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Biotech Science

Treating the Dead 246

FlyByPC writes "According to a NewsWeek article, oxygen deprivation doesn't kill patients as much as the resumption of oxygen does. This discovery could bring about new ways of resuscitating people whose hearts have stopped."
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Treating the Dead

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  • by zappepcs ( 820751 ) on Tuesday May 01, 2007 @10:12PM (#18950431) Journal
    the number of things that we, as humans, seem to learn about ourselves each day and week. Theoretically, this could save thousands of people if they figure it out, and would possibly change how we look at the actual moment of death. Might this also be helpful in cryogenics? or how many other branches of medicine? Could this make organ transplants more safe? Could it make heart surgery safer?
  • by mpn14tech ( 716482 ) on Tuesday May 01, 2007 @10:19PM (#18950481)
    It does not do any good to have a working body if I am still brain dead at the end of the process.
    It might be useful so organs could be used for a transplant.
  • by Score Whore ( 32328 ) on Tuesday May 01, 2007 @10:24PM (#18950547)
    Less breath == less oxygen. You'll still be doing roughly the same number of compressions per minute:

    bcccbcccbcccbcccbcccbcccbcccbcccbccc...

    bccccccccccbccccccccccbccccccccccb...
  • by nbauman ( 624611 ) on Tuesday May 01, 2007 @10:41PM (#18950705) Homepage Journal
    Yeah, reprofusion injury http://en.wikipedia.org/wiki/Reperfusion_injury [wikipedia.org].

    I wrote about that >20 years ago, when I was writing for a biotechnology newsletter. After >20 years of research, they understand it much better today.

    Every surgeon knows about reprofusion injury. You can go to Barnes & Noble and look it up in a surgery textbook.

    I don't understand why Newsweek says it's new or that it wasn't known in 1993. I assume those doctors came up with some new detail in its treatment.
  • by Anonymous Coward on Tuesday May 01, 2007 @10:56PM (#18950831)
    Is this flamebait? I mean, seriously, talking about cell apoptosis and you start slinging around framing like "Materialist Medicine"?

    Details please. I mean, I'm all against ethnocentrism as much as the next guy, but if you're going to trumpet "Alternative" "traditional" or "holistic" medicine this way, I sort of expect some shred of evidence. (And no, aphorisms from the Tao Te Ching don't count.)

    I lived in Hong Kong for several years, and let me tell you nothing about the traditional medicine over there says "aware of the cellular chemistry of oxygen resumption" to me.
  • by Nutria ( 679911 ) on Tuesday May 01, 2007 @10:57PM (#18950833)
    Huang, Ahmad, Silvfast, Skifvars, Vanden Hoek, Khan - all good American names :)

    Yes, actually, they are good American names.

  • Thank you (Score:1, Insightful)

    by Anonymous Coward on Tuesday May 01, 2007 @11:15PM (#18950945)
    Jokes aside, this guy & his team need some serious credit. Improving any method from 15% to 80% is impressive, but one that saves lives? That's just amazing. You, Sir, have my thanks & admiration.
  • by neoshmengi ( 466784 ) on Wednesday May 02, 2007 @12:22AM (#18951623) Journal
    The article has a strange focus on the '5-minute window' of oxygen deprivation to heart muscle. Heart muscle can survive and recover far beyond that 5 minutes. Clot busting drugs can be give hours after a coronary artery becomes occluded, restoring blood supply to heart cells that have been without oxygen that whole time.

    It's the brain that's exquisitely sensitive to oxygen deprivation. That 5-minute window refers to irreversible brain damage that begins to occur after ischemia, not heart damage. It's also well known that brain tissue releases toxic metabolites after oxygen deprivation doing damage above and beyond what the lack of oxygen itself did. There are a number of therapies aimed at reversing or blocking this phenomenon, but none have been successful yet.

    The intervention that has been shown to be most effective in changing survival outcome once someone's heart has stopped beating is good quality CPR as soon as possible. Most of these other innovations like cooling have only a minimal effect changing a dismal outcome to a not-quite-as-dismal-but-still-pretty-dismal outcome. Most of these intra and post resuscitative interventions only succeed in allowing a patient to linger in the ICU for a few extra days before finally dying.
  • by jd ( 1658 ) <imipak@yahoGINSBERGo.com minus poet> on Wednesday May 02, 2007 @12:40AM (#18951835) Homepage Journal
    From the sounds of other posters, this is 20+ year old knowledge and I'm guessing the theory is much further along. I'd also guess that the ultraconservative medical practices out there are reluctant to use this knowledge. Well, can you blame them if they are? If they did something different from tradition and it failed, they're in for a lawsuit from hell. Even if it succeeded, but wasn't perfect, you can bet people would sue them to hell and back for malpractice. And if it was perfect, they end up with having to treat more patients in hospitals that are already overloaded and understaffed. They can't win for losing.

    However, yes, this would likely be useful in cryogenics. If it takes an hour for a cell to start to die, then you can afford to be much more gentle on tissue when thawing it, and therefore should be able to develop methods that are much less damaging. It should also increase the number of transplantable organs, as there'd be a far larger window of opportunity.

  • by NIckGorton ( 974753 ) on Wednesday May 02, 2007 @01:10AM (#18952161)
    Actually the primary reasoning for the change was largely to keep it simple. This means there is ONE ratio to remember for all lay-rescuer (single person) CPR for anyone that is not an infant.

    There is not a single 'ideal' compression to ventilation ratio. We know that for garden variety cardiac arrest due to V-Fib, ventilation in the first minute or so is probably almost meaningless. We also know that for hypoxic arrests (like a drowning) that ventilation is far more important. We also know that VFib makes up a greater percent of adult arrests and hypoxic arrests are more common in kids (all of whom get the same ratio.) Moreover the AHA made this decision knowing that they didn't even know the ideal ratio for the single most common type of arrest in the community (from VFib.) The 30:2 ratio was a way of keeping it simple that is not perfect for every kind of arrest, but is a reasonable compromise to try to deliver at least a reasonably acceptable type of CPR to all victims of arrest.

    That is a good thing for lay-rescuers, but the AHA understands that people who are more highly trained and knowledgeable will guide their actions based on that knowledge. For example, if my partner grabbed his chest and collapsed, I would run to the phone, call 911. Return to him, check for a pulse, and if he had none, start wailing on his chest like a crazed weasel on crack. I would not even consider breaking compressions to give a breath till at least minutes had passed - or more trained people arrived and ACLS could be initiated. If however, I pulled him out of a pool, I would check for breathing and if none, give two full rescue breaths. Then check for a pulse, if none, start CPR with probably about a 15-20:2 ratio. I would stop for a moment at 1 minute. If he had a pulse, I would continue breathing for him a full minute or two before I ran to the phone. If he had no pulse, I would give two last breaths and run for the phone.

    Those are drastically different methods that I chose knowing that they would give him the best chance in either situation. But if you try to teach lay-rescuers that, you will get blank stares and some shitty-assed CPR. So it is better to make things as simple as possible and make them so at least everyone gets 'reasonable' CPR.

    Nick
  • by nietsch ( 112711 ) on Wednesday May 02, 2007 @06:04AM (#18954065) Homepage Journal
    So basically you are saying that people will choose a more unhealthy lifestyle and that the spending per capita goes up if healthcare is free? So name me any country where this has happened? And if the reverse can be found in overwhelming numbers, will you admit your whole theory is just a fantasy based on party ideology instead of reality?
    In that case, I urge you too look at any country in Europe that has this socialized healthcare you detest so much. Europeans are much more healthy and spend an order of magnitude less on healthcare than USians.

    Now it is time to stick your head in the sand again...
  • by ojQj ( 657924 ) on Wednesday May 02, 2007 @09:33AM (#18955759)
    I doubt though that people base decisions about how healthy their lifestyle will be on the question of whether or not someone will pay for their illness. After all, most of us like being healthy regardless of how much or how little money that will cost us. This is one of the arguments *for* socialized health care. It's not like in other industries where people will shop around for the best price/quality quotient. They want the best possible service, or the quickest possible service, but rarely the cheapest possible service. This is one reason that it is reasonable to call healthcare a "natural monopoly" (like water, sewage, or electricity). There are good arguments to be made for saying that health should be taken over or heavily regulated by the government.

    Still I'm not convinced.

    Where economic incentives do help with a market-based health insurance system is when employers have to pay for health insurance (as it is in most cases of full-time employment in the US). I suspect that the most important component of your lifestyle is what you do at work. By forcing employers to pay for health insurance, you provide an incentive for employers to provide a healthier environment for their employees since that means lower insurance premiums. Results of this that I've seen are: company cafeterias with a greater emphasis on also providing healthy food, on-site exercise centers, and improved emphasis on ergonomics and safety.

    I also think that Europe's social, and physical structure works better for keeping people healthy: less relocations and more vacation mean less stress and more contact to friends and family, denser cities and better public transportation means more exercise, less wealth means less excessive eating. I don't believe that socialized healthcare is the primary factor in the health gap between the US and Europe.

    In addition socialized healthcare has negative consequences which I have had to directly bear. My old doctor closed his practice because he couldn't earn enough to support himself and his family. My new doctor is great; I'm really happy with him, but the appointments are very short -- he's obviously over-worked. It's problems like this and others that have brought me to opt out of the German socialized healthcare system.

    P.S. In Germany you pay between 12-15% of your salary for socialized health care. I'm not going to compare that to the US, since I don't actually know the percents in the US. I'm just putting that out there for anybody who does know the US number and wants to compare.

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