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Submission + - Scientists strip zebrafish of their stripes (washington.edu)

vinces99 writes: Within weeks of publishing surprising new insights about how zebrafish get their stripes, the same University of Washington group is now able to explain how to “erase” them. The findings – the first published Aug. 28 in Science and the latest in the Nov. 6 issue of Nature Communications – give new understanding about genes and cell behaviors that underlie pigment patterns in zebrafish that, in turn, could help unravel the workings of pigment cells in humans and other animals, skin disorders such as melanoma and cell regeneration.

“Using zebrafish as a model, we’re at the point where we have a lot of the basic mechanisms, the basic phenomenology of what’s going on, so we can start to look at some of these other species that have really different patterns and start to understand them,” said David Parichy, a UW professor of biology and corresponding author on both papers.

Zebrafish, a tropical freshwater fish about 1.5 inches long, belongs to the minnow family and is a popular addition to home aquariums. Adults have long horizontal blue stripes on their sides, hence the reference to “zebra.” These patterns have roles in schooling, mate selection and avoiding predators. Given their importance, scientists have long wanted to know where these pigment cells come from and how they make stripes and other arrangements.

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Scientists strip zebrafish of their stripes

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