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Biotech Science

Creating Prion-Free Cows 340

Science Daily is reporting that the U.S. Department of Agriculture's Agricultural Research Service (ARS) is reporting positive results from a recent study designed to create genetically engineered prion-free cattle. From the article: "ARS studied eight Holstein males that were developed by Hematech Inc., a pharmaceutical research company based in Sioux Falls, S.D. The evaluation of the prion-free cattle was led by veterinary medical officer Juergen Richt of ARS' National Animal Disease Center (NADC) in Ames, Iowa. The evaluation revealed no apparent developmental abnormalities in the prion-free cattle."
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Creating Prion-Free Cows

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  • Dead sheeps (Score:5, Insightful)

    by Per Abrahamsen ( 1397 ) on Tuesday January 02, 2007 @06:34AM (#17430186) Homepage
    This is great! Now we can go back to feeding the cows a healthy diet of dead sheep, which was how the whole "mad cow" thing started.
  • by abscissa ( 136568 ) on Tuesday January 02, 2007 @06:34AM (#17430188)
    ... or you could just not feed them parts of their dead relatives?
  • Re:Dead sheeps (Score:5, Insightful)

    by WindBourne ( 631190 ) on Tuesday January 02, 2007 @06:38AM (#17430208) Journal
    Actually, that is not proven. It it THOGUGHT that scrapies is the same as Madcow ( and MC CWD CJD), but they are not certain. But even with that, I want to know how accurate is the test these days? It is great that they did not have any positive in what was suppose to be negative cattle. But will they get a good positive in an infected animal?
  • by Oswald ( 235719 ) on Tuesday January 02, 2007 @06:50AM (#17430252)
    Isn't it encouraging to know that, while your solution works in theory, it's not good enough in practice because you can't trust people not to do that.

    Doesn't seem that hard, really, but people are pretty stupid.

  • by Futurepower(R) ( 558542 ) on Tuesday January 02, 2007 @07:16AM (#17430354) Homepage
    Yes, but the Finns have a government that serves the people.
  • Re:New cows? (Score:3, Insightful)

    by aussie_a ( 778472 ) on Tuesday January 02, 2007 @08:25AM (#17430606) Journal
    Not until we know the full effects it has in animals.
  • by Anonymous Coward on Tuesday January 02, 2007 @09:11AM (#17430810)
    A bigger worry is the fact that a company (read capitalism) will be holding the patents on our food supply. Much like what big agra has on corn, soybeans, etc.
  • by punterjoe ( 743063 ) on Tuesday January 02, 2007 @09:12AM (#17430818)
    I too wondered why "big science" would try to come up with a way to create cattle that can still be fed 'cannibal chow' without getting sick, instead of just changing the feed to something healthy, when I realised there are no IP licensing rights for natural, healthy cattle. This 'super cow' is surely patentable :(
        My other disappointment is that so much time & resourcefulness was spent on this rather than a way to prevent prion diease from taking it's toll on the untold people who have eaten infected 'industrial-beef' through fast food & other sources but won't show symptoms for many years.
  • Re:New study! (Score:2, Insightful)

    by Vellmont ( 569020 ) on Tuesday January 02, 2007 @09:17AM (#17430832) Homepage

    Hmm... Removing natural things... Nope, doesn't sound like a good idea to me.

    If you believe natural==good, I'd suggest a nice big bowl of anthrax this morning. It's 100% natural, so it must be in some way good for you, right? You could also eat some nice castor beans, which contain one of the most toxic poisons known as ricin. The feces in cows is also 100% natural, so you'll probbably get some disease from not eating that, right?

    If you think that "messing with nature" is a bad thing, you should probbably stop eating entirely. We've been using selective breeding techniques on basically our entire food supply for thousands of years.
  • Re:New study! (Score:3, Insightful)

    by Vellmont ( 569020 ) on Tuesday January 02, 2007 @09:53AM (#17430994) Homepage

    I simply stated that they'd be fools to mess with things they don't know anything about yet.

    See, the thing is we actually DO know a lot about nutrition and proteins. At the very least we know that prions provides us nothing we need in our diet. It sounds like you're the one that knows nothing about it. In the future I'd suggest not talking about things you know nothing about.
  • Re:Dead sheeps (Score:4, Insightful)

    by slashbob22 ( 918040 ) on Tuesday January 02, 2007 @10:27AM (#17431228)

    But will they get a good positive in an infected animal?
    As far as I understand with MC, CWD, Scrapies, CJD and Varient CJD the only way to ensure accuracy of tests is through a biopsy of the brain tissue of a dead subject. While there are tests for live subjects (clinical observations) they are not definitive [wikipedia.org].
  • No. (Score:2, Insightful)

    by Programmer_Errant ( 1004370 ) on Tuesday January 02, 2007 @10:40AM (#17431360)
    Normal high tempurature sterialization of surgical instruments that have been used for brain surgury doesn't destroy prions. You have to use more exotic techniques that are a little rougher on surgical instruments. It's a big problem for hospitals. So mere cooking wouldn't affect prions.
  • by Gordonjcp ( 186804 ) on Tuesday January 02, 2007 @10:56AM (#17431496) Homepage
    As for vegetarians, unless their idea of going vegetarian is going from hamburger and fries and soda to more fries and soda, it's not hard for them to eat healthier than their omnivore peers.

    Oh, I wouldn't be so sure. While I agree that our western diet (I'm in the UK, so not so very far west compared to probably most of the /. readership) probably has too much meat in it at the moment, I'd urge people to be cautious if they are only going to eat vegetables. Intensively-farmed vegetables may have all kinds of nasty chemicals on them. Extensively farmed and organic vegetables won't be free of them either, and with organic farming comes "organic fertiliser". You really want to make sure you clean and cook those organic veggies *very* thoroughly. Faecal bacteria will make a mess of you.

    I'd say that my meat is probably safer by far than most shop-bought vegetables. The problem that most people run into is they want to eat as cheaply as possible, and this is fundamentally incompatible with having good-quality food. Most people put more attention into the kind of oil and petrol they use in their car than the fuel and lubricants they use in their body. You can't cut out fat, your joints will fail. You need to get the right kind of fats. You don't get these from a Big Mac and Fries. It costs roughly three times as much for an organic free-range chicken than an el-cheapo battery hen. Is it worth it? Well, yes - the hen has had a better life, a better diet, and has probably been slaughtered and prepared a bit more carefully. Once you've had *real* meat instead of factory-farmed crap, you'll never ever go back. Spend the money, eat a little less of something better, and the environment, your wallet and your waistline will thank you.
  • by Anonymous Coward on Tuesday January 02, 2007 @11:44AM (#17431848)
    Another example of humans fighting Darwinism. People like that would have been weeded out a long time ago, but now they're breeding and producing offspring who can only eat hydroponically grown organic grass and drink triple reverse-osmosis'd & ozonated water.
  • by ebuck ( 585470 ) on Tuesday January 02, 2007 @01:28PM (#17433050)
    To a real scientist, "no apparent developmental abnormalities" means that they're hedging their bets. They haven't seen any developmental abnormalities, but as scientists, they know that it is impossible to observe every detail in their lifetime, so they're just saying that they haven't discovered one yet.

    A scientist doesn't have a strong interest in not finding things, finding things is what makes a scientist's career successful.

    Business sponsored research isn't science. Business sponsored research usually employs people called scientists who then don't use (or misrepresent) the scientific procedure, producing results which were probably dictated before the experiment was started.

    A popular misconception is that if a scientist says it, it's science. Science is about the procedure, not the person. If a scientist says he can save 15 minutes to picking up his dry cleaning, it's not science. But if an experiment is performed which accurately measures dry cleaning pickup times, and by changing how dry cleaning is picked up the times decrease by 15 minutes, then that's science.

    Remember, appeal to authority only works in authoritarian systems. In law, (authoritarian system) the judge is an authoratative figure, what he says and does has a real impact on the case. In science, a scientist isn't an authoritarian figure. Sure, a scientist may become famous, but that's celebrity. A famous scientist can still be wrong, but the procedure eventually aligns the "model of how things work" with the "world in which things happen".

    So trust your science, but don't get it from Newsweek, FOX, CNN, etc. Any findings without a description of the procedure and the control is a fluff piece that might totally misrepresent the discovered facts, the observations, the deductions based from the observations, and the findings of the experiment. The reason U.S. Citizens have such a cynical view of scientists is partially due to sloppy "BIG HEADLINES" reporting that takes the least consequential detail out of context for the biggest impact.
  • by WryCoder ( 18961 ) <[moc.xobnitsop] [ta] [30kbk]> on Tuesday January 02, 2007 @03:38PM (#17434628)
    A prion is an 'infectious' protein which causes similar proteins to change their structure, rather like seeding a supersaturated solution. What has been done is to clone cattle which lack the protein which could be altered by the prion.
  • by Syrrh ( 700452 ) on Tuesday January 02, 2007 @08:32PM (#17437812)
    Presumably the testing isn't over, the researchers just decided that 2 years is a pretty good success indicator, especially when they've been injecting BSE prions *directly into the brains* of the test animals. If the infection can't take hold in that condition, I'd say it pretty well surpasses any naturally occuring scenarios. Still too early to say with absolute certainty, but they have good reason to celebrate so far.

    I'm more interested in where this heads beyond the BSE scare, since it'll be a lot harder to genetically scrub out CJD and CWD, but at least the possibility is opening up. I'm really interested to see if this manipulation ends up with no side-effects since it means that genetic cruft is seriously dangerous. With the genome mapped, will there be mumbles about getting the non-functional buffer sections tailored and zeroed out to ward off other mysterious and rare afflictions?
  • Re:A better idea (Score:3, Insightful)

    by zenhkim ( 962487 ) on Tuesday January 02, 2007 @11:02PM (#17439118) Journal
    >> Those meatarians out there should give life a long good look as decide how do I want to enjoy life: quick and painfull (and ignorant), or slow and healthy.
    >
    > Perhaps it is you who are "ignorant" of the fact that the human body is built around an omnivorous diet.

    *Sigh* Where to begin?

    Humans are omnivorous largely by choice (just because we like the taste of meat) or necessity (because there aren't always enough veggies around to keep us from starving). Nature, however, gives us clues as to what our optimal diet should be.

    Go to a mirror and study your teeth. Notice how most of your teeth have flat edges or large crushing surfaces? Those are the teeth of a herbivore: the teeth up front and center are suited for biting off plant matter, while the teeth in back are excellent for grinding the stuff down. The few pointed teeth we have are woefully inadequate for killing and devouring prey -- if you don't believe me, go out into the wilderness and try to take down and eat an animal with nothing but your teeth.

    Next, get a reference book on human anatomy and look at the diagrams of the digestive system. Notice the extremely long and twisty intestines? That's the mark of a herbivore -- true meat-eaters have short digestive tracts in order to process food as quickly as possible. They also produce a specific acid to rapidly break down meat once it is ingested, yet humans lack that digestive acid.

    Now look up 'dietary fiber' and its value for the digestive system. Nutritionists are in agreement that dietary fiber is not only beneficial, it is essential for good health. That means a diet that is rich in fruits, vegetables, breads and cereals -- all of which contain dietary fiber. By contrast, meat has absolutely *no* fiber.

    "But you can't get adequate/complete protein nutrition on a vegetarian diet!" Not so: the average adult human requires only 40 to 50 grams of protein per day, and can get complete protein nutrition by eating certain foods such as

    - peanuts and wheat (i.e.: peanut butter sandwich on wheat bread)
    - beans and rice (the staple of Mexican food)
    - chickpeas and sesame seeds (hummus, anyone?)
    - soybeans

    Sure, humans can sustain themselves on an omnivorous diet. However, just because we can do something doesn't mean we have to -- or that we ought to. Now, if you'll excuse me, I'm going to finish my bowl of vegetarian chili. Mmmm... meatless chili, mmmm... :-D

It's a naive, domestic operating system without any breeding, but I think you'll be amused by its presumption.

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