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Science

Researcher Builds Life-Like Cells Made of Metal 259

Sven-Erik writes "Could living things that evolved from metals be clunking about somewhere in the universe? In a lab in Glasgow, UK, one man is intent on proving that metal-based life is possible. He has managed to build cell-like bubbles from giant metal-containing molecules and has given them some life-like properties. He now hopes to induce them to evolve into fully inorganic self-replicating entities. 'I am 100 per cent positive that we can get evolution to work outside organic biology,' says Lee Cronin at the University of Glasgow. His building blocks are large 'polyoxometalates' made of a range of metal atoms — most recently tungsten — linked to oxygen and phosphorus. By simply mixing them in solution, he can get them to self-assemble into cell-like spheres."
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Researcher Builds Life-Like Cells Made of Metal

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  • I for one (Score:3, Funny)

    by Aighearach ( 97333 ) on Thursday September 15, 2011 @03:09AM (#37407138)

    welcome our new polyoxometalate overlords.

  • by mdenham ( 747985 ) on Thursday September 15, 2011 @03:15AM (#37407158)

    Please make sure that these are vulnerable to projectile weaponry. The last time we had to deal with life forms of this sort, it was a real pain.

    Signed,
    Col. Jack O'Neill

  • by gstrickler ( 920733 ) on Thursday September 15, 2011 @03:15AM (#37407160)

    They're coming. Run for you lives.

  • Shameful hype (Score:5, Insightful)

    by Linzer ( 753270 ) on Thursday September 15, 2011 @03:31AM (#37407210)
    This has to be the most overhyped, buzzword-ridden science story I've read in months. As a researcher, I hate to see whatever credibility we have spent on things like this.
  • by gilleain ( 1310105 ) on Thursday September 15, 2011 @03:32AM (#37407214)

    When asked in a talk [ted.com] on this, he claimed that they would have fully replicating matter (IE : 'living' inorganic matter) in 2 years. The host who asked the question sounded startled when he said "That would be, er, something amazing, yes" - in other words "Yeah, right!".

    On the other hand, the lab's publication list is quite impressive, and full of cool looking polygonal structures : http://www.chem.gla.ac.uk/cronin/publications.php [gla.ac.uk]

  • by satuon ( 1822492 ) on Thursday September 15, 2011 @03:50AM (#37407272)
    Without self-replication I wouldn't call them life, evolution can't work without self-replication of some sort.
    • by backslashdot ( 95548 ) * on Thursday September 15, 2011 @04:56AM (#37407494)

      You don't have to have the ability to replicate in order to be alive. For example worker bees can't reproduce, yet they may be considered alive. Also women past menopause and kids are alive yet they can't replicate. Or even some people who many not be fertile for whatever reason.

      Also you can't make "ability" to evolve as part of the definition of life.

    • by Anonymous Coward on Thursday September 15, 2011 @05:00AM (#37407512)

      Viruses can evolve. They can't self-replicate, but use the host's machinery.

      That said, the old "are viruses alive?" debate still goes on...

    • by Your.Master ( 1088569 ) on Thursday September 15, 2011 @05:58AM (#37407748)

      Evolution requires replication, not necessarily self-replication. An earlier poster mentioned viruses, which are an example of a thing, living or not (I'd say not), that evolves without replicating itself.

      Broadly speaking, "human men" and "human women" are each not self-replicating, but the system of "human men and human women" is self replicating. Still, you can speak of features that evolved in women distinctly from men, such as prominent breasts, even though human women in isolation do not self-replicate. So as a gedankenexperiment, imagine you have an imperfect cloning machine and a world of only men (the clones pop out full-grown). This single-sex could use it to replicate indefinitely and evolve. And if those men maintain, repair, and build new cloning machines, then you have a species which doesn't self-replicate by itself, but the species-cloning-machine system is self-replicating, much as the man-woman system is self-replicating. Now you can imagine that no new cloning machines are ever made but the one was built to last a hundred million years. Now there is *no* system that's self-replicating but the men still replicate, with the help of the cloning machine, and therefore still evolve.

      I don't see why evolution would be a requirement of life anyway. Evolution is merely an inescapable consequence of anything which replicates iteratively and imperfectly, whether or not it is life.

      I do know some traditional definitions of life require self-replication, at the species level.

      • by Kamiza Ikioi ( 893310 ) on Thursday September 15, 2011 @09:15AM (#37408604)

        I was about to say the same thing in response to GP. The "self" in self replication does apply, imo, to life, but not to evolution. The meme and the virus are two forms with arguably no "self" replication, just replication.

        However, you did make one general error:

        ...imagine you have an imperfect cloning machine and a world of only men (the clones pop out full-grown). This single-sex could use it to replicate indefinitely and evolve.

        Actually, there is no substantial evolution in cloning. The reason is this. Evolution mainly affects embriology, a step your hypothetical cloning process is bypassing. Also, you are missing the massive gene randomization during creation of the sperm and egg (1/2 of parents genes chosen at random) as well as the shuffling during conception when each 1/2 comes together. Without this step, a clone only mutates by random mutations after this point. Normally, this doesn't get passed on. And in cloning, it doesn't get passed on either.

        With the trillions of cells that "could" mutate (and very few actually do that isn't repaired), you'd have to pick cells that mutated for cloning. What you are talking about is a probability of a mutation (low) and a probability that such a mutation was one of the cells picked to clone (very very low). You would have to introduce artificial low rates of forced mutation to have any chance of evolution with clones. Otherwise, they could go tens of thousands of generations with no change at all, especially if you don't choose new cells each generation, and just work from a batch of original stem cells, which is much more likely. Otherwise, you risk other complications.

        It would simply be impossible for any real evolution to take place. Dawkins covers this in "The Greatest Show on Earth" on why evolution is about changing a recipe, and not a clone or "blueprint".

      • by ceoyoyo ( 59147 ) on Thursday September 15, 2011 @11:14AM (#37409902)

        It's pretty tough to get natural life without evolution. It has to spring forth fully formed. And evolution (as in Darwinian) is not an inescapable consequence. You need to have reasonable levels of mutation, some means of crossing strains and reasonable robustness to both processes.

  • by Lundse ( 1036754 ) on Thursday September 15, 2011 @03:54AM (#37407290)

    Sound like Erewhon [slashdot.org]. Purge the machines that think!

  • Cells, riight (Score:4, Insightful)

    by qbast ( 1265706 ) on Thursday September 15, 2011 @04:04AM (#37407320)
    So he made some 'bubbles' that don't dissolve and can mimic some simplest properties of a cell like porous membrane. Without self-replication it is not cell or anything resembling life and without some way to change and pass those changes onto next generation there can be no evolution. In related news: I took a cardboard box and painted 'screen' and 'keyboard' on it. It totally proves that laptop can be made from cardboard. Of course it does not work, but this is just a little detail that can be worked out later.
    • Re:Cells, riight (Score:5, Informative)

      by Sockatume ( 732728 ) on Thursday September 15, 2011 @05:05AM (#37407532)

      Given that reproducing the properties of the membrane is one of the biggest outstanding problems in the creation of artificial cells, it seems pretty obvious that this is a step forward.

    • Re:Cells, riight (Score:5, Insightful)

      by silentcoder ( 1241496 ) on Thursday September 15, 2011 @05:45AM (#37407684)

      > Without self-replication it is not cell or anything resembling life

      Nobody ever said self replication has to work the same way it does for us. The article does say he found ways for the cells to use other cells as templates for modification and indeed replication.
      It's an interesting approach to replication - as it changes one existing cell into a replica of another, but it's quite feasible. More-over we have no actual idea what the earliest organic structures looked like, or even how they came to exist. There are dozens of viable theories on abiogenesis and none of them are currently provable - for all we know, that is exactly how the earliest replicating life began ! What were we BEFORE we were cells ? Surely we were simpler, more primitive cells with less of the features of current ones, and before that ? Well the mitochondria we have INSIDE our cells were once a seperate organism... now what used to be something alive in it's own right, is just a component of our cells. How many other components of our cells began as seperate, simpler, life form but didn't leave us fossils to conveniently prove it with ?

      This research is in fact incredibly exciting because it shows a way of experimenting with ways early life may have begun. It's using different materials - but that's actually a GOOD thing, as it stops us from trying to just recreate what we have when we don't know what, what we have, used to be. It forces us to think from scratch, as life would have started... and that IS exciting.
      More-over, if it works, if it gets far enough... it opens up entire new avenues of consideration in terms of how life may have evolved on other worlds.

      • by gilleain ( 1310105 ) on Thursday September 15, 2011 @06:18AM (#37407826)

        This research is in fact incredibly exciting because it shows a way of experimenting with ways early life may have begun. It's using different materials - but that's actually a GOOD thing, as it stops us from trying to just recreate what we have when we don't know what, what we have, used to be. It forces us to think from scratch, as life would have started... and that IS exciting.

        Well, you make a better case for his research than he does :)

        Indeed, it is a good idea to have model systems that show the same features, but are not necessarily 'what happened'. They can show the principles are general enough to occur spontaneously with a reasonable probability. Another thing about inorganic cells is they are one of the possibilities for part of the systems in early life. In other words; something had to concentrate the chemicals and simple macromolecules that were starting to form so that they could react efficiently. The synthesis reactions also had to be driven in one direction, which can be done by sorting across a barrier (eg : a cell membrane)

    • by justsayin ( 2246634 ) on Thursday September 15, 2011 @08:15AM (#37408220)
      Have you seen the new Dell laptops? I think they have proven that laptops can damn well be made of cardboard.
    • by MightyMartian ( 840721 ) on Thursday September 15, 2011 @10:08AM (#37409124) Journal

      I've read of some theories that suggests that the earliest kinds of life, before RNA or DNA, may not have self-replicated as we understand it, but may have used external forces, like wave action or turbidity to physically cause cell division. You really have to stretch your mind here and get past a lot of the assumptions we've built up because we live in a world with fully-evolved life forms.

  • by Zandali ( 2440080 ) on Thursday September 15, 2011 @04:12AM (#37407348)
    Self replicating nanobots scare me...but only on this planet. Anywhere else and it's a friggin' miracle.
  • by Viol8 ( 599362 ) on Thursday September 15, 2011 @05:27AM (#37407620) Homepage

    Perhaps *in theory* you could create some system using metals, but in practice in the real world if there was any carbon around in the system than whatever kicks off "life" would be more likely to end up using that simply because of the flexibility it allows and metal based organisms would soon be outcompeted and go extinct. Also its curious to note that his system still requires water.

    Wasn't silicon the carbon alternative a few decades back? Whatever happened to the ideas of alternative life based on that (no, not electronics)?

  • by Hentes ( 2461350 ) on Thursday September 15, 2011 @05:45AM (#37407686)
    What he did was inventing a metal-based soap. Wich is impressive, but very far from life.
  • by paiute ( 550198 ) on Thursday September 15, 2011 @07:36AM (#37408064)
    The threat is not Skynet. The threat is Beakernet.
  • by sl4shd0rk ( 755837 ) on Thursday September 15, 2011 @09:43AM (#37408820)

    Do they know what Tastey Wheat tastes like?

  • by elrous0 ( 869638 ) * on Thursday September 15, 2011 @10:35AM (#37409460)

    Since I first heard Metallica's Kill 'Em All.

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