Moderna and Merck say their personalized mRNA melanoma vaccine significantly reduced both cancer recurrence and spread in a late-stage trial. The treatment could reach patients as soon as next year if regulators approve it. Reuters reports: Moderna developed the vaccine with Merck and tested it together with immunotherapy drug Keytruda, a widely used treatment for melanoma. [...] This is the first positive late-stage trial result for an mRNA cancer vaccine, which trains a patient's immune system to fight tumors by targeting specific mutations in those cells and the first such study to show that adding a treatment to Keytruda worked better than that therapy alone. Similar approaches are being tested against lung, breast and pancreatic cancers.

[...] The cancer treatment combines Merck's Keytruda with a made-to-order mRNA vaccine from Moderna that is based on an analysis of mutations found in the patients' own tumors. The trial enrolled 1,137 high-risk patients with stage IIB-IV melanoma that had been surgically removed. Volunteers were randomized to receive up to nine doses of Keytruda plus the personalized vaccine or Keytruda alone for about one year. The companies said no new safety signals have emerged in the trial. In January, the companies announced results of a mid-stage trial of the treatment showing that it reduced the risk of recurrence or death by 49% after five years. Karen Knudsen, CEO of the Parker Institute for Cancer Immunotherapy, said the Moderna results could signal a new era for treating solid-tumor cancers. "The positive hit here leads us into truly this next phase in immunotherapy," Knudsen said. "This is an auspicious start -- this is where things begin."

Moderna shares more than doubled on the news, adding about $30 billion to its market value.

A study of more than 64,000 people born around the end of Britain's postwar sugar rationing found that those exposed to less sugar during their first 1,000 days had lower rates of five cancers decades later, including roughly 69% lower liver cancer risk and 36% lower breast cancer risk. They also "showed signs of slower biological aging" and "continued to consume less sugar and had healthier diets overall," according to the authors of a new study published in The Conversation. From the report: After the second world war, sugar remained rationed in Britain for several years. But in September 1953, rationing ended and people started eating a lot more sugar. Consumption nearly doubled. This meant that children born just a few months apart had very different levels of sugar exposure both in the womb and during early childhood. For our study, we used data from over 64,000 people born in Britain between 1951 and 1956. Those born earlier spent a larger share of their first 1,000 days under sugar rationing, while those born later experienced progressively less of it.

[...] What is most surprising, however, is not the cancer results or the biological markers of ageing. It's how early-life sugar exposure continued to affect people's diets even 50 years later. We found that people who experienced sugar rationing early in life still consumed less sugar in adulthood, around age 50. They also ate less overall, and their diets were healthier and more diverse. This suggests that the level of sweetness people are exposed to very early in life may shape their taste preferences for a long time.

"We are in a 21st century space race," U.S. Senator Ted Cruz has said. And this week CNN noted a competition that for decades loomed in the background of geopolitics "is now roaring to the forefront," with China "demonstrating rapid advances in space technology" while the U.S. is "ratcheting up rhetoric about a looming battle for control of the cosmos." It's the fact that China plans to build a permanent settlement on the moon by 2040 that has prompted an urgent response from [U.S.] lawmakers... They've declared a new space race, and NASA is pledging to build a lunar outpost of America's own.... Both the United States and China plan to send robotic explorers to the south pole later this year, paving the way for human explorers to follow close behind.

The US is relying on the private sector to develop and build low-cost, exploratory robotic landers... Meanwhile, China is aiming to launch its robotic Chang'e-7 mission as soon as this month. The complex endeavor will seek to use four different robotic vehicles — an orbiter, lander, rover and mobile "hopper" — working in tandem to attempt to gather unprecedented data. The effort will include tools to drill for and directly analyze water ice, a feat that the US will only attempt with robotic missions slated for next year at the earliest. "If lunar water ice is successfully located, it could significantly reduce the cost and time required to transport water from Earth, facilitating the establishment of a human base for long-term activities on the moon and enabling further exploration of Mars or deep space," Tang Yuhua, the deputy chief designer of the Chang'e-7 mission, said in a 2025 interview with state media.

The oncoming flurry of south-pole-centric activity, with few established international laws to govern the outcomes, is heightening the drama of this rivalry... But with a much more ambitious goal — a future in which people attempt to flourish within permanent settlements rather than just visit the moon — the stakes of this new space race are even higher, according to Clayton Swope, the deputy director of the Aerospace Security Project at the Center for Strategic and International Studies, a bipartisan nonprofit. "The long-term vision will take generations to execute on," Swope said. "But in my mind, it's a scenario where there are people being born, people dying, their families, children growing up in a place that is not Earth — so that looks a lot like a city, more than it looks like an expedition to the south pole." If such a future comes to fruition, Swope added, his hope is that such extraterrestrial colonies would be governed by rules reminiscent of Western ideals and democratic principles. Whether China would be on the same page is an open question.
China is already fine-tuning its plans for a lunar settlement, CNN writes: The country envisions the International Lunar Research Station, or ILRS, as a sprawling science-focused facility on the moon's surface that can be operated robotically, "with the prospect of subsequent human presence," according to a government's ILRS website. China could partner with Russia to build a massive nuclear reactor to power the base, though questions remain regarding how the war in Ukraine may impact Russia's ability to deliver... China and Russia were mapping these plans long before the US announced its own intention to build a nuclear reactor on the moon last year and detailed its plans for a lunar settlement spanning hundreds of square miles... Who will write the rules? And how, exactly, will the use of lunar resources be policed on the international stage?
Meanwhile, NASA "still does not have a vehicle capable of getting astronauts down to the lunar surface," the article points out: Returning to the moon is not as simple as repeating Apollo. The space agency cannot — and does not wish to — replicate its 20th century lunar-landing success. The supply chains, skilled machinists and factories that built Apollo's rockets, landers and command modules no longer exist. And while the Apollo landings stuck close to the lunar equator, landing near the south pole is substantially more complex and requires more powerful vehicles.... China, meanwhile, has been laser focused on its lunar exploration program since 2004, using its top-down, central planning system to keep resources flowing toward specific goals.

An anonymous reader shares this report from Space.com: On Saturday evening (Aug. 15), SpaceX set another mark, for the shortest time between orbital flights: It launched two Falcon 9 rockets just 38 minutes apart, besting its old mark — set on Aug. 31, 2024 with two Starlink missions — by 27 minutes.

The first liftoff, from Florida's Cape Canaveral Space Force Station, occurred Saturday at 9:12 p.m. EDT (0112 GMT on Aug. 16) and carried eight satellites to low Earth orbit (LEO) for Louisiana-based telecom company Globalstar. All eight spacecraft were deployed successfully, separating over a six-minute span beginning 56.5 minutes after liftoff, SpaceX announced via social media. While that Falcon 9 was powering its way to low Earth orbit, another one launched from Vandenberg Space Force Base, on California's central coast. That liftoff, at 9:50 p.m. EDT (6:50 p.m. local time; 0150 GMT on Aug. 16), kicked off a mission for the U.S. Space Force called USSF-366...

Both of Saturday's missions featured successful rocket landings. The Falcon 9 first stage that launched the Globalstar mission came back for a touchdown at Cape Canaveral about eight minutes after launch. It was the 14th flight for that particular booster. The USSF-366 Falcon 9 first stage, meanwhile, came back to Earth about 8.5 minutes after its launch, touching down in the Pacific Ocean on the SpaceX droneship "Of Course I Still Love You." That booster now has 18 missions under its belt.

Saturday's doubleheader brought the tally of Falcon 9 launches in 2026 to 96. The vast majority of those — about 75% — have been Starlink missions.

Phys.org reports: Future fusion power plants aim to recreate the heart of a star here on Earth to power our future energy needs. While the core fusion plasma will burn at hundreds of millions of degrees, the surrounding structural components must handle sudden, punishing heat loads that rival the extreme temperatures faced by spacecraft upon reentry into Earth's atmosphere. Copper and its alloys are primary candidates for handling these intense heat fluctuations, making it vital to understand exactly how the metal behaves when pushed to its melting point.

Now, researchers at the Department of Energy's SLAC National Accelerator Laboratory and collaborators have captured a detailed, step-by-step look at copper atoms as they underwent extreme heating. Published in Nature Communications, the results revealed a key parameter that allowed copper's crystal lattice to melt steadily rather than collapse instantaneously, as earlier simulations predicted. "These results greatly improve the simulations we use to predict which materials have the best shot at surviving the extreme conditions of future fusion reaction chambers," said Mianzhen Mo, a SLAC staff scientist who led the research. "They also demonstrate the incredible, atomic-scale resolution imaging we can achieve at SLAC's electron camera...."

Researchers use computer simulations, aided by AI and machine learning, to sift through innumerable combinations of elements and identify promising candidate materials for real-world testing.
"Whether the copper melts slowly or suddenly collapses, by the time the researchers look, the sample resembles nothing more than a metallic brown puddle," the article points out. But SLAC's powerful electron camera captures atomic and molecular movements down to the femtosecond — a millionth of a billionth of a second — and revealed that at around 1,424 degreesC (2,595 degreesF) there was still gradual melting as the temperature rose beyond the superheating limit, with real-world conditions showing the atoms shifted and retained some order.

"It's a straightforward solution," said Mianzhen Mo, a SLAC staff scientist who led the research. "But molecular dynamics simulations had been overlooking it for years. When you have complex simulations attempting to capture every aspect of reality, down to individual atoms, it takes real-world data to show you what's missing from the calculations."

Astronomers using the James Webb Space Telescope say they may have found a new class of object: a "black hole star," in which a black hole is wrapped in dense gas and radiates in ways that resemble an enormous star. The Guardian reports: The international team made the breakthrough after focusing their attention on a mysterious red spot in images of the early universe captured by Nasa's James Webb space telescope. The object was lurking in the constellation of Cetus, the Whale, billions of light years from Earth. It is thought to have formed 660m years after the big bang, astronomers' leading theory as to how the universe began. Measurements of the exotic body found that while it resembles an immense star, it releases 100bn times more energy than any known star can produce. The energy output is far closer to that observed from black holes than stars. The findings have been published in the journal Nature.

Astronomers using JWST have found three actively feeding supermassive black holes in the distant galaxy J0148-4214, seen as it existed about 1.2 billion years after the Big Bang. Two sit just 620 light-years apart near the galaxy's center and are expected to merge within a few hundred million years. Phys.org reports: Theories of galaxy evolution -- based on observations -- suggest that, early in the history of the universe, galaxies came very close to one another and merged. In the process, black holes at their centers also merged, giving rise to even more massive black holes at the centers of the merged galaxies. The analysis yields black hole masses of approximately 80 million, 0.6 million and 2 million solar masses. The most massive black hole is accreting at a lower rate than the nearby black hole with a mass of 0.6 million solar masses, which is actively feeding and even exceeding the maximum accretion rate predicted by basic theories of black hole growth (the Eddington limit).

"The JWST data allowed us not only to identify the three black holes, but also to estimate their masses, accretion rates and the stellar mass of the galaxy," says Dr. Giovanni Mazzolari, second author of the study and researcher at MPE. "We find a total stellar mass of about 1.3 billion solar masses, and the black holes represent a significant fraction of that."

The central black hole pair is expected to merge within the next few hundred million years. "These results are extremely exciting," adds Roberto Maiolino, professor at the University of Cambridge and co-author of the study. "They suggest that black hole merging may be an additional, fast route for their rapid growth in the early universe." The third black hole, located off-nucleus, may be the remnant of a previous merger, be displaced from the center by a gravitational recoil kick, or be currently migrating inward. The findings have been published in the journal Astronomy & Astrophysics.

alternative_right shares a report from ScienceDaily: Researchers have found a clever new way to map a part of Earth's upper atmosphere that is notoriously difficult to observe. Using orbital data from roughly 1,200 Starlink satellites, they reconstructed changes in atmospheric density about 500 kilometers above Earth. [...] The resulting density patterns also showed strong consistency with observations from the European Space Agency's SWARM satellites, which measure changes in atmospheric density along their orbital paths.

The work expands on an earlier study by the same team. In that research, scientists estimated how thermospheric density changed over time and altitude using general orbital information called Two-Line Element, or TLE, data from Starlink satellites. The new analysis adds another dimension by examining how density varies horizontally across latitude and longitude, revealing more of the thermosphere's geographic structure.

The findings could have practical benefits as the number of objects orbiting Earth continues to grow. More accurate information about atmospheric density can improve predictions of satellite motion, helping reduce the chance of collisions between satellites and between satellites and space debris. The technique could also eventually support near-real-time measurements of atmospheric density around satellites. Such monitoring could improve space weather forecasting and contribute to safer, more dependable satellite operations in the future.

An anonymous reader quotes a report from The Guardian: Miniature human organs and other tissues are to be grown from NHS patients' cells in a drive to improve medicine testing and reduce the number of animals used in drug development. Scientists will use the clumps of tissue to learn how diseases vary between patients, helping them identify which treatments are best for different people based on the particular pathology underlying their condition. The move marks a shift away from the traditional use of animals as models for human disease, towards what researchers believe will be more accurate and reliable tests based directly on human tissues.

Researchers have been growing tiny clumps of human organs, known as organoids, for more than a decade. Tests show that pieces smaller than a millimeter can mirror key features of full-scale organs and tissues, including how they falter with disease and respond to drugs. Armed with organoids grown from diseased human tissues, scientists can investigate whether new drug candidates reverse pathological changes in all or a subset of patients, and quickly identify ineffective drugs early in the process. Historically, more than 90% of drugs that clear animal testing go on to fail in human trials, raising questions about the value of the tests. US and European medicines regulators now encourage other approaches if available. "It's going to have a major impact on the numbers of animals used and the way we develop new drugs in the future," said Matthias Zilbauer, a clinical professor of paediatric gastroenterology at the Cambridge Stem Cell Institute. "We're not saying there won't be any animal use in the near or foreseeable future, because there are still certain issues that cannot be tested in these new models, but the reduction is very real."

"A lot of human diseases either do not occur in animals or occur in a different way because they're not human," added Zilbauer. "We want tests and models that can tell us which treatments work, and in what patients, and a mouse cannot tell us that."

Longtime Slashdot reader sbinning shares a press release: The U.S. Department of Veterans Affairs announced the launch of a new clinical trial to evaluate the effectiveness and safety of psilocybin to treat major depression in Veterans, including those with concurrent PTSD. The new trial comes after a recent executive order on "Accelerating Medical Treatments for Serious Mental Illness," which aims to increase clinical trial participation and accelerate innovative research models and drug approvals for psychedelic drugs.

[...] The randomized, controlled trial will enroll Veterans diagnosed with treatment-resistant major depressive disorder, with or without concurrent PTSD, and will compare outcomes between two psilocybin dosage levels. The study will also assess participants' levels of depression before and after treatment, tolerability of side effects, and overall patient-reported depression. [...] In addition to this trial, VA is involved in 20 active clinical trials focused on psychedelic therapies for mental health conditions. All VA research -- including research into psychedelics -- is conducted under strict safety protocols and in full compliance with federal guidelines.

After 13 years of observations and data processing, astronomers have released the largest two-dimensional map of the universe ever assembled, "offering a sweeping new view of nearly 4 billion celestial objects across roughly three-quarters of the sky," reports Space.com. From the report: The new map, created by the Dark Energy Spectroscopic Instrument (DESI) Legacy Imaging Surveys team, contains a staggering 5.6 trillion pixels and combines more than 263,000 telescope exposures collected over more than a decade. The observations span visible and near-infrared wavelengths, providing an enormous portrait of stars, galaxies and other cosmic phenomena across the sky, according to a statement from the National Science Foundation (NSF) NOIRLab. "It's part of the fabric of astronomy research now," David Schlegel, co-lead of the Legacy Surveys and a scientist at the U.S. Department of Energy's Lawrence Berkeley National Laboratory, said in a statement. "When you're working with astronomical objects today, you often start by pulling up the Legacy Imaging Viewer to see what you're looking at."

Wired reports that consumer neurotechnology is rapidly moving from the lab into workplaces and homes, with companies including Apple, Meta, and Snap developing products that can monitor or interpret brain activity. Researchers warn that as these systems improve, neural data could become the next major privacy battleground. Some neuroscientists are already calling for a series of core rights, coined "neurorights," that protect "mental privacy," "identity," and personal "agency." Here's an excerpt from the article: Over the past two decades, researchers using functional magnetic resonance imaging (fMRI), which tracks the iron in the hemoglobin supplying oxygen to neurons, have been building up increasingly detailed maps and inventories of the mammalian cortex. Thanks to huge advances in machine-learning artificial intelligence -- computer algorithms that are able to sort through enormous amounts of information and use statistical methods to make classifications and predictions -- fMRI scans can now be used to identify everything from depressive thoughts to the nuanced feelings of envy and schadenfreude. Other algorithms have been able to accurately piece together reconstructions of movie clips watched by subjects, just by analyzing their brain scans; or have detected, in probing the brain activity of swing voters in the US presidential election, responding to photographs and videos of presidential candidates, which candidates provoked anxiety or even disgust, and which elicited positive responses or feelings of empathy.

In just the last few years, neuroscience researchers have progressed from decoding images and emotions as they play across the cortex to sounds, words, phrases, and even language. In 2023, in a remarkable demonstration of this emerging technology, a woman called Ann Johnson, who had been paralyzed for 18 years by a brain-stem stroke, was able to speak again through the insertion of a grid of 253 electrodes onto the surface of her brain, which translated her neuronal signals into sentences, in real time, at a rate of 78 words per minute (just about half the speed of standard conversation). The research team at the University of California, led by neurosurgeon Edward Chang, had combined this brain-computer interface with an animated avatar of Johnson's head, which spoke in her own voice, as reconstructed from a recording of a 15-minute toast she had given at her wedding. Just as the avatar's mouth spoke Johnson's words as she thought them, so its expressions were similarly influenced by the nuances of her brain activity, which turned her thoughts about facial gestures into displays of emotion -- from smiles to pursed lips and frowns.

[...] The more invasive the recording equipment, the richer and more detailed the data. Surgical interventions are at the vanguard of neuroscience and remain very rare -- fewer than 100 people on the planet have brain-computer interfaces like Johnson's embedded beneath their skulls. Yet almost inevitably, a concerted trickle-down effect is occurring. In the summer of 2023, a team at the University of Texas demonstrated that they could use fMRI to translate brain scans into words and sentences, after subjects listened to 16 hours of the storytelling podcasts The Moth Radio Hour and The New York Times' Modern Love to train an AI model. When the subjects then listened to new podcasts, the algorithm was able to convert the gist of what they heard, as it manifested in their brains, into words, phrases, and sentences that roughly captured the stories. As the team's lead computational neuroscientist, Alexander Huth, put it in an interview with Science, "Our thought when we actually had this working was, 'Oh my God, this is kind of terrifying.'" Now noninvasive, wearable brain scanners are beginning to proliferate beyond the lab, making their way into our workplaces and, through the vast global consumer market, into our homes too.

alternative_right shares a report from Phys.org: Scientists from the Czech Republic have created microscopic cleanup robots that successfully removed microplastics from both soil and aquatic environments in the lab. Details of their work are published in the journal npg Asia Materials. To build the robots, researchers started with microscopic MXene particles made of ultrathin, stacked layers. The material has a large surface area and surface chemistry that help it attract and hold plastic. They then coated the particles with magnetic nickel nanoparticles so rotating magnetic fields could drive the tiny robots.

Then came the testing phase. The team placed swarms of these microbots into water and soil samples contaminated with plastic. The externally generated magnetic fields made the robots spin and tumble through the liquid and squeeze through tiny water-filled gaps in the soil. "In soil environments, the microrobots can navigate through water-permeated soil microenvironments, actively disrupt microplastic entrapment within soil matrices, and extract them," the study authors commented in their paper. As they moved, their sticky surfaces collided with microplastics, binding to them and dragging them along. The researchers then used a magnet to pull the microrobots, along with their trapped plastic cargo, out of the samples.

They performed well. In water, they removed about 94% of test polystyrene particles and 89% of PET (polyethylene terephthalate) in around an hour. In the model soil, they removed about 81% of the polystyrene and 72% of PET. This outperformed the same MXene material used without magnetic motion, which relied on passive adsorption rather than actively moving through soil and water.

sciencehabit shares a report from Science Magazine: For more than half a century, physicists have searched for one of the strangest particles predicted by modern theory. It would be made almost entirely of gluons, the elusive subatomic particles that carry the strong nuclear force. Now, using a particle collider in Beijing, researchers say they have effectively proved the existence of such a "glueball."

In a preprint posted last month on arXiv and in a presentation last week at the International Conference on High Energy Physics (ICHEP), the researchers argue that a particle called X(2370), which they produced by smashing electrons into positrons at high energies, has the properties expected of a glueball. "It's an experimental triumph," says Colin Morningstar, a particle physicist at Carnegie Mellon University who was not involved in the finding. "It's the strongest evidence yet that particles dominated by a glueball component can exist in nature."

An anonymous reader quotes a report from the BBC: England is on track to become one of the first countries in the world to eliminate hepatitis C, a dangerous virus that attacks the liver, figures show. The target of treating 80% of all known cases has already been met, and deaths from the virus have fallen by 36% in the last decade, just short of what is needed by 2030. Taking antiviral tablets for 8 to 12 weeks can cure more than 95% of cases. Initiatives including A&E blood tests, GP registration testing and free at-home tests have helped to find people who were previously undiagnosed, says NHS England.

NHS England says that since 2015, more than 100,000 people have been diagnosed and treated for hepatitis C, meaning the country is already meeting that target. Another goal -- a 65% reduction in hepatitis C-related mortality compared with 2015 levels -- has yet to be met, but might be before the 2030 target date. Around 50,200 adults are living with hepatitis C, figures for England in 2024 suggest. Estimates indicate 84.6% of those living with hepatitis C have been diagnosed -- just short of the 90% target. The Hepatitis C Trust says England is "on the cusp" of one of the most significant public health achievements in our country's history.