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Biotech Science

Need A New Retina? Look No Further 310

wap writes "Restoring sight to the blind is a Bibical miracle, a sign of divine powers. Now it is being tested at the Boston Retinal Implant Project, with some very limited success, according to Technology Review. They only have fifteen electrodes implanted, but it's a start. Great quotes: 'The eye doesn't like stuff inside it, that's why it doesn't have a zipper.' Will artificial eyes and retinal replacements someday be as good as good human eyes?"
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Need A New Retina? Look No Further

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  • More info (Score:5, Informative)

    by caitsith01 ( 606117 ) on Thursday August 19, 2004 @06:46AM (#10010756) Journal
    Some info about the various types of bionic eyes currently being built can be found on Wired. [wired.com]

    Brain implant [dobelle.com] anyone?
  • by Jeff Kelly ( 309129 ) on Thursday August 19, 2004 @07:35AM (#10010959)
    Just some clarification.

    These devices won't restore eyesight to people who were born blind. Only those who, at one time in their life, actually could see will profit from such technical replacements.

    When you are born you are nearly blind. It takes four to six years for the visual cortex to develop fully. After the age of six this development stops and thats the end of it.

    If you are born blind then the cortex will not be trained and no magic eye surgery will restore your vision, because after the age of six the visual cortex will no longer adapt to the new situation.

    Even if your eyes are restored to 20/20 vision you will not see a thing because your vision center doesn't know how to interpret the pictures. So these kinds of surgery will only help people which went blind and not those who were born blind. (Still cool stuff)

    BTW. It is the same with deafness.
  • by vofka ( 572268 ) on Thursday August 19, 2004 @07:38AM (#10010972) Journal
    Why replace your real eye to do this if it is perfectly healthy? Take a look at EyeTap [eyetap.org]. This research, mainly by Professor Steve Mann [toronto.edu] at the University of Toronto has the potential to do everything you describe, and much more besides!
  • by JosKarith ( 757063 ) on Thursday August 19, 2004 @07:49AM (#10011015)
    AFAIK it's something to do with the frequency of the laser used. They use a uv laser to burn away pieces of the lens to re-shape it and. Your retina is composed of cones and rods - the cones are responsible for daylight vision and colour, the rods only see in black and white and are more light-sensitive so work better at night. I'm only guessing at this point but since the rods don't see colour, just intensity, then they are more likely to be affected by a powerful light source outside our normal visual frequencies.
  • by vofka ( 572268 ) on Thursday August 19, 2004 @07:50AM (#10011023) Journal
    The night vision problem is caused by the way the surgery is performed, and it depends on which type of surgery is carried out. The problem that is caused is a "starburst" effect around the point where the front of the eye is opened and re-sealed, or around the points where modifications have been made to the eye.

    Usually these effects wear off after a couple of weeks, and some people never experience them at all, but for a minority of patients, they are left with a permanent "starburst" effect, which is worst in any high-contrast light-on-dark situation, such as driving at night.

    The problem is serious enough that some governments have banned any person who has had laser eye surgery from driving at all - which is annoying for those who had their vision corrected to bring it into the range acceptable for driving in the first place!
  • by Anonymous Coward on Thursday August 19, 2004 @07:56AM (#10011053)

    It just corrects flaws in the lenses, which should make all types of vision better. Anyone? I'm considering it, that's why I'm interested.


    It doesn't "correct flaws in the lenses". It has no effect on the eye's anatomical part called a"lens". Typical near/far sightedness isn't caused by any geometric flaws, but rather by the eye's inability to refocus the "baseline" position of the lens due to skeletal changes forcing geometry changes of the eyeball. Astigmatism is due to corneal flaw in shape but the cornea is still perfect in terms of surface. Contrary to some myths, it is not due to muscle problems, it's that the lens isn't anywhere it needs to be where the muscles can do some good. Laser surgery cuts away at the cornea to change the refractivity of it so that the lens' accomodation range is back in the active area for the optical system consisting of cornea, lens, retina (the same way contact lenses and glasses work).

    These cuts cause flaws. In addition, the contrast and reflectivity of the cornea is adversely affected. It is still much better than the older techniques. What some people forget is that laser surgery is still surgery. It is still butchery, its just that the laser is relatively more precise and allows smaller scale cuts than a knife.
  • useful but not great (Score:3, Informative)

    by cyberwitz ( 767170 ) on Thursday August 19, 2004 @08:15AM (#10011125)
    6 months ago I had cataract sugery and an interocular implant. The implant is fantastic, it took me from functionaly blind, in that eye, to pretty usable vision in the eye.

    There is absolutely no equal to the organic material of the eye, though. As good as the implant is, it's still like looking at a bad reprint of a picture.

    When it comes to the human body, third party products are decent if you can't get the real thing. But, they really aren't (and probably won't be) better.
  • by xenicson ( 214967 ) on Thursday August 19, 2004 @08:32AM (#10011205)
    Actually, it depends on where the blindness occurs... there are several different "kinds" of blindness... problems with the visual cortex, problems with the optic nerve, and problems with the actual eye structure (though I'm sure there are many more)... it is entirely possible for someone to be born with a working visual cortex and optic nerve, but broken eyes that this would be able to help.
    BTW, Why is this just making news here, now? I saw a spot on CNN probably a year ago or more about a guy that was blind, but had stuff implanted into his brain and a little camera to allow him to see... It's still really cool, but it isn't really new.
  • Re:As good??? (Score:2, Informative)

    by Anonymous Coward on Thursday August 19, 2004 @08:53AM (#10011356)
    No need. Remember that color perception is not done as absolutes, since different lighting conditions would wildly change the perceived color. Rather, it's done as a matter of differences between the object and its surroundings: it's an edge detection effect, and this is documented in all sorts of visual illusions and neurological studies since the 1960's when Jerry Lettvin at MIT started putting electrodes on single neurons.

    Adding another 3 colors would expand the edge handling required from 3 colors, and the resulting 2+1 = 3 differentials, to 5+4+3+2+1= 15 differentials to resolve. Forget it, it's too complex to easily manage and doesn't really buy you much additional resolution of real objects that isn't present in RGB.
  • Not Analog, Optical. (Score:1, Informative)

    by Anonymous Coward on Thursday August 19, 2004 @09:56AM (#10011874)
    It's not called "analog zoom". It's "optical zoom". Big difference.

    When you zoom an OPTICAL LENS, you're still working with the original subject matter (light), and you haven't really degraded what you want to sample. Just the opposite. But if you don't zoom the original optical image, instead sampling it at low quality, and then expect to magically use digital technology to make low quality data into high quality data, then obviously, you'll be disappointed.

    On the other hand, if you make a DIGITAL, OPTICAL LENS, it would quite possibly be better than analog lenses, but no one has invented such a thing yet.
  • by The_K4 ( 627653 ) on Thursday August 19, 2004 @10:47AM (#10012433)
    Yes there IS a "digital" base for all things (and your examples were good ones) HOWEVER there unless the digital technology you are using sufficiently advanced then the analog process might produce better results. For example for a long time digital cameras and printeres were not able to produce pictures as good as film/photo paper becasue the digital technology was unable to get the resolution as high. So for so applications analog is currently still better then digital (however that set is shrinking).

    Remember that the f/2 is the minimum sampling rate to be able to caputer a signal, in most cases that will NOT provide all the spectral info needed. Think of a sign wave, if you hit it just right you would see a flat line with f/2 sampling. Often for GOOD reproduction you need to sample more then 2x withing the period of the wave, often times 10x is much better.
  • Re:As good??? (Score:2, Informative)

    by Lonewolf666 ( 259450 ) on Thursday August 19, 2004 @10:51AM (#10012470)
    Actually, the raw data you get from a CCD is better than the raw data you would get from the back of the human retina. The retinal is covered with blood vessels, has a big hole in it (the blind spot), had a great deal of noise (phosphene activity).

    On the other hand, the human eye has pretty good resolution in the point of best vision, something like an arc minute. At the same time, it offers motion detection over a rather large arc. This allows you to notice something happening at the edge of your field of vision.
    Let us assume for a moment that you want to emulate these features with a "standard" CCD that has a uniform resolution over its surface. The field of vision shall be 90 degrees horizontally. You would then need a resolution of 90*60 by (let's assume the traditional 4:3 ratio) 90*45 pixels.
    That would be a 5400x4050 pixel CCD. AFAIK such CCDs do exist, but at a size that would not fit into a human eye.

    Considering noise, most of today's cameras still need a flash or a floodlight to make decent pictures at night. So add some low-light amplification to your CCD, if you want to compete with the human eye ;-)

    Bottom line:
    Technology has to improve some more before it can give better results than a human eye from an eyeball-sized camera.
  • by skkellymit ( 806715 ) on Thursday August 19, 2004 @11:19AM (#10012885)
    This implant is meant for people suffering from retinitis pigmentosa and macular degeneration. It is not meant as a replacement for functional eyes. :)

    It will likely not be as good as normal vision for a *very* long time, if ever; it is meant to return some mobility and possibly face and detail recognition to people who have gone blind by retinal degeneration.

    Furthermore, this is not a "cure" for these diseases. The rods and cones still die, but are "replaced" by an external camera and some implanted circuits and electrodes to stimulate the retinal nerves which form the optic nerve.

    In response to those asking whether this is new: it's not. Most of the groups working on artificial vision (retinal implants, cortical implants, optic nerve implants) have been at it for well over a decade. What is new is the development by some of these groups of actual implantable devices, as shown in the Technology Review article. Previous experiments typically involved electrodes inserted into the eye of a blind volunteer for a short time, with all of the electronics remaining outside.

  • by Jeff Kelly ( 309129 ) on Thursday August 19, 2004 @03:42PM (#10016134)
    "Uh... How do you know? If they're just developing this technology, then no one has ever benefitted from it before and you can't be sure whether or not the brain can cope."

    I know because there are other conditions which, to some extend, lead to the same phenomenon. If you are suffering from strabismus or nystagmus since birth the same could happen to you. If you suffer from strabismus then you get diplopic images since right and left eye are not parallel.

    The brain cannot cope with this kind of double vision because it cannot combine the two images (from the left and right eye) to form a threedimensional image.

    So the brain ignores the image from the weaker of the two eyes and the part of the visual cortex, which processes the images from this eye will no longer be used.

    This leads to bad vision which cannot be corrected with glasses or lasik since its the visual cortex who cannot correctly process the data.

    If this remains untreated to the age of six or seven you will never recover your vision. Due to strabismus and nystagmus the vision of my right eye is only at 5% so i am a good example of that myself.

    A popular treatment for this is to use eyepatches. You disable perception from the better eye and force the brain to use the weaker one so that this part of the visual cortex will also be trained. But this treatment has to start when you are still young for it to have any effect.

    HTH

    Jeff

    p.s. i hope i have explaned it correctly since i am not a native speaker (Had to look up some words in the dictionary)
  • Re:Quote (Score:2, Informative)

    by narcc ( 412956 ) on Thursday August 19, 2004 @03:44PM (#10016151) Journal
    Who was it that said "any sufficiently advanced technology is indistinguishable from magic"?

    Arthur C. Clarke (Famous author of: 2001, Childhoods End, Songs of Distant Earth, and many others)

    The quote you're discribing the third of Clarkes Three Laws[1] first published in an essay titled "Hazards of Prophecy: The Failure of Imagination", in Profiles of the Future

    There is also a corollary to the third law that states any technology distinguishable from magic is insufficiently advanced (Gregory Benford [2] first proposed this in Foundation's Fear[3])

    Hope that Helps.

    References:
    [1] Clarke's Three Laws, Wikipedia.org [wikipedia.org]
    [2] Gregory Benford, Wikipedia.org [wikipedia.org]
    [3] Foundation's Fear, Wikipedia.org [wikipedia.org]
  • Sight to Blind (Score:2, Informative)

    by Anonymous Coward on Thursday August 19, 2004 @08:15PM (#10018601)
    The Boston Foundation for Sight has restored good sight to over 600 people with cornea problems using a plastic liquid filled jumbo lens. find them at bostonsight.org

An authority is a person who can tell you more about something than you really care to know.

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