Long-Lasting Enzyme Chews Up Cocaine

MTorrice (2611475) writes "Despite cocaine's undeniable destructiveness, there are no antidotes for overdoses or medications to fight addiction that directly neutralize cocaine's powerful effects. A natural bacterial enzyme, cocaine esterase, could help by chopping up cocaine in the bloodstream. But the enzyme is unstable in the body, losing activity too quickly to be a viable treatment. Now, using computational design, researchers tweaked the enzyme (full paper, PDF) to simultaneously increase stability and catalytic efficiency. Mice injected with the engineered enzyme survive daily lethal doses of cocaine for an average of 94 hours."