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Biotech Science

Researchers Simulate Building Block of Rat's Brain 224

slick_shoes passes on an article in the Guardian about the Blue Brain project in Switzerland that has developed a computer simulation of the neocortical column — the basic building block of the neocortex, the higher functioning part of our brains — of a two-week-old rat. (Here is the project site.) The model, running on an IBM Blue Gene/L supercomputer, simulates 10,000 neurons and all their interconnections. It behaves exactly like its biological counterpart. Thousands of such NCCs make up a rat's neocortex, and millions a human's. "Project director Henry Markram believes that with the state of technology today, it is possible to build an entire rat's neocortex. From there, it's cats, then monkeys and finally, a human brain."
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Researchers Simulate Building Block of Rat's Brain

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  • Re:but why? (Score:5, Insightful)

    by chatgris ( 735079 ) on Sunday December 23, 2007 @10:40PM (#21802342) Homepage
    What? Your post is so wrong I don't even know where to begin.

    First off, why not just use a human brain if you want an identical machine? Well, for sending probes to mars. Or to the depths of the ocean. Or any other place that is too dangerous to send humans, but that a machine could survive in. Even if the brain was a replica of someone's personality, all they'd have to do is find someone who thinks it would be really cool to go to mars, and replicate their brain. It'd be a hell of a lot more intelligent than a traditional AI system at this point.

    Secondly, if we want an AI system that better than the human brain, THIS IS THE WAY TO GO. Figure out exactly how the human brain handles thing that are really hard for computers, like object recognition. Once you've got that, you can replace//add on parts that do things better/faster than humans, like math. In terms of adaptability and general purpose use, NOTHING in AI comes anywhere close to the human brain right now. So trying to make an AI system that is better than the brain, a good first step is to try and make the human brain, then start tweaking that.

    The point is to try and understand how biological brains do what they do, and how we can make computers do those things (which computers currently suck at). Sure, you can emulate basic behaviour in a pre-define environment, but try making a system that can differentiate a food source the 'rat' may never have seen before based on sight and smell in an environment that it's never been in.

  • Re:but why? (Score:1, Insightful)

    by Anonymous Coward on Sunday December 23, 2007 @10:46PM (#21802374)
    I disagree. The human brain would be perfect to use as a model to create something "better" than the human brain.

    The reason is that the artificial brain would have the benefits of intelligence, creativity, etc... that we see in people, but none of the limitations.

    Imagine the smartest person you know, but with essentially unlimited memory, constantly increasing processing capability (with newer/faster processors) and the ability to live forever without a decline in function. That's better than a real human brain for sure.

    But that's all science fiction, for now. If we could replicate even the modest abilities of a normal person, or even a primate, we'd be well on our way to true artificial intelligence (if not already there ...).
  • by PolarBearFire ( 1176791 ) on Sunday December 23, 2007 @10:58PM (#21802442)
    Not to be a doubting Thomas but I think that they are underestimating the complexity of a brain. There are many different chemicals and biochemical reactions going on in the body, that science has only a vague idea of their mechanisms. Look at any drug in the market, most of them only give conjecture on why they work. My feeling is that until one day when we can create computer models that reliable predict the effects of drugs in the brain or in the body in general, these models are nowhere near what real brains are. But I would also love to be proven wrong.
  • Subject (Score:3, Insightful)

    by Legion303 ( 97901 ) on Monday December 24, 2007 @12:06AM (#21802702) Homepage
    "and finally, a human brain."

    Why stop there?
  • by MOBE2001 ( 263700 ) on Monday December 24, 2007 @12:36AM (#21802828) Homepage Journal
    From the article:

    Markram is banking on Moore's law holding steady, as a computer with the power of the human brain, using today's technology, would take up several football pitches and run up an electricity bill of $3bn a year. But by the time Markram gets around to mimicking a full human brain, computing will have moved on.

    It's amazing how some people want the computing resources to simulate a rat's brain but still can't simulate a honeybee's brain and the resultant behavioral complexity. After all, a bee's brain has only about a million neurons. It could probably be done on a desktop machine and yet, a bee's behavior is amazingly sophisticated. Is it me or does it seem that some people have no clue as to what constitutes intelligence and would rather spend the taxpayer's money on what can only be qualified as useless goals?

    Would it not be much better to implement a downsized version of the human brain (with all the various cortices) and see if it can learn and adapt to the environment? But then again, that would be too much to ask since Markram et al don't have an overall theory of brain operation. It's better to keep your sights as high as possible and have an excuse as to why your artificial brain or cortical column is no more intelligent than a flea: you always need faster and more expensive computers. And more funding. Yeah.
  • by TopSpin ( 753 ) * on Monday December 24, 2007 @12:55AM (#21802914) Journal

    Can this rat brain fly a plane?
    Probably, and why not? Flying is the product of billions of tiny brains all over the planet. Piloting an aircraft is comparatively easy to what we witness birds do routinely. Never mind that automated aircraft are flying sophisticated missions using computers a couple orders of magnitude smaller than an IBM Blue/Gene L, and several additional orders of magnitude less complex than a rat brain. Flying is easy, as far as nature and computers are concerned.

    Yet no doubt when a competent emulation of a bird brain exists and is observed flying around, you will raise the bar again. Not long ago recognizing natural speech was offered as you offer the test of flight. We have since moved the bar because our inexpensive, portable, battery powered cell phones now understand the simple noises we make with accuracy approaching our own. Bipedal walking, land navigation, chess and facial recognition are more examples of tests offered that once solved, for some reason, no longer count.

    Consider this; we're having to move the bar with greater frequency all the time. At what point does the realization occur that the problem of thought is finite and solvable? I believe that very soon we will have at least parity between ourselves and our machines. Not because the machines are tremendously powerful, but because we're not.

    The count of neurons (100G+) and synapses (up to 10K per neuron) is well known. The switching speed of this finite set of electrical and chemical circuits is measured in (comparatively slow) milliseconds. Our brains run on a couple calories a minute and operate at approximately body temperature. In contrast to the infinite supply of uniform opinions offered here that effectively assert that the brain is too elaborate for it's own comprehension, there simply isn't enough space or energy involved to convince me that the brain is some unapproachably complex enigma forever beyond our capacity to emulate.

    Every new milestone passed only reinforces my belief, regardless of how fast you raise the bar.

  • by ywl ( 22227 ) on Monday December 24, 2007 @01:14AM (#21803036)
    Research is indeed a funding game but there is no need to be so cynical...

    First, we know more about mammalian brains and neurons than the honey-bee ones. The research in the last half century was mostly centered around the mammalian systems. Unless the governments are willing to fund projects on insects, or some wealthy philantropist is willing to take up the bills, expect similar things for the near future.

    Second, the structure and organization of the cortex is quite similar across the whole brain and mammals. As the cortex (or more exactly, neocortex) is general regarded where most important cognitive processes occur, if you want to have some insight on a general computation network/machine, it's a reasonable place to start.

    Third, it's probably easier to simulate the neocortex than the brain of honey bees, since as I said, we know more about mammals. Moreover, a lot of the structures and organization are quite regular in a cortical column, therefore, you'll have a better chance of guessing the missing information correctly.

    Finally, don't be silly, a desktop won't make it. If you want a realistically simulation, you'll first need to have a good idea of the geometrical shapes of all the neurons and their projections, then a reasonable guess of the strength and locations of their synaptic contacts. You'll also need to have a good estimation of the channel density and distribution of the ionic channels. then the non-linear differential equations that govern their behaviors. Most of these numbers are not even measurable with current experimental technologies. I think these groups use some mathematical tricks to estimate these numbers ... which is at least plausible for rat or mouse brain.

    People have been dreaming of an abstract, reduced and simplified theory of the human brain since the study of the nervous system started. Nobody has quite managed yet... why don't you try? :)
  • by Hamster Lover ( 558288 ) * on Monday December 24, 2007 @02:39AM (#21803492) Journal
    Wow, these scientists really were shooting for the stars. Why not start small, like say the brain of a GOP presidential candidate or that of a Britney Spears fan?
  • by mjsottile77 ( 867906 ) on Monday December 24, 2007 @03:39AM (#21803740)
    I think your critique is woefully out of date. You are correct if you limit the neural network to the basic neural network models of decades past. From what I've seen at conferences in the HPC world lately, the more recent models do more than just use capacity to increase the size and connectivity of the network, but take into account more realistic physical models such as the electrical properties of the brain and mechanisms by which signals propagate both within neurons and across synapses. You're not looking at just a bigger back propagation network with sigmoid nonlinearities here -- the neural modeling world has moved far beyond that, in part due to increased interest and participation of neuroscientists. Unfortunately, most CS folks fail to learn much about the current state of the art beyond the basics such as the material from Simon Haykin's text (which, mind you, is pretty good).
  • by Troed ( 102527 ) on Monday December 24, 2007 @05:15AM (#21804114) Homepage Journal
    Your body is destroyed and a copy of you comes out the other end, thinking that it's the original ... which makes it me, the original, for all purposes.

  • Re:Hitler 2.0 (Score:3, Insightful)

    by mcrbids ( 148650 ) on Monday December 24, 2007 @09:03AM (#21804810) Journal

    They guy that invented QWERTY did just fine. You are probably just missing his goal. The goal was to slow down typists. With a manual hammer type typewriter, typing too fast jams the machine.
    Congratulations! You've just perpetuated [straightdope.com] an urban [earthlink.net] legend [reason.com].

    I strongly consider you to perform a modicum of research [google.com] before you regurgitate knowledge you got at a party while partly intoxicated, and hoping to get that girl-in-the-green-dress' phone number.

    Oh wait... do you get invited to those kinds of parties? Perhaps you think digital watches are a pretty cool idea?
  • by stonecypher ( 118140 ) <stonecypher@gm[ ].com ['ail' in gap]> on Monday December 24, 2007 @02:24PM (#21807974) Homepage Journal

    After all, a bee's brain has only about a million neurons. It could probably be done on a desktop machine

    You have a fantastically broken sense of scale. The important bit isn't the neuron count; it's the interconnect count. In the sub-oesophageal ganglia alone you're looking at billions of interconnects. If you think that would run on a desktop machine, especially after you just (failed to) read the document explaining how much horsepower it took to deal with a rat's neocortex, then I have a bridge to sell you.

    Maybe you should wait until you've actually tried this stuff before you start preaching about what can or cannot be done on a PC.

    a bee's behavior is amazingly sophisticated.

    No, it isn't. A swarm's behavior is relatively easily described as the emergent properties of about two dozen behavioral rules. Consider taking a time machine back to the mid 1980s, when we started figuring this stuff out, so that you won't be so far behind when you begin the necessary process of playing catch-up.

    Is it me or does it seem that some people have no clue as to what constitutes intelligence

    Both.

    and would rather spend the taxpayer's money on what can only be qualified as useless goals?

    Just because you don't understand it doesn't mean it's useless. The implications of a testable simulation of a biological brain are startling. Besides, the EPFL is a private institute (not everything with "federal" in the name is governmental,) and the vast bulk of this research was paid for by IBM.

    Would it not be much better to implement a downsized version of the human brain (with all the various cortices) and see if it can learn and adapt to the environment?

    Yeah, because if we've just now for the first time managed to simulate something that constitutes about half of one percent of a rat's brain, then surely we're in a position to implement a scaled-down human brain. Oh, and by the way, if it's scaled down, its results wouldn't be useless, or anything. Oh, and we all know how to scale a human brain down: it's in every textbook on "fantasy science for people with no ability to think through what they're saying," which they teach at the Zsa-zsa Gabor School of Diesel Mechanics.

    In the meantime, we now have confirmation that our understanding of the basic principles of rat cerebral biology is complete enough that we can accurately simulate a significant and complex chunk of its brain in pure mathematics. I can't imagine how even a layman would be so dense as to think that useless. Maybe we should simulate you; lord knows we have the computing power for it.

    But then again, that would be too much to ask since Markram et al don't have an overall theory of brain operation.

    Wait, let me get this straight. Something you suggest is too much to ask because other people don't know how to do it? Did it occur to you to just not say it, then? Or were you too busy feigning familiarity with something you know not even the most fundamental basic principles of? You suggested something so startlingly vague that I can't even begin to imagine what precisely you mean, and now you want it to be these other, actual productive scientist's faults that your fantasy doesn't make any sense?

    What exactly would you suggest is the nature of a "scaled down human brain" ? Be precise.

    It's better to keep your sights as high as possible and have an excuse as to why your artificial brain or cortical column is no more intelligent than a flea

    Yes, because simulating half a percent of a rat brain is a much loftier and more vapid goal than some arbitrary reduction of the human brain, cough. By the by, if you had actually read anything about the research, you wouldn't be making comparisons to fleas, since the simulated rat brain is actually quite capable. But, don't let knowledge or famili

  • by stonecypher ( 118140 ) <stonecypher@gm[ ].com ['ail' in gap]> on Monday December 24, 2007 @02:47PM (#21808172) Homepage Journal

    People have been dreaming of an abstract, reduced and simplified theory of the human brain since the study of the nervous system started. Nobody has quite managed yet... why don't you try? :)

    I am and I have.

    Bullshit. An abstract computer chess simulation routed through the physical world mimics a reduced human brain in the same way that playing with legos is a reduced version of engineering a skyscraper. You've managed to fill a webpage with a bunch of blathersceit and big words. Way to go, jack. In the meantime, all you've really got is an Armitron driver. Why chess is even on that page is something of a mystery, since your software doesn't know how to play chess - it can't even make legal moves in any more significant frequency than dice.

    Trying to use computers to simulate neurons in all their biological glory is a pipe dream.

    Yes yes, clueless amateurs have been saying this for decades. Go sit at the back of the class with Minsky where you belong - you're replying to an article where something has been done by saying "this is a pipe dream and cannot be done." I'm reminded of the story of the Kitty Hawk newspaper reporter who was thrown into jail for fraud, claiming that a heavier than air machine had flown; when shown photographs, the police officer who'd made the arrest calmly remarked that they were obvious fakes, and that science forbode such a thing from happening.

    Well, sir, all I can say is that I'm glad your kind aren't cops anymore.

    We know how several types of neurons work on a higher and simpler level: they send and receive spikes via synapses.

    That's one of more than a dozen known mechanisms, actually. There are several involved mechanisms with electricity alone - pulse amplitude, duration and frequency are all involved in the electrical system, and that's before you get into what the chemicals around them are doing. Chemicals are involved in the system too. Or did you think that cocaine was just a bunch of tiny batteries?

    That's the only level that needs to be simulated to achieve intelligence

    This is demonstrably false. Several classes of injury and disease that rob a previously functioning brain of its ability to think have literally nothing to do with its electrical system, something you'd know if you weren't a talentless hack also ran with neither education in the matter nor any form of degree. Go find out what happens in a mye

    The brain is a discrete temporal mechanism

    The brain isn't discrete, as the various parts of the brain operate distinctly from one another, at different speeds, using different mechanisms. The brain isn't a temporal mechanism, something which anyone with multiple sclerosis knows in a deeply tragic way. The brain is not, in fact, even a mechanism, since a mechanism has a definite design, and brains are grown (and differently, to boot.) People's brains are actually shaped differently, have different sized bits and pieces. Lots of the brain is specific purpose, but lots of it is general purpose, and the way that people handle many fundamental tasks is quite significantly different from individual to individual. Hell, not even all of us end up with cognition in the same lobe of the brain - that bit about "left brained" and "right brained" was based on actual science, something none of what you've said seems to be. If the brain was a mechanism, we'd all be working the same way.

    So, not discrete, not temporal, and not a mechanism. I smell failure, and its name is MOBE2001.

    discrete temporal mechanism that uses multiple integrated networks

    Wait, it's discrete and it uses integrated clusters? Just what do you think discrete means?

    I'm sure Markram et al are aware of this but being biologists, they can't seem to move beyond the low-level complexities.

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