Mini-Brains Grown In the Lab 170
fustakrakich sends news that researchers from the Austrian Academy of Sciences have used embryonic stem cells to grow a tiny human brain in a laboratory. The miniature brain, roughly the size of a pea, is at the same level of development as that of a 9-week-old fetus. From the BBC:
"They used either embryonic stem cells or adult skin cells to produce the part of an embryo that develops into the brain and spinal cord - the neuroectoderm. This was placed in tiny droplets of gel to give a scaffold for the tissue to grow and was placed into a spinning bioreactor, a nutrient bath that supplies nutrients and oxygen. The cells were able to grow and organise themselves into separate regions of the brain, such as the cerebral cortex, the retina, and, rarely, an early hippocampus, which would be heavily involved in memory in a fully developed adult brain. The tissues reached their maximum size, about 4mm (0.1in), after two months. The 'mini-brains' have survived for nearly a year, but did not grow any larger. There is no blood supply, just brain tissue, so nutrients and oxygen cannot penetrate into the middle of the brain-like structure."
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Most people have ended up viewing stem cells as a promising way of repairing damaged tissues. But, for many scientists, they're now providing a way of studying mutations and processes that are too difficult to examine any other way. Techniques like organoid formation provide additional tools to make these studies as relevant to human biology as they possibly can be.
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