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Biotech Science

Alzheimer's Cause Identified? 71

JediJeremy writes "Naturehas this article on the possibility that researchers have identified the cause of Alzheimers. Their research says that amyloid beta, a protein in the brain, may cause plaques and makes an enzyme -BACE1-that causes dimentia. In the study mice, those without BACE1 did not get dimentia, while the others did. The article also says that there are current market drugs that can stop BACE1 production and all that needs to be done is for a human trial to begin. Looks like there is hope for those that suffer."
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Alzheimer's Cause Identified?

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  • by DrJAKing ( 94556 ) on Saturday January 10, 2004 @08:34PM (#7941255)
    I don't think anything can give you back brain function lost through dementia. The aim of anti-Alzheimer's treatment so far has been to slow down (or ideally stop) the decline. That means the trick is to spot it early enough, and there are quite a few projects developing tests for this. But reversing the damage is another matter; initially what is lost tends to be memory, and it may be that once the affected brain regions have been damaged, the memories are lost for good.
  • by astrashe ( 7452 ) on Saturday January 10, 2004 @08:50PM (#7941349) Journal
    I'm not a doctor, but it sounds to me that the treatments they're proposing would prevent the plaques from building up in the first place -- I'm not sure that they'd remove it once it was in place.

  • by Anonymous Coward on Saturday January 10, 2004 @10:44PM (#7941947)
    Does anyone else find it really sad that there are only 14 comments regarding this breakthrough whereas any tidbit about the latest slight modification to the Linux kernel gets hundreds of comments?
  • by frovingslosh ( 582462 ) on Sunday January 11, 2004 @03:17AM (#7943189)
    One of the ugly little side effects of dementia correcting drugs is that they eventually stop working.

    But here the drug isn't being used for dementia correcting, it's being used to stop BACE1 production. As long as the drug continues to do that, it holds the promise of preventing Alzheimer's. Of course, the last line of the Slashdot story (Looks like there is hope for those that suffer.) is off the mark - block BACE1 production and you may prevent the disease; but there's no reason to think that if you block production you somehow crue those who already have the disease and the plaques.

  • by AllUsernamesAreGone ( 688381 ) on Sunday January 11, 2004 @02:36PM (#7945675)
    Yes, and I'm sure that you could tell us a lot about using the energy of crystals and the amazing powers of homeopathic medicine..

    Now, if you'll excuse us, some people actually prefer real science, based on research and evidence than your so-called "facts".
  • by nimblebrain ( 683478 ) on Sunday January 11, 2004 @05:46PM (#7946903) Homepage Journal

    I read a few days ago an article about figuring out how to bust apart the prions in BSE (mad cow) - but cannot for the life of me find the link. There's a similar disease in sheep, scrapie, which they've had some success using monoclonal antibodies [usnews.com] to reduce the damage from.

    That would be a next step in Alzheimer research - if we can bust apart the amyloid beta plaques in sufferers, we might not be able to get back all old function, but it would very likely help current sufferers. One we have the ounce of prevention - it would be nice to have the pound of cure, too.

  • by sharkdba ( 625280 ) on Sunday January 11, 2004 @07:17PM (#7947515) Journal
    Yes, and I'm sure that you could tell us a lot about using the energy of crystals and the amazing powers of homeopathic medicine..

    I agree the grandparent is way out of line with his statement, but I wouldn't disregard homeopathy that easily.

    For many years western medicine did not recognize, and either ignored or laughed at any "alternative" medical treatments. This has changed though, check Harvard's Osher Institute [caregroup.org]

    Just think how homeopathic cures came by: most likely people in the past discovered that certain things helped cure sick people. They might not necessarily understand why, and there were no easy ways to explain it, but as long as certain treatments helped, they were used. Today's science doesn't understand a lot of these things either, but just because it doesn't, it doesn't mean they are worthless. There is something to it, and one day science will help us understand what. I still consider our sciences, specially human sciences like medicine, psychology, etc., in just a beginner phase. There is still A LOT to learn about ourselves.
  • by Anonymous Coward on Monday January 12, 2004 @12:02AM (#7949422)
    In addition, we have good binocular vision. This is a characteristic of hunters and sometimes scavengers. Animals that are evolved to be herbivores typically have eyes set much farther apart, on the sides of the head... like mices, cows, brontosauri, etc.

    Humans (and primates in general) are clearly evolved to be omnivores. It doesn't mean meat is the optimal food, but it does mean an awful lot of vegetarian activists are idiots.

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