NIH Confirms Protocol To Reverse Type 1 Diabetes 116
FiReaNGeL writes "In 2001, researchers at Massachusetts General Hospital demonstrated the efficacy of a protocol to reverse type 1 diabetes in diabetic mice. New data from a study performed at the National Institutes of Health provides additional confirmation of the ability to reverse type 1 diabetes and on the role of spleen cells in islet regeneration. Spleen cells appear to contribute to islet recovery more in mice who are older and with more advanced diabetes compared with younger mice with less advanced diabetes, in which regeneration of remaining islets may be the dominant mechanism."
Hype or not? (Score:1, Interesting)
Re:Type I, not Type II (Score:3, Interesting)
Type 2 diabetes deteriorates if not kept well-controlled. In advanced stages, the hyperglycemia oxidizes proteins and kills off pancreatic islets, until the pancreas is unable to produce insulin, just as in Type 1.
So if an advanced type-2 diabetic fixed up their insulin resistance, they might still be unable to produce insulin. And the therapy in the article might then be helpful to them too!
Re:Type I, not Type II (Score:3, Interesting)
You are right on the result (pancreas no longer able to produce insulin), but your mechanism (oxidative stress) is at best only part of the picture. If oxidized proteins induced by hyperglycemia were cytotoxic, a lot more cell types in addition to pancreatic islets would be killed off.
The exact mechanism of beta cell burn out in advanced type II diabetes is unclear
http://diabetes.diabetesjournals.org/cgi/content/
however it certainly related to a prolonged an inappropriately high production of insulin (hyperinsulinemia) in response to high levels blood glucose.