Scientists unveiled on Wednesday the first blueprint of human skeletal development as they make progress toward the goal of completing a biological atlas of every cell type in the body to better understand human health and diagnose and treat disease. From a report: The work is part of the ongoing Human Cell Atlas project that was begun in 2016 and involves researchers around the world. The human body comprises roughly 37 trillion cells, with each cell type having a unique function. The researchers aim to have a first draft of the atlas done in the next year or two.

Aviv Regev, founding co-chair of the project and currently executive vice president and head of research and early development at U.S. biotech company Genentech, said the work is important on two levels. "First of all, it's our basic human curiosity. We want to know what we're made of. I think humans have always wanted to know what they're made of. And, in fact, biologists have been mapping cells since the 1600s for that reason," Regev said. "The second and very pragmatic reason is that this is essential for us in order to understand and treat disease. Cells are the basic unit of life, and when things go wrong, they go wrong with our cells, first and foremost," Regev said.

SpaceX's Starship rocket successfully completed its sixth launch today. Not only did it carry the first-ever payload but it also briefly re-lit one of its six Raptor engines about 38 minutes into flight, a crucial milestone for future space missions. Space Magazine reports: SpaceX landed Starship's huge first-stage booster, known as Super Heavy, back at the launch tower on the vehicle's most recent flight, which occurred on Oct. 13. The company aimed to repeat that feat -- which the tower achieved with its "chopstick" arms -- today, but the flight data didn't support an attempt. "We tripped a commit criteria," SpaceX's Dan Huot said during the company's Flight 6 webcast. So Super Heavy ended up coming down for a controlled splashdown in the Gulf of Mexico instead, hitting the waves seven minutes after liftoff.

Today's mission aimed to do far more than just bring Super Heavy back to Earth in one piece. SpaceX also wanted to put Starship's upper stage -- a 165-foot-tall (50 m) spacecraft called Starship, or simply "Ship" -- through its paces. The launch sent Ship on the same semi-orbital trajectory that it took on Flight 5, targeting a splashdown in the Indian Ocean off the northwestern coast of Australia about 65 minutes after liftoff. But Ship also achieved some new milestones along the way this time. For example, Flight 6 carried the first-ever Starship payload -- a plush banana onboard Ship, which served as a zero-gravity indicator. (It was not deployed into space.) In addition, Ship briefly re-lit one of its six Raptor engines about 38 minutes into the flight. (Super Heavy also employs Raptors -- a whopping 33 of them.)

This burn helped show that Ship can perform the maneuvers needed to come back to Earth safely during orbital missions. Indeed, Ship is designed to be fully and rapidly reusable, just like Super Heavy; SpaceX eventually intends to catch it with the chopstick arms as well, and will likely try to do so on a test flight in the near future. Flight 6 also tested modifications to Ship's heat shield, which protects the vehicle during reentry to Earth's atmosphere.

Ranga Dias, a physics professor who made headlines with claims that he had discovered a room-temperature superconductor and then was found to have engaged in research misconduct, is no longer employed by the University of Rochester. WSJ: A spokeswoman for the university confirmed on Monday that Dias is out but declined to comment on the terms of his departure. The Wall Street Journal previously reported that Rochester President Sarah Mangelsdorf had called for terminating his position in an August letter to the chair and vice chair of the university's Board of Trustees.

Dias leaves the university after years of accusations that he had misrepresented data in multiple papers. He is a senior author on at least five papers retracted in just over two years. One of those, which identified a material that functioned as a superconductor at room temperature, was pulled by the journal Nature after several co-authors told the journal that Dias had misrepresented information in the paper. Dias didn't respond to requests for comment. He has previously denied manipulating or misrepresenting data.

His departure follows a monthslong university investigation completed in February that was led by three outside experts who reviewed documents and data from Dias's laboratory computers and interviewed Dias and his collaborators. The investigative panel found evidence of misconduct in four papers in which Dias is a senior author and in a grant proposal he submitted to the National Science Foundation. Then-provost David Figlio accepted the conclusions and referred his case to a faculty committee "for potential removal." Dias sued the university in February claiming that the probe into his work was biased and didn't follow university policies.

India plans to build a moon-orbiting space station by 2040 that will support crewed missions to the moon and serve as a hub for scientific research. Space Magazine reports: If all goes according to plan, the lunar space station will be completed around the same time the nation's astronauts land on the moon, with construction of a permanent base on the surface before 2050. The lunar space station appears to be the third and final phase of India's moon exploration efforts. [...]

The lunar space station may be similar to the one India plans to build in Earth orbit, known as the Bharatiya Antariksh Station, or BAS. The development of this station's first module, BAS-1, was greenlit by the Indian government in September. Officials have said the first module will be launched to low Earth orbit by 2028, and the entire station will be operational by 2035.

Dr. Adam Rodman, a Boston-based internal medicine expert, helped design a study testing 50 licensed physicians to see whether ChatGPT improved their diagnoses, reports the New York TImes. The results? "Doctors who were given ChatGPT-4 along with conventional resources did only slightly better than doctors who did not have access to the bot.

"And, to the researchers' surprise, ChatGPT alone outperformed the doctors." [ChatGPT-4] scored an average of 90 percent when diagnosing a medical condition from a case report and explaining its reasoning. Doctors randomly assigned to use the chatbot got an average score of 76 percent. Those randomly assigned not to use it had an average score of 74 percent.

The study showed more than just the chatbot's superior performance. It unveiled doctors' sometimes unwavering belief in a diagnosis they made, even when a chatbot potentially suggests a better one.

And the study illustrated that while doctors are being exposed to the tools of artificial intelligence for their work, few know how to exploit the abilities of chatbots. As a result, they failed to take advantage of A.I. systems' ability to solve complex diagnostic problems and offer explanations for their diagnoses. A.I. systems should be "doctor extenders," Dr. Rodman said, offering valuable second opinions on diagnoses.
"The results were similar across subgroups of different training levels and experience with the chatbot," the study concludes. "These results suggest that access alone to LLMs will not improve overall physician diagnostic reasoning in practice.

"These findings are particularly relevant now that many health systems offer Health Insurance Portability and Accountability Act-compliant chatbots that physicians can use in clinical settings, often with no to minimal training on how to use these tools."

Nyx is a new reusable space capsule that "safely and affordably carries cargo to and from space stations," according to the web page of its European-based manufacturer, The Exploration Company, "launching from any heavy launcher worldwide."

And the company "just closed a large funding round to further its mission of building Europe's first reusable space capsule," reports TechCrunch — pointing out that right now, "Only two companies currently provide cargo delivery to and from the International Space Station, and both are based in the United States." The $160 million Series B round will fund the continued development of the Nyx spacecraft, which will be capable of carrying 3,000 kilograms of cargo to and from Earth. The company, which was founded three years ago by aerospace engineers Hélène Huby, Sebastien Reichstat, and Pierre Vine, is aiming to conduct Nyx's maiden flight to and from the International Space Station in 2028.

"We are the first company in the world where this is for the first time mainly funded by private investors," Huby said in a recent interview. This is in contrast to SpaceX's Dragon capsule, which she said was "mainly funded by NASA." The new funding, which was led by Balderton Capital and Plural, brings the startup's total funding to date to over $208 million. The Series B also included participation from Bessemer Venture Partners, NGP Capital, and two sovereign European funds, French Tech Souveraineté and DeepTech & Climate Fonds. "We've been able to deliver on promises in the past three years," Huby said. "We've been able to meet our cash target ever quarter ... The investors, they could see that we basically can deliver on time, on cost, on quality."

The startup has made traction with the European Space Agency, which has recognized the need to foster native space launch and transportation capabilities... It's a promising start, but equally promising is the traction The Exploration Company is seeing on the commercial side. Around 90% of the startup's $770 million contract backlog has come from private station developers Vast, Axiom Space, and Starlab, according to recent reporting...

The second sub-scale demonstrator mission, called Mission Possible, is scheduled to launch on a SpaceX Falcon 9 next year.
TechCrunch quotes Huby as saying "I highly respect what SpaceX has been able to achieve.We are trying to learn as much as possible from that, we are inspired by what they have achieved."

In a CNBC interview, Huby says "It's a big market, and it's growing about a bit more than 10% per year because more nations want to fly their astronauts and more nations want to go to the moon. So there is an increased demand for sending people to stations, sending cargo to stations."

"Join us on our mission to democratize access to space," says a home-page link to the company's recruiting page — with a link further down titled "Book a mission."

A reusable uncrewed spaceplane was unveiled this week for delivering and returning cargo from the Chinese Tiangong space station. It was built by the Chengdu Aircraft Design and Research Institute (part of the state-owned Aviation Industry Corporation of China). (See YouTube footage here...)

Long-time Slashdot reader Geoffrey.landis writes: Like the Sierra Space "Dream Chaser" [still under development], the vehicle is to be launched as a payload on a separate launch vehicle, and land horizontally on Earth on a runway. The design is aerodynamically a hybrid, incorporating features of both winged and lifting-body designs. A model of the Haolong will make its debut at the 15th "Airshow China", November 12 to 17 in Zhuhai.
"The China Manned Space Agency shortlisted the spacecraft as one of two proposed affordable cargo spacecraft designs," reports Aviation Week.

Chances of intelligent life emerging in our Universe "and in any hypothetical ones beyond it" can be estimated by a new theoretical model, reports the Royal Astronomical Society.

Since stars are a precondition for the emergence of life, the new research predicts that a typical observer [i.e., intelligent life] should experience a substantially larger density of dark energy than is seen in our own Universe... The approach presented in the paper involves calculating the fraction of ordinary matter converted into stars over the entire history of the Universe, for different dark energy densities. The model predicts this fraction would be approximately 27% in a universe that is most efficient at forming stars, compared to 23% in our own Universe. Dark energy makes the Universe expand faster, balancing gravity's pull and creating a universe where both expansion and structure formation are possible. However, for life to develop, there would need to be regions where matter can clump together to form stars and planets, and it would need to remain stable for billions of years to allow life to evolve.

Crucially, the research suggests that the astrophysics of star formation and the evolution of the large-scale structure of the Universe combine in a subtle way to determine the optimal value of the dark energy density needed for the generation of intelligent life. Professor Lucas Lombriser, Université de Genève and co-author of the study, added: "It will be exciting to employ the model to explore the emergence of life across different universes and see whether some fundamental questions we ask ourselves about our own Universe must be reinterpreted."
The study was funded by the EU's European Research Council, and published in Monthly Notices of the Royal Astronomical Society.

Thanks to long-time Slashdot reader schwit1 for sharing the news.

Remember those 43 monkeys that escaped from a U.S. research lab? They've caught 35 of them — but haven't yet caught the other eight.

But even worse... The Independent reports that now another animal escape has led to "reports of two large emus running riot..." The birds' owner, Sam Morace, took to social media to plead with locals for their patience, saying: "For everyone that keeps seeing an emu, yes it is mine. There are 2 of them out." Morace said their two flightless birds broke loose three months ago.... "They are feral and not trained like the ones we have at the house."
This provoked some discussion on Facebook. ("Does nobody learn to lasso anymore?") But Morace responded that you "can't lasso a bird you have to grab them by their feet. Their necks are super long and fragile." In another post Morace detailed efforts to capture their birds. "Local law enforcement has already been at my house, we are trying to get a tranquilizer approved so we can bring them home.

"Thank you for all the concerns and questions. But if the emus were that easy to catch they would be home already.

If you're wondering how the escaped monkeys are doing out in the wild, someone who photographed them earlier this week said they appeared "playful, curious and jumping from tree to tree." The Guardian reports local officials have now "requested that the public avoid using drones near the facility. Earlier in the week, they reported that a drone incident 'spooked' the monkeys, increasing their stress levels and complicating efforts to recapture them."

Their article also notes reports that the facility houses 7,000 monkeys. And this isn't the first time some have escaped... In 2016, 19 monkeys escaped from the same facility, according to the Post and Courier newspaper, but were returned after six hours. Earlier, in 2014, 26 macaques reportedly escaped and were captured within two days. Documents from federal regulators from previous years revealed other incidents at the facility, as reported by the New York Times. One involved a primate escaping while being transported to the medical clinic and subsequently disappearing into the woods. Another involved two monkeys breaking out of their outdoor chain-link enclosure, which reportedly resulted in one monkey being lured back inside and the other dying shortly after being recaptured. In 2017, the Department of Agriculture fined the company more than $12,000 partly due to failures to contain the animals, according to the New York Times.
The Guardian also links to a related read from February: "Plan for US 'mini-city' of 30,000 monkeys for medical research faces backlash." Over the next 20 years, the facility will assemble a mega-troop of about 30,000 long-tailed macaques, a species native to south-east Asia, in vast barn-like structures in Bainbridge, Georgia, which has a human population of just 14,000... But the plan faces fierce opposition, with some Bainbridge residents calling on local authorities to block the construction of the proposed primate manse. "They're an invasive species and 30,000 of them, we'd just be overrun with monkeys," claimed Ted Lee, a local man. "I don't think anybody would want 30,000 monkeys next door," added David Barber, who would live just 400ft from the new facility.

"NASA has emphasized the ISS crew is in no immediate danger," reports Space.com. "The leaking area in the Russian segment of the orbital complex has been ongoing for five years," and "there was a temporary increase in the leak rate that was patched earlier this year..."

Former astronaut Bob Cabana emphasized that troubleshooting is ongoing during a brief livestreamed meeting on Wednesday. But NASA and Roscosmos "don't have a common understanding of what the likely root causes or the severity of the consequences of these leaks." "The Russian position is that the most probable cause of the cracks is high cycling caused by micro-vibrations," Cabana said, referring to flexing of metal and similar components that heat and cool as the ISS orbits in and out of sunlight. "NASA believes the PrK cracks are likely multi-causal — including pressure and mechanical stress, residual stress, material properties and environmental exposures," Cabana continued.

NASA and Russia disagree about whether "continued operations are safe", he added, but the remedy for now is to keep the hatch closed between the U.S. and Russian side as investigations continue.

The two agencies will continue meeting to seek "common understanding of the structural integrity", Cabana pledged, but he did not provide a timeline. Academic and industry experts will also be consulted.

Slashdot reader jjslash brings word that Casio "has reintroduced its iconic calculator watch featuring a retro design with green text on a negative LCD and a classic keypad layout."

TechSpot reports that the watch was based on the Casio Mini personal calculator first released in the early 1970s — even offering a keypad using the original fonts (with numbers separated by grid lines): Even the mode button, colored red, is a nod to the calculator's power indicator. The watches' calculator function can add, subtract, multiply, and divide up to eight digits. As for watch functions, you get dual time, an alarm, stopwatch functionality, and more...

Casio's original personal calculator debuted in 1972, and cost $59.95. It featured a six-digit display, was a quarter the size of its competitors, and cost just a third of rival products. The calculator was an instant hit for Casio, selling a million units in the first 10 months on the market and more than six million units over the span of the series.
Long-time Slashdot reader antdude says "I still wear one! Casio Data Bank 150 model...!"

Share your own vintage calculator memories in the comments...

China's Chang'e-6 mission made history by retrieving the first surface samples from the moon's far side, revealing evidence of volcanic activity spanning 1.4 billion years. Reuters reports: Researchers said on Friday the soil brought back from the Chang'e-6 landing site contained fragments of volcanic rock - basalt - dating to 4.2 billion years ago and to 2.8 billion years ago. This points to a long period of volcanic activity - at least 1.4 billion years - on the far side during the first half of the moon's history, when it was a more dynamic world than it is today. The moon, like Earth, formed about 4.5 billion years ago. Volcanism on the moon, Earth and other planetary bodies involves the eruption of molten rock from the mantle - the layer just under the outer crust - onto the surface. The landing site in the South Pole-Aitken Basin, an impact crater, is an area with the thinnest crust on the moon, helpful for finding evidence of volcanism.

The samples contained various volcanic rock fragments, and the researchers used a method called radioisotope dating to determine their age. Lunar basalt samples previously were obtained from the moon's near side, which perpetually faces Earth, during U.S. Apollo, Soviet Luna and Chinese Chang'e-5 missions. These showed that volcanism on the near side had occurred as long ago as 4.0 billion years ago and continued for at least two billion years, Li said. "The exact timing and duration of lunar volcanism is elusive and maybe varied across different regions. Some small-scale volcanism may have also occurred on the near side as late as about 120 million years ago as recorded by volcanic glass beads from Chang'e-5 samples" collected in 2020, Li said.

The new study also found that the basalt dating to 4.2 billion years ago differed in composition from the basalt dating to 2.8 billion years ago, meaning they originated from different sources of molten rock - magma - in the mantle, Li said. The Chang'e-6 samples, Li said, also differ in composition compared with previously collected lunar samples from the near side.

"NASA has squandered $27 billion on the SLS moon rocket -- $6 billion over budget and 5 years late," writes longtime Slashdot reader schwit1. "The SLS isn't reusable so even if they finished it -- it is already obsolete. It is clear to everyone that the boondoggle has failed but the newest plan is to find a way to blame Trump. There is a big desire for big changes." Futurism reports: According to Ars Technica senior space reporter Eric Berger's insider sources, there's an "at least 50-50" chance that the rocket "will be canceled." "Not Block 1B. Not Block 2," he added, referring to the variant that was used during NASA's uncrewed Artemis I test flight in 2022 and a more powerful design with a much higher translunar injection payload capacity, respectively. "All of it." To be clear, as Berger himself points out, we're still far "from anything being settled." Nonetheless, the reporter's sources have historically been highly reliable, suggesting the space agency may indeed be getting cold feet about continuing to pour billions of dollars into the non-reusable rocket. [...] "Honestly the people who will ultimately make this decision aren't even in place yet," Berger wrote in a followup tweet, likely referring to the incoming Trump administration. "But there is a big desire for big changes."

Rocket Lab says it has signed the first customer for its Neutron launch vehicle, with a launch planned for mid-2025. SpaceNews reports: The company announced Nov. 12 that it signed a contract with an undisclosed "commercial satellite constellation operator" for two launches of Neutron, one in mid-2026 and the other in 2027, a deal that could lead to additional launches for the same customer. "We see this agreement as an important opportunity that signifies the beginning of a productive collaboration that could see Neutron deploy this particular customer's entire constellation," Peter Beck, chief executive of Rocket Lab, said in an earnings call Nov. 12 to discuss the company's third quarter financial results. [...]

Beck said Rocket Lab is "deep into the qualification testing" of flight hardware, including vehicle structures and the Archimedes engine, which was hotfired for the first time in August at the Stennis Space Center in Mississippi. "Our engine test cadence in Mississippi has doubled over the quarter, and we've bought multiple engines to the test stand," he said. Neutron is a key part of the company's ambitions to deploy its own constellation, something that Beck has hinted at in some previous earnings calls. His presentation called that constellation the third pillar for Rocket Lab, after launch services and spacecraft production, both of which support the constellation.

"We're not ready to reveal details on what this constellation or application may be," he said, "but I think it's important to understand the strong foundation we've built up across launch and space systems to enable it in due course." That includes Neutron, with Beck citing SpaceX's use of Falcon 9 to deploy its Starlink constellation. "Everything is irrelevant without a reusable high cadence launch. So, Neutron is really the key to unlocking that."

sciencehabit shares a report from Science Magazine: What if, rather than scouring the internet, ChatGPT could search all of the DNA on Earth? That future just got a bit closer with Evo, an AI model reported today in Science. The program -- trained on billions of lines of genetic sequences -- can design new proteins and even whole genomes. Previous AIs could only interpret and predict relatively short sections of DNA, and they could only work with groups of nucleotides -- the A, C, G, T alphabet of DNA -- not individual nucleotides. To take things to the next level, researchers trained Evo on 300 billion nucleotides of sequence information.

In a first test, Evo bested other AI models on predicting the impact of mutations on protein performance. The team then had Evo design new versions of the CRISPR genome editor; the best designs were as good at cutting DNA as a commercial version. And in what study author Brian Hie, a computational biologist at Stanford University, calls the "most futuristic and crazy" part of the study, the researchers asked Evo to generate DNA sequences that are long enough to serve as genomes for bacteria -- a step toward AI-designed synthetic genomes.

Much of the work on AI occurs in secret at companies. But the researchers have released Evo publicly so that other researchers can use it, and Hie says the team has no plans to commercialize its creation. "For now, I see this as a research project."