MIT Engineers World's First Schizophrenic Mice 159
Frosty Piss writes "MIT researchers have created a schizophrenic mouse that pinpoints a gene variation predisposing people to schizophrenia. Research with the mouse may lead to the first genetically targeted drugs for the disease, which affects 1 percent of the population worldwide. This is the first study that uses animals who demonstrate an array of symptoms observed in schizophrenic patients to identify specific genes that predispose people to the disease."
and how do you diagnose this? (Score:2, Informative)
actually they dont even know how to diagnose it exactly.
"People diagnosed with schizophrenia usually experience a combination of positive (i.e. hallucinations, delusions, racing thoughts), negative (i.e. apathy, lack of emotion, poor or nonexistant social functioning), and cognitive (disorganized thoughts, difficulty concentrating and/or following instructions, difficulty completing tasks, memory problems). "
http://www.schizophrenia.com/diag.php#diagnosis [schizophrenia.com]
now, how do you find out if a mouse has those problems?
besides, only a psychiatrist can diagnose schizophrenia, which we learned yesterday from slashdot posters, is just another 'left wing conspiracy' major, an evil liberal arts degree, when what this country really needs is more engineers blah blah blah etc etc etc.
Re:This may be a really ignorant question, but... (Score:5, Informative)
Schizophrenia - Mice With Defective Memory May Hold Clues
Main Category: Schizophrenia News
Article Date: 23 Jan 2006 - 21:00 PDT
Re:This may be a really ignorant question, but... (Score:5, Informative)
Animal models of these complex psychiatric diseases are always a bit questionable. This one seems to have bad memory formation, attention problems, and poor social skills. The researchers believe that's enough to call it a model of schizophrenia, but that's very difficult to say for sure.
Re:This may be a really ignorant question, but... (Score:4, Informative)
Right. These are just 'schizotypical' symptomps. Many other disorders feature schizotypical behaviour, including several developmental disorders, such as multiple-complex developmental disorder [google.com] and other disorders like shizotypical personality disorder [psyonline.nl], which feature schizotypical behaviour but are not true schizophrenia. I suspect that these mice have more of the latter disorders (which are thought to be genetic) rather than actual schizophrenia (which may or may not be genetic).
Re:I'm conflicted (Score:3, Informative)
There are well-established standards for the treatment of laboratory animals. Any institution that runs an animal lab is supposed to meet rigorous standards for living space, quality of food, cleanliness, etc., and have a veterinarian on staff (or at least on call) to look after the animals' well-being. They also need to take careful measures to avoid inflicting pain on the animals whenever possible. Now, I'm not saying that all labs live up to this, by a long shot, but I'd be willing to bet that MIT's labs do. And if the standards are followed, then even with the experimentation, the lab animals have much better, longer, healthier lives than their counterparts in the wild. Also, a lot of them end up as pets after their working lives are done; they get to spend their retirement being taken care of, generally very well, by the lab techs who know them best. Honestly, it's not a bad deal.
Re:Wrong. (Score:3, Informative)