Hugh Pickens writes "Once feared for its grotesque pustules and 30% death rate, smallpox was eradicated worldwide as of 1978 and is known to exist only in the locked freezers of a Russian scientific institute and the US government. There is no credible evidence that any other country or a terrorist group possesses smallpox, but if there were an attack, the government could draw on $1 billion worth of smallpox vaccine it already owns to inoculate the entire US population and quickly treat people exposed to the virus. The vaccine, which costs the government $3 per dose, can reliably prevent death when given within four days of exposure. David Williams writes that over the last year, the Obama administration has aggressively pushed a $433-million plan to buy an experimental smallpox drug, despite uncertainty over whether it is needed or will work. So why did the government award a "sole-source" procurement to Siga Technologies Inc., whose controlling shareholder is billionaire Ronald O. Perelman, calling for Siga to deliver 1.7 million doses of the drug for the nation's biodefense stockpile at a price of approximately $255 per dose. 'We've got a vaccine that I hope we never have to use — how much more do we need?' says epidemiologist Dr. Donald A. Henderson who led the global eradication of smallpox for the WHO. 'The bottom line is, we've got a limited amount of money.'"