An anonymous reader writes "Scientists have silenced the extra copy of a chromosome that causes Down syndrome in laboratory stem cells, offering the first evidence that it may be possible to correct the genes responsible for the disorder. The discovery provides the first evidence that the underlying genetic defect responsible for Down syndrome can be suppressed in cells in culture."
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coondoggie writes "Two dead stars smashing into each other and releasing massive amounts of energy may have created all of the heavy elements such as gold found on Earth. That's the main conclusion of Harvard-Smithsonian Center for Astrophysics (CfA) researchers who estimated such a collision and subsequent blast of energy known as a gamma-ray burst produced and ejected as much as 10 moon masses worth of heavy elements — including gold."
MTorrice writes "A new study suggests there's more to nanoparticle toxicology than cell life and death. Although immune cells treated with iron oxide particles appeared healthy in standard toxicology tests, they struggled to perform one of their key jobs: engulfing pathogenic bacteria. The researchers wonder if exposure to significant levels of the nanoparticles could lead to dysfunction in people's immune systems."
sciencehabit writes "When surgeons can't determine the edges of a tumor, it's a problem. Cut too much, and they risk hurting the patient. Cut too little, and they may leave stray cancer cells behind. Now, researchers have developed a surgical knife that can sniff the smoke made as it cuts tissue, almost instantly detecting whether cells are cancerous or healthy. The 'intelligent knife,' or iKnife could distinguish normal and tumor tissues from different organs, such as breast, liver, and brain, and could even identify the origin of a tumor that was a metastasis, a secondary growth seeded by a primary tumor elsewhere in the body."
An anonymous reader writes "New observations (PDF) from ESO's Very Large Telescope show for the first time a gas cloud being ripped apart by the supermassive black hole at the center of the galaxy. The cloud is now so stretched that its front part has passed the closest point and is traveling away from the black hole at more than 10 million km/h, whilst the tail is still falling towards it."
An anonymous reader writes "I recently (within the past couple years) graduated from college with a bachelor's degree in Computer Science and currently work as a programmer for a large software consulting firm. However, I've become gradually disillusioned with the financial-obsession of the business world and would like to work for the overall betterment of humanity instead. With that in mind, I'm looking to shift my career more toward the scientific research side of things. My interest in computer science always stemmed more from a desire to use it toward a fascinating end — such as modeling or analyzing scientific data — than from a love of business or programming itself. My background is mostly Java, with some experience in C++ and a little C. I have worked extensively with software analyzing big data for clients. My sole research experience comes from developing data analysis software for a geologic research project for a group of grad students; I was a volunteer but have co-authorship on their paper, which is pending publication. Is it realistic to be looking for a position as a programmer at a research institution with my current skills and experiences? Do such jobs even exist for non-graduate students? I'm willing to go to grad school (probably for geology) if necessary. Grad school aside, what specific technologies should I learn in order to gain an edge? Although if I went back to school I'd focus on geology, I'm otherwise open to working as a programmer for any researchers in the natural sciences who will take me."
Dave Knott writes "A tiny, previously unknown moon circling Neptune has been spotted by astronomers using the Hubble telescope. The moon, which is currently known as S/2004 N1, was found on July 1 by Mark Showalter of the SETI Institute in Mountain View, Calif., NASA announced Monday. It is less than 20 kilometres wide and its orbit is 105,000 kilometres from Neptune, between those of Larissa and Proteus, two of Neptune's other 14 known moons. It circles Neptune once every 23 hours."
New submitter Aras Esor writes "When a network is broken — an electrical grid, the World Wide Web, your neurological system — one math model created by a PhD student at Northwestern University suggests that the best way to fix it may be to break it a little more. 'Take the web of interactions within a cell. If you knock out an important gene, you will significantly damage the cell's growth rate. However, it is possible to repair this damage not by replacing the lost gene, which is a very challenging task, but by removing additional genes. The key lies in finding the specific changes that would bring a network from the undesirable state A to the preferred state B. Cornelius's mathematical model (abstract) provides a general method to pinpoint those changes in any network, from the metabolism of a single cell to an entire food web.'"
astroengine writes "With the help of rover Curiosity, we now know that ancient Mars had large quantities of liquid water flowing across its surface. However, evidence for large bodies of water — i.e. seas/oceans — has been hard to come by. But using high-resolution orbital data, Caltech scientists now think they've found a long-dry river delta that once flowed into a very large body of water. Welcome to the Aeolis Riviera — the strongest evidence yet for a Martian coastline. "This is probably one of the most convincing pieces of evidence of a delta in an unconfined region — and a delta points to the existence of a large body of water in the northern hemisphere of Mars," said Roman DiBiase, Caltech postdoctoral scholar and lead author of the paper that was published (abstract) in the Journal of Geophysical Research."
An anonymous reader writes "A Newtown couple, both scientists, who lost their daughter in the school shooting, are wondering whether there were clues in the shooter's physiological makeup — his DNA, his blood, his brain chemistry. They are now involved in a search for biomarkers, similar to those that may indicate disease, for violence. They are raising money to help fund this research, but the effort is running into obstacles, in part, over ethical concerns. 'I'm not opposed to research on violence and biomarkers, but I'm concerned about making too big of a leap between biomarkers and violence,' said Troy Duster, a researcher at the University of California at Berkeley. There is concern that science may find biomarkers long before society can deal with its implications."
Rebecka writes "Hurricane Sandy, which pelted multiple states in Oct. and created billions of dollars in damage, was a freak occurrence and not an indication of future weather patterns, according to NASA's Goddard Institute for Space Studies via LiveScience. The study (abstract), which calculated a statistical analysis of the storm's trajectory and monitored climate changes' influences on hurricane tracks, claims that the tropical storm was merely a 1-in-700-year event. 'The particular shape of Sandy's trajectory is very peculiar, and that's very rare, on the order of once every 700 years,' said senior scientist at NASA and study co-author, Timothy Hall. According to Hall, the extreme flooding associated with the storm was also due to the storm's trajectory which was described as being 'near perpendicular.' The storm's unusual track was found to have been caused by a high tides associated with a full moon and high pressure that forced the storm to move off the coast of the Western North Atlantic."
astroengine writes "A planned six-hour spacewalk outside the International Space Station came to a dramatic and abrupt end on Tuesday when water started building up inside the helmet of Italian astronaut Luca Parmitano. Parmitano and NASA astronaut Chris Cassidy were less than an hour into their spacewalk, their second in a week, when Parmitano reported that his head felt wet. 'My head is really wet and I have a feeling it's increasing,' Parmitano reported to ground control teams at the Johnson Space Center in Houston. Parmitano returned safely to the space station interior, but the cause of the leak was not immediately known."
First time accepted submitter CherryLongman writes "If you feel as if every mosquito in a 50-mile radius has you locked in its sights, while your friends are rarely bitten, you could be right. Up to 20 percent of us are highly alluring to mosquitoes — and scientists have discovered some surprising reasons."
sciencehabit writes "Europe's first farmers helped spread a revolutionary way of living across the continent. They also spread something else. A new study reveals that these early agriculturalists were fertilizing their crops with manure 8000 years ago, thousands of years earlier than previously thought."
sciencehabit writes "The tragic opera Rigoletto may move you to tears, but here's a more literal application of the moving power of sound. Sound waves with frequencies just above human hearing can levitate tiny particles and liquid droplets and even move them around, a team of engineers has demonstrated. The advance could open up new ways to handle delicate materials or mix pharmaceuticals."
vinces99 writes "Swarms of small earthquakes often precede a volcanic eruption. They can reach such rapid succession that they create a "harmonic tremor" that resembles sound made by some musical instruments. A new analysis of an eruption sequence at Alaska's Redoubt Volcano in March 2009 shows the harmonic tremor glided to substantially higher frequencies and then stopped abruptly just before six of the eruptions. Scientists at the U.S. Geological Survey's Alaska Volcano Observatory have dubbed the highest-frequency harmonic tremor at Redoubt Volcano 'the screams' because the episodes reach such high pitch compared with a 1-to-5 hertz starting point. Alicia Hotovec-Ellis, a University of Washington doctoral student in Earth and space sciences and an author of two papers examining the phenomenon, has created a 10-second recording and a one-minute recording that provides a 60-times faster representation of harmonic tremor and small earthquakes."
First time accepted submitter eionmac writes "The BBC reports that Archaeologists believe they have discovered the world's oldest lunar 'calendar' in an Aberdeenshire field. Excavations of a field at Crathes Castle found a series of 12 pits which appear to mimic the phases of the moon and track lunar months. A team led by the University of Birmingham suggests the ancient monument was created by hunter-gatherers about 10,000 years ago. The pit alignment, at Warren Field, was first excavated in 2004. The experts who analyzed the pits said they may have contained a wooden post. The Mesolithic calendar is thousands of years older than previous known formal time-measuring monuments created in Mesopotamia. The analysis has been published in the journal Internet Archaeology."
united_notions writes "An international team from UCSD and Philips Research have published a paper (article paywalled; extensive free related resources at UCS here) in the Journal of the Acoustical Society of America, showing the results of real-time magnetic resonance imaging conducted on a beatboxing performer. The authors make interesting comparisons to sounds in many minority languages around the world (such as the 'click' consonants in many African languages); they also show how beatboxing sounds can be represented using the International Phonetic Alphabet (IPA)."
Garin writes "The late Permian saw the greatest mass extinction event of all-time. The causes for this extinction are hotly debated, but one key piece of the puzzle has recently been revealed: while the deep-water environments were anoxic, shallower waters showed clear signs of being oxygenated. This rules out global anoxia, and strongly suggests that other factors, such as the Siberian Traps vulcanism, must have played a dominant role. From the article: 'Rather than the direct cause of global extinction, anoxia may be more a contributing factor along with numerous other impacts associated with Siberian Traps eruption and other perturbations to the Earth system.' See the full research article (behind a paywall) here."
symbolset writes "Discovery News is covering a project by two engineers from the University of Michigan to pair cubesats with tiny ion engines for inexpensive interplanetary exploration. The tiny plasma drive called the CubeSat Ambipolar Thruster (CAT) will ionize water and use it as propellant with power provided by solar cells. In addition to scaling down the size of ion engines they hope to bring down the whole cost of development and launch to under $200,000."