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Science

Submission + - Robot brings patch-clamping to the masses (nature.com)

scibri writes: Robots designed to perform whole-cell patch-clamping, a difficult but powerful method that allows neuroscientists to access neurons' internal electrical workings, could make the tricky technique commonplace.

Scientists from MIT have designed a robot that can record electrical currents in up to 4 neurons in the brains of anaesthetized mice at once, and they hope to extend it to up to 100 at a time. The robot finds its target on the basis of characteristic changes in the electrical environment near neurons. Then, the device nicks the cell’s membrane and seals itself around the tiny hole to access the neuron's contents.

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Robot brings patch-clamping to the masses

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