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Medicine

Gates: Large Epidemics Need a More Agile Response 140

jones_supa writes: Writing in the NY Times about the recent Ebola crisis, Bill Gates says this disease has made the world realize we are not properly prepared to deal with a global epidemic. Even if we signed up lots of experts right away, few organizations are capable of moving thousands of people, some of them infected, to different locations on the globe, with a week's notice. Data is another crucial problem. During the Ebola epidemic, the database that tracks cases has not always been accurate. This is partly because the situation is chaotic, but also because much of the case reporting has been done first on paper.

There's also our failure to invest in effective medical tools like tests, drugs and vaccines. On average, it has taken an estimated one to three days for test results to come back — an eternity when you need to quarantine people. Drugs that might help stop Ebola were not tested in patients until after the epidemic had peaked, partly because the world has no clear process for expediting drug approvals. Compare all of this to the preparation that nations put into defense, which has high-quality mobile units ready to be deployed quickly.
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Gates: Large Epidemics Need a More Agile Response

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    • by Anonymous Coward on Wednesday March 18, 2015 @12:50PM (#49284383)
      Medicine, Motherfucker

      Do you practice it?

      We are a community of motherfucking clinicians who have been humiliated by pseudoscientific quackery for years. Do you know what they call alternative medicine that works? Medicine, Motherfucker.

      We are tired of antivaxxers, homoeopaths, naturopaths, chiropractics, acupuncturists, faith healers, and anyone else getting in the way of Medicine, Motherfucker.

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      Signed,
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      And the Medicinal Motherfuckers.

      • You sound angry. Perhaps some nice Cognitive Behavioral Therapy [wikipedia.org].

        Or just a nap.

    • Yeah, that was my first thought, followed by involuntary cringing. It's sad how something that was supposed to bring hope to developers buckling under the yoke of waterfall development has instead become associated with every unreasonable request made by every airline-magazine reading executive.

  • by Cpt_Kirks ( 37296 ) on Wednesday March 18, 2015 @12:28PM (#49284143)

    I don't think infected individuals should be moved, or at least not moved far.

    The number one concern is to limit contamination, so quarantine should be as absolute as possible.

    Hard hearted? Maybe, but definitely practical.

    • So when they're found in an airport, they should be quarantined there instead of going to, like, a hospital or whatever? Are you going to quarantine an entire flight of people at once in an airport?
      • by Cpt_Kirks ( 37296 ) on Wednesday March 18, 2015 @12:44PM (#49284329)

        As I said, not moved far.

        Take that as "moved as little as possible".

        If they are in a city, move them to the closest hospital IN THAT CITY.

        With the last ebola mess, they were flying obviously infected people all over the place.

        • by ShanghaiBill ( 739463 ) on Wednesday March 18, 2015 @01:07PM (#49284549)

          With the last ebola mess, they were flying obviously infected people all over the place.

          For a disease like ebola, that is no big deal. It is important to keep a grip on reality. There was a lot of scare-mongering over ebola, nearly all of it misplaced. Ebola can easily be stopped dead in its tracks by soap and/or hand sanitizer. It spread in Liberia, Sierra Leone, and (especially) Guinea, because those three countries have basically no health infrastructure, deep mistrust of outsiders, very low literacy, and little understanding of the germ theory of disease. Ebola was never able to gain a foothold in neighboring countries, such as Senegal, Ghana, or Nigeria, which have higher literacy and at least rudimentary health care systems. To think that ebola could spread in first world countries like America, or Europe is not realistic.

          • Exactly this. Ebola was a boon for the media and a disaster for the people involved but it was never a threat to the first or second world.

            Not quite as hard to catch as HIV, but much harder to catch than influenza or measles. A bit aside from Gate's issue which seems to be predicated on some nonsensical idea that these places in deep, dark Africa without even clean (much less running) water, without even soap and without even a concept of the germ theory of disease - much less electronics and computers

      • Re: (Score:3, Insightful)

        by Penguinisto ( 415985 )

        Are you going to quarantine an entire flight of people at once in an airport?

        Not to be a heartless dick, but it's not that hard to do if someone shows symptoms en route. The airplane is a somewhat sealed metal tube, and an airport has a lot of acreage that can park that plane out far enough away from everyone else....

        • by itzly ( 3699663 )

          Depends on the symptoms. Are you going to quarantine an entire flight when a passenger has a fever or is throwing up ?

          • by ShanghaiBill ( 739463 ) on Wednesday March 18, 2015 @01:26PM (#49284807)

            Depends on the symptoms. Are you going to quarantine an entire flight when a passenger has a fever or is throwing up ?

            No, because you are not going to know about it. What possible incentive does a stewardess have to report that illness, when she knows that she will be quarantined along with the passengers, and possibly left to die on a sealed airplane? The problem with draconian solutions is that they incentivize counter-productive behavior.

            • by itzly ( 3699663 )

              My question was a rhetorical one, but since it got moderated "-1 don't understand", I'll rephrase it in a more direct way.

              Not to be a heartless dick, but it's not that hard to do if someone shows symptoms en route

              The problem is that most symptoms that are developed en route are going to be simple things like a fever or vomiting. These aren't clear enough to be recognized as a symptom of a dangerous disease. Taking a blood or mucus sample, and running a real test could take hours, if not days, and that's too long to keep a plane full of people waiting.

              • by jedidiah ( 1196 )

                Running a real test will not "take days". However, a blood test may not be helpful for days. The last doctor we imported for treatment was like this. Despite the fact that he was starting to exhibit symptoms, blood tests didn't indicate he had Ebola.

                Properly quarantining people is problematic enough when it's just one obnoxious nurse. Forget about an entire plane full of entitled 1st worlders.

                • Add to that the fact that with most infectious diseases, the symptoms that would make it evident that they are ill are unlikely to manifest just on the flight. Most of the time, there's a gestation period of a few days to a week before the person who caught shows symptoms, and in some cases they can pass it on before they become symptomatic.

                  That's the biggest problem with relying on quarantine. Either you always quarantine every incoming international flight until you make sure that no one on board has som

    • by Penguinisto ( 415985 ) on Wednesday March 18, 2015 @12:42PM (#49284301) Journal

      Agreed.

      While yes, the act of moving someone to an advanced care facility would be preferable for the person involved, I would counter that maybe, just maybe, that advanced care facility (or as much of it as possible) should be relocated to where the infected are. The absolute last thing you want to do is to start flying infected people outside of the infection zone to other places.

      I already know the problems presented: The infected area is usually in some third-world shithole with little-to-no infrastructure, much of the equipment is big, heavy, and expensive, etc... but much of it can be made portable with sufficient engineering, and a good chunk of it doesn't even have to be brought along, or can be minimized (e.g. the ventilation/filtering systems that the centers here have to keep quarantine).

      If Bill Gates wants to do something with all that cash, maybe he can hire a few engineers an medical types to build a deployable care center that can be flown out to $3rdWorldShitHole in less than 24 hours, and be put to use immediately when an epidemic strikes. Hell, build a bunch of them, include a big pile of needed supplies with each, then pre-position them in or near areas that are most likely to see recurring epidemics.

      • a deployable care center that can be flown out to $3rdWorldShitHole in less than 24 hours, and be put to use immediately when an epidemic strikes. Hell, build a bunch of them, include a big pile of needed supplies with each, then pre-position them in or near areas that are most likely to see recurring epidemics.

        This is exactly what the summary is talking about. We have "high-quality mobile units ready to be deployed quickly" for military but
        we don't have the equivalent on the medical side. It was insane that we did not have deployable quarantine units that could be sent to
        the location so instead we attempted to fly them to a quarantine unit elsewhere. To add to the insanity, the only plane that was
        capable of transporting an ebola patient could only transport ONE passenger at a time. I'm pretty sure that's the

        • You do realize that Medicine Without Borders was able to contain the Ebola epidemic with not much beyond plastic sheets, gloves, goggles and bleach. If they had a couple of C17's with pallets of that stuff and the buy in from locals who are still stuck in a witchcraft-based culture they could have done much better. High tech pods really weren't needed.

          Pretty much all of the epidemic infectious diseases can be treated similarly. What is needed is a long term commitment to the issue and some way to get th

          • That's the point everyone keeps missing. We don't need some high tech pod with a billion circuits and electronics, we need modular low-tech pods with diesel generators, solar panels, and sanitation facilities. People keep trying to throw technology at places like Africa... this isn't star trek. We don't have replicators and magic wave-this-to-fix-it beams that can maintain high tech stuff without any local support infrastructure. Anything going to something like the Ebola outbreak needs to be fixable with d

      • I already know the problems presented: The infected area is usually in some third-world shithole with little-to-no infrastructure, much of the equipment is big, heavy, and expensive, etc... but much of it can be made portable with sufficient engineering, and a good chunk of it doesn't even have to be brought along, or can be minimized (e.g. the ventilation/filtering systems that the centers here have to keep quarantine)

        If Bill Gates wants to do something with all that cash, maybe he can hire a few engineers

      • by mspohr ( 589790 )

        I think they should model it on the Red Cross which has extensive protocols for equipment and people to respond to a disaster. They also have pre-positioned supplies in areas where they have a likelihood of disaster.
        The WHO is not prepared or organized to do this but the Red Cross (just down the street in Geneva) is so perhaps the WHO could take a walk down the hill and learn from them.

    • The number one concern is to limit contamination, so quarantine should be as absolute as possible.

      Many health professionals think this is one of the dumbest things you can do. Strict quarantine policies discourage people from reporting infections, and cause people to flee at the first sign of trouble, so they can get out before the quarantine cordon is in place. During the ebola outbreak, some quarantines were imposed, and, in hindsight, they are regarded as a mistake. As people flee, they are crammed onto crowded buses, deprived of sleep, exposed to the weather, and dispersed far away from the healt

      • by moeinvt ( 851793 )

        Interesting. I was not aware that there was a debate about the practice of quarantine. The idea of "moving" infected, or possibly infected people certainly seems counter-intuitive.

        • Interesting. I was not aware that there was a debate about the practice of quarantine.

          You didn't hear about the political backlash over the NY and NJ quarantines, that were imposed to deal with the zero infections that occurred there?

          The idea of "moving" infected, or possibly infected people certainly seems counter-intuitive.

          They idea that broad and draconian quarantines cause more people to move, also seems counter-intuitive, but it is true. Limited quarantines of actually infected people, that are being effectively treated, usually makes sense. Going beyond that is generally counter-productive.

          The best way to stop ebola is soap, not draconian quarantines.

  • ebola (Score:5, Insightful)

    by itzly ( 3699663 ) on Wednesday March 18, 2015 @12:31PM (#49284167)

    The major reason why ebola was able to grow was simply poor basic health care practices in some countries. Simple rules, like not touching dead or sick people, and washing your hands regularly would have helped a lot more than "databases" and "global warning and response systems".

    • Re: (Score:2, Troll)

      by moeinvt ( 851793 )

      Washing hands? These primitive savages still haven't figured out that you should keep human waste in a central location far away from your water supply and that you shouldn't bathe in water that you're later planning to drink.

    • Simple rules like not touching dead people or sick people? Simple rules, like not touching dead or sick people, and washing your hands regularly would have helped a lot more than "databases" and "global warning and response systems.

      It is not reasonable to expect people to not touch dead or sick people and it is absurd to think that proper hand washing would prevent the transmission of Ebola. Ebola is primarily a caregivers disease because the people most likely to get it are those caring for someone near t

      • by itzly ( 3699663 )

        It is not reasonable to expect people to not touch dead or sick people

        If the consequence is that you'll catch the disease and end up with a serious chance of dying yourself, it's a very reasonable request. And when people refuse to follow such basic advice, there's little hope that a "global warning and response systems" can save them.

      • by khallow ( 566160 )

        It is not reasonable to expect people to not touch dead or sick people and it is absurd to think that proper hand washing would prevent the transmission of Ebola.

        Sure, it's reasonable. And proper hand washing doesn't have to completely prevent transmission, it just has to help reduce new transmissions to below the point where exponential growth in infections occurs. Through these means, exponential growth of Ebola has ceased in West Africa.

  • Not to mention all the coverups and stupid mistakes being made. Is there no SOP for all of this?
    • Probably not. Consider that most countries in Africa are run by some very corrupt mofos, up until recently Ebola was something that only happened in some isolated village, and logistics can be a nightmare when the port/airport authorities all want bribes before they allow you to bring your stuff in past their little checkpoints...

  • He clearly suggested spending less on Defense Dept and more on socialist anarchist anti-American [[sarcasm]] !

    We can't have that now, can we?

  • "partly because the world has no clear process for expediting drug approvals."

    The vast majority of drugs should be fast track. The number of deaths that occur with letting a drug out early (before full problems are realized) is vastly smaller than the numbers of deaths that occur because drugs are held up ten years.

    The FDA is built on a mathematically false premise. But you konw, a dead guy from some drug, boy can those politicians decry "unconscionable profits".

    How many are standing up to decry the ten

    • There are times that a drug looks promising in small trials, but after larger trials, shows no significant benefit. Premature release means a lot of waste AND a lot of people who will have a false sense of security. Then there's DES (Diethylstilbestrol) and Thalidomide ...
      • by gewalker ( 57809 )

        DES was approved by the FDA, so clearly the FDA was not helpful in preventing the drug from reaching the market.

        Thalidomide was not approved by the FDA primarily due to bureaucratic delay. While the FDA doctors would not approve it as they were waiting for evidence it was safe and effective, they would have approved it eventually were it not for the birth defects that starting showing up in other countries. Drug testing protocols simply did not test pregnant women. I.e., the US was largely spared thalidomid

  • One way to be more agile is to have more hospitals, equipment, and trained acute care physicans and nurses available to respond. It is much easier to have digital record systems if you have properly equiped hospitals and clinics that are connected to each other. Every nation should have properly equiped hospitals and on-site training programs—facilities that can emergency and critical care type situations, as well as mortuaries. Here are a couple of quotes from a recent article [lrb.co.uk] by Paul Farmer, one of the founders of Partners in Health [pih.org] that explains a little about the health systems of countries in West Africa:

    Both nurses and doctors are scarce in the regions most heavily affected by Ebola. Even before the current crisis killed many of Liberia’s health professionals, there were fewer than fifty doctors working in the public health system in a country of more than four million people, most of whom live far from the capital. That’s one physician per 100,000 population, compared to 240 per 100,000 in the United States or 670 in Cuba. Properly equipped hospitals are even scarcer than staff, and this is true across the regions most affected by Ebola. Also scarce is personal protective equipment (PPE): gowns, gloves, masks, face shields etc. In Liberia there isn’t the staff, the stuff or the space to stop infections transmitted through bodily fluids, including blood, urine, breast milk, sweat, semen, vomit and diarrhoea. Ebola virus is shed during clinical illness and after death: it remains viable and infectious long after its hosts have breathed their last. Preparing the dead for burial has turned hundreds of mourners into Ebola victims.

    He concludes the article stating:

    Fifth, formal training programmes should be set up for Liberians, Guineans and Sierra Leoneans. Vaccines and diagnostics and treatments will not be discovered or developed without linking research to clinical care; new developments won’t be delivered across West Africa without training the next generation of researchers, clinicians and managers. West Africa needs well-designed and well-resourced medical and nursing schools as well as laboratories able to conduct surveillance and to respond earlier and more effectively. Less palaver, more action.

  • I think we should let them run their course. There are too many people here as it is.
  • by ilsaloving ( 1534307 ) on Wednesday March 18, 2015 @01:12PM (#49284617)

    We will never be prepared for a global epidemic as long as anti-scientific morons are able to influence and/or dictate policy.

    For example: The vaccination efforts of the last century have effectively been wiped out thanks to the idiotic anti-vaxxer movement, causing measles cases to surge, and are continuing to increase. I'm planning on talking to my doctor about the possibility of a measles booster just to keep my family safe.

    And then there's the whole Thimerosol thing, which single-handedly destroyed our ability to easily distribute vaccines en masse. All because some assholes with zero chemistry knowledge freaked out because there was a mercury atom in the molecule. It doesn't occur to these people that if they took common table salt and consumed their component elements, your body would dissolve, punctuated by explosions.

    So no, I expect that we are going to see more and more small epidemics of various diseases, and it's probably going to get significantly worse, all thanks to uneducated morons who think their ignorance has the same weight as hard-won knowledge.

  • Deploying any kind of sizable mobile force (military or otherwise) takes months. The ebola epidemic had pretty much run it's course by then.
  • With the help of Microsoft Surface Tablets running Microsoft Windows, connected to Microsoft Windows Servers and running Microsoft Windows Apps will fix everything, trust Bill, just spend the money and he will magically fix everything....

  • "...few organizations are capable of moving thousands of people, some of them infected, to different locations on the globe"

    Why in the hell would you want to move infected people to different locations on the globe? Furthermore, why would you move '1000's of people together when some of them might be infected? Putting a few sick people on a crowded bus or a plane is a great way to spread disease.

    The typical response to a disease outbreak is quarantine because you want to keep the infection localized and

    • by Anonymous Coward

      To spread the disease. He has already managed to get the virus "Windows" onto almost every PC -- for this he has also shipped thousands of infected CD-ROMS across the globe.
      Now his next target are humans.

  • Is this article little more than more self-promotion in yet another attempt by Mr. Gates to have history view him in a better light?
  • The US recently paid a scrapper 1 cent to cut up a retired aircraft carrier for scrap. Just imagine the resources you could pack onto an aircraft carrier. Fully staffed and outfitted hospital, housing, power generation, decon facilities, communications, transportation. It doesn't even have to be self-powered - it could be towed to where it's needed. What a waste.
    • by MrL0G1C ( 867445 )

      I bet the maintenance(and fuel) cost of an aircraft carrier is 10x what is would cost to set up and maintain emergency sites in 99.9% of the world.

    • by jedidiah ( 1196 )

      A towed mega boat. Not the most efficient means of travel. Certainly not something you want to wait on when you are trying to get ahead of something quickly.

  • Speaking of epidemics, there is that HIV epidemic in Africa. And how does the Gates Foundation help? By promoting male genital mutilation, aka circumcision -- which is damn well proven to be completely useless to prevent HIV infections. [circumstitions.com]

    • by MrL0G1C ( 867445 )

      And he's a giant hypocrite, he invests his money into bad companies that f**k the world up and then acts the saint trying to make the world a better place with the interest.

    • by mspohr ( 589790 )

      Your circumstitions.com website belongs with the anti-vaxers and flat earth societies.
      Please, try a Google search and pick a reputable web site such as this:
      http://www.who.int/hiv/topics/... [who.int]
      From the WHO:
      "There is compelling evidence that male circumcision reduces the risk of heterosexually acquired HIV infection in men by approximately 60%. Three randomized controlled trials have shown that male circumcision provided by well trained health professionals in properly equipped settings is safe. WHO/UNAIDS reco

      • Now here [circumstitions.com] is an explanation of why that study is simply worthless, why that "60%" number is meaningless, and how, even if it was absolutely correct, it would mean 56 circumcisions would be necessary to prevent a single case of HIV infection, and it would still fail to prevent another case -- whereas giving everyone condoms instead would have prevented both cases.

  • As much as I hate to agree with Bill Gates, I do think we could do a better job when it comes to handling epidemics.

    BTW, a "global epidemic" is called a pandemic, but perhaps that's splitting hairs.

    Anyway, an epidemic can turn into a pandemic pretty quickly these days, so we need to be more nimble.

  • >> few organizations are capable of moving thousands of people, some of them infected, to different locations on the globe,

    Isn't that a good thing? I mean Quarantining is a good idea right?

  • Narcissism and sociopathy are probably the most harmful diseases currently known to man, leading directly to wholesale slaughter, destruction of the environment, rampant poverty, etc. The sooner that we can put people like the referenced into a controlled medicated environment where they can no longer have such a negative affect on the world the better.

  • Microsoft Windows. Solve that (AKA Linux bug #1) and the world will be a better place.

  • Longer piece [nejm.org] on same topic for different audience in the New England Journal of Medicine.

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