Every breath people take in their homes or car probably contains significant amounts of microplastics small enough to burrow deep into lungs, new peer-reviewed research finds, bringing into focus a little understood route of exposure and health threat. The Guardian: The study, published in the journal Plos One, estimates humans can inhale as much as 68,000 tiny plastic particles daily. Previous studies have identified larger pieces of airborne microplastics, but those are not as much of a health threat because they do not hang in the air as long, or move as deep into the pulmonary system.

The smaller bits measure between 1 and 10 micrometers, or about one-seventh the thickness of a human hair, and present more of a health threat because they can more easily be distributed throughout the body. The findings "suggest that the health impacts of microplastic inhalation may be more substantial than we realize," the authors wrote.

A U.S.-China research team has developed the world's first one-step process to convert mixed plastic waste into gasoline and hydrochloric acid with up to 95-99% efficiency, all at room temperature and ambient pressure. InterestingEngineering reports: As the authors put it, "The method supports a circular economy by converting diverse plastic waste into valuable products in a single step." To carry out the conversion, the team combines plastic waste with light isoalkanes, hydrocarbon byproducts available from refinery processes. According to the paper, the process yields "gasoline range" hydrocarbons, mainly molecules with six to 12 carbons, which are the primary component of gasoline. The recovered hydrochloric acid can be safely neutralized and reused as a raw material, potentially displacing several high-temperature, energy-intensive production routes described in the paper. "We present here a strategy for upgrading discarded PVC into chlorine-free fuel range hydrocarbons and [hydrochloric acid] in a single-stage process," the researchers said. Reported conversion efficiencies underscore the potential for real-world use. At 86 degrees Fahrenheit (30 degrees Celsius), the process reached 95 percent conversion for soft PVC pipes and 99 percent for rigid PVC pipes and PVC wires.

In tests that mixed PVC materials with polyolefin waste, the method achieved a 96 percent solid conversion efficiency at 80 degrees Celsius (176 degrees Fahrenheit). The team describes the approach as applicable beyond laboratory-clean samples. "The process is suitable for handling real-world mixed and contaminated PVC and polyolefin waste streams," the paper states. SCMP points to an ECNU social media post citing the study, which characterized the achievement as a first, efficiently converting difficult-to-degrade mixed plastic waste into premium petrol at ambient temperature and pressure in a single step.

An anonymous reader quotes a report from TechCrunch: SpaceX has long marketed Starship as a fully and rapidly reusable rocket that's designed to deliver thousands of pounds of cargo to Mars and make life multiplanetary. But reusability at scale means a space vehicle that can tolerate mishaps and faults, so that a single failure doesn't spell a mission-ending catastrophe. The 10th test flight on Tuesday evening demonstrated SpaceX's focus on fault tolerance. In a post-flight update, SpaceX said the test stressed "the limits of vehicle capabilities." Understanding these edges will be critical for the company's plans to eventually use Starship to launch Starlink satellites, commercial payloads, and eventually astronauts.

When the massive Starship rocket lifted off on its 10th test flight Tuesday evening, SpaceX did more than achieve new milestones. It purposefully introduced several faults to test the heat shield, propulsion redundancy, and the relighting of its Raptor engine. The heat shield is among the toughest engineering challenges facing SpaceX. As Elon Musk acknowledged on X in May 2024, a reusable orbital return heat shield is the "biggest remaining problem" to 100% rocket reusability. The belly of the upper stage, also called Starship, is covered in thousands of hexagonal ceramic and metallic tiles, which make up the heat shield. Flight 10 was all about learning how much damage the ship can accept and survive when it goes through atmospheric heating. During the tenth test, engineers intentionally removed tiles from some sections of the ship, and experimented with a new type of actively cooled tile, to gather real-world data and refine designs. [...]

Propulsion redundancy was also put to the test. The Super Heavy booster's landing burn configuration appeared to be a rehearsal for engine failure. Engineers intentionally disabled one of the three center Raptor engines during the final phase of the burn and used a backup engine in its place. That was a successful rehearsal for an engine-out event. Finally, SpaceX reported the in-space relight of a Raptor engine, described on the launch broadcast as the second time SpaceX has pulled this off. Reliable engine restarts will be necessary for deep-space missions, propellant transfers, and possibly some payload deployment missions. [...] The next step is translating Flight 10 data into future hardware upgrades to move closer to routine operations and days when, as Musk envisioned, "Starship launches more than 24 times in 24 hours."

An anonymous reader quotes a report from ScienceAlert: A genetically modified pig lung transplanted into a brain-dead human patient functioned for nine days in a new achievement that reveals both the promise and significant challenges of xenotransplantation. Over the course of the experiment, the patient showed increasing signs of organ rejection before scientists at the First Affiliated Hospital of Guangzhou Medical University in China terminated the experiment, allowing the recipient to pass away. It's the first time a pig lung has been transplanted into a human patient, demonstrating a significant step forward, and giving scientists new problems to solve as they develop this emerging medical technique further. [...]

The goal of the experiment was not to achieve a successful transplantation on the first try -- that would have been pretty incredible, but not a realistic expectation. Rather, the researchers wanted to observe how the patient's immune system responded to the transplanted organ. The patient was a 39-year-old man who was declared brain-dead by four separate clinical assessments after undergoing a brain hemorrhage. His family provided written informed consent for the experiment. The donor pig is what is known as a six-gene-edited pig, a Bama miniature pig with six CRISPR gene edits, housed in an isolated facility with rigorous disinfection protocols. These edits are all focused on minimizing the immune and inflammatory responses of the patient.

In a careful surgical procedure, the pig's left lung was placed into the patient's chest cavity, and connected to their airways, arteries, and veins. The paper does not explain the fate of the pig, but donor pigs do not typically survive the removal of a major organ. The patient was also treated with a number of immunosuppressants that the researchers adjusted according to changes observed in the patient's body over time. Initially, all seemed well, with none of the immediate signs of hyperacute rejection in the critical few hours following the procedure. However, by 24 hours after the transplant had taken place, severe swelling (edema) was observed, possibly as a result of blood flow being restored to the area of the transplant. Antibody-mediated rejection damaged the tissue further on days three and six of the experiment. The result of the damage was primary graft dysfunction, a type of severe lung injury occurring within 72 hours of a transplant, and the leading cause of death in lung transplant patients. Some recovery was taking place by day nine, but the experiment had run its course. The research has been published in Nature Medicine.

Air pollution from oil and gas causes more than 90,000 premature deaths and sickens hundreds of thousands of people across the US each year, a new study shows, with disproportionately high impacts on communities of color. From a report: More than 10,000 annual pre-term births are attributable to fine particulate matter from oil and gas, the authors found, also linking 216,000 annual childhood-onset asthma cases to the sector's nitrogen dioxide emissions and 1,610 annual lifetime cancer cases to its hazardous air pollutants. The highest number of impacts are seen in California, Texas, New York, Pennsylvania and New Jersey, while the per-capita incidences are highest in New Jersey, Washington DC, New York, California and Maryland.

Swiss researchers have determined that fermentation degree controls beer foam stability after seven years of study published in Physics of Fluids. Triple-fermented Belgian beers maintained the longest-lasting foam while single-fermented lagers produced the shortest duration. The team tested six commercial beers including Westmalle Tripel, Tripel Karmeliet, and Swiss lagers Feldschlosschen and Chopfab.

Surface viscosity dominated foam stability in single-fermented beers. Marangoni stresses from surface tension differences stabilized double- and triple-fermented beer foams. Lipid transfer protein 1 underwent progressive denaturation through successive fermentations. Single fermentation produced small round protein particles. Double fermentation created net-like protein structures. Triple fermentation broke proteins into hydrophobic and hydrophilic fragments that function as surfactants. ETH Zurich's Jan Vermant said breweries can now improve foam using these specific mechanisms rather than adjusting multiple factors simultaneously.

An anonymous reader quotes a report from Reuters: AbbVie will buy an experimental depression drug from partner Gilgamesh Pharmaceuticals for up to $1.2 billion, the companies said on Monday, seeking to access a fast-growing market for psychedelic-based treatments. The deal is the latest in the more than $20 billion AbbVie has spent on acquisitions since 2023 for drugs that can drive growth as its flagship rheumatoid arthritis treatment, Humira, lost patent protection. The companies had signed a partnership last year to develop therapies for psychiatric disorders, with privately held Gilgamesh set to receive up to $1.95 billion in option fees and milestone payments. The deals with Gilgamesh, which is also developing treatments for anxiety and post-traumatic stress disorder, also launch AbbVie into the race to develop psychedelic compounds for psychiatric conditions -- a potential $50 billion market, according to Cantor Fitzgerald analyst Josh Schimmer.

The deal, which includes an upfront payment and development milestones, could also bolster AbbVie's neurological conditions portfolio after its experimental schizophrenia drug, which it gained access to through an $8.7 billion purchase of Cerevel Therapeutics, failed in two mid-stage studies last year. Gilgamesh's lead candidate for depression, bretisilocin, activates the 5-HT2A serotonin receptor -- also targeted by classic psychedelics such as psilocybin, found in magic mushrooms, and LSD. The companies said bretisilocin has been shown to exert a shorter duration of psychoactive experience while retaining an extended therapeutic benefit in early and mid-stage studies. AbbVie will advance the drug into late-stage studies. "Large Pharma has been less active exploring psychedelic compounds due to potential regulatory concerns ... making today's deal more significant," said BMO Capital Markets analyst Evan Seigerman.

Russia's new Soyuz-5 rocket is set for a December debut as Moscow seeks to end reliance on Ukrainian technology and replace its aging Proton-M fleet. Ars Technica reports: According to the report, translated for Ars by Rob Mitchell, the debut launch of Soyuz-5 will mark the first of several demonstration flights, with full operational service not expected to begin until 2028. It will launch from the Baikonur spaceport in Kazakhstan. From an innovation standpoint, the Soyuz-5 vehicle does not stand out. It has been a decade in the making and is fully expendable, unlike a lot of newer medium-lift rockets coming online in the next several years. However, for Russia, this is an important advancement because it seeks to break some of the country's dependency on Ukraine for launch technology.

Struggling small biotech firms are pivoting into cryptocurrencies, rebranding as "crypto treasuries" or stockpiling digital assets like Ether and Litecoin as a last-ditch effort to boost share prices amid stalled funding and weak drug pipelines. Bloomberg reports: Shares of 180 Life Sciences Corp., now doing business as ETHZilla, tripled after the Peter Thiel-backed company said it had accumulated Ether tokens worth over $350 million. Less than two weeks later, the stock's gains have been erased. In July, Sonnet BioTherapeutics Holdings soared 243% in one volatile session on plans to transform into a public crypto treasury while MEI Pharma Inc. initially doubled on plans to sell shares to fund a Litecoin treasury.

Such about-faces are a tried-and-true formula for small firms when funds are low and shares are under pressure. For drugmakers it can be a sudden shift to chase after trendy new treatment targets, still other companies rebrand with buzzwords like artificial intelligence to juice returns. Now some biotech executives are using digital coins to pump new life into flagging shares. So far in 2025, at least 10 biotechs have announced a pivot into digital assets. The announcements frequently spark frenzied, but short-lived, spikes in shares. "If they're low on ideas, if they can't find relevance in drug development, they're going to try to justify their existence as management in another way," according to Mike Taylor, lead portfolio manager of the Simplify Health Care ETF. "You have a handful of companies trying to reinvent themselves into some other tangent. And, most, if not all won't work out."

"For a few dozen people in the world, the downside of living with a rare immune condition comes with a surprising superpower — the ability to fight off all viruses..." notes an announcement from Columbia University. "At first, the condition only seemed to increase vulnerability to some bacterial infections. But as more patients were identified, its unexpected antiviral benefits became apparent." Columbia immunologist Dusan Bogunovic discovered the individuals' antiviral powers about 15 years ago, soon after he identified the genetic mutation that causes the condition... Bogunovic, a professor of pediatric immunology at Columbia University's Vagelos College of Physicians and Surgeons, soon learned that everyone with the mutation, which causes a deficiency in an immune regulator called ISG15, has mild, but persistent systemic inflammation... "In the back of my mind, I kept thinking that if we could produce this type of light immune activation in other people, we could protect them from just about any virus," Bogunovic says.

Today, Bogunovic is closing in on a therapeutic strategy that could provide that broad-spectrum protection against viruses and become an important weapon in next pandemic. In his latest study, published August 13 in Science Translational Medicine, Bogunovic and his team report that an experimental therapy they've developed temporarily gives recipients (hamsters and mice, so far) the same antiviral superpower as people with ISG15 deficiency. When administered prophylactically into the animals' lungs via a nasal drip, the therapy prevented viral replication of influenza and SARS-CoV-2 viruses and lessened disease severity. In cell culture, "we have yet to find a virus that can break through the therapy's defenses," Bogunovic says...

Bogunovic's therapeutic turns on production of 10 proteins that are primarily responsible for the broad antiviral protection. The current design resembles COVID mRNA vaccines but with a twist: Ten mRNAs encoding the 10 proteins are packaged inside a lipid nanoparticle. Once the nanoparticles are absorbed by the recipient's cells, the cells generate the ten host proteins to produce the antiviral protection. "We only generate a small amount of these ten proteins, for a very short time, and that leads to much less inflammation than what we see in ISG15-deficient individuals," Bogunovic says. "But that inflammation is enough to prevent antiviral diseases...."

"We believe the technology will work even if we don't know the identity of the virus," Bogunovic says. Importantly, the antiviral protection provided by the technology will not prevent people from developing their own immunological memory to the virus for longer-term protection.
"Our findings reinforce the power of research driven by curiosity without preconceived notions," Bogunovic says in the announcement. "We were not looking for an antiviral when we began studying our rare patients, but the studies have inspired the potential development of a universal antiviral for everyone."

More coverage from ScienceAlert.

"The truly universal properties of languages are not independent of our physiology and cognition," argues the co-author of a new study. Instead he says their research "strengthens the idea that intonation units are a universal feature of language."

Phys.org explains: Have you ever noticed that a natural conversation flows like a dance — pauses, emphases, and turns arriving just in time? A new study has discovered that this isn't just intuition; there is a biological rhythm embedded in our speech...

According to the study, led by Dr. Maya Inbar, alongside Professors Eitan Grossman and Ayelet N. Landau, human speech across the world pulses to the beat of what are called intonation units, short prosodic phrases that occur at a consistent rate of one every 1.6 seconds. The research analyzed over 650 recordings in 48 languages spanning every continent and 27 language families. Using a novel algorithm, the team was able to automatically identify intonation units in spontaneous speech, revealing that regardless of the language spoken, from English and Russian to endangered languages in remote regions, people naturally break their speech into these rhythmic chunks. "These findings suggest that the way we pace our speech isn't just a cultural artifact, it's deeply rooted in human cognition and biology," says Dr. Inbar.

"We also show that the rhythm of intonation units is unrelated to faster rhythms in speech, such as the rhythm of syllables, and thus likely serves a different cognitive role...." Most intriguingly, the low-frequency rhythm they follow mirrors patterns in brain activity linked to memory, attention, and volitional action, illuminating the profound connection between how we speak and how we think.
The work is published in the journal Proceedings of the National Academy of Sciences.

"The ultimate test of climate projections is to compare them with what has played out..." says earth sciences professor Torbjörn Törnqvist, lead author on a new study published in the open-access journal Earth's Future (published by the American Geophysical Union).

But after "decades of observations," he says his researchers "were quite amazed how good those early projections were, especially when you think about how crude the models were back then, compared to what is available now." "For anyone who questions the role of humans in changing our climate, here is some of the best proof that we have understood for decades what is really happening, and that we can make credible projections...."

A new era of monitoring global sea-level change took off when satellites were launched in the early 1990s to measure the height of the ocean surface. This showed that the rate of global sea-level rise since that time has averaged about one eighth of an inch per year. Only more recently, it became possible to detect that the rate of global sea-level rise is accelerating. When NASA researchers demonstrated in October 2024 that the rate has doubled during this 30-year period, the time was right to compare this finding with projections that were made during the mid-1990s, independent of the satellite measurements.

In 1996, the Intergovernmental Panel on Climate Change published an assessment report soon after the satellite-based sea-level measurements had started. It projected that the most likely amount of global sea-level rise over the next 30 years would be almost 8 centimeters (3 inches), remarkably close to the 9 centimeters that has occurred.

But it also underestimated the role of melting ice sheets by more than 2 centimeters (about 1 inch). At the time, little was known about the role of warming ocean waters and how that could destabilize marine sectors of the Antarctic Ice Sheet from below. Ice flow from the Greenland Ice Sheet into the ocean has also been faster than foreseen.
"The findings provide confidence in model-based climate projections," according to the paper. Again, its two key points:

• The largest disparities between projections and observations were due to underestimated dynamic mass loss of ice sheets

• Comparison of past projections with subsequent observations gives confidence in future climate projections

Thanks to Slashdot reader Mr. Dollar Ton for sharing the news.

The mysterious X-37B space-plane — the U.S. military's orbital test vehicle — "serves partly as a platform for cutting-edge experiments," writes Space.com

And "one of these experiments is a potential alternative to GPS that makes use of quantum science as a tool for navigation: a quantum inertial sensor." This technology could revolutionize how spacecraft, airplanes, ships and submarines navigate in environments where GPS is unavailable or compromised. In space, especially beyond Earth's orbit, GPS signals become unreliable or simply vanish. The same applies underwater, where submarines cannot access GPS at all. And even on Earth, GPS signals can be jammed (blocked), spoofed (making a GPS receiver think it is in a different location) or disabled — for instance, during a conflict... Traditional inertial navigation systems, which use accelerometers and gyroscopes to measure a vehicle's acceleration and rotation, do provide independent navigation, as they can estimate position by tracking how the vehicle moves over time... Eventually though, without visual cues, small errors will accumulate and you will entirely lose your positioning...

At very low temperatures, atoms obey the rules of quantum mechanics: they behave like waves and can exist in multiple states simultaneously — two properties that lie at the heart of quantum inertial sensors. The quantum inertial sensor aboard the X-37B uses a technique called atom interferometry, where atoms are cooled to the temperature of near absolute zero, so they behave like waves. Using fine-tuned lasers, each atom is split into what's called a superposition state, similar to Schrödinger's cat, so that it simultaneously travels along two paths, which are then recombined.

Since the atom behaves like a wave in quantum mechanics, these two paths interfere with each other, creating a pattern similar to overlapping ripples on water. Encoded in this pattern is detailed information about how the atom's environment has affected its journey. In particular, the tiniest shifts in motion, like sensor rotations or accelerations, leave detectable marks on these atomic "waves". Compared to classical inertial navigation systems, quantum sensors offer orders of magnitude greater sensitivity. Because atoms are identical and do not change, unlike mechanical components or electronics, they are far less prone to drift or bias. The result is long duration and high accuracy navigation without the need for external references.

The upcoming X-37B mission will be the first time this level of quantum inertial navigation is tested in space.
The article points out that a quantum navigation system could be crucial "for future space exploration, such as to the Moon, Mars or even deep space," where autonomy is key and when signals from Earth are unavailable.

"While quantum computing and quantum communication often steal headlines, systems like quantum clocks and quantum sensors are likely to be the first to see widespread use."

alternative_right shares a report from ScienceDaily: Southwest Research Institute led a James Webb Space Telescope (JWST) survey, discovering a previously unknown tiny moon orbiting Uranus. A team led by SwRI's Dr. Maryame El Moutamid discovered the small object in a series of images taken on Feb. 2, 2025, bringing Uranus' total moon count to 29. "As part of JWST's guest observer program, we found a previously unknown satellite of the ice giant, which has been provisionally designated S/2025 U 1," said El Moutamid, a lead scientist in SwRI's Solar System Science and Exploration Division in Boulder, Colorado. "This object, by far the smallest object discovered to date, was detected in a series of 10 long exposures obtained by the Near-Infrared Camera."

Located in the outer solar system, Uranus is the seventh planet from the Sun. Known as "the sideways planet" for its extreme axial tilt, the cyan-colored ice giant has a deep atmosphere composed of hydrogen, helium and methane. Scientists think Uranus' larger moons are roughly equal parts water ice and silicate rock. "Assuming that the new moon has an albedo comparable to other nearby satellites, this object is probably around six miles (10 km) in diameter," El Moutamid said. "It is well below the detection threshold for the Voyager 2 cameras."

alternative_right shares a report from Phys.org: Now, for the first time, quantum scientists at the Quantum Control Laboratory at the University of Sydney Nano Institute have demonstrated a type of quantum logic gate that drastically reduces the number of physical qubits needed for its operation. To do this, they built an entangling logic gate on a single atom using an error-correcting code nicknamed the "Rosetta stone" of quantum computing. It earns that name because it translates smooth, continuous quantum oscillations into clean, digital-like discrete states, making errors easier to spot and fix, and importantly, allowing a highly compact way to encode logical qubits.

The curiously named Gottesman-Kitaev-Preskill (GKP) code has for many years offered a theoretical possibility for significantly reducing the physical number of qubits needed to produce a functioning "logical qubit." Albeit by trading efficiency for complexity, making the codes very difficult to control. Research published in Nature Physics demonstrates this as a physical reality, tapping into the natural oscillations of a trapped ion (a charged atom of ytterbium) to store GKP codes and, for the first time, realizing quantum entangling gates between them.

Led by Sydney Horizon Fellow Dr. Tingrei Tan at the University of Sydney Nano Institute, scientists have used their exquisite control over the harmonic motion of a trapped ion to bridge the coding complexity of GKP qubits, allowing a demonstration of their entanglement. "Our experiments have shown the first realization of a universal logical gate set for GKP qubits," Dr. Tan said. "We did this by precisely controlling the natural vibrations, or harmonic oscillations, of a trapped ion in such a way that we can manipulate individual GKP qubits or entangle them as a pair." [...] Across three experiments described in the paper, Dr. Tan's team used a single ytterbium ion contained in what is known as a Paul trap. This uses a complex array of lasers at room temperature to hold the single atom in the trap, allowing its natural vibrations to be controlled and utilized to produce the complex GKP codes. This research represents an important demonstration that quantum logic gates can be developed with a reduced physical number of qubits, increasing their efficiency.