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Comments: 298 +-   Thimerosal Does Not Cause Autism on Tuesday January 08 2008, @02:46PM

Posted by kdawson on Tuesday January 08 2008, @02:46PM
from the nice-theory-though dept.
biotech
science
jamie found an article over at Washington Monthly discussing the recent finding that there is no link between thimerosal and autism. It seems that after the mercury-based vaccine preservative was withdrawn from use in 1999, no drop in autism rates has been observed in a large California study. Here's the Science Daily writeup on the study, published in the Archives of General Psychiatry.
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  • That chemical preservative isn't used anymore because of Autism fears...

    Because of that our vaccines are significantly les stable and have shorter shelf lives!
    • by Altus (1034) on Tuesday January 08 2008, @03:00PM (#21958900) Homepage

      Don't forget the added "benefit" that now people are extra scared of vaccines because of all of this.
          • Re: (Score:3, Informative)

            I read these summaries of studies which claim to demonstrate that there is no link, and I can't help but think bullshit.

            These are researchers looking to make a huge splash, and their premise is faulty. While it is possible that the removal of the thimerosal is making no change, it is impossible at this point to reach that conclusion. We would need to have a stable rate for autism in the general population before this sort of statistical analysis is adequate.

            That being said, it could very well turn out that
            • Re: (Score:3, Insightful)

              Of course it's possible to reach that conclusion, the evidence has not ever supported the supposed link with autism. This new study is nothing more than another nail in the coffin of this conspiracy theory.

              As for "safety", what is much more unsafe than a tiny amount of mercury is vaccinating less people against horrible diseases. Many vaccines have always been slightly unsafe (e.g. those made from weakened but complete germs) and that has never been an argument for avoiding vaccination.

                • Re: (Score:3, Interesting)

                  Do not conflate the MMR theory with that of thimerosal as a cause of autism. The two are totally different [...]

                  Actually, there is absolutely no way to separate them. They are being promoted by the exact same people (Wakefield went from attacking MMR in the UK to attacking Thimerosal in the US without batting an eyelid - of course, he's facing severe charges of scientific fraud if he ever shows his face in the UK again), and one of the arguments is that Thimerosal is used in the production of MMR and other multi-vaccines to help combine the individual component vaccines into one. Of course, once Thimerosal was con

    • Re: (Score:2, Informative)

      This little nugget can't be understated. Irrational fear mongering has caused a lot of problems. The bad news is even after all the research showing there is no link, we won't get it back, so we have to keep looking for other methods (that maybe more dangerous and/or costly.)
      • Regardless of the Autisim link (which was thin at best) ethylmercury hasn't had the sort of widescale toxicity tests that bioaccumulating mercury compounds (e.g methylmercury) have had.

        Until that point, I'm not big on the idea of injecting a solution containing a large amount of ethylmercury into my body. Most mercury compounds aren't really anything that anyone would want to inject.

        It's no better to be irrationally pro-ethylmercury just because it's a good preservative...The reason the uninformed freak out
      • Re: (Score:3, Informative)

        That's just trying to divert the issue.

        What is not in question is that, since 1999, the amount of Mercury children have been receiving via Thimerosol has dropped drastically but the rate of autism diagnosis is still increasing.

        Turned on its head you could argue that since the rate of autism has increased since the removal of Thimerosol, then Thimerosol must actually have a protective effect against autism. (That assertion is, of course, utter nonsense. But that's what you get when you go chasing a non-corre
      • Re: (Score:3, Informative)

        The infrastructure makes a real difference in the need for good preservatives, agreed. That said, there are lots of reasons to go ahead and build that infrastructure in the third world.

        1. lots of clinics with reliable refrigeration will let those clinics preserve samples where an outbreak of something really nasty, such as Ebola Zaire, is suspected. Better roads, or even runways and committed planes, will let local governments and the UN respond to such outbreaks more quickly. A dedicated radio type link w
  • by KublaiKhan (522918) on Tuesday January 08 2008, @02:59PM (#21958880) Homepage Journal
    Given that the folks shrieking the loudest about the thimerosal-autism 'link' (as if a single study that's since been discredited many, many times can be called a 'link') tend to be parents of autistic children who also tend to go in for bogus new-age nonsense like 'chelation' and 'collodial silver' treatments, I don't think the whole nonsense is quite over yet. It's definitely a nice step in the right direction, but no amount of proof will really convince conspiracy theorists that their pet paranoia is without merit--they merely will claim that the 'truth' is being 'covered up' by the Big Pharmaceutical companies, and that the government is out to poison your children with the evil vaccinations that 'confuse your immune system' leaving you 'open to illness.' Most of them would benefit from a good solid course in basic logic (to overturn the fallacies they base their 'theories' on) and in basic biology and chemistry. The best we can hope for, I suppose, is that they'll select themselves out of the gene pool by applying nonsensical and hazardous treatments to themselves and their offspring.
    • by solar_blitz (1088029) on Tuesday January 08 2008, @03:08PM (#21959054)
      Dear God, I would like to file a bug report.
      • God's apparently like Microsoft...you can file a bug report, but you'll not get it fixed unless you decompile the binary and fix it y'self. Pity he didn't hand out a copy of the source code along with every chromosone set....unless that's what the Bible Code -really- is...
    • Re: (Score:2, Funny)

      "Most of them would benefit from a good solid course in basic logic (to overturn the fallacies they base their 'theories' on)"

      I used to be a grader at Lehigh for the Informal Logic course - trust me, there are some folks you CAN'T teach logic to.

      And if there's anyone out there who took the course between about '87 & '90: I'm the one who graded your homework "0 plus" on a scale from 0 to 2 - you may have handed it in, but there was no resemblance in any of your answers to anything remotely resembling log
    • What I would like to know is just how much research have people like you done into the issue? And I mean PROPER research, not just newspaper knowledge of fragments you've gleaned over the years. Because I know a hell of a lot people, including some within the vaccine industry, who, if they posted here, could destroy every single one of your arguments.

      Most of the so called "fallcies" you claim are far from that. The people I know who are anti-vaccine generally tend to be more intelligent, better educated and
      • by KublaiKhan (522918) on Tuesday January 08 2008, @03:42PM (#21959690) Homepage Journal
        "What I would like to know is just how much research have people like you done into the issue?" Ad hominem attack. I would note that, as conspiracy theories are an area of special interest to me, I take great pains to research not only the nutbag nonsense, but the real science behind any claims. "Because I know a hell of a lot people, including some within the vaccine industry, who, if they posted here, could destroy every single one of your arguments." Appeal to authority. If you can't make your own argument, then kindly keep your mouth shut. "Most of the so called "fallcies" you claim are far from that." Caught two already. "The people I know who are anti-vaccine generally tend to be more intelligent, better educated and questioning than the people who aren't." I'm a bit rusty on my fallacies, for I've misremembered the name of this one--but no, you cannot claim that because your particular group is somehow 'smarter' your argument is automatically correct. It's a non sequitur. "If you had a child who was suffering from autism" Appeal to emotion, another fallacy. "How many medical experts have you spoken to about vaccines?" Appeal to authority, again. Namedropping the various folks at various departments of health whom I've spoken with about this will not 'prove' anything. The argument should stand on its own, without recourse to celebrity. "How many books have you read? How many studies have you read?" Many, including those disproving the only study to have claimed the aformentioned alleged 'link'. "Anyone who is at least interested in educating themselves" ...would do far better to take a course in basic logic and biology, like I said before, rather than reading that crackpot bit of nonsense. "I realise I am wasting my time here," Then why post? " I am sick of uneducated people bashing those who are anti-vaccine when they're uninformed. " Ad hominem, again. "If you've done all the research and still feel it's bogus, then fair play to you." I have, thank you. " someone I know" Friend of a friend third-hand knowledge is not valid for consideration, thank you. "Please, educate yourself. READ studies on vaccines etc... And I mean government studies, not the PR material that the companies put out." Yes, and that's why I know the alleged link was disproved. For someone who claims not to indulge in fallacy, you've certainly a great deal of it in your post.
        • Re: (Score:3, Insightful)

          by Anonymous Coward
          Wow...

          He puts the same level of fact (and coincidentally, about the same mix of ad hominem and frustration) as in your original post, and you tear him apart.
      • by Stormcrow309 (590240) on Tuesday January 08 2008, @04:27PM (#21960488) Homepage Journal

        Cite or get off the pot. Speaking of which, I would suggest this paper [ehponline.org] and this paper [informaworld.com] as a good start. There is major concern from Thimerosal toxicity in long term treatments, such as blood plasma programs, due to the introduction of more Thimerosal to the system then ethylmercury, the type of mercury that Thimerosal becomes, can be cleared. However, there seems to be more risk from dental amalgam then a single vaccination. Concern should be for long term series, such as a long term gamma globulin series, which is becoming rare.

      • by DES (13846) * <des@des.no> on Tuesday January 08 2008, @05:41PM (#21961758) Homepage

        And to be honest, your attitude is sickening. If you had a child who was suffering from autism, you'd do anything you could to try and help them.
        Indeed. If I had children who were suffering from autism, I would do anything I could to try to help them. But running around trying to find someone to pin the blame on would not help them at all; in fact, it would rob them of what they, like any other children, need most, which is their parents' time and attention and tender love and care.

        Western society (and, it seems, the US in particular) has developed into a culture of blame. In some ways, it is understandable, as it is much easier to find someone to blame and from whom to demand retribution than to face up to the harsh realities of life, but it is not very productive. People need to understand that life is hard and often unfair, that they need to take responsibility for themselves and their kin, and that sometimes things get broken that you just can't fix - you have to cope and move on.

        Autism is a very complex subject. Autism-spectrum disorders are actually much more common than one would think, and statistics seem to show they are on the rise. Part of the reason is that it was previously (and may still be) underdiagnosed due to social stigma and a poor understanding of the milder forms. Another part of it is that there seems to be a correlation between autism-spectrum disorders and other characteristics which are favorable to success and survival in an industrial society, which basically means that natural selection is currently working in favor of autism (just like natural selection works in favor of sickle-cell anemia in parts of Africa because it is linked with improved resistance to malaria). The most blatant evidence in favor of the latter interpretation is that autism-spectrum disorders seem to occur more often in children whose parents both work in IT or engineering.

        Personally, I suspect that once we come to realize and accept that far more people thank we think suffer from varying degrees of autism, it will become clear that autism is in fact hereditary and that neither Thimerosal nor any other chemicals really have anything to do with it.

        By the way, autism is far more survivable / treatable than was previously believed (or than many people still seem to think). Forget Rain Man; many autistic children who even thirty years ago would have been doomed to a life in an institution can actually be taught to function in normal life if you take the time to try to understand them (something medical professionals used to think was below their dignity). Elizabeth Moon (author of the Paksenarrion series) was told some twenty-odd years ago that her son was congenitally incapable of processing language, yet she taught him to speak, and to interact socially, and in the process developed a different idea of what autism is than what was prevalent at the time (in particular, she considers autism a developmental problem rather than a cognitive one). She has also written both fiction and non-fiction on the subject, which you may find worth your time to look up.
    • Re: (Score:3, Insightful)

      This parent of an autistic child became a hard boiled skeptic on "miracle cures" like chelation very quickly. Some autistics DO respond favorably to a restricted diet but but by no means all. The only thing that I'm convinced works consistently is intensive structured activities. I'm honestly not sure whether or under what conditions thimerosal is harmful. Even if it isn't terribly harmful to adults, I have severe doubts about pumping large amounts of it into very small very young bodies. It is true th
  • by tgibbs (83782) on Tuesday January 08 2008, @03:08PM (#21959064)
    After all, other countries have eliminated or dramatically reduced mercury in vaccines with zero effect on autism rates, and the mercury fanatics never batted an eye. Nor are they troubled by the fact that the neurological effects of actual mercury poisoning don't resemble autism.

    It's a bit like homeopathy in reverse. Many of these guys have a superstitious fear of "toxins," and no matter how low the level might be, they will be convinced that it is poisoning their kids.

    Of course, the real problem is that the age at which autism symptoms develop is about the same as the age when kids normally get their shots. A reasoned explanation of the difference between correlation and causality is often beyond the grasp of parents who are desperate for an explanation, or better yet, somebody to blame.
      • by tgibbs (83782) on Tuesday January 08 2008, @05:16PM (#21961334)

        Autism symptoms don't develop at 2 months, the time when the first vaccine is mandated.

        Or, heck, even at birth, now that Hep-B shots before leaving the hospital are all the rage.


        And you are presenting this in favor of the hypothesis that vaccines cause autism? Seriously?

        With "factual analysis" by morons like you backing them up, it's little wonder crap statistical analyses like "this doesn't cause Autism" is the major focus, when spending the money on finding out what *does* cause it would be real science, but that ain't happenin'.


        And who told you this? The guys selling "vaccines cause autism" books and quack chelation therapy? I was at the Neuroscience meeting in San Diego last year, and I saw row on row of posters describing work on the causes of autism. Try this: go to PubMed [nih.gov] and type "autism" into the search box. There have been some important recent breakthroughs indicating a genetic basis for autism [harvardmagazine.com]. Identifying the genes is an important step toward figuring out what goes wrong and developing a therapy. What doesn't contribute is investing yet more time and money pursuing the long-rejected notion that mercury or vaccines causes autism.

        If you had half a brain cell to rub together, you might also be interested in this article, which has not been refuted by anyone.


        Oh wow, an article in the respected scientific journal Rolling Stone. And it has not been refuted by anyone? Not even here? [blogs.com] Or here? [blogspot.com] Or here? [aappublications.org] Or here? [neurodiversity.com]
  • This is established (Score:5, Informative)

    by Otter (3800) on Tuesday January 08 2008, @03:09PM (#21959078) Journal
    The link between thimerosal and autism has already been pretty thoroughly disproven [corante.com]. (Link to a blog rather than the paper because 1) it's a good summary and 2) I'm not sure whether the link is freely readable.) Whatever merit this hypothesis had in the past, any future work on it that "activists" manage to force clearly comes at the expense of projects that might be genuinely useful.
  • Currently, pediatricians are calling for autism screening to be standardized and performed at 18 and 24 months of age. However, there is no current standard for testing or for the age to test.

    Taking screening at 24 months (autism can take up to 19 months or so before it becomes evident), that means the test is using 6 years of data -- 6 years during which the testing times for screening autism have changed and the tests themselves have changed. This means that a lot of children who would not have been fla
    • From all the studies I've read, earlier definitive diagnoses of Autism are possible - at 18 months instead of 30, and early warning flags can be detected even in the first year.

      I have no idea why these earlier tests aren't being used (looking for rapid excessive head growth, lack of eye contact, etc) - especially since they don't require fancy equipment or major investments.

      I find the head growth particularly fascinating (here's a link to the abstract)
      http://jcn.sagepub.com/cgi/content/short/22/10/1182 [sagepub.com]

  • 'no statistical correlation' != 'doesn't cause'
    'statistical correlation' != 'causes'

    I know enough people who have observed a direct correlation between their children being injected with mercury and an observable shift in behaviour to be concerned about injecting mercury into my children. I also know enough people who have observed a correlation between chelation and improvement in the child's intelligence, even in later years, to try chelation if I ever have an autistic child.

    I know that some people, when
  • by Borealis (84417) on Tuesday January 08 2008, @04:09PM (#21960102) Homepage
    Curiously though I think there is a distinct lack of studies that show how the use of multiple vaccines at earlier ages affect autism. Given that a child's immune system is at best only partially developed before the age of six months, it's somewhat irritating to me that doctors regularly inject 7 vaccines at a time into children as young as 1 month of age. My own son developed infantile spasms (a degenerative seizure disorder) a week after his 3 month checkup where he was inject with the MMR, DtAP, and Varicella vaccines (MMR and DtAP each are combinations of 3 vaccines, giving him 7 total).

    Anecdotally, of the 6 children in my son's special education kindergarten class, 3 of the children developed seizure disorders within a week of similar vaccinations, one of which was administered at one week of age. Most countries wait until at least 6 months of age before beginning the injections of MMR and DtAP vaccines.

    Personally I think that thimerisol is a red herring distracting folks from considering any contributing factors of age and volume of vaccines administered. I think we'd do well to compare current vaccinations correlation to autism versus a program that staggers vaccinations with individual vaccines starting at 6 months of age to see how much that contributes to the rate of autism.
    • Given that a child's immune system is at best only partially developed before the age of six months, it's somewhat irritating to me that doctors regularly inject 7 vaccines at a time into children as young as 1 month of age.

      Um, there's your answer. Your 5 year old does not need as much protection as your 5 month old, because the 5 year old is more capable of fighting infection. The only reason we don't give newborns a full round of shots as soon as they come out of mom is that they have to reach a certain age to respond well to most shots (not so to hep B.)

      Most countries wait until at least 6 months of age before beginning the injections of MMR and DtAP vaccines.

      First off, its DTaP, not DtAP (which becomes important below.)

      Second your statement is quite untrue. If you look at the WHO's vaccine information, you can see the va

    • Re: (Score:3, Insightful)

      I don't think in most cases it's about money. As a parent, there's a very low-level part of the brain that has a real need to defend one's child, and that means identifying threats to them and protecting them. When something goes wrong, there's a huge emotional drive to figure out what caused it, and to protect any other children from that threat. I'm sure there are a few folks who are in it for the money, but I think most of them just feel a need to figure out what caused harm to their child. Have a little
      • Re: (Score:3, Insightful)

        I do sympathize with these parents, profoundly. But the fact is that very few of them have the expertise or the knowledge to make valid judgments about this issue, and yet they continue to spread unsupported claims about vaccination as though they were facts. This is potentially harmful to others and should be curtailed, regardless of how noble or humane their motivations might be.
                • Re: (Score:3, Insightful)

                  I do understand. My sister has an autistic son as does my wife's brother. They level of autism is vastly different as are the distances. I hate to use the word ignorance because frankly I am pretty ignorant when it comes to biology. I would but my knowledge at about the same level as a good first year college student but not any higher. I would say it is more fear, panic, and guilt. If it is genetic then it is one or both of the parents faults "in their mind". If it is something in the environment then it
          • Re: (Score:3, Informative)

            Nobody here seems to be aware of where this rumour started. The doctor responsible, Wakefield, published an article with cooked results largely on the request of an ambulance-chasing law firm which was suing the drug companies, and for whom Wakefield was making a lucrative career as an expert witness. The motivation was greed, pure and simple. Wakefield's article got picked up by reporters in England and they made an hour documentary about it on TV, and all hell broke loose.

            It quickly became obvious to othe
    • Re: (Score:3, Interesting)

      No, the scientists and physicians who claimed a link have been in a very small minority. Nice attempt to discredit the climate science by implication, though.

      The anti-thimerisol movement has been driven largely by parents of autistic children looking for an explanation (I'm not unsympathetic, but that shouldn't affect the scientific method) and the anti-vaccination lobby, which is a mix of paranoiacs and people who can't see that a small number of vaccine-caused deaths is preferable to a larger number of d
    • Re: (Score:3, Informative)

      Thimerasol includes Mercury in the way that Water includes Hydrogen.

      The link to autism has never been there, every study has shown it. Its time to spend money looking for the real culprit and not blaming vaccines.

      A more likely route is look at the age of the fathers, there seems to be evidence pointing to parental age having to be a likely cause of autism rates rising (that and the mass over diagnosis, and more mental illnesses being classified as Autism.)

      This is not a simple issue. And the mercury = autism
      • Re: (Score:3, Insightful)

        Well, mercury on its own isn't particularly toxic. However, most organic mercury compounds are toxic, usually more so than mercury itself. In fact, one of the nastiest chemicals around, dimethylmercury, is an organic mercury compound - incredibly toxic, passes rapidly through all types of laboratory gloves, no real treatment. (This was first discovered after a chemist spilled a couple of drops on her glove by accident. She didn't show symptoms until several months later, then died a few weeks after that des
        • Re: (Score:2, Funny)

          by Anonymous Coward

          I love the way my earlier post is modded as a troll. NOTE TO FUCKWIT MOD: Having a contrary opinion backed up by actual knowledge is NOT a troll.

          Do you have links to your "actual knowledge" for verification? Note that GeoCities pages with animated spinning GIF skulls and flames are not considered reliable sources of information.

    • Re: (Score:3, Insightful)

      Thimerasol has NOT been ruled out in causing individual cases of autism. Just that it is not the SOLE cause of autism. It's still a documented fact that US infants exposure to thimerosal increased starting around 1990, and that correlates with a huge spike in autism rates. ..... It doesn't say thimerosal is safe, the study just shows it's not the ONLY cause of the tenfold increase in the rates of autism.

      Correction, there's been a big increase in the rates of diagnosis of autism, which is an entirely differe
      • You should bare in mind the reason autism rates have increased is because the criteria for autism has been expanded since the 1980's. What previously wouldn't be counted as autism now is.

        That's for sure. My nephew is autistic, and I have met some of the other children who receive IBI therapy with him. I know that autism is a continuum and not a binary variable, but I think that calling some of those kids autistic is a bit of a stretch. Admittedly, I an no expert in such matters, and for all I know, the exp

    • by seebs (15766) on Tuesday January 08 2008, @03:15PM (#21959198) Homepage
      A fascinating theory, but one as yet unsupported by data, and indeed, contrary to the data.

      Even if it were just "triggering" autism, the removal of thimerosal would, eventually, result in a change of the frequency of observed autism. It doesn't.
    • Re: (Score:2, Informative)

      You should check out this stuff: http://www.dhmo.org/ [dhmo.org]

      It's EVERYWHERE!
    • Re:Mercury (Score:4, Informative)

      by Dr.Enormous (651727) on Tuesday January 08 2008, @03:23PM (#21959376)
      Sodium(0) catches fire/explodes on contact with water.
      Sodium(I) is critical for sustaining life.

      Just because Mercury is toxic, and organomercury compounds will kill you stone dead, doesn't mean every single compound with mercury in it isn't safe. Oxidation state and ligands make all the difference. Linking to "Mercury hazards" is meaningless.
      • I forget where I first read this (I think it was one of the Quackwatch articles). Credit to whomever first said it.

        Oxygen and hydrogen are explosive and flammable gasses. Water is made of oxygen and hydrogen. It is obviously wrong, though, to posit that drinking water will cause a person to catch fire and explode.

        It's not a completely parallel situation, natch, but it's vivid enough an example that people might actually listen.
    • Actually, because Americans are drinking so much bottled water, Fluoride exposure has decreased (resulting in increased cavities), so you would expect autism to do so too if they were related.
    • Is that the active ingredient in flour?
    • "One business-class ticket for the Crazy Train, please."
      "Coming right up, sir. Enjoy your trip."
    • by slcdb (317433) on Tuesday January 08 2008, @04:52PM (#21960900) Homepage
      Most likely, there are a number of things that are causing a rise in the rate of children diagnosed with autism. What makes the anti-thimerosal camp so certain that it can be pinned down on any one thing?

      Here are my top five "better suggestions":

      5) Increased genetic susceptibility among the human race as a whole.
      4) Increased awareness of autism spectrum disorders.
      3) Better diagnostic methods.
      2) Relaxed criteria for positive diagnosis.

      And my #1 favorite:

      1) Any of a number of synthetic chemicals children might be exposed to in increasing amounts today, rather than decreasing amounts like thimerosal.

      It could be any combination of any, all, or none of the above. Chances are it's more than just one thing and, as this study suggests, thimerosal does not appear to be one of them.

    • by Dachannien (617929) on Tuesday January 08 2008, @06:30PM (#21962402)

      Global Warming.
      Increasing gas mileage and alternate energy
      Voting machine fraud, WMD's, Kennedy, John Lennon, Ghandi, Tim Leary,
      GM vs. Organic food. Smoking causing or not causing cancer, Marijuana
      Tesla, Laithwaite, Hutchinson, Darwin, Galileo, Copernicus, Columbus
      Perendev, Searl, Cold Fusion, The Earth Being round, String Theory, E8,Quantum Physics , Roswell
      Jesus, Moses, Noah, The Ark of the covenant, the chalice, Troy, 12/12/2012, the holocaust, revelations.
      Everybody now! We didn't start the fire....

    • But I had NO issues with the vaccine having thiemerasol. WHy? Because there has been NOTHING credible about it in 10 years. In fact, 2 of the 3 scientist who wrote the ONLY real paper on it, now refute it. Were either of my children injected with it? I have no idea. There are FAR more important issues to worry about rather than something as ridiculous as that.

      BTW, children can die by water, even in a bath. ANd that is fact, not just "alter" of science. I know. I have pulled them from the bottom of a lake.
What's the matter with the world? Why, there ain't but one thing wrong with every one of us -- and that's "selfishness." -- The Best of Will Rogers