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First Image Taken With an Ultra Low Field MRI

Posted by kdawson on Sat Nov 10, 2007 01:57 PM
from the swimming-with-the-squids dept.
KentuckyFC writes "MRI machines are about to get smaller, much smaller. Most of their bulk is taken up by the huge superconducting magnets required to generate fields of a few Teslas. Now a team at the Los Alamos National Lab in New Mexico has built a machine that can produce images using a field of only a few microTesla (PDF, abstract here). So giant superconducting magnets aren't necessary, a development that has the potential to make MRI machines much smaller, perhaps even suitcase-sized. The one-page paper shows sections of the first 3D brain image taken with the device."
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  • Hidden monkeys (Score:4, Informative)

    by LiquidCoooled (634315) on Saturday November 10 2007, @01:59PM (#21308117) Homepage Journal
    I thought the images were of monkeys at first, however when I went to have a look at MRI images of a human head was thankfully proven wrong (some of us have our monkey origins hidden better than others).

    So, for comparison here is a page with images of human heads in a normal MRI [fbi.gov].
    (single image here [fbi.gov])

    I hope they get the focusing better (which is what I understand the power is used for) because this will be a good progression.
  • by IvyKing (732111) on Saturday November 10 2007, @02:07PM (#21308169)
    This may be the first image of a human head with an ultra low field MRI, but ULF MRI images have been made for at least a decade and a half. Magritek, a New Zealand company, makes a low cost unit ULF MRI system, though the image volume is limited to about one liter.


    Another company, Vista Clara, is using a novel form of ULF MRI to map groundwater.

    • Should be big enough for early creationists.

      Bert
    • by ceoyoyo (59147) on Saturday November 10 2007, @04:14PM (#21308913)
      The summary is VERY incorrect.

      This isn't an ultra low field MRI, it's a DUAL field MRI. In a normal scanner you have a big, static magnetic field that polarizes the sample and remains for readout. In one of these dual field scanners you use the big field (or a bigger field, it's usually a resistive electromagnet so it can't be anywhere near as strong as a superconductor) to polarize the sample then you shut it off and use a much smaller field for readout. There are a few advantages, the one the abstract focuses on is that you can do things like MEG in a very low field. The other is that energy deposition is related to the field strength so by using a small field you can use imaging sequences that would otherwise pump too much energy into the subject.

      One of the guys working on this technology visited my lab last year. It was a very interesting presentation.

      I believe someone has produced an MR image using the Earth's magnetic field. They've certainly done nMR in the Earth's field. You can't get much lower than that on this planet.
  • by flyingfsck (986395) on Saturday November 10 2007, @02:07PM (#21308177)
    Hmm, they use a prepolarization field of 30 mT for 1 second before using the weaker measurement field of 46 uT. So I'm wondering why they don't just use the 30 mT field and be done with it.
    • by IvyKing (732111) on Saturday November 10 2007, @02:28PM (#21308323)
      The Larmour frequency for 30 mT is about 1.28 MHz, which is in the AM broadcast band. Interference is likely to be a significant problem.
      • Re: (Score:2, Interesting)

        by Anonymous Coward

        The Larmour frequency for 30 mT is about 1.28 MHz, which is in the AM broadcast band. Interference is likely to be a significant problem.

        If that was the reason, they would just pre-polarize to a different field. Most MRI happens in the middle of some radio band, and at ~2 KHz, there is going to be lots of interference from 60/50 Hz harmonics or other mains related EM radiation. The interference is removed by shielding the magnet / room. In this case, I think they also used a gradiometer coil which is pretty

  • MRI accidents (Score:4, Interesting)

    by l00sr (266426) on Saturday November 10 2007, @02:09PM (#21308185)
    Hopefully this will also put an end to those pesky MRI accidents [nytimes.com]. Not that they're common, but still, those things aren't toys.

    • Not that they're common, but still, those things aren't toys.

      Thank you for pointing out that MRI's are not toys.

      ;-)

    • I was in a gown prepared to get an MRI for my back and a little old lady in the waiting room with me refused to give the MRI tech her purse. She was in a gown holding her giant purse with metal snaps and buckles tightly. (An amusing image. I lol'd)

      She said "I don't want to leave my purse behind. I'll hold it really tight."

      The tech said "You can't hold it. It'll tear your arms off."

      She said "I'll just set it on a chair next to me."

      He said "You can't bring it with you. There's a big magnet in the room and it
      • Re: (Score:3, Interesting)

        That's what I thought. People with a pacemaker for instance, can not be imaged with an MRI anymore now. Hopefully that'll change in the near future.
  • other implications (Score:4, Interesting)

    by SuperBanana (662181) on Saturday November 10 2007, @02:10PM (#21308189)
    Off the top of my head, some plusses and negatives.

    Plusses: less (very expensive) liquid helium or (less expensive but still $$) liquid nitrogen. Less of a magnetic field means much higher MRI safety; everything from oxygen cylinders to chairs to guns have been drawn into/against MRIs (the gun was a prison guard who got pushy and DEMANDED to be in the same room as a prisoner. Yeah, the gun went off. No, nobody was hurt.)

    Negatives: since the MRI isn't as strong, it might be more affected by local magnetic fields from wiring, ferrous objects, etc. Dunno. Right now, MRIs are installed into big rooms that have as little ferrous material as possible, and then very carefully "shimmed" to adjust for the building and local magnetic fields by a technician. Even if an MRI gets down to "suitcase" size, the necessity of a "clean" environment and calibration for each location might make moving them around very tough.

    As a side note, there are already shielded MRI machines which work in a trailer and require little setup time, but being outdoors makes things easier- no building infrastructure to mess with the magnetic fields.

    • Yeah, the gun went off. No, nobody was hurt.

            I was going to make some witty comment about the bullet not going very far, but then again lead isn't paramagnetic, is it? :)
      • Re: (Score:3, Informative)

        I was going to make some witty comment about the bullet not going very far, but then again lead isn't paramagnetic, is it? :)

        Nope, though not all bullets are lead.

        Jokes aside, the field is very strong and ALWAYS on. The oxygen cylinder incident killed the kid who was in the MRI machine at the time; gooooo White Plains Medical center!

        Another benefit I forgot to mention is that the machine won't need to be powered up for very long, nor will it need to be quenched in the event of an emergency (which

    • Re: (Score:3, Interesting)

      Some twenty-odd years ago when I was doing some research software for a teaching hospital in the city, I had noticed there was some significant construction going on, some kind of addition to the main building. I didn't know what it was for at the time. A couple months later I was walking down a hallway with one of the doctors I was working with, and noticed what looked like a two-foot-square hole in the wall that hadn't been there the day before. It had been crudely patched with plasterboard. The doctor to
      • by 2short (466733) on Saturday November 10 2007, @06:16PM (#21309587)
        Ten years ago my girlfriend at the time was involved in research using NIHs 4T human machine, a 3-story tall superconducting magnet. There was a fence outside part of the building with signs saying keep out, strong magnetic fields. But one day my girlfriend told me how the director had to go running outside because some workmen digging a trench were taking down a section of the fence, preparing to bring a backhoe through. After arguing a bit with the construction foreman about this being where the trench was supposed to go, and how he really didn't think a magnet was going to hurt his backhoe, she took one of their shovels and stuck it to the wall. That got their attention long enough to explain how many millions of dollars they would owe her if their backhoe gets sucked though the side of the building and breaks her magnet.
        • Re: (Score:3, Interesting)

          Man, I'd love to get the details on that! I'm an architect that specializes in MRI facility design & construction and I'd love to be able to document that story.

          Another similar story, an MRI facility in Arkansas had just been built and the Fire Marshal was on his way to do the final inspection. However, before he got there, the sprinkler contractor decided to take the oxyacetylene torch rig into the room to fix a leaky sprinkler head. The magnet grabbed the tanks, drew them inside, snapped the valve off
  • by Animats (122034) on Saturday November 10 2007, @02:10PM (#21308193) Homepage

    Very nice. The images are still very blurry (resolution 81×61×11), and the detectors, at 37mm, are big, but it's a start.

  • by pair-a-noyd (594371) on Saturday November 10 2007, @02:11PM (#21308201)
    I had to have several MRI & CT scans and that friggin tunnel is more than I can handle.
    They tried to put me in one with the normal little tunnel (about as big around as a five gallon bucket) and I freaked out before I got 2' into it and made them back me out. Then they put me in an "open" MRI machine but it was like being crushed under a car. No way Jose. Abort #2.
    So I went to another city where they had a different kind that was a little more "open" than #2.
    This one then pumped me full of Xanax and I survived it.

    The CT scan was not quite as bad because it was like a large doughnut and there was only about 1' of my body inside it but it still freaked me out.
    Xanax on that one too.

    I swore I'll die before I ever go in one of those damn things ever again.
    They need to come up with a better way. Some people can't handle that crap.
    I hope these new ones are a break away from the "trapped in a pipe" or "crushed under a car" machines.
    • by Dunbal (464142) on Saturday November 10 2007, @02:21PM (#21308275)
      For some reason I find that your comment suits your screen name just fine...

      Of course I understand completely that people don't have to justify their phobias, but you have to admit that you must have caused quite a few shaken heads, raised eyebrows, and sighs of exasperation on behalf of the medical staff. Especially considering that because of their scarcity such machines usually have a line of people waiting for them.
      • by kailoran (887304) on Saturday November 10 2007, @02:45PM (#21308427)
        I'd assume those shaking heads were muttering "geez, another one" rather than "omg wtf how can someone be afraid of it". Claustrophobia isn't all that unheard of, and being shoved into a friggin pipe is somewhat a powerful trigger.
        • Re: (Score:3, Insightful)

          It's indeed scary to be in that pipe. Not only is it very narrow and you can't get out yourself, but the machine makes very loud noises when in operation. Being inside a working MRI machine is not a fun experience.
      • by Nyago (784496) on Saturday November 10 2007, @02:52PM (#21308479) Homepage
        If it were easy (or even moderately hard) to control a phobia, I suspect most people would. Justification is irrelevant. It matters only that the fear exists. Conquering a phobia typically requires exposure (with neutral or rewarding consequences) to the fear-provoking stimulus. In his case, gradual exposure to being in the tube.

        I realize that many people find it difficult to understand the lack of control inherent in a phobia. I (with my injection phobia) am often told (by medical professionals) simply to get over it. Unfortunately, when a needle is present, I descend into blind animal panic. My rational mind ceases to function. The thoughts of controlling and pushing through the fear don't even occur to me. It is a pure flight-or-fight response, and I have done both.

        Additionally, the guilt of having wasted time (of the doctors or other patients) needlessly adds to the unpleasantness of the situation. His attempts to undergo the procedure are, in my opinion, courageous.

        People need help, not guilt or reprimands.
        • With all respect, I doubt there are hundreds of MRIs in a single location. The price tags run into millions. Not tens or hundreds of thousands - millions. Perhaps you can provide us with the name of this facility?

          As far as the claustrophobia goes, MRI is a bad time to find out.
    • by RallyNick (577728) on Saturday November 10 2007, @02:43PM (#21308409)

      I had to have several MRI & CT scans and that friggin tunnel is more than I can handle.

      Why not use a cloth eye cover?

    • I'm having an MRI done next week to find out if I'm claustrophobic. :)

      All kidding aside, I've had two MRIs in the last few years. I'm not at all claustrophobic, so the tube doesn't bother me; I've been in tighter places than that several hundred feet underground. Just close your eyes, listen to the nice music, and try not to think about it.

    • Re: (Score:3, Informative)

      I had to have several MRI & CT scans and that friggin tunnel is more than I can handle.

      I haven't seen one in person yet, but there's apparently a company which produces something called the Fonar 360 [fonar.com], which instead of having a tunnel basically turns the entire room is a magnet. This is useful not just for reducing claustrophobia, but also hypothetically allows for surgery to occur while somebody is inside of an MRI. I think the spatial resolution however is quite a bit weaker than typical scanners.

      The s
  • by Anonymous Coward
    about 50 microteslas http://hypertextbook.com/facts/1999/DanielleCaruso.shtml [hypertextbook.com].

    according to the Fine Article:

    The measurment field in the article is 46 microteslas.
    (A "pre-polarization" field of 30 mT (milliteslas) is appled for one second before each meaurement)
  • Smaller is nice, but what really needs to be done is to make them cheaper to purchase and operate. That way, even the local small hospitals can, hopefully, afford one. When you're sick and living out in the country, having to drive a hundred miles to the nearest machine can be quite a chore.
  • In home MRI scanner (Score:4, Interesting)

    by backslashdot (95548) on Saturday November 10 2007, @02:22PM (#21308283)
    I wonder if this could finally lead to an "in home" MRI scanner? If it costs under a thousand bucks and a person has a family history of cancer, why not invest in one?

    Basically the device would be conveniently rolled over the bed once a month or so and scan. It will utilize advanced 3D image analysis to compare with last couple month's scan and see if you have any growing tumors. If so then you go get a proper scan done.

    This will go well with the "in toilet" piss or shit tester that will tell you if you're going diabetic or may be developing some other medical conditions for example like kidney disease or cancer, etc..
    • I wonder if this could finally lead to an "in home" MRI scanner? If it costs under a thousand bucks and a person has a family history of cancer, why not invest in one?

      because it will interfear with our tin foil hats of course.
    • Like other medical imaging technologies such as ultrasound, the images are medically pretty much worthless without a qualified operator to read them.
      For ultrasound systems, a far cheaper technology, the cheapest systems seem to be around $10,000. And while I could see the geek appeal of messing around with ultrasounding various animate and inanimate objects, I am sure that if the price should reach sub-1000's, it would quickly become another weapon in the arsenal of hypochondriacs and hysteric pregnant wome
        • No (Score:3, Informative)

          No. It can say "the machine was unable to detect any of the types of large solid tumors we can recognize".

          Do people sue pregnancy test kits if it tells them they weren't pregnant and they drank alcohol and the baby was born with problems? Or condom manufacturs for getting deadly diseases?

          If they do, they havent been very successful .. cause those products still exist on the market.

          Disclaimers. Use them.

          DISCLAIMER: The above post is not meant to encourage or discourage anyone from getting into the home MRI b
    • Re: (Score:3, Informative)

      For cancer scanning, you'd really want a PET (positron emission tomography)
      • Why would someone have to wait 5 weeks for a MRI? The two major hospitals in my area have 1 or 2 MRI's each and this is in a town of less than 100,000 people.
  • Maybe this will help bring down health care costs as hopefully these will be a lot cheaper - and hopefully no longer will hospitals in the middle of nowhere have to spend several million dollars on an MRI machine.

    Technology certainly doesn't have all the answers, but things like this can only lead to good.
    • Maybe this will help bring down health care costs as hopefully these will be a lot cheaper - and hopefully no longer will hospitals in the middle of nowhere have to spend several million dollars on an MRI machine. Technology certainly doesn't have all the answers, but things like this can only lead to good.

      While some of your hospital bill is due to the cost of acquiring and maintaining the expensive machines, are you also aware that part of your bill is due to people who use the hospital's services but
  • by imsabbel (611519) on Saturday November 10 2007, @03:01PM (#21308547)
    Its not like the effect used in NMR is _only_ viable at high field strengts.

    Its just that higher fields (or more correctly put, higher field gradients) allow for higher resolution.
    Looking at this publication, they archived about 5mm resulution with a 50uT field.
    Real high-end small bore scanners can get 3 orders of magniture higher.

    And the "maybe can it fit in a glovebox" part is _severely_ limited by the use of 7(!) Squids... Each of which will need a LN/LH cryosystem.

    Still, this looks quite interesting, but its not like it completely depricates the current stuff.
    • by ceoyoyo (59147) on Saturday November 10 2007, @04:24PM (#21308963)
      Not quite. Higher gradients give you faster imaging. Higher fields give you better signal to noise. Better signal to noise can allow you to actually use those higher gradients without ending up with a big mess of noisy pixels.

      If you've got lots of time you can achieve more or less any resolution you want with any field strength you like. The problem is, the darn patients keep getting impatient and moving.

      The summary is pretty wildly inaccurate. This is actually a dual field scanner that uses a stronger field to polarize the sample and a weaker one for readout. It's pretty cool, but it's a niche thing... these guys want to do MEG scanning along with MRI and MEG is allergic to large magnetic fields. It won't be replacing the regular superconducting scanners and it won't be making cheap in-home scanners possible.

      You can do nMR in the Earth's magnetic field if you want to. It's actually possible to set it up at home. I think someone was selling science kits for a while.
    • by kmac06 (608921) on Saturday November 10 2007, @02:24PM (#21308295)
      Well you could always go back to the 19th century and avoid hospitals if you don't like modern medical advances (which are quite expensive).
      • by Turn-X Alphonse (789240) on Saturday November 10 2007, @03:08PM (#21308589) Journal
        Or you could have a sensible health care system where the rich can have giant breasts and the poor don't die from common and curable things.

        You know, just a thought.
        • Re: (Score:3, Insightful)

          Or you could have a sensible health care system where the rich can have giant breasts and the poor don't die from common and curable things.

          When you can figure out how to do that without holding a gun to my head to force me to pay for it, I'll back you 100%.
      • by jpfed (1095443) <.jerry.federspiel. .at. .gmail.com.> on Saturday November 10 2007, @04:41PM (#21309073)
        I was recently charged $3000 for a CT scan. Talking to an Indian coworker, I found out that a CT scan in his country would've cost less than $50. So I guess I could've flown out to India, gotten the CT, and flown back, for less money than getting the CT in America.

        It's a good thing I did get that expensive modern medical advance in America, though, because of the high-quality analysis and follow-up I got from the clinic. In total, I got one sentence out of it- "Your intestines are a little constricted." I don't think they could provide that kind of advanced analysis in India with their cheap CT scans.

        I guess I'm wondering- are modern medical advances really as expensive as we're led to believe they are in America?
        • To add insult to injury, apparently it's a growing trend to send the CT images electronically to India for a specialist to analyze.
        • Re: (Score:3, Interesting)

          IN GENERAL:
          Medical research happens when there's money behind the disease. Once the advance is made and commoditized for great loads of money to the first world (and the research is the main thing priced, not the build construction), it can be exported to the developing world and add value slightly to their firstworld sales numbers, for little extra effort.

          If the first world didn't exist, then the developing world wouldn't have the luxury of down-marketting - they would have to get by without the tech bein
    • by guruevi (827432) <evi@smokingcube.CURIEbe minus physicist> on Saturday November 10 2007, @03:50PM (#21308801) Homepage
      I work at one of those MRI places and we do research and we are a non-profit. Although we're quite fully booked every day the use of the MRI still cost ~$500/hour. Basically the cost of operation divided by the number of scans done last year makes the price. Or do you think supercooling magnets to ~5K (that's Kelvin, convert to Celsius or Fahrenheit yourself) 24/7, the machine itself (~$3m) and support contract (~$125k) are paid for by the government not talking about the workstations to process the data and of course, my daily food?

      About the article: those pictures are pretty unclear but it's promising.
        • Re: (Score:3, Informative)

          I believe the post you are referring to mentioned a CT scan, not an MRI. While both are imaging techniques, they are quite different in how they work. MRIs are much, much more expensive in general. They require the supercooled magnets and such. A CT is essentially using the same type of radiation as in used in a normal X-RAY to get sliced images. CTs are much faster at acquiring images and the equipment is much cheaper than an MRI. Both of the factors make it much less expensive overall.