Researchers Create Beating Heart In Lab 258
Sunday Scientist writes "Minnesota researchers have created a beating heart in the laboratory. In a process called whole organ decellularization, they grew functioning heart tissue by using dead rat and pig hearts as a sort of flesh matrix, and reseeding them with a mixture of live cells. The goal is to grow replacement parts, using their own stem cells, for people born with defective tickers or experiencing heart failure."
Comment removed (Score:5, Interesting)
Interesting engineering opportunities (Score:5, Interesting)
blimey. (Score:4, Interesting)
so there are a few options I see...
1. one use a dead donor heart as a shell and recellularize (that cannot be the correct term) with the patients stem cells assuming you can get them while he survives on what is left of his old heart and then transplant and hope there is no rejection
2. transplant the patient with an artificial heart until his old one can be repaired in the lab
3. find some way to create a fake heart "shell"? maybe extract some tissue from his current heart but not enough to kill him and create a template that the stem cells can be used to grow him a new heart over a few months.
of course they still need to manufacture a sufficient source of patient stem cells. does this sound reasonable?
of course in the UK, we have just got a new source of donors... http://news.bbc.co.uk/1/hi/health/7186007.stm [bbc.co.uk] our prime minister has just decided to add the entire country onto the donor list unless we explicitly opt out. Gill the Arm would be amused...
Re:Interesting engineering opportunities (Score:5, Interesting)
The "other piece" is also nearly there. (Score:4, Interesting)
Given that another project also underway is "writing" synthetic organs using a rapid prototyping system (3D plotter) loaded with live cells, structural proteins, and growth factors, the salvaged-and-decellularlized organ should be rendered unnecessary in short order.
The fact that a substrate with the right chemical markers can be repopulated into a working organ means the process can proceed in two steps. This may make it easier to accomplish - especially by reducing the need for functioning blood-supply plumbing to provide nutrition and oxygenation in the eary stages of construction.
Re:Wizard of Oz (Score:2, Interesting)
Re:Install several in parallel (Score:3, Interesting)
Re:Big Step (Score:3, Interesting)