    • by Anonymous Coward

      Or at least that a lot of people make too many assumptions about [deoxy]ribonucleic acids. I think it's well understood that viruses can mutate, and can be vectors of all types of malady. Evolution itself is the issue in question, and the reason it's not better understood is mainly because there are zealots making sure it stays that way. (And always have been)

    • by Anonymous Coward on Saturday May 09, 2015 @12:04AM (#49651987)

      Huh? It was already known that the eye is a potential reservoir for viruses. The inner eye has what's called "immune privilege". That is, to protect against damaging inflammation in the eye, the inner eye has a protective membrane impermeable to normal immune cells. If a virus manages to make it into the eyeball, it's more-or-less protected from the body's normal immune system.

      See http://en.wikipedia.org/wiki/Immune_privilege

      Doubtless there's a ton we don't know about our biology and the biology of viruses, but this wasn't one of them. The only gap in knowledge here was knowing whether the suspicions were correct--that Ebola could persist in the eye. It was long suspected, but because most Ebola patients die, and outbreaks were so quickly contained, there were never enough survivors to study. But now there are thousands of survivors.

      You know, all of this is very well discussed in the news articles.

    • As another commenter has pointed out, this is not news. It is well known that viruses can cause Uveitis. Several are well known for it. Others not. In the absence of a rheumatological disease, unresolved Uveitis is presumed to be viral. A couple of years ago I had what I thought was the flu. It started to go away, I was on the mend, then it destroyed me. Several days in bed, 107 fever, rigors, probable encephalitis. 6 weeks later I developed Uveitis. My doctor has yet to identify a virus. Twice I'

  • This isn't going to do well for the stigma already suffered by ebola survivors. I believe that the survivors are generally thought to be immune to further infection as well, so it's a bit scary that the virus can still find repositories in the body where it can hang out for longer periods of time.

    • Re:ebola stigma (Score:5, Insightful)

      by NormalVisual ( 565491 ) on Friday May 08, 2015 @05:03PM (#49650425)
      I believe that the survivors are generally thought to be immune to further infection as well, so it's a bit scary that the virus can still find repositories in the body where it can hang out for longer periods of time.

      It's not anything particularly new - we've known for decades that anyone that's had chicken pox still has the dormant virus in a number of nerve ganglia near the spine, and sometimes it reactivates and causes shingles.
      • Re:ebola stigma (Score:5, Interesting)

        by CrimsonAvenger ( 580665 ) on Friday May 08, 2015 @05:47PM (#49650635)

        It's not anything particularly new - we've known for decades that anyone that's had chicken pox still has the dormant virus in a number of nerve ganglia near the spine, and sometimes it reactivates and causes shingles.

        And speak of the devil. My chicken pox virus was apparently hiding in the nerves associated with my left hip. Two weeks ago, I woke up with my left hip hurting. Later that day when I bitched about it, the wife looked at my behind and said "you've got shingles". Doctor agreed.

        It's almost done. Left hip only hurts a little, most of the pox is scabbed over or gone. Should be fine Real Soon Now.

        And as soon as I'm over this, have to get shingles vaccine. Which they only give to people at high risk for same. Having gotten it at a relatively young age (young by Shingles standards), I now qualify as being "at high risk for Shingles" according to the Doc....

        A bit more on-topic, Ebola has now established that it can establish a reservoir in a survivor, so ANY of the people who survived the latest round is a potential carrier.

        Plus Ebola has now established that it can transmit sexually (ebola is now a VD), if only rarely.

        So does this mean all ebola survivors need to be extremely careful about who they screw, and likewise anyone who might feel the urge to bang an ebola survivor?

        • Shingles sucks, that's for sure. I had it make a visit via my trigeminal nerve when I was 29. The eye doctor was freaking out for a little while, but fortunately it ran its course without any eye complications.
      • Which is what Ebola did to this guy.

    • by cookiej ( 136023 )
      Well, a stigma deserved, it would seem. I wonder where that Nurse is that refused to isolate herself because she was "cured".
      • by Anonymous Coward

        It's because she never had it to start with. She was told to enter quarantine as a precaution, she didn't do so.

        A judge sided with her.

        For what it matters, she was right. She never had it.

      • Re: (Score:3, Informative)

        by Anonymous Coward

        She wasn't "cured", because she never had Ebola to begin with. She tested negative for the virus and was asymptomatic. It was the stupid politicians that overrided the doctors' conclusion that she wasn't infected.

        • by dbIII ( 701233 )

          It was the stupid politicians that overrided the doctors' conclusion that she wasn't infected.

          Correct me if I'm wrong, but wasn't it the prick who shut down the tollbridge up to stupid games again?

      • Apparently you skipped over the part where the patient was described as "not contagious".

        • by cookiej ( 136023 )
          Apparently you skipped over the part where he was declared "ebola free" by the same group who are declaring him not contagious.

          My issue is that this "cure" appeared recently and from my (admittedly layman's) perspective, it hasn't had enough time to prove it's completely effective. And given the risks involved if someone is wrong, it seems foolhardy to just trust that it will work.

          And when I read that the doctors are "stumped" as to why the disease wasn't completely eliminated, it scares the hell out
    • The virus appears to be good at hiding in non-blood body fluids. That might include spinal fluid, brain fluid, and several internal organs. Maybe this is how HIV survives so well.
    • by Anonymous Coward

      it's a bit scary that the virus can still find repositories in the body where it can hang out for longer periods of time.

      The eye has something like the blood/brain barrier to isolate it from the rest of the body and keep infectious agents out. Unfortunately, if something gets through that barrier, it can also hide out there from medications and some elements of the immune system.

  • by TheCreeep ( 794716 ) on Friday May 08, 2015 @04:59PM (#49650407)
    We have detected ebola in patient's eye.
    Under no circumstances is anyone to make eye contact with the patient
    I repeat, no eye contact.
  • by Grog6 ( 85859 ) on Friday May 08, 2015 @04:59PM (#49650411)

    This is the start; a simple mutation that allows it to spread unnoticed throughout the population...

    "I totally got this eye infection, but it made my eyes this really rad color of green! Uh...Do you Smell Brains?!!" :)

  • by Virtucon ( 127420 ) on Friday May 08, 2015 @08:14PM (#49651313)

    Don't give me pink eye you goddamn hippies!

  • I wasn't planning on sleeping tonight anyhow.

  • Research is ongoing to determine whether and how to protect from this lingering ebola infection.

    So they're also considering just fucking off and leaving him be?

  • The newest cosmetic treatment coming soon.

    Tired of those drab blue eye? Make them green with Etox.

Beware of all enterprises that require new clothes, and not rather a new wearer of clothes. -- Henry David Thoreau

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