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Biotech Science

Effective Vaccine For Malaria 24

PeterM from Berkeley writes "According to this news story, researchers may have finally developed a vaccine effective against malaria. Malaria kills 1 million people per year and sickens about 300 million, and is one of the big reasons the 3rd world is a mess. And as a bonus, it may be that the same vaccine may also protect against smallpox."
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Effective Vaccine For Malaria

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  • Well, uh, this is good. :)
  • by dbglt ( 668805 ) on Monday May 26, 2003 @06:52PM (#6042565)
    Excuse my ignorance, yet I do not know much about malaria. Why is it such a problem in the third world? I know it has something to do with mosquitoes... yet it is not a problem in the western world.

    Why is it unheard of here, yet so rife in 3rd world countries? Do we have ways of prevention? I heard about an asian country trying to kill off their mosquito population to try eradicate this.

    If I remember correctly it was DDT or something similar used in Europe to kill off the anopheles mosquito that causes malaria.

    And finally, how long is it before the disease evolves to be resistant to this vaccine? We know this is the case with me any other so called "cures".
    • by baywulf ( 214371 ) on Monday May 26, 2003 @07:04PM (#6042642)
      "Excuse my ignorance, yet I do not know much about malaria. Why is it such a problem in the third world? I know it has something to do with mosquitoes... yet it is not a problem in the western world."

      I saw a show the other day about mosquitoes in Florida. Florida spends 2-3 billion dollars from my recollection to combat mosquitoes. I doubt most 3rd worlds countries can afford this much.
    • by nosferatu-man ( 13652 ) <spamdot@homonculus.net> on Monday May 26, 2003 @07:23PM (#6042748) Homepage
      It has everything to do with mosquitos. The disease (which kills something on the order of 5,000 people every single day) is caused by a plasmodium spread by the anopheles mosquito. Endemic malaria is therefore bounded by the home range of the mosquitos that carry it.

      It doesn't help that the areas of the world where the disease is endemic tend to be places where there is no history of a robust public health infrastructure (Brazil, West Africa, Southeast Asia). There were widespread spraying programs throughout the '60s that cut the rate of infection dramatically, but there's no political will -- nor, to be fair, sufficient resources -- to keep the program going. Uganda (or possibly Kenya, I forget) has been very successful with the simplest of malaria control measures: insecticide-treated mosquito nets, which cut infection rates dramatically.

      Malaria is so brutal because it not only kills, but also debilitates an additional 500,000,000 people a year, who can't do anything -- can't work, can't care for children or sick family, anything. It's not for nothing that malaria is increasingly being viewed as an issue not just of public health, but also of economic development.

      A fair argument could even be made that malaria (in addition to schistosomiasis and trypanosomiasis) basically prevented the formation of cities beyond a certain population density. Check out William MacNeill's Plagues And Peoples for an excellent treatment of the impact of disease on human cultural development.

      'jfb
    • The only countries I have knowledge about with mosquito eradication are France and the U.S.

      France was a cesspool from run off from the alps before engineers practically terraformed their country and drained all the swamps (Thus was invented the French Drain).

      The U.S. had similar operations. They also used a massive campaign of DDT which had trucks crossing the countryside covering everything in DDT. (I have heard stories of kids chasing the trucks around to play in the fog sprayed from them.)

      It takes a
  • by pstemari ( 579210 ) <paul_j@ste-marie.org> on Monday May 26, 2003 @07:35PM (#6042795) Homepage Journal
    Check out Robert Desowitz's The Malaria Capers [amazon.com] for why taking a grain of salt with this announcement may be advised. The plasmodium parasite has multiple life stages that must be protected against to develop full immunity. Protection against one does not provide protection against the others.

    Also, calling anything based on the vaccinia virus "safe" in such a blanket fashion is vast overkill. Unlike most vaccines, vaccinia-based ones are live virus and cause severe complications if they get into the bloodstream--rather like the difference between cutaneous anthrax and pulmonary anthrax. Check out the CDC [cdc.gov] for just how nasty vaccinia can get if it escapes the vaccination site.

  • by pphrdza ( 635063 ) on Monday May 26, 2003 @09:12PM (#6043440)
    Using a strain of the smallpox vaccine known as MVA, the researchers found it had "a rare ability to selectively boost" T-cells - critical immune cells that attack invading disease - that have been primed in advance by the malaria protein...
    MVA is also being used in trials in Africa in an effort to boost the immune response to AIDS.

    The MVA (smallpox) vaccine is much safer, although less effective against smallpox. But its main purpose in this case is to boost the immune system, especially in fighting malaria. Sounds promising, especially given the low cost and safety.

  • by curunir ( 98273 ) * on Tuesday May 27, 2003 @01:20AM (#6044973) Homepage Journal
    ...and had to deal with the resulting, acid-trip-like dreams vivid enough to rival the experience on even the most expensive of illicit substances, I have this to say:

    "Your vaccine is not welcome!"
    • On the contrary, perhaps the vaccine will _prevent_ us from having to take malaria tablets in future.

      I too suffered horrendous nightmares and sleep disturbances for a month when I took a course of malaria tablets. It left me feeling totally drained and fed up during the daytime and apprehensive as hell about going to bed, because I knew what a rough ride the night would be.

      But then I figure, what's a month's sleep disturbance compared to a recurring parasitic infection that can wreck your whole life?

      I s
      • On the contrary, perhaps the vaccine will _prevent_ us from having to take malaria tablets in future.

        You seemed to have missed the point of my previous comment.

        Malaria pills are notorious for having widely different side effects depending on the person taking them. Whereas some people experience horrendous nightmares like you did, other's (like me ;) experience wonderful, vividly colorful dreams. Contrary to feeling totally drained like you did, I awoke refreshed and ended up having to sleep less to re
        • Durr ... sorry!

          I guess I was so fed up after my experience that I applied my own little message-interpreation-filter to what you wrote.

          Happy malarial-zone travel ... guess they'd bust you if you repeatedly asked for prescriptions then never travelled anywhere ;-)

        • My dreams just got really, really strange. I have surreal dreams normally but for the month and a half I was on the pills I had the weirdest of my life. Not scary, not delightful, just odd.

          The Statue of Liberty lays an egg and then has to defend it against King Kong in a parking lot, but then they both kind of morph into sort of African tribal sculptures, and then there's a bunch of cartoon cells and viruses swirling around...

  • the header tries to give impression as if the whole third world is greatly impacted by malaria. this is not true. it is true that most cases of malaria are in third world, but most of the third world is not in mess because of malaria. nearly 80-90 % of the estimated 1.5 to 2.7 million deaths occur in sub-sahara africa where about 90% of the infected people leave (www.idrc.ca/books/reports/1996/01-07e.html). this means 10-20% of 1.5-2.7 million deaths occurs in rest of the third world. taking middle figures,

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