Lasrick tips this report from Reuters: "Despite the more than $50 billion that U.S. pharmaceutical companies have spent every year since the mid-2000s to discover new medications, drugmakers have barely improved on old standbys developed decades ago. Research published on Monday showed that the effectiveness of new drugs, as measured by comparing the response of patients on those treatments to those taking a placebo, has plummeted since the 1970s. 'While experts agree that tougher trials and similar factors explain some of the decline in drugs' reported effectiveness, something real is going on here,' said Olfson. 'Physicians keep saying that many of the new things just aren't working as well,' and therefore prescribe antidepressant drugs called tricyclics (developed in the 1950s) instead of SSRIs (from the 1980s), or diuretics (invented in the 1920s) for high blood pressure instead of newer anti-hypertensives.'"

MarkWhittington writes "Andrew Nelson, the chief operating officer of XCOR Aerospace, a company that proposes to take paying customers on suborbital jaunts on its Lynx rocketplane, posted some good news/bad news concerning some proposed rule changes from the State Department on June 3, 2013. On the good news side, the Department of State has proposed changes (PDF) that would move satellites from the Department of Defense's Munitions list, where they have been since 1999, to the Department of Commerce's commerce control list. 'This is a great step for the industry. Since the time commercial satellites were placed on the munitions list in 1999, the commercial satellite industry was almost wiped out.' On the bad news side, the State Department proposes to place commercial manned spacecraft on the DOD munitions list, making it very difficult if not impossible to fly them outside the United States. 'This is the same backward path provided to the US satellite manufacturing and launch community two decades ago that almost decimated that industry.'"

The Bad Astronomer writes "Astronomers announced today that they have taken a direct image of the lowest mass exoplanet ever seen. HD 95086 b has a mass about 4 to 5 times that of Jupiter, and orbits a star 300 light years away that is slightly more massive and hotter than the Sun. The planet is not 100% confirmed, but it appears very likely to be real. If so, it's a hot gas giant, still cooling from its formation less than 20 million years ago. The picture, taken in the infrared, clearly shows the planet, making it one of fewer than a dozen such planets seen in actual telescopic images."

astroengine writes "In October 2014 and again February 2016 Proxima Centauri, the closest star system to our Solar System, will pass in front of two distant stars allowing astronomers a rare opportunity to use Einstein's General Relativity to potentially detect hidden exoplanets around the star system. As Proxima Centauri blocks the distant starlight from our perspective, the gravitational field will bend the distant light to create a microlensing event. The transient brightening can then be analyzed and the gravitational presence of any worlds may be revealed. The research, announced Monday at the American Astronomical Society meeting in Indianapolis, has been submitted for publication in the Astrophysical Journal."

ananyo writes "Researchers have shown for the first time that the act of mating induces permanent chemical modifications in the chromosomes (epigenetic changes), affecting the expression of genes that regulate sexual and monogamous behavior in prairie voles. Prairie voles have long been of interest to neuroscientists and endocrinologists who study the social behavior of animals, in part because this species forms monogamous pair bonds — essentially mating for life. The voles' pair bonding, sharing of parental roles and egalitarian nest building in couples makes them a good model for understanding the biology of monogamy and mating in humans (abstract)."

First time accepted submitter Maxime Perrotin writes "Following the successful past two editions of SOCIS, the European Space Agency is pleased to announce the launch of the 2013 edition of its Summer of Code in Space. The project is now open for mentoring organizations to submit project proposals until the 20th of June. Projects have to be open-source/free software; students who participate can get up to 4000€ if the project is achieved."

CowboyRobot writes "This week NASA kicks off its second Sample Return Robot Challenge, in which teams compete for a chance to win $1.5 million. Participants must demonstrate a self-operated robot capable of locating and collecting geologic samples from diverse terrain. Eleven teams from the U.S. and overseas gather for the challenge from June 5 through 7 at the Worcester Polytechnic Institute (WPI) in Worcester, Mass. The Sample Return Robot competition is part of NASA's Centennial Challenges program launched by the Space Technology Mission Directorate, which develops and tests hardware for use in NASA's future missions. NASA said the goal of the challenge is to encourage innovation in autonomous navigation and robotics technologies, which the agency could potentially use to explore a "variety of destinations in space" and in "industries and applications on Earth.""

antdude writes "A British Medical Journal (BMJ) research report says that 'Surgeries on Friday Are More Frequently Fatal ... compared to those who opt for really bad Mondays, Britons who have a planned surgery on a Friday are 44 percent more likely to die. And the few patients who had a leisurely weekend surgery saw that number jump to 82 percent. The skeleton staff working on weekends might be to blame.'"

adeelarshad82 writes "Researchers at the University of Illinois at Urbana-Champaign (UIUC) have determined the precise chemical structure of the HIV 'capsid,' a protein shell that protects the virus's genetic material and is a key to its virulence. The experiment involved mapping an incredible 64 million atoms to simulate the HIV capsid, pictured here. Interestingly no current HIV drugs target the HIV capsid and researchers believe that understanding the structure of the HIV capsid may hold the key to the development of new and more effective antiretroviral drugs. What makes this whole experiment even more fascinating is the use of Blue Waters, a Cray XK7 supercomputer with 3,000 Nvidia Tesla K20X GPU accelerators."

coondoggie writes "NASA wants to test out 3-D printing technology onboard the International Space Station to find out if the technology could be used to manufacture parts in space." NASA may not be creating any production parts this way for a long time yet, but they've got to start somewhere.

A virus that has so far killed nearly thirty people in seven countries faces a non-medical obstacle to treatment: Patents. Reader Presto Vivace writes with this excerpt from the Council on Foreign Relations: "At the center of the dispute is a Dutch laboratory that claims all rights to the genetic sequence of the Middle East Respiratory Syndrome coronavirus [MERS-CoV]. Saudi Arabia's deputy health minister, Ziad Memish, told the WHO meeting that "someone"--a reference to Egyptian virologist Ali Zaki--mailed a sample of the new SARS-like virus out of his country without government consent in June 2012, giving it to Dutch virologist Ron Fouchier of Erasmus Medical Center in Rotterdam."

An anonymous reader writes " A Wyoming high school student who built a nuclear reactor in his dad's garage was disqualified from the International Science and Engineering Fair this month on a technicality.' His crime: competing in too many science fairs."

Zothecula writes "Imagine if there was a voice in your head that regularly threatened to harm you or your loved ones, or that even ordered you to do so yourself. Awful as that would be, such auditory hallucinations are one of the most common symptoms of schizophrenia, with approximately one in four sufferers continuing to experience them even after taking anti-psychotic drugs. Fortunately, scientists have recently helped some schizophrenics gain control of their condition, by turning those voices into interactive avatars."

Rambo Tribble writes "As reported by the BBC, astronomers are hoping to reap a black-hole-hunting windfall when a giant gas cloud passes through an area within our galaxy thought to contain numerous small black holes (abstract). When the cloud interacts with the black holes, the resultant emission of X-rays should allow scientists to finally confirm their existence. 'The idea is that as the cloud speeds past these small black holes — some slightly more massive than our Sun but just a few tens of km across — gas will spiral around them faster and faster, heating up to millions of degrees and emitting X-ray light. It is a bit like allowing a giant sink to empty through thousands of tiny drains and looking for any evidence of swirling water.'"

An anonymous reader writes "Asteroid 1998 QE2 has an estimated diameter of 2.7 km. This asteroid will have a close approach with Earth at about 15.2 LD (Lunar Distances = ~384,000 kilometers) or 0.0392 AU (1 AU = ~150 million kilometers) at 2059 UT on 2013 May 31 and it will reach the peak magnitude ~10.8 on May 31 around 2300 UT." Radar images of the asteroid taken Wednesday show that 1998 QE2 has its own tiny moon, about 600 meters wide. Phil Plait explained how the images were taken, and what further information we gleaned from them. 'The very presence of the moon is a good thing. By measuring how long it takes to go around the primary, the mass of the primary can be found using math known for centuries (the more massive the big asteroid, the faster the moon will go around it at a given distance). We also know the size of the primary, so that means we can find its density, and therefore what it’s made of (probably mostly rock).'

AvailableNickname writes "I am currently pursuing a bachelor's in CompSci and I just spent three hours working on a few differential equations for homework. It is very frustrating because I just don't grok advanced math. I can sort of understand a little bit, but I really don't grok anything beyond long division. But I love computers, and am very good at them. However, nobody in the workforce is even going to glance at my direction without a BSc. And to punish me for going into a field originally developed by mathematicians I need to learn all this crap. If I had understood what I was doing, maybe I wouldn't mind so much. But the double frustration of not understanding it and not understanding why the heck I need to do it is too much. So, how important is it?"

An anonymous reader writes "A new study based on observations last September by the Curiosity rover on Mars has confirmed that pebble-containing slabs of rock found on the Martian surface were part of an ancient streambed. The work provides some of the most definitive evidence yet that water once flowed on Mars. '[The pebbles'] smooth appearance is identical to gravels found in rivers on Earth. Rock fragments that bounce along the bottom of a stream of water will have their edges knocked off, and when these pebbles finally come to rest they will often align in a characteristic overlapping fashion. ...It is confirmation that water has played its part in sculpting not only this huge equatorial bowl but by implication many of the other landforms seen on the planet.' According to NASA, 'The stream carried the gravels at least a few miles, or kilometers, the researchers estimated. The atmosphere of modern Mars is too thin to make a sustained stream flow of water possible, though the planet holds large quantities of water ice. Several types of evidence have indicated that ancient Mars had diverse environments with liquid water. However, none but these rocks found by Curiosity could provide the type of stream flow information published this week. Curiosity's images of conglomerate rocks indicate that atmospheric conditions at Gale Crater once enabled the flow of liquid water on the Martian surface.'"

redletterdave writes "In trying to solve the 'mechanical mismatch' between humans and electronics — particularly wearables — special projects chief Regina Dugan unveiled two new projects currently in development at Google's Motorola Mobility centered on rethinking authentication methodology, including electronic tattoos and ingestible pills. Of the pill, which Dugan called her 'first superpower,' she described it as an 'inside-out potato battery' that when swallowed, the acids in one's stomach serve as the electrolyte to power an 18-bit ECG-like signal that essentially turns one's body into an authentication token. 'It means my arms are like wires and my hands are like alligator clips [so] when I touch my phone, my computer, my door, I'm authenticated,' Dugan said. 'This is not science fiction.'"

Necroloth sends this quote from an article at Wired: "For the first time, scientists have visually captured a molecule at single-atom resolution in the act of rearranging its bonds. Until now, scientists were only able to infer molecular structures. Using atomic force microscopy (abstract), the individual atomic bonds that connect the carbon molecule's 26 carbon and 14 hydrogen atoms are clearly visible and look startlingly similar to the stick diagrams in chemistry textbooks."

schwit1 writes "Parents in Polk County, Florida are outraged after learning that students in area schools had their irises scanned as part of a new security program without obtaining proper permission. Two days before their Memorial Day weekend break, kids from at least three different public schools — Bethune Academy (K–5), Davenport School of the Arts (K–5, middle, and high school), and Daniel Jenkins Academy (grades 6–12) — were subjected to iris scans without their parents' knowledge or consent. The scans are essentially optical fingerprints, which the school intended to collect to create a database of biometric information for school-bus security."