New Research Reveals the Circadian Clock Influences Cell Growth, Metabolism, and Tumor Progression (phys.org) 19
An anonymous reader quotes a report from Phys.Org: In a new University of California, Irvine-led study, researchers define how the circadian clock influences cell growth, metabolism and tumor progression. Their research also reveals how disruption of the circadian clock impacts genome stability and mutations that can further drive critical tumor-promoting pathways in the intestine. In this study, researchers found that both genetic disruption and environmental disruption of the circadian clock contribute to the mutation of the adenomatous polyposis coli (APC) tumor suppressor, which is found in the vast majority of human colorectal cancers (CRC). APC point mutations, deletions, and loss of heterozygosity (LOH) events have been reported in approximately 80 percent of human CRC cases, and it is these mutations that drive the initiation of intestinal adenoma development.
"As a society, we are exposed to several environmental factors that influence our biological clock, including night shift work, extended light exposure, changes in sleep/wake cycles and altered feeding behavior," said Selma Masri, Ph.D., assistant professor of biological chemistry at UCI School of Medicine. "Strikingly, we have seen an alarming increase in several young-onset cancers, including colorectal cancer. The underlying cause of this increased incidence of cancer in adults in their 20s and 30s remains undefined. However, based on our findings, we now believe that disruption of the circadian clock plays an important role." The study has been published in the journal Science Advances.
"As a society, we are exposed to several environmental factors that influence our biological clock, including night shift work, extended light exposure, changes in sleep/wake cycles and altered feeding behavior," said Selma Masri, Ph.D., assistant professor of biological chemistry at UCI School of Medicine. "Strikingly, we have seen an alarming increase in several young-onset cancers, including colorectal cancer. The underlying cause of this increased incidence of cancer in adults in their 20s and 30s remains undefined. However, based on our findings, we now believe that disruption of the circadian clock plays an important role." The study has been published in the journal Science Advances.
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It won't be the disruptions to the clock per se (Score:2)
It'll be the stress of still putting in a full days work with those disruptions.
TL;DR version (Score:5, Funny)
Doubt it (Score:2)
Rotating/alternating shift work is the real killer.
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Daylight Saving Time Causes Cancer
But only in California.
Have a constituent schedule (Score:3)
https://www.youtube.com/watch?... [youtube.com]
Get up at the same time 7 days a week
Get sunlight in the first hour after waking
No caffeine after 2pm
Turn off the indoor bright lights at 8pm
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Great... (Score:2)
So not only do I get to live with being constantly tired, I can also look forward to it killing me "before my time".
Granted, if I can make it to my kids growing into adults, it might be a welcome relief.
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id happily go back to the caveman era and have to fight for every meal and die at 30
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id happily go back to the caveman era and have to fight for every meal and die at 30
Despite our profligate advances in convenience, entertainment, and long-tail EOL longevity, readings of history and classical literature do not seem to suggest that this brave new world of ours is in fact happier, more meaningful, or more fulfilling for the creatures born into it, than subsistence hunter-gatherer tribespeople.
This is especially true with regard to the destruction of labor as something you do continuously, integrated into your everyday life and social relationships, which has been replaced b
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i thought the die at 30 bit made it obvious but i dont want to go back to that time tl;dr sarcasm
In other words, get off your damn phone (Score:4, Interesting)
Pray tell, what group is most glued to their phones for a multitude of hours each day, including late into the night? And what group is next in line for staring at their screens [cnn.com]?
Yeah, yeah, correlcation doesn't equal causation, but damn, the evidence is strong.
A destructive spiral (Score:2)
Altered work/sleep schedues means altered meal-times, which is a destructive spiral for the metabolism of many people. Work was the biggest killer, either directly or through the physical/mental health consequences. The policy to make work less dangerous, means people are surviving long-enough to make ill-health a pandemic among older workers. But governments are demanding we keep working until we're 70 while older workers can no longer fit into shift-work or a 8-hour day.