Scientists Change Our Understanding of How Anaesthesia Messes With the Brain ( 92

schwit1 shares a report from ScienceAlert: It's crazy to think that we still don't quite understand the mechanism behind one of the most common medical interventions -- general anaesthetic. But researchers in Australia just got a step closer by discovering that one of the most commonly used anesthetic drugs doesn't just put us to sleep; it also disrupts communication between brain cells. The team investigated the drug propofol, a super-popular option for surgeries worldwide. A potent sedative, the drug is thought to put us to sleep through its effect on the GABA neurotransmitter system, the main regulator of our sleep-and-wake cycles in the brain. But anyone who's been "put under" will know that waking up from a general anesthetic feels rather different from your usual morning grogginess. On top of that, some people can experience serious side-effects, so scientists have been trying to figure out what else the drugs might be doing in the brain.

Using live neuron cell samples from rats and fruit flies, the researchers were able to track neurotransmitter activity thanks to a super-resolution microscope, and discovered that propofol messes with a key protein that nerve cells use to communicate with each other. This protein, called syntaxin1A, isn't just found in animal models - people have it, too. And it looks like the anesthetic drug puts the brakes on this protein, making otherwise normal brain cell connections sluggish, at least for a while. The researchers think this disruption could be key to how propofol allows for pain-free surgery to take place - first it knocks us out as a normal sleeping pill would, and then takes things up a notch by disrupting brain connectivity.
The research has been published in Cell Reports.

Apple Health Data Is Being Used As Evidence In a Rape and Murder Investigation ( 185

An anonymous reader quotes a report from Motherboard: Hussein K., an Afghan refugee in Freiburg, has been on trial since September for allegedly raping and murdering a student in Freiburg, and disposing of her body in a river. But many of the details of the trial have been hazy -- no one can agree on his real age, and most notably, there's a mysterious chunk of time missing from the geodata and surveillance video analysis of his whereabouts at the time of the crime. He refused to give authorities the passcode to his iPhone, but investigators hired a Munich company (which one is not publicly known) to gain access to his device, according to German news outlet Welt. They searched through Apple's Health app, which was added to all iPhones with the release of iOS 8 in 2014, and were able to gain more data about what he was doing that day. The app records how many steps he took and what kind of activity he was doing throughout that day. The app recorded a portion of his activity as "climbing stairs," which authorities were able to correlate with the time he would have dragged his victim down the river embankment, and then climbed back up. Freiburg police sent an investigator to the scene to replicate his movements, and sure enough, his Health app activity correlated with what was recorded on the defendant's phone.

New Ingestible Pill Can Track Your Farts In Real Time ( 76

A group of Australian researchers have developed an ingestible electronic capsule to monitor gas levels in the human gut. "When it's paired with a pocket-sized receiver and a mobile phone app, the pill reports tail-wind conditions in real time as it passes from the stomach to the colon," reports Ars Technica. The invention has been reported in the journal Nature Electronics. From the report: The authors are optimistic that the capsule's gas readings can help clear the air over the inner workings of our intricate innards and the multitudes of microbes they contain. Such fume data could clarify the conditions of each section of the gut, what microbes are up to, and which foods may cause problems in the system. Until now, collecting such data has been a challenge. The capsule is 26mm in length, with a 9.8mm external diameter -- like a large vitamin. Its polymer shell surrounds sensors for temperature, CO2, H2, and O2, as well as a button-size silver oxide battery and a transmission system. One end of the capsule contains a gas-permeable membrane that allows for fast diffusion of gut gases.

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