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Cod Enzyme Kills Bird Flu

Posted by samzenpus on Wed Jan 17, 2007 08:47 PM
from the fish-your-flu-away dept.
Jon Golden writes "An Icelandic cod enzyme might be the cure for bird flu. A recent experiment, which the Icelandic company Ensímtaekni hf. took part in, indicates that in five minutes, the isolated fish enzyme killed 99 percent of H5N1 viruses. The killer enzyme, called penzim, was extracted from the intestines of cod by Ensímtaekni and is currently being developed for beauty products and various types of medicine. The experiment on the H5N1 virus was conducted in London. CEO of Ensímtaekni and biochemist Jón Bragi Bjarnason said he is very excited about the results of the bird flu experiment. "People have feared that the bird flu virus will change into a human flu virus and now we have a likely cure in case that happens." Bjarnason also believes that penzim might prove a cure for common flu and cold, eczema in children and arthritis."
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  • Cure? (Score:5, Insightful)

    by nebaz (453974) on Wednesday January 17 2007, @08:53PM (#17657344)
    Not to state the obvious here, but if it kills 90% of the virus, doesn't that just mean that next year we'll get a flue completely immune to this stuff?
    • Re:Cure? (Score:5, Insightful)

      by HappySqurriel (1010623) on Wednesday January 17 2007, @08:58PM (#17657398)
      As a guess, I would assume that this would involve much further study to determine why the enzyme was so successful in the first place and then try to make it much more potent; essentially, they see the possibility of making a cure from this but it is not ready yet.

      [ Parent ]
      • Re:Cure? (Score:5, Interesting)

        by cosmicaug (150534) on Wednesday January 17 2007, @09:05PM (#17657484)
        As a guess, I would assume that this would involve much further study to determine why the enzyme was so successful in the first place and then try to make it much more potent; essentially, they see the possibility of making a cure from this but it is not ready yet.


        As a wild assed guess, it is so successful in the first place because it is probably some fairly potent and fairly non selective protease. The fact that it kills viruses in a test tube means almost nothing. For this to be effective as a drug it must be able to kill these viruses in a living organism and it must do so while producing minimal damage to said living organism.
        [ Parent ]
        • Re: (Score:3, Insightful)

          Indeed. I can destroy a heap of viruses in a test tube too too, just by adding perchloric acid. Of course it also destroys the test tube.

          Probably not a promising approach to killing viruses in the body!

    • Re:Cure? (Score:5, Informative)

      by malsdavis (542216) on Wednesday January 17 2007, @09:05PM (#17657482)
      The virus may mutate into a form resistant to the enzyme in the future but it would then no longer be the same virus strain, the virus would have to start all over again and it may not even succeed. There is no reason why other 'cured' viruses like smallpox & polio couldn't have mutated and beat their cures (although influenza does mututate more than small pox) but they didn't and now the world is free of them.

      If proven effective in the real world then it is still a cure, saying otherwise is like saying "Why bother trying to cure the disease, everyone is going to die someday".
      [ Parent ]
      • Re:Cure? (Score:4, Insightful)

        by TheLink (130905) on Thursday January 18 2007, @02:37AM (#17659942) Journal
        Just a note: Polio is not eradicated yet. And may even be making a comeback due to stupid countries like Nigeria.
        [ Parent ]
    • Re: (Score:3, Insightful)

      The concern about the bird flu is that it's completely alien to humans, and is therefore very deadly. Once people have been exposed to it, their immune systems will be much more resistant to mutated strains. Also note that new viruses, such as swine and av
    • Re:Cure? (Score:5, Insightful)

      by tloh (451585) on Wednesday January 17 2007, @09:38PM (#17657852)

      There is an infectious threshold that a contagion needs to pass before it can spread through a population as an epidemic. If used properly, a drug that is 99% effective can nip it in the bud before the epidemic stage provides an opportunity for widspread replication and the chances for mutation.. If it doesn't reproduce much in the wild, it doesn't get a whole lot of opportunity to mutate into something dangerous. Used incorrectly, or abused in obviously stupid ways to serve other ends, be it political or otherwise, resistance *will* be a problem in the future.

      The problem of non-human hosts (birds, obviously, but also swines), however, complicates the picture a bit. Using drugs to treat human cases goes a long way toward keeping an epidemic in check. This is especially true considering how mobile we are in this day and age. The agriculture industry has also had mixed success in keeping domestic livestock safe. But what worries a lot of experts are migratory wild birds. They are the one variable we have almost no control over.

      On a slightly different note, the flu seems to be giving up a lot of its secrets. There is a timely article [yahoo.com] from reuters via Yahoo that highlights some new (?maybe old but uncirculated in the mainstream press?) information researchers have uncovered about the 1918 flu and the similarities to H5N1.

      As such, maybe this drug, if developed and used properly, is enough to deal with the problem. Kill 99% with the drug. Let the immune system, unmolested and unprovoked, deal with the remaining 1%.
      [ Parent ]
    • Probably not, but it does mean that the 10% of the virii that are left will probably be really ticked off that we killed a couple hundred million billion of their brothers.

      Seriously, there's nothing that something left in that 10% wouldn't turn into a p
    • Not an issue. (Score:2)

      Cod in that part of the world is virtually extinct, due to overfishing. It's at 5% of the pre-1960s stock and at 1% of the pre-1900s size (based on assorted studies on decline in fish populations and variation that the BBC has linked to from time to time).
    • Re: (Score:2)

      Only if it's used improperly.

      Used properly, a person is more or less isolated, to try and prevent the spread of infection. While the enzyme itself may only kill 90% (Actually, I think it was 99%) of the virii, the idea is that the person's body will take
      • Re:Cure? (Score:5, Funny)

        by megaditto (982598) on Wednesday January 17 2007, @09:19PM (#17657642)
        Since this sounds too good to be true, I think it has to be taken with a grain of salt.

        Well, a 1-in-10 dilution of chlorine-based household bleach will kill 100% of the germs. But what's good for treating biohazard might not be good for treating children.

        I know it's Troll Wednesday, but what the hell...
        [ Parent ]
        • Re:Cure? (Score:4, Funny)

          by cluckshot (658931) on Wednesday January 17 2007, @10:22PM (#17658282)

          Actually there is a medical tool that can do nearly as well as the bleach solution without killing the patient. Specifically if you take a 910nm YAG pulsed 1/10,000 sec 10 times per sec at about 250 watts for a duration of about 30 seconds and applied locally to the site of the infection, very nearly any virus or bacteria known and even some other agents can be blasted into oblivion while assisting the life processes of the human tissues surrounding.

          No this isn't an American technology. No it isn't fiction or fantasy. The process has been tested against even HIV and Hep C. It works. The WOW that it is applies to a wide range of medical problems. The specific process is known as cold lasers in sports medicine. Yes you could have the flu and be treated in a few seconds without drug side effects. I personally have seen this technology resolve a MRSA cyst about 1/2 the size of a large egg over night. The amount of treatment time was 30 seconds. The cyst was in an 82yo female who had acquired this post surgical and it was treated unsuccessfully with 30 day of intense IV medication including Vancomycin and other meds.

          This works by driving the life function of the human cells directly by photosynthetic process. It would appear that the process also overdrives the material in the infectious agents. Thus the process causes health in 2 ways. It will remove edema (swelling) in a few seconds. It causes very fast healing. It relieves most pain issues in seconds of at most over a course of 3 or 4 treatments a few hours apart. It is so effective it should be required as a post-op treatment for patients. It is a treatment that is so effective it can literally stop the flu or even destroy deep in tissue infections like those hard to treat sinus infections with nearly instant effect. As such the Bird Flu and any other flu epidemic should be a few laser pulses from oblivion.

          [ Parent ]
          • Re: (Score:3, Interesting)

            How do you kill hundreds of thousands of viruses with a laser that causes photosynthesis? Bah. Have you been reading too much of the national Exagerator?

            Photobiomodulation, according to Wikipedia, sounds like what you're talking about, but the article is r
      • Re: (Score:3, Funny)

        I think it has to be taken with a grain of salt. It isn't likely that it'll work as well as they hope.
        Huh, in my day it was a 'spoonful of sugar', but each to their own, I guess...
  • I'm sure that it would be much more lucrative if it also cured foot in mouth disease in politicians!

    Today is a good day, cured bird flu and cancer all in one day. Alzhiemer's is near a cure, and there are more discoveries every day it seems. I think we nee
  • Act of Cod? (Score:5, Funny)

    by halovaa (774219) on Wednesday January 17 2007, @08:55PM (#17657366)
    What God giveth, Cod taketh away
  • Yes, but... (Score:3, Funny)

    by Anonymous Coward on Wednesday January 17 2007, @08:56PM (#17657382)
    "Bjarnason also believes that penzim might prove a cure for common flu and cold, eczema in children and arthritis."

    That's all great, but I've been using Dr. Wurster's Miracle Decoction for 70 years. I'll be darned if I'll switch unless it also cures migraines and decapitation, at least.
    • Re: (Score:2)

      That's all great, but I've been using Dr. Wurster's Miracle Decoction for 70 years.

      I'm sure that low-dose cocaine would make anyone feel well for a little while.

      But since you've been using it for 70 years, it must not be that effective at curing the proble
  • WTF??? (Score:3, Insightful)

    by cosmicaug (150534) on Wednesday January 17 2007, @08:59PM (#17657406)
    WTF? Bleach also kills H5N1 viruses. That does not make bleach a cure for the bird flu.
    • Re: (Score:2, Interesting)

      Bleach will also kill you. This enzyme, seeing as it was already in development for medicine and beauty products, hopefully won't.

      Though I wouldn't go out and wolf down covergirl if you get the sniffles.
    • Re: (Score:2)

      Even simpler than bleach, I'm sure heat will also kill them. Just strike match and burn the city down to kill all viruses...
  • The amazing Cod (Score:5, Funny)

    by Giant Ape Skeleton (638834) on Wednesday January 17 2007, @08:59PM (#17657408) Homepage
    Cod...is there anything they can't do?
  • by gd23ka (324741) on Wednesday January 17 2007, @09:03PM (#17657460) Homepage
    and why I am sick and tired of the subject...

    There are at least a dozen _known_ diseases that will just as gleefully sicken or even kill the human animal.
    Why we're so upset about the bird flu and what makes it special, I don't know, except of course that the entire
    subject is pushed into our faces and through our ears nonstop through the media. (Just to forestall some
    comments: The rabies virus could mutate too and become airborne for all we know. Gnade uns Gott should that ever
    happen).

    One thing that is however noteworthy about the bird flu (wohoo!) is that "Tamiflu" the experimental drug that is
    supposed to alleviate its symptoms was developed by Gilead Sciences, the company Donald Rumsfeld was Chairman
    of the Board of during 1997 until being sworn in as Secretary of Defense in 2001. Another noteworthy thing is
    that the United States Government has purchased and stockpiled large amounts of this largely unproven medication
    and guess who still owns stock in Gilead? (La Rouche pharmaceuticals produces the drug but it pays royalties to
    Gilead).

    • by cosmicaug (150534) on Wednesday January 17 2007, @09:22PM (#17657660)
      There are at least a dozen _known_ diseases that will just as gleefully sicken or even kill the human animal.
      Why we're so upset about the bird flu and what makes it special, I don't know, except of course that the entire
      subject is pushed into our faces and through our ears nonstop through the media. (Just to forestall some
      comments: The rabies virus could mutate too and become airborne for all we know. Gnade uns Gott should that ever
      happen).


      That's a pretty fucking awful example to pick.

      It is bloody unlikely that rabies will mutate into an airborne virus anytime soon. It would essentially have to become a completely different virus.

      Influenza, on the other hand, is known for it's amazing mutational and recombinational "ability".

      Rabies is not known for causing great pandemics associated producing very substantial mortality.

      Influenza, on the other hand, is known for causing great pandemics producing very substantial mortality.

      Rabies does not truly have the potential to create massive epidemics in livestock animals which may serve as a reservoirs from whence a human disease outbreak may start.

      Avian influenza, on the other hand, does.

      Rabies does not truly have the potential to create massive epidemics in wild animals which may serve as widespread infectious sources for domestic animals and as a reservoir from whence a human disease outbreak may start.

      Avian influenza, on the other hand, does.

      Animal infected by rabies are very rarely (if ever) the types to engage in the sorts of great migrations which may sometimes literally span the globe.

      Animals infected by avian influenza, on the other hand, sometimes are.

      I could probably go on (or maybe not --but I'm not about to try).
      [ Parent ]
      • Re: (Score:2, Interesting)

        I picked rabies for the "Shock and Awe" effect (remember that slogan from somewhere?). I suppose
        Ebola virus or the lesser known Marburg virus would be better candidates. But then you might
        also note that Rabies has claimed to our knowledge more human lives
        • Re: (Score:3, Interesting)

          Nevertheless, in contrast to most every other disease, an influenza pandemic *did* suddenly kill ~50 million people less than a century ago. This proves that it can happen, and nothing fundamental has changed that would prevent it from happening again. Non
    • by derdesh (652578) on Wednesday January 17 2007, @09:53PM (#17657998)

      One reason epidemiologists are especially concerned about avian flu because flu pandemics have killed tens of millions of people before [wikipedia.org]. This was in 1918 when the public health system was less developed, but population densities and the mobility of the human population are much greater today.

      Another respondent has already detailed the other reasons why an avian flu is logistically more threatening. Your political/conspiracy theory may be completely true and valid, but the fact remains that people are concerned about the flu rather than ebola or airborne rabies because it's the disease that has been observed to kill in great numbers in the recent, documented past.

      The fact that Donald Rumsfeld might be profiteering from the hype [globalresearch.ca] does not mean that avian flu is not a real threat.

      [ Parent ]
    • Re: (Score:2)


      Influenza variations concern the CDC more than any other disease vector.

      FYI.

      C//
    • Re: (Score:3, Informative)

      There are at least a dozen _known_ diseases that will just as gleefully sicken or even kill the human animal. Why we're so upset about the bird flu and what makes it special, I don't know, except of course that the entire subject is pushed into our faces a
  • Smells fishy... (Score:2, Insightful)

    Seriously.

    It is highly unlikely that any enzyme can be developed into any useful cure for a virus infection, for pharmacokinetics, transport and stability issues alone.

    It is not difficult to kill anything. The same amount of bleach would kill reliably 100%
        • Re: (Score:3, Informative)

          Most plants do not require other organisms. While some plants use nitrogen fixers (like legumes, peanuts and clover), there are others, like cotton, which do not rely on nitrogen fixers and will just suck all the nitrogen out of the soil. This is why Geo
  • This May Bring Back The Old Cure-All (Score:4, Insightful)

    by Soloact (805735) on Wednesday January 17 2007, @09:06PM (#17657490) Homepage Journal
    This might bring back the old use of Cod Liver Oil. Our Grandmothers weren't stupid, they knew its health benefits.
  • Beautiful (Score:4, Interesting)

    by digitalhermit (113459) on Wednesday January 17 2007, @09:11PM (#17657550) Homepage
    Many species of cod are endangered or near-endangered. A while ago some politician (don't remember who) made a statement to the effect that, "who cares about insect." Would be funny if human survival ended up being dependent on some obscure snail.
    • Re: (Score:3, Interesting)

      I remember reading that Cod were getting smaller, because the smaller fish escaping the nets, were breeding with smaller fish escaping the nets.. Looked for a link and can't find the story... maybe I dreamed it.. Never mind.
  • This is great. A story hyping a cure for an ultra-hyped disease. This will be handy if bird flu actually becomes a real problem rather than a drive-by media hype-fest.

    I hope they also cure SARS, maybe with some kind of halibut mucus.
  • Birds/Fish (Score:5, Funny)

    by Nux'd (1002189) on Wednesday January 17 2007, @09:12PM (#17657566)
    Nice one nature..

    Give the ability to fight off bird flu to an animal most unlikely to encounter a bird.

    Lucky fishes..
  • Well that explains it (Score:5, Funny)

    by mgabrys_sf (951552) on Wednesday January 17 2007, @09:21PM (#17657652) Journal
    Probably why I've never seen a Cod sneeze before.
  • Stop the presses! (Score:2, Insightful)

    Wow! An enzyme destroys bird flu viruses under carefully controlled lab conditions in saline buffer, therefore it will also kill them in a greasy and presumably protein-denaturing cosmetic preparation! Not only is this horrible non-disease that has so far
  • A cure for everything likely doesn't cure anything...

    Let's drink, a drink, a drink,
    to Lilly the Pink, the pink, the pink,
    The saviour of the human race.
    For she invented,
    Medicinal compound,
    which saved the world of misery.
  • Good thing there's enough cod to go around!

    Oh, wait, we've overfished cod into near extinction [google.com] already, before we've even started grinding them up for birdflu shots.
  • Can it cure E.D. too? (Score:2, Interesting)

    You know what else kills bird flu (in much less than 5 minutes)? Ajax (the cleaner), bleach, fire, sulfuric acid, and I'm sure rat poison will do *something*

    I'd like to see what this ass-grease (I mean, intestinal enzyme) does when it's actually injected i
    • Re: (Score:2)

      indicates that in five minutes, the isolated fish enzyme killed 99 percent of H5N1 viruses
      You missed part of the sentence there, which completely changes the meaning. 99 percent was killed of within 5 minutes, it doesn't really state how much more was