Nanoparticles Heated By Radio Waves Switch On Genes In Mice

ananyo writes "Researchers have used radio waves to remotely activate engineered insulin-producing genes in mice. In the long term, the work could lead to medical procedures in which patients' genes are triggered on demand. The researchers coated iron oxide nanoparticles with antibodies that bind to a modified version of a temperature-sensitive ion channel. They injected these particles into tumors grown under the skins of mice, then heated the nanoparticles with low-frequency radio waves. The nanoparticles heated the ion channel, activating it and allowing calcium to flow into cells. The influx of calcium switched on an engineered calcium-sensitive gene that produces insulin (abstract)."