waderoush writes "At a time of sequesters and shrinking R&D spending, critics are attacking President Obama's proposed Brain Research Through Advancing Innovative Neurotechnologies (BRAIN) initiative, which would have a $100 million budget starting in 2014. But in fact, the project 'runs the risk of becoming a casualty of small-bore thinking in science business, and politics,' argues Xconomy national life sciences editor Luke Timmerman. The goal of the BRAIN initiative is to develop technologies for exploring the trillions of synapses between neurons in the human brain. If the $3 billion Human Genome Project and its even more productive sequel, the $300-million-per-year Advanced Sequencing Technologies program, are any guide, the initiative could lead to huge advances in our understanding of Alzheimer's disease, epilepsy, and consciousness itself. Only government can afford to think this big, argues Timmerman. 'Even though $100 million a year is small change by federal government standards,' Timmerman writes, 'it is enough to create a small market that gives for-profit companies assurance that if they build such tools, someone will buy them. We ought to be talking about how we can free up more money to achieve our neuroscience goals faster, rather than talking about whether we can afford this puny appropriation at all.'"