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Medicine Science

Doctors Baffled, Intrigued By Girl Who Doesn't Age 599

phyrebyrd writes "Brooke Greenberg is the size of an infant, with the mental capacity of a toddler. She turned 16 in January. Brooke hasn't aged in the conventional sense. Dr. Richard Walker of the University of South Florida College of Medicine, in Tampa, says Brooke's body is not developing as a coordinated unit, but as independent parts that are out of sync. She has never been diagnosed with any known genetic syndrome or chromosomal abnormality that would help explain why. Brooke's hair and her nails are the only two things that grow, Howard said. 'She has pajamas and outfits that are 10 or 12 years old,' he said."
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Doctors Baffled, Intrigued By Girl Who Doesn't Age

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  • by cml4524 ( 1520403 ) on Friday June 26, 2009 @10:34AM (#28482191)

    It just struck me reading that... it must really, REALLY suck being the first person to ever have a particular disease.

  • She seems to grow (Score:2, Insightful)

    by guruevi ( 827432 ) on Friday June 26, 2009 @10:40AM (#28482345)

    Just very slowly. In the pictures it looks like features are developing but it's on a very, very slow pace. Maybe she might live to be 400 or 800 if her bone structure will remain supportive over time and her cells don't stop dividing like they do with 'normal' aging. I think the parents might already have tried it but she could probably learn to speak or at least communicate over the years - the brain of a toddler is very open to it (unless her brain plasticity has been aging).

  • Wow...great stuff (Score:5, Insightful)

    by scuba_steve_1 ( 849912 ) on Friday June 26, 2009 @10:40AM (#28482349)
    Wow...that is absolutely amazing...and she is so fortunate to have a family that sees the situation so positively...and who supports related research by the scientific community to see if there is a potential broader benefit here. Frankly, it must be tough for them at times, but I am sure that my wife would *love* it if our little girl never grew up. Thank goodness her sisters are supportive, because they will most likely need to take care of her in the future after her parents advance in age. Great stuff.
  • by SIBM ( 1114319 ) on Friday June 26, 2009 @10:44AM (#28482417)
    What took this so long to hit the media? Must have been a slownewsday
  • by tomhudson ( 43916 ) <barbara,hudson&barbara-hudson,com> on Friday June 26, 2009 @10:48AM (#28482515) Journal

    The article says that her brain has hardly changed at all - it's still an infant's brain. If you read the article, you'll see that the parents and those around her who claim to see changes or improvements in her ability to communicate are projecting their wishes, same as people do with their pets - except that pets CAN grow and learn. Brooke can't.

    Imagine if your brain suddenly never changes. You can never learn a new thing, remember anything from even 5 minutes ago, etc. Before the movie "50 First Dates", there was a sci-fi short story that posited this, with horrifying consequences. It would be the worse than having Alzheimers.

  • by MyLongNickName ( 822545 ) on Friday June 26, 2009 @10:48AM (#28482525) Journal

    Dude. Lay off the weed.

  • by mg127 ( 1074701 ) on Friday June 26, 2009 @10:56AM (#28482699)
    Usually the doctor that "discovers" the disease has it named after him/her.
  • by Anonymous Coward on Friday June 26, 2009 @10:57AM (#28482723)

    Well, from our point of view, it must suck to be that person. But are people with, say, Alzheimer's aware of what they are missing out on? We project our own fear onto those people, and don't realize that it is impossible to know whether or not the afflicted are enjoying life, unaware of their disadvantages.

  • by tomhudson ( 43916 ) <barbara,hudson&barbara-hudson,com> on Friday June 26, 2009 @11:06AM (#28482921) Journal

    I got the sense that she's more like the family pet than a toy ... but yes, it's sad.

    And for all those who downmodded this sort of discussion, it shows more concern with form over function, a lack of understanding about what really makes us human. and/or a knee-jerk reaction to anything that doesn't conform to your initial perception of "don't harm the cute baby." It's not a "cute baby" - it's a grotesque parody of a human, with no potential, no real personality (the brain has not changed since infanthood - she can't talk, and reacts the same as an infant to outside stimuli).

    About the only positive thing to say at this point is that baby diapers are cheaper than Depends.

    Her bones are aging at an almost normal rate, so there's no question of her living to be centuries old, and "just developing slower". Maybe they can transplant the genes into "Chicken Little".

  • by aepervius ( 535155 ) on Friday June 26, 2009 @11:08AM (#28482961)
    Some of her body part , like bone structure, are 10 years old. Thus it sounds doubtful she will reach the multi-centenarian age you cited. They tried to communicate with her , tried to teach her speaking but it failed. Anyway there is a rearrangement of the pharynx/larynx at the venerable age of 1/2 years old which is needed to be able to physically speak. Without it you can't. Maybe a doctor/biologist can chime in.
  • by Fallingcow ( 213461 ) on Friday June 26, 2009 @11:11AM (#28483009) Homepage

    Meh, she'd still accumulate cellular damage and die of cancer eventually. Heart disease would also still be a possibility.

    She'd probably die at 85 of pancreatic cancer or something, but look good doing it.

  • by brian0918 ( 638904 ) <brian0918.gmail@com> on Friday June 26, 2009 @11:13AM (#28483033)
    Right, because the body has no means of correcting cellular damage...
  • by Vahokif ( 1292866 ) on Friday June 26, 2009 @11:17AM (#28483103)
    Why? There's probably a perfectly good evolutionary reason for dying of old age. It's just bad (?) for us as individuals.
  • by marcello_dl ( 667940 ) on Friday June 26, 2009 @11:19AM (#28483171) Homepage Journal

    Old age is a feature, not a bug. With less turn-over it would be difficult to life as a whole to adapt to changing environment. It has drawbacks as knowledge lost by the dead individual. Advanced life forms overcome that with culture.

    Earlier simpler life forms probably lacked the aging feature, and were superseded by others who had it.

  • Comment removed (Score:3, Insightful)

    by account_deleted ( 4530225 ) on Friday June 26, 2009 @11:20AM (#28483177)
    Comment removed based on user account deletion
  • by tonycheese ( 921278 ) on Friday June 26, 2009 @11:20AM (#28483185)
    This idea doesn't seem reasonable. There are definitely many, many disadvantages to being in a vulnerable infant stage for 20 years of your life. Old age isn't good, but not being able to quickly reach a stage where you can fend for yourself is a major problem.
  • by Anonymous Coward on Friday June 26, 2009 @11:20AM (#28483189)

    I think the reason most people don't kill babies is because they are people

  • by goffster ( 1104287 ) on Friday June 26, 2009 @11:21AM (#28483205)

    As a possible fountain of youth.

  • by c6gunner ( 950153 ) on Friday June 26, 2009 @11:21AM (#28483209) Homepage

    A disease, by definition, is something abnormal. Since all living things age and die, she IS abnormal. Saying that all living things are diseased and she's the only normal one would just be silly.

    Of course, the other problem is that she probably IS aging. There's not enough info in the article, and I haven't been able to find any details online, but the story does suggest that parts of her body are aging and developing at different paces. Also, they say that there's nothing unusual about her chromosomes/DNA, meaning, I assume, that the telomeres in her DNA are no different than yours or mine. That would mean that, assuming she doesn't die early from disease or a complication of her condition, she'll probably die at the same age as the rest of us - she just won't develop into an adult first.

  • by mdm-adph ( 1030332 ) on Friday June 26, 2009 @11:22AM (#28483233)

    Meh, she'd still accumulate cellular damage and die of cancer eventually. Heart disease would also still be a possibility.

    She'd probably die at 85 of pancreatic cancer or something, but look good doing it.

    I'd take that deal.

  • by ashtophoenix ( 929197 ) on Friday June 26, 2009 @11:30AM (#28483385) Homepage Journal

    the parents and those around her who claim to see changes or improvements in her ability to communicate are projecting their wishes,

    How are you in a better position to comment on that than the people around her? And what do the people who are saying her brain has hardly changed know? They diagnosed her with brain tumor and a few days later she was declared tumor-free? How much do we know about the brain to comment? I would rather accept what her family and friends are saying based on direct observation rather than statements based on half-knowledge made by ignorant doctors.

  • by GauteL ( 29207 ) on Friday June 26, 2009 @11:30AM (#28483389)

    "Before the movie "50 First Dates", there was a sci-fi short story that posited this, with horrifying consequences"

    It must suck that your example of this is a crappy rom-com with Adam Sandler rather than a brilliant film like Memento [imdb.com].

  • by Cinnaman ( 954100 ) on Friday June 26, 2009 @11:31AM (#28483407)

    Looking through the slideshow, she does appear to be ageing in some ways even if she hasn't changed much physically. If she survived into old age I imagine she still would have wrinkly skin and white hair etc.
    From the information available it looks like rather than not ageing, she hasn't grown up.

  • by Anonymous Coward on Friday June 26, 2009 @11:36AM (#28483477)

    It just struck me reading that... it must really, REALLY suck being the first person to ever have a particular disease.

    What also really, really, REALLY sucks is having to change her diapers for 16 years.

  • by Anonymous Coward on Friday June 26, 2009 @11:37AM (#28483507)

    You don't need a citation to explain shitty parenting.

  • by fuzzyfuzzyfungus ( 1223518 ) on Friday June 26, 2009 @11:38AM (#28483525) Journal
    Many of those "earlier simpler life forms" are still around and doing fine. Bacteria, most notably.
  • Re:Check out TFA (Score:3, Insightful)

    by SnarfQuest ( 469614 ) on Friday June 26, 2009 @11:41AM (#28483573)

    Why isn't there an "insensitive" mod point?

  • Old age is a feature, not a bug. With less turn-over it would be difficult to life as a whole to adapt to changing environment.

    Not necessarily. Older organisms and younger organisms must still compete for the same resources and prove their fitness to survive.

  • by GauteL ( 29207 ) on Friday June 26, 2009 @11:49AM (#28483699)

    "Well, from our point of view, it must suck to be that person. But are people with, say, Alzheimer's aware of what they are missing out on?"

    I take it you have no experience with Alzheimer's.

    Alzheimer's is not instant. It happens over a long period with slow degradation of your memory. During this period, it is very hard on the person it happens to. They realise that something is not right, and they start to struggle with social situations.

    They slowly start loosing grip on their own personality and they see what this is doing to their family and friends, making them even more distressed.

    Even far into the condition, they sometimes have moments of clarity which mostly just serve to remind them of what they have lost.

  • by wrf3 ( 314267 ) on Friday June 26, 2009 @12:25PM (#28484269) Homepage

    I'll take age and treachery against youth and strength any day.

  • Comment removed (Score:4, Insightful)

    by account_deleted ( 4530225 ) on Friday June 26, 2009 @12:38PM (#28484479)
    Comment removed based on user account deletion
  • by Anonymous Coward on Friday June 26, 2009 @01:06PM (#28484991)

    The cause is the fact that selective pressure decreases with age on account of mishaps associated with being alive. For example, after 10 years, a fly not subject to old age will have a far greater chance of being eaten by a spider than a 10-day old fly, so whatever genes allowed the former to live that long are most likely already lost.

    A 10-year-old fly is more likely to be eaten than a 10-day-old fly? I would expect the odds to be, at the very least, the same. If we're talking about entities capable of learnnig from their experience (or better yet, the experiences of those around them), then I would expect the older, cannier entity to be less likely to die in a mishap. Of course, there is also the possibility that with increased age comes a high degree of ennui, leading an intelligent being to take greater risks for the excitement.

    You actually mean that the probability of an immortal fly surviving 10 years without a fatal incident is far lower than the probability that the fly will survive a mere 10 days, so the genes for immortal flies don't get passed on as often. But how can that be? The immortal fly reproduces just as early and often as the mortal fly. Plus, the immortal flies that do avoid mishap continue to reproduce long after the mortals have died of old age. All else being equal, the immortals are passing on their genes more often than the mortals. How does this select against immortality?

  • by juancnuno ( 946732 ) * <juancnuno@gmail.com> on Friday June 26, 2009 @01:19PM (#28485177)
    Her intelligence seems affected though. Shouldn't she have normal mental development if it was just HGH insensitivity? She's 16 and still talks like a baby.
  • by Effexor ( 544430 ) on Friday June 26, 2009 @01:43PM (#28485547)

    The 'child' is a primordial dwarf. Her symptoms fit to the last detail.

    This story has done time on Digg and Fark already, probably several other sites as well, and it seems everywhere large numbers of non-doctors can use Google to compare her symptoms to a RARE but known medical condition. The poor kid's doctors either don't know how to research or are otherwise incompetent.

    Or maybe, just a wild thought here, maybe they have a slightly better insight into her symptoms, having actually examined her and seen her test results, and they have already ruled that out for reasons which your cursory diagnosis, based on reading an ABCnews article and several minutes of medical training, missed.

  • by Anonymous Coward on Friday June 26, 2009 @01:46PM (#28485581)

    Old age is a feature, not a bug.

    And a major turn off for the pedophiles. I fully expect there to be some muddying of the legal waters in a couple years when she becomes legal. As if age and appearance weren't disjointed enough already. Give this disease (syndrome?) a name, and we'll have found the new keyword for kiddy porn searches.

  • by ibbie ( 647332 ) on Friday June 26, 2009 @11:17PM (#28491039) Journal

    If she's not suffering, and her family isn't suffering (it's difficult to tell just from an article) there's absolutely no reason why it should be considered "bad" to learn from a condition like this. Hell, it'd be criminal to not take advantage of such an opportunity to learn more about how we live, age, and die.

    If doctors, scientists, etc 150 years from now can still learn from this case - perhaps personally, as opposed to relying upon another person's observations - all the better, for us as a species.

    I understand that people in general don't like to be considered a medical experiment, but if something abnormal is going on, that's exactly what one becomes. One simply has to remember that in the process of trying to understand the abnormality, a doctor is also trying to help you.

    (Unless they're an asshole. Then they're wondering if they can write a paper on you so they can buy another yacht. In which case, one should remember that just because they're an asshole, doesn't mean that they can't help you.*)

    * Admittedly anecdotal evidence shows that this is the case in most professions.

"When the going gets tough, the tough get empirical." -- Jon Carroll

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