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Biotech Science

Sense of Smell Tied To Quantum Physics? 169

SpaceAdmiral writes "A controversial theory that proposes that our sense of smell is based not on the shape of the molecules that enter our nose but on their vibrations was given a boost recently when University College London researchers determined that the quantum physics involved makes sense. The theory, proposed in the mid-1990s by biophysicist Luca Turin, suggests that electron tunneling initiates the smell signal being sent to the brain. It could explain why similarly shaped molecules can have very different smells, and molecules with very different structures can smell similar." Turin has now formed a company to design odorants using his theory, and claims an advantage over the competition of two orders of magnitude in rate of discovery. The article concludes, "At the very least, he is putting his money where his nose is."
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Sense of Smell Tied To Quantum Physics?

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  • by drinkypoo ( 153816 ) <drink@hyperlogos.org> on Monday December 11, 2006 @06:36PM (#17200924) Homepage Journal
    On the other hand, if it turns out to be true, it has far-reaching implications. A lot of people have been saying for a long time that quantum effects simply cannot be a factor in the brain, or causing neurons to fire or not, because their effect is too weak. This would be a counterexample and might cause us to look more seriously at quantum activity in the brain. One theory of the mechanism of memory is that it is stored as a series of quantum oscillations creating a sort of holographic pattern...
  • Quantum Chemistry (Score:1, Interesting)

    by opencode ( 28152 ) on Monday December 11, 2006 @06:45PM (#17201038) Homepage
    The UCL team calculated the rates of electron hopping in a nose receptor that has an odorant molecule bound to it.

    --

    He had me until this sentence (although the line that he found the theory interesting enough to refute was a very nice touch).

    Electrons, photons, and protons are all merely models to explain in tangible terms what the **** is going on down there, so I become skeptical when these terms are utilized to explain/demonstrate quantum mechanics. We know how to use electricity, buy it, sell it, how to protect our kids from it, yet we really don't know what it is. Two and a half degrees in Chemistry has taught me little that's applicable to the English speaking world, save this: we don't have a clue what's going on at that level of reality, but we're absolutely certain it involoves nothing at all that could be described as little balls orbiting other balls and emitting electrical charges. That's merely a model to make sense of it, and an imitation of life at best.

    Something else about Quantum Mechanics/Chemistry: If what anyone says doesn't sound medeival, they're probably thinking too hard and incorrectly. It's gotta sound really strange or it's not QM/C.

  • by Oriumpor ( 446718 ) on Monday December 11, 2006 @06:45PM (#17201052) Homepage Journal
    A poet once said, "The whole universe is in a glass of wine." We will
    probably never know in what sense he meant that, for poets do not write to
    be understood. But it is true that if we look at a glass of wine closely
    enough we see the entire universe. There are the things of physics: the
    twisting liquid which evaporates depending on the wind and weather, the
    reflections in the glass, and our imagination adds the atoms. The glass is
    a distillation of the earth's rocks, and in its composition we see the
    secrets of the universe's age, and the evolution of stars. What strange
    array of chemicals are in the wine? How did they come to be? There are the
    ferments, the enzymes, the substrates, and the products. There in wine is
    found the great generalization: all life is fermentation. Nobody can
    discover the chemistry of wine without discovering, as did Louis Pasteur, the
    cause of much disease. How vivid is the claret, pressing its existence into
    the consciousness that watches it! If our small minds, for some
    convenience, divide this glass of wine, this universe, into parts --
    physics, biology, geology, astronomy, psychology, and so on -- remember that
    nature does not know it! So let us put it all back together, not forgetting
    ultimately what it is for. Let it give us one more final pleasure: drink it
    and forget it all!

            - Richard P. Feynman, The Feynman Lectures on Physics, v. 1, p. 3-10
                (This lecture is also one of the six lectures featured in a book &
                audio edition entitled "Six Easy Pieces")
  • by whathappenedtomonday ( 581634 ) on Monday December 11, 2006 @07:07PM (#17201308) Journal
    Their claim that signals can be translated through tunneling in a biological system which likely swamps those potential signals with noise is what really troubles me.

    Actually, there seems to be quite a lot of noise in our brain. [zdnet.com]

  • by BWJones ( 18351 ) * on Monday December 11, 2006 @07:40PM (#17201740) Homepage Journal
    Dammit! Mad props to you as I was thinking alanine. That of course is exactly why Slashdot gets you in trouble. You type stuff in off the top of your head to get your entry in and sometimes you get it wrong. The cool thing is that there are folks on Slashdot that will catch you.

  • by blank axolotl ( 917736 ) on Monday December 11, 2006 @07:41PM (#17201764)
    I disagree. My (non-expert) impression is that this research is really about the physics of receptor (detector) proteins. The neural system is irrelevant because what we are worried about here is whether the receptor triggers a reaction or not. Once the receptor is triggered, the psychology is the same: a signal passing down the nerve into the brain.

    The idea seems plausible to me, at least it is worth investigating. What it proposes is a new way a receptor could be triggered by a molecule. Here, once the molecule has 'docked' into the receptor, if its electronic vibrations are matched to the receptor it will allow a charge to tunnel from one part of the receptor protein to another, triggering a larger reaction (like in photosynthesis). So, this receptor can detect electronic vibrations.

    Actually, I think that how receptors and other membrane proteins work is fairly poorly understood (compared to other areas of physics), and there is a lot of research time going into it. Even the protein for photosynthesis isn't totally understood (though we know a lot). Last summer I was considering doing some modelling of a potassium channel, a homolog of the one essential to our nervous system. "The" potassium channel. Actually, we don't really know how it works! Previous models have suggested that some charged cylinders slide through the protein, pulled by the potential across the membrane and causing it to open, however the new theory (based on the recent crystallography data) is that it is actually a charged lever that gets pulled by the potential, opening the channel as it tilts. In other words, we still in the educated guessing stage, even for this essential protein.

    My Point: How these proteins work really isn't understood. The idea seems plausible on surface glance. Maybe this guy is on to something big!

  • by Ungrounded Lightning ( 62228 ) on Monday December 11, 2006 @09:16PM (#17202636) Journal
    I think the point of the criticisms of Penrose isn't over whether quantum-mechanical stuff is going on, but whether quantum-mechanical wierdness (such as entanglement) is involved in the brain's computations or whether they can be fully explained by the classical physics and chemistry approximations (and can thus be adequately modeled by algorithms run on ordinary computers rather than requiring a quantum computer).
  • by rhombic ( 140326 ) on Monday December 11, 2006 @09:28PM (#17202744)
    Yep, Landsteiner got the Nobel in 1930 for ABO typing-- nothing to do w/ chiral recognition. That work was done later with van der Scheer, in the 20's, not part of the ABO work & not what the Nobel was awarded for. I am remotely familiar w/ my science in this area ;). And a little bit of the history, too.

    Understood about confusing glycine & alanine, but when you're pointing out chiral recognition and you choose as an example the one and only non-chiral amino acid, somebody's gonna call you on it.

  • by cnettel ( 836611 ) on Monday December 11, 2006 @09:55PM (#17202946)
    I wouldn't even call it that unconventional. There are lots of examples of ligand-protein interactions where you can't get the experimental affinity right, unless you make the energy-minimization time-dependent and compute the mean. This is not only a matter of the fact that the protein will adapt slightly when binding the ligand, but really that we have a continuous movement going on. A conformation where one vibration would suddenly be totally fixed, although it looks fine if you look at the static average, might be quite disastrous. This will be important if we ever want to be really good at engineering new enzyme specificities, or new ligands. Creating perfumes is of course a rather useless special case of the latter, and while it might be news to the odor industry, it shouldn't raise any eyebrows in the pharmeceutical industry. (At least if TFA is anywhere close to describing the actual theory...)

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