Scientists at Melbourne's Peter Doherty Institute for Infection and Immunity are working on a Crispr-based treatment -- delivered as a nasal spray or injection -- that could stop influenza infections by targeting the virus's RNA and disrupting its ability to replicate inside human cells.

The approach uses the Cas13 enzyme, a lesser-known cousin of the DNA-cutting Cas9, which can be engineered to seek out conserved regions of influenza's genetic code that are found in virtually all flu strains and are crucial to the virus's survival. The delivery mechanism would use lipid nanoparticles to ferry two molecular instructions to flu-infected cells in the respiratory tract: an mRNA that tells cells to produce Cas13 and a guide RNA that directs the enzyme to specific parts of the influenza virus's code.

Cas13 then cuts the viral RNA and effectively stops the infection at the genetic level, Sharon Lewin, the infectious diseases physician leading the project, told Wired. Early safety testing at Harvard's Wyss Institute used a "lung on a chip" model to examine whether human cells producing Cas13 could fight off flu strains including H1N1 and H3N2. The institute's founding director Donald Ingber says the studies showed no off-target effects.

"The ancient evolution of fish mouths could help solve a modern source of plastic pollution," writes ScienceAlert.

"Inspired by these natural filtration systems, scientists in Germany have invented a way to remove 99 percent of plastic particles from water. It's based on how some fish filter-feed to eat microscopic prey." The research team has already filed a patent in Germany, and in the future, they hope their creation will help curb a ubiquitous form of plastic pollution that many are unaware of. Every time a load of laundry is done, millions of microplastics are washed from the fibers of our clothes into local waterways. By some estimates, up to 90 percent of plastic in 'sewage sludge' comes from washing machines. This material is then often used in agriculture as soil or fertilizer, possibly exposing those who eat the resulting crops to these pollutants...

Unlike other plastic filtration systems on the market, this one reduces clogging by 85 percent.

An anonymous reader shared this report from the Independent: Candida auris, a type of invasive yeast that can cause deadly infections in people with weakened immune systems, has infected at least 7,000 people [in 2025] across 27 U.S. states, according to data from the Centers for Disease Control and Prevention. The fungus, which can spread easily in healthcare settings such as hospitals and nursing homes, is gaining virulence and spreading at an "alarming" rate, the CDC says. Some strains of the fungus are particularly troublesome — and even considered a superbug — because they're resistant to all types of antibiotics used to treat fungal infections, The Hill reports.

While healthy people may be able to fight off the infection on their own, the fungus can be deadly, especially in healthcare settings, where it can quickly spread amongst a vulnerable population. "If you get infected with this pathogen that's resistant to any treatment, there's no treatment we can give you to help combat it. You're all on your own," Melissa Nolan, an assistant professor of epidemiology and biostatistics at the University of South Carolina, told Nexstar...

A recent study found that Candida auris is gaining virulence and spreading rapidly, not just in the U.S., but also globally. Candida auris has already been found in at least 61 countries on six continents.
Some context from Newsweek: There are strategies available to combat Candida auris infection. While the superbug can develop ways to evade the immune response, vaccination and treatment strategies are possible, but researchers would like them to be strengthened. Four classes of antifungal drugs are currently available, with varying degrees of efficacy, and three new drugs are currently in trials or at newly approved stages

An AI chatbot to answer probate questions from Alaska residents "was supposed to be a three-month project," said Aubrie Souza, a consultant with the National Center for State Courts told NBC News. "We are now at well over a year and three months, but that's all because of the due diligence that was required to get it right." "With a project like this, we need to be 100% accurate, and that's really difficult with this technology," said Stacey Marz, the administrative director of the Alaska Court System and one of the Alaska Virtual Assistant (AVA) project's leaders... While many local government agencies are experimenting with AI tools for use cases ranging from helping residents apply for a driver's license to speeding up municipal employees' ability to process housing benefits, a recent Deloitte report found that less than 6% of local government practitioners were prioritizing AI as a tool to deliver services. The AVA experience demonstrates the barriers government agencies face in attempting to leverage AI for increased efficiency or better service, including concerns about reliability and trustworthiness in high-stakes contexts, along with questions about the role of human oversight given fast-changing AI systems. These limitations clash with today's rampant AI hype and could help explain larger discrepancies between booming AI investment and limited AI adoption.
The chatbot was developed with Tom Martin, a lawyer/law professor who designs legal AI tools, according to the article. But the project "had to contend with the serious issue of hallucinations, or instances in which AI systems confidently share false or exaggerated information." "We had trouble with hallucinations, regardless of the model, where the chatbot was not supposed to actually use anything outside of its knowledge base," Souza told NBC News. "For example, when we asked it, 'Where do I get legal help?' it would tell you, 'There's a law school in Alaska, and so look at the alumni network.' But there is no law school in Alaska." Martin has worked extensively to ensure the chatbot only references the relevant areas of the Alaska Court System's probate documents rather than conducting wider web searches.
The article concludes that "what was meant to be a quick, AI-powered leap forward in increasing access to justice has spiraled into a protracted, yearlong journey plagued by false starts and false answers." But the chatbot is now finally scheduled to be launched in late January. "It was just so very labor-intensive to do this," Marz said, despite "all the buzz about generative AI, and everybody saying this is going to revolutionize self-help and democratize access to the courts.

"It's quite a big challenge to actually pull that off."

"Starlink is beginning a significant reconfiguration of its satellite constellation focused on increasing space safety," announced Michael Nicolls, Starlink's vice president of engineering: "We are lowering all Starlink satellites orbiting at ~550 km to ~480 km (~4400 satellites) over the course of 2026. The shell lowering is being tightly coordinated with other operators, regulators, and USSPACECOM. Lowering the satellites results in condensing Starlink orbits, and will increase space safety in several ways... Starlink satellites have extremely high reliability, with only 2 dead satellites in its fleet of over 9000 operational satellites. Nevertheless, if a satellite does fail on orbit, we want it to deorbit as quickly as possible. These actions will further improve the safety of the constellation, particularly with difficult to control risks such as uncoordinated maneuvers and launches by other satellite operators.
But orbits are being lowered for another reason (besides quick de-orbiting), notes Space.com. Within the next four years the period of least solar activity is expected, a period which coincides with decreased atmospheric density, Nicolls added, "which means the ballistic decay time at any given altitude increases." [Bringing the satellites lower] will mean a >80% reduction in ballistic decay time in solar minimum, or 4+ years reduced to a few months," Nicolls wrote in his X post. "Correspondingly, the number of debris objects and planned satellite constellations is significantly lower below 500 km, reducing the aggregate likelihood of collision...." The downward migration in 2026 involves roughly half of SpaceX's Starlink megaconstellation, which currently consists of nearly 9,400 operational spacecraft (though that number is always growing).

A small section of the International Space Station that has experienced persistent leaks for years appears to have stopped venting atmosphere into space. ArsTechnica: The leaks were caused by microscopic structural cracks inside the small PrK module on the Russian segment of the space station, which lies between a Progress spacecraft airlock and the Zvezda module. The problem has been a long-running worry for Russian and US operators of the station, especially after the rate of leakage doubled in 2024. This prompted NASA officials to label the leak as a "high likelihood" and "high consequence" risk. However, recently two sources indicated that the leaks have stopped. And NASA has now confirmed this.

"Following additional inspections and sealing activities, the pressure in the transfer tunnel attached to the Zvezda Service Module of the International Space Station, known as the PrK, is holding steady in a stable configuration," a space agency spokesman, Josh Finch, told Ars. "NASA and Roscosmos continue to monitor and investigate the previously observed cracks for any future changes that may occur."

For the better part of half a decade, Russian cosmonauts have been searching for the small leaks like a proverbial needle in a haystack. They would periodically close the hatch leading to the PrK module and then, upon re-opening it, look for tiny accumulations of dust to indicate the leak sites. Then the Russian cosmonauts would apply a sealant known as Germetall-1 (which has now been patented) to the cracks. They would close the hatch again, monitor the pressure inside the PrK module, and begin the search anew for additional leaks. This process went on for years.

A new sweeping meta-analysis has found no reliable link between economic inequality and well-being or mental health, challenging a long-held assumption that has shaped public health policy discussions for decades. The study, led by Nicolas Sommet at the University of Lausanne and Annahita Ehsan at the University of British Columbia, synthesized 168 studies involving more than 11 million participants across most world regions. The researchers screened thousands of scientific papers and contacted hundreds of researchers to compile the dataset, extracting more than 100 study features from each paper and linking them to more than 500 World Bank indicators.

They also replicated their findings using Gallup World Poll data spanning 2005 to 2021, which surveyed more than two million respondents from more than 150 countries. People living in more economically unequal places did not, on average, report lower life satisfaction or happiness than those in more equal places. The average effect across studies was not statistically significant and was practically equivalent to zero. Studies that did find links between inequality and poorer mental health turned out to reflect publication bias, where small, noisy studies reporting larger effects were over-represented in the literature. The study adds: Further analyses showed that the near-zero averages conceal more-complex patterns. Greater income inequality was associated with lower well-being in high-inflation contexts and, surprisingly, higher well-being in low-inflation contexts. Greater inequality was also associated with poorer mental health in studies in which the average income was lower. We conclude that inequality is a catalyst that amplifies other determinants of well-being and mental health (such as inflation and poverty) but on its own is not a root cause of negative effects on well-being and mental health.

A Guardian investigation published Friday found that Google's AI Overviews -- the generative AI summaries that appear at the top of search results -- are serving up inaccurate health information that experts say puts people at risk of harm. The investigation, which came after health groups, charities and professionals raised concerns, uncovered several cases of misleading medical advice despite Google's claims that the feature is "helpful" and "reliable."

In one case described by experts as "really dangerous," Google advised people with pancreatic cancer to avoid high-fat foods, which is the exact opposite of what should be recommended and could jeopardize a patient's chances of tolerating chemotherapy or surgery. A search for liver blood test normal ranges produced masses of numbers without accounting for nationality, sex, ethnicity or age of patients, potentially leaving people with serious liver disease thinking they are healthy. The company also incorrectly listed a pap test as a test for vaginal cancer.

The Eve Appeal cancer charity noted that the AI summaries changed when running the exact same search, pulling from different sources each time. Mental health charity Mind said some summaries for conditions such as psychosis and eating disorders offered "very dangerous advice."

Google said the vast majority of its AI Overviews were factual and that many examples shared were "incomplete screenshots," adding that the accuracy rate was on par with featured snippets.

Every human body contains a small population of cells that are not genetically its own -- cells that crossed the placenta during pregnancy and that persist for decades after birth. These "microchimeric" cells, named after the lion-goat-serpent hybrid of Greek mythology, have been found in every organ studied so far, though they are exceedingly rare: one such cell exists for every 10,000 to 1 million of a person's own cells.

The cells were first noticed in the late 1800s when pathologist Georg Schmorl described placenta-like "giant cells" in the lungs of people who had died from eclampsia. In 1969, researchers detected Y-chromosome-containing white blood cells in people who would later give birth to boys. For more than two decades, scientists presumed these cells were temporary. That changed in 1993 when geneticist Diana Bianchi found Y-chromosome cells in women who had given birth to sons up to 27 years earlier.

The cells appear to have regenerative properties, transforming into blood vessels or skin cells to promote wound healing. They also challenge a central assumption of immunology -- that the immune system classifies cells as either "self" or "non-self" and rejects foreign material. Microchimeric cells should trigger rejection but do not. Higher-than-typical concentrations have been found in people with autoimmune conditions including diabetes, lupus, and scleroderma.

Mark Thomson, a professor of experimental particle physics at the University of Cambridge, takes over as CERN's director general this week, and one of his first major decisions during his five-year tenure will be shutting down the Large Hadron Collider for an extended upgrade. The shutdown starts in June to make way for the high-luminosity LHC -- a major overhaul involving powerful new superconducting magnets that will squeeze the collider's proton beams and increase their brightness. The upgrade will raise collisions tenfold and strengthen the detectors to better capture subtle signs of new physics. The machine won't restart until Thomson's term is nearly over.

Thomson is far from disconsolate about the downtime. "The machine is running brilliantly and we're recording huge amounts of data," he told The Guardian. "There's going to be plenty to analyse over the period." Beyond the upgrade, Thomson must shepherd CERN's plans for the Future Circular Collider, a proposed 91km machine more than three times the size of the current collider. Member states vote on the project in 2028; the first phase carries an estimated price tag of 15 billion Swiss francs (nearly $19 billion).

A UK-based company has successfully powered up a microwave-sized space factory in orbit, proving it can run a 1,000C furnace to manufacture ultra-pure semiconductor materials in microgravity. "The work that we're doing now is allowing us to create semiconductors up to 4,000 times purer in space than we can currently make here today," says Josh Western, CEO of Space Forge. "This sort of semiconductor would go on to be in the 5G tower in which you get your mobile phone signal, it's going to be in the car charger you plug an EV into, it's going to be in the latest planes." The BBC reports: Conditions in space are ideal for making semiconductors, which have the atoms they're made of arranged in a highly ordered 3D structure. When they are being manufactured in a weightless environment, those atoms line up absolutely perfectly. The vacuum of space also means that contaminants can't sneak in. The purer and more ordered a semiconductor is, the better it works.

[...] The company's mini-factory launched on a SpaceX rocket in the summer. Since then the team has been testing its systems from their mission control in Cardiff. Veronica Viera, the company's payload operations lead, shows us an image that the satellite beamed back from space. It's taken from the inside of the furnace, and shows plasma - gas heated to about 1,000C -- glowing brightly. [...]

The team is now planning to build a bigger space factory -- one that could make semiconductor material for 10,000 chips. They also need to test the technology to bring the material back to Earth. On a future mission, a heat shield named Pridwen after the legendary shield of King Arthur will be deployed to protect the spacecraft from the intense temperatures it will experience as it re-enters the Earth's atmosphere.

NASA is closing its largest research library at the Goddard Space Flight Center amid budget cuts and campus consolidation, putting tens of thousands of largely non-digitized historical and scientific documents at risk of being warehoused or discarded. The New York Times reports: Jacob Richmond, a NASA spokesman, said the agency would review the library holdings over the next 60 days and some material would be stored in a government warehouse while the rest would be tossed away. "This process is an established method that is used by federal agencies to properly dispose of federally owned property," Mr. Richmond said.

The shutdown of the library at NASA's Goddard Space Flight Center in Greenbelt, Md., is part of a larger reorganization under the Trump administration that includes the closure of 13 buildings and more than 100 science and engineering laboratories on the 1,270-acre campus by March 2026. "This is a consolidation not a closure," said NASA spokeswoman Bethany Stevens. The changes were part of a long-planned reorganization that began before the Trump administration took office, she said. She said that shutting down the facilities would save $10 million a year and avoid another $63.8 million in deferred maintenance.

Goddard is the nation's premiere spaceflight complex. Its website calls it "the largest organization of scientists, engineers, and technologists who build spacecraft, instruments, and new technology to study Earth, the Sun, our solar system, and the universe." [...] The library closure on Friday follows the shutdown of seven other NASA libraries around the country since 2022, and included three libraries this year. As of next week, only three -- at the Glenn Research Center in Cleveland, the Ames Research Center in Mountain View, Calif., and the Jet Propulsion Laboratory in Pasadena, Calif. -- will remain open.

An anonymous reader quotes a report from the New York Times: For a while, it seemed the notion that light drinking was good for the heart had gone by the wayside, debunked by new studies and overshadowed by warnings that alcohol causes cancer. Now the American Heart Association has revived the idea in a scientific review that is drawing intense criticism, setting off a new round of debate about alcohol consumption. The paper, which sought to summarize the latest research and was aimed at practicing cardiologists, concluded that light drinking -- one to two drinks a day -- posed no risk for coronary disease, stroke, sudden death and possibly heart failure, and may even reduce the risk of developing these conditions.

Controversy over the influential organization's review has been simmering since it was published in the association's journal Circulation in July. Public health groups and many doctors have warned on the basis of recent studies that alcohol can be harmful even in small amounts. Groups like the European Heart Network and the World Heart Federation have stressed that even modest drinking increases the odds of cardiovascular disease. "It says in all our guidelines right now, 'If you don't drink, don't start.' There's not enough evidence to suggest conclusively that it prevents heart disease," said Dr. Mariell Jessup, the chief science and medical officer at the heart association, adding that the review was not meant to serve as a guideline and that the group's advice to patients has not changed.

Critics argue that suggesting any heart-health benefits from alcohol is dangerous given its well-documented risks, and they accuse the heart association of selectively weighing studies. They also say a past tie to the alcohol industry by one author should have disqualified him from participating.

"The cardiovascular benefits of moderate drinking are questionable at best," said Dr. Elizabeth Farkouh, an internist and alcohol researcher. "But even if there was a benefit, there are so many other ways to reduce cardiovascular risk that don't come with an associated cancer risk."

The new review's conclusion is also at odds with the CDC's guidance on alcohol, which notes that "even moderate drinking may increase your risk of death and other alcohol-related harms, compared to not drinking." It also seems to diverge from the heart association's diet and lifestyle recommendation to consume "limited or preferably no alcohol," along with its 2023 statement that recent research suggests there is "no safe level of alcohol use."

The Wall Street Journal reports that a growing number of tech startups are stocking offices with free nicotine pouches as founders and employees chase sharper focus and stamina in hyper-competitive AI-era work environments. The Wall Street Journal reports: Earlier this year, two nicotine startups -- Lucy Nicotine and Sesh -- made branded vending machines filled with flavored products for analytics company Palantir Technologies. Both machines are in the company's Washington, D.C., offices. The pouches are free for employees and guests over the age of 21, a spokeswoman for Palantir said. Palantir pays to stock the nicotine products.

Alex Cohen, a startup founder based in Austin, Texas, said he was first exposed to nicotine pouches in the workplace after seeing tins of Zyns on the desks of his software engineers. His company, Hello Patient, makes AI-powered healthcare-communication software. "They were very productive, so I thought maybe there's something here," he said. Those engineers soon asked him if he could buy it for the office.

Cohen said he initially bought the nicotine pouches as a joke for social media. He posted a picture of a drawer in his startup's office filled with nicotine pouches made by different brands with the caption, "We're hiring." "Then, I accidentally got addicted," said Cohen. He said he uses around two to three pouches a day. His go-to flavors are mango or minty. Cohen said he has attention-deficit/hyperactivity disorder, or ADHD, and he has found that the pouches can provide a quick productivity boost. "It helps with reining in my focus because it is a stimulant," he said. Today, Hello Patient has a nicotine-pouch fridge in its office kitchen.

An anonymous reader shares a report: Getting to space is hard. In many ways, getting back is even harder. NASA soon aims to pull off the kind of re-entry it last conducted more than 50 years ago: safely returning astronauts to Earth after they fly to the moon and back. The mission is a big moment for NASA, which will put a crew on its Orion ship for the first time. The flight will test the spacecraft's heat shield, designed to protect the astronauts on board.

Re-entries of vehicles from orbit remain one of the high-stakes parts of any human spaceflight, given the stress they put on spacecraft. In 2003, NASA's Columbia Space Shuttle broke apart as it came back from low-Earth orbit due to a breach on the vehicle that occurred during launch. All seven astronauts on board were killed. Orion will be coming back to Earth from much further away than low-Earth orbit, where all recent human spaceflights have been conducted. That means its velocity and the energy it needs to disperse will be greater, putting even more stress on the heat shield.

During a test flight in 2022 that didn't include astronauts, Orion's heat shield didn't perform as expected. That sparked worries about crew safety on future missions, prompting NASA to investigate and address what happened. NASA will launch Orion with the astronauts on board as soon as February. [...] When the vehicle initially re-enters the Earth's atmosphere, it will be traveling around 25,000 miles an hour and face temperatures of 5,000 degrees as it slows down. The Orion craft, developed by Lockheed Martin for NASA, has a shield that is almost 17 feet in diameter. Installed on the vehicle's underside, the shield is covered in what is called an "ablative" material, which is designed to shift heat away from the craft during re-entry by burning off in a controlled manner.