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Science

End To Blindness? 102

Kevin writes "For the first time ever, researchers from a company called Optobionics surgically implanted an artificial retina into three patients who are blind from retinitis pigmentosa. These highly-experimental prosthetic devices, made of silicone computer chips, are intended to restore ambulatory vision, thereby giving people the freedom to walk without the assistance of a cane or guide dog. Researchers are begining to develop computer chips that might function in place of damaged photoreceptor cells."
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End To Blindness?

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  • It's the year 2000, and people STILL can't get this right?
  • thats good to hear , as I have hope that if the retinitis pigmentosa I have every starts to degrade my vision I can look forward to this technology
  • by malus ( 6786 )
    I hope science can build some bug detecting retinal implants for the netscape developmnet team.

  • This seems like a pretty big deal, but I wonder what percentage of blindness it would actually 'cure'? I, for example, lost my right eye due to a vascular tumor when I was unborn. The tumor caused damage to the optical nerve, so this wouldn't work for myself or others in a similar situation.
  • by Soko ( 17987 ) on Wednesday October 25, 2000 @02:06PM (#675653) Homepage
    ..isn't silicone used in other, more uh, cosmetic [implantinfo.com] prosthesies? You mean silicon, I hope...
  • e-Spleen!(tm) - Never knew you had one, never knew you needed one! Yet now, surf the 'net with your spleen! Although I do have to wonder, how sensitive are these suckers? I mean, couldn't theorhetically an EMP shatter your eye? I mean, I don't know much about photoreceptors, but that's just a thought...
  • This is an interesting step toward integration of electronic technology and biology.
    A similar device could, for instance, be used to enhance the vision of an already healthy eye. Maybe interfacing with another device to allow concurrent interpretations of multiple images.

    I'm not sure if I am excited or scared.

    The Borg tried to assimilate the humans, they should have let them assimilate themselves.
  • Anyone got bets on a date to world domination?

    I'd like to "see" this tech in action. I hope it's an improvement over the ultrasound ones I've seen. They look horrible; however, I've never really been totally blind, just mostly blind.
    Something like this combined with a good wearable PC and I'll never need to enter meatspace again.
  • It's understandable. After all, we're talking implants here, right?
  • by tie_guy_matt ( 176397 ) on Wednesday October 25, 2000 @02:15PM (#675658)
    I heard that when they restore people's vision after they were blind their entire life, formerly blind people still can't "see" very well. The signals might be going to your brain again but it will take a while for your brain to figure out how to make sense of it all. This is better than nothing but if you really want to cure blindness you have to do it to very young people so they can learn how to use their eyes like everyone else.
  • I wonder what percentage of blindness it would actually 'cure'?

    As I understand it, not much. I saw something very similar to this a few months ago, but the new retina consisted of about 6 pixels, which were wired directly into the optic nerve. They were triggered when the wearer was close to something, or when confronted by a bright object.

    Now, although the resolution isn't great, it's a hell of a lot better than nothing - the patient they tested it on could distinguish some objects, and tell when he was close to walls and stuff.

    The big difference though, was that the retina was external, mounted on his forehead, I think, but it still wired into his optic nerve, which was the important advance.

  • I can see at 1600x1200 what about you?

    You Like Science?
  • ...the scientists all went back to Tleilax, and continued to binge on spice.

    -or, for the Ender fan in you-

    ...Olhado plugged the cable *right in his eye*, and replayed some of the best family beatings.

  • by MustardMan ( 52102 ) on Wednesday October 25, 2000 @02:23PM (#675662)
    And here all this time i've been drooling over the microoptical [microopticalcorp.com] glasses mount display, Why bother when I can have a chip implanted into my eyeball and just use the hardware to directly superimpose an image on my field of vision.
  • Cool! Just in time for Halloween. Wonder what I can make my eyes look like ... ?
  • I shudder to think how much the R&D costs for this are.
    80% of all blindness is preventable with current techniques. The most common cause, cataracts, can be cured with a relatively simple operation
    Trachoma, the second most common cause, can easily be prevented with proper hygiene, and cured with inexpensive antibiotics. The third most common cause, glaucoma, is more difficult to treat, but vision loss can be prevented or minimised if it is discovered early.
    The point is, seeing as most of the worlds blindness can be prevented or cured at low cost, maybe resources would be better spent striving for this rather than pursuing newsworthy but extremely limited solutions such as these implants.
    -"Oh, THAT power button"
  • These won't cure all blindness - you need to be able to replace / repair the optic nerve. Anyone know of any of this actually being worked on?

    Cyano

    Oh yeah - whoever registered my /nick on yahoo mail can suck my cock...
  • Diabetes-related Blindess is controllable if detected early.
  • by empesey ( 207806 ) on Wednesday October 25, 2000 @02:33PM (#675667) Homepage
    Now they'll have to be more selective about who they date.

  • Man, I want this, and I've got 20/20 vision!

    Next stop cybernetic implants! I wanna make myself a superhero! ;)

    -Phlod
  • by blakestah ( 91866 ) <blakestah@gmail.com> on Wednesday October 25, 2000 @02:36PM (#675669) Homepage
    The device is kinda neat. It is 40 microns thick and consists of solar cells (miniature) connected to stimulating electrodes.

    Perhaps it is cooler that someone is simply attempting to cure blindness in such a way. The sensory periphery for audition and vision is amenable to implants - in vision, for example, the retina holds about a million nerve cells arranged in a nice topographic array. In the cochlea there are a few tens of thousands of hair cells in a nice spiral array. A company spawned from the Otolaryngology labs at UCSF makes the only US designed cochlear implants (Advanced Bionics).

    Of course, the optobionics device will be out of focus since the eye focusses light on the retina and not on the silicon chip. But hey - it'd be amazing if they could simply get enough current out of their device to stimulate a neuron. You'd need at least 10 microamps. The upside is that you do not need a power supply or wire lead into the retina - a tricky engineering feat for other retinal implant designs.

    They didn't report if any of their patients implanted in late June had any vision yet. Guess what - they would be seeing by now if the implant worked. So my guess is that the device is a bust. And unfortunately, you don't really get that many clinical trials to fail in your device, no matter how well capitalized you are.

    The other difficult thing about retinal implants is the number of stimulating sites required. You can hear speech with 8 stimulating electrodes and very good temporal fidelity. For vision - temporal fidelity is not so stringent, but you need at least 100 stimulating electrodes, each capable of pushing 10 microamps (AC, for a brief brief period). The problem is that you need to power the chip, and to do that you need a cable running into the eye. That probably necessitates the cutting or at least paralysis of the eye muscles, and a very tricky connection through the cornea. So you can see the allure of the optobionics device.

    These guys are, however, great at marketing and fundraising. There will be a flurry of such press releases and fund raising bouts, for optobionics and other retinal stimulation companies. The presidents of the companies will get rich. I just hope one of them recruits a decent engineer so that someone gets to see again too. It doesn't seem like their approach is hopeless - but it certainly needs modification.

  • My friend suffers from RP(retinatis pigmentosa) and is actively watching this research work. He noted to me that these new chips will be useful for him, but not for people who lost their vision from other causes. For example, children who were born blind, can probably not be helped with an artificial retina. In addition, those that have never known sight may not be able to process the images in their brain. This work does look very promising for RP sufferers. When this technology becomes a reality for him, I figure I'll take him on down to the strip club, since it has been a while.
    Stuart Eichert
  • ..but isn't the thing they're fixing here just one of many reasons for blindness?

    I'm not a doctor, but it seems to me that there's more than one way for a person's eyes to not, or stop, work(ing), simply by excersising a bit of common sense. I mean, it's like saying that breast removal "cures cancer". Not quite.. it fixes one FORM of cancer (or, well, it can).

    More power to these guys if it helps even a fraction of the blind folks out there.. but without more information than a press release, I remain skeptical that this is going to help everyone that has an eye problem. All the information available indicates it only repairs a rather narrow brand of blindness.

    I'd just be wary of labelling these guys gods. Minor deity's, perhaps, because the achievment is pretty major.. but it seems to me it's only one step in the entire staircase.
  • <RANT TYPE="OFF-TOPIC (BUT INSPIRED BY)" TONE="SARCASTIC">

    This just goes to prove a pet peeve of mine: not even quasi-scientific journalists can write a decent headline!

    Title of actual article:

    "Vision Researcher First to Implant an Artificial Retina in Humans"

    I mean, c'mon: it's an artificial RETINA. It's a darn good thing it was a VISION researcher that did it first; just imagine the poor patients if a cutting-edge proctologist had done the implantation - no telling how THAT would "come out in the end" (proctology humor, sorry). And it's not even like the article is on some generic news site where they need to be extra-specific just to pander to the LCD (that's Lowest Common Denominator, not Liquid... oh nevermind). It's on blindness.org [blindness.org] for cryin' out loud! I highly doubt they run a lot of stories about podiatry or stomach ulcer research...

    </RANT>

  • We've seen for a long time how people who lose the use of one part of their body can remap the nerve cells that control that part for other purposes. Brains are, after all, just literally big neural networks, and it's remarkably easy to reshape that network when changing a few constraints. All it takes is some relearning and motivation, which these people have.
  • Umm, babies have never seen sight until they are born, and they don't seem to have a problem, unless I'm mistaken
  • Just interesting to note that this page is not readable by machines that help the blind surf the web. They have not added any extra code to help their audience receive this information.

    This is a gross mistake on the part of blindness.org. How do they intend to help if their audience can't read their page?

    Ugh.
  • Well in case you were unaware retinitis pigmentosa is a genetic disease passed throug ussually the mother if I remember correctly so the prevention would have to be DNA testing Jon
  • What would happen if some guy with the silicon eye implates stares at some chick's silicon brest implants? Gotta be careful... don't want him going off on his own and, um, making himself go blind all over again! =)
  • Date: 2006
    This just in:

    With all the new optical eye companies abounding there seem to be 2 main choices:

    1) IBM PCEye -- You get very fast refresh rates but it costs significantly more for a more "true color" version of the optical eye.

    2) AppleEye -- You get perfectly true color and are able to see the world in ways few people do. The problem with this, though, is that the current refresh rate is 3 times per second -- and it costs a QUITE significant amount of money to purchase an optical eye that has a better refresh rate.

    Back to you George. . .
  • how about this for a power-supply?
    A tiny laser, possibly IR or some other frequency, positioned on the rim of a pair of glasses, pointed through the iris to a photocell receiver inside the eye? No messy cables or paralysis.
  • At least the chronic ones, that is. Most heart disease can be prevented by proper diet and exercise. Most colon cancer can be prevented by proper diet. Most lung cancer can be prevented by not smoking (right, nicotineman? ;-).

    Even many infectious diseases can be prevented with cheap stuff you can find around the home. Most STDs can be prevented by cheap latex barriers. Most malarial diseases can be prevented by proper screens and nettings. Most intestinal parasites can be prevented by proper sewage disposal.

    The question you have to ask yourself, though, is can a buck be made by handing out this free and sensible advice? Most problems could be solved at lower cost by addressing these causes directly instead of treating their symptoms, but it's not as sexy and it runs contrary to human nature.
  • ...What does the output of the sensors look like? Is it kinda like Geordi LaForge's visor in Star Trek TNG?

    Sure, we may never be able to find the answer. Try asking one of these patients what color a flower is. If it wasn't instilled in their mind, they wouldn't know.

  • wasn't this reported on a few months ago? or is this a different technology? i also rember another experiment where they implanted fetal retinal tissue into damaged maculas to try and have it regrow naturally being a sufferer of damaged retina myself i like to hear about this stuff
  • The story description for this that is posted on /.s main page looks to me like the first paragraph from the story it links to. Although the link points to the original work, you seem to be crediting the submiter of the story for that (apparently) copied paragraph. You might want to update that. =)
  • yeah last year sometime there was soem hub-bub about those things being able to see through clothing under certain conditions in the nighttime setting... not like you'll get much detail... you're better off going to the mall with one of those "x-ray" glasses
  • AppleEye -- You get perfectly true color and are able to see the world in ways few people do. The problem with this, though, is that the current refresh rate is 3 times per second -- and it costs a QUITE significant amount of money to purchase an optical eye that has a better refresh rate.

    However, the good news about the Apple version, is they'll be able to daisy chain other sensory functions off of the eyes. Experiments are being right now, to see if this is a viable solution to male impotence.

  • welll yeah... the motivation part is harder than it sounds i'm guessing... anyone ever saw that movie with mira sorveno and val kilmer? even if the desire is there i think human fear of the unknown is going to stand in the way of the remapping.. but presumably a younger child will have a much easier time adapting to such changes... according to popular psychology anyhows
  • I don't mean to be a killjoy, but what a letdown after that headline! This will hardly be an end to blindness. People lose their sight in many different ways to many different degrees. Transplant or artificial replacement technologies for different parts of the eyes are great, but none individually will bring about an "end to blindness."

    Why would you even want to say this is the case? I think a headline like "Further progress made restoring sight" would have been just as exciting and not at all a letdown when I read the actual article. Why claim miracles when simply describing current technology is amazing enough?

  • Actually, the article itself should be completely readable by a blind user. The text comes out perfectly fine in Lynx, so a basic speech browser should have no problems reading the article to a blind user. The top navigation uses an image map, which could pose some potential difficulties, but if you go to the front page of their site there is a link to a text only version, which should also be readable by speech browsers.

    Not sure where you got the idea that the article wasn't readable by blind users.
  • Trust me, you DO NOT want retinitis pigmentosa. I have it. I'm almost totally blind at night. During the day, I'm totally blind in several areas of my field of vision. In 10-15 years I get to look forward to having around a 10% field of vision. You may think it's funny until you're trying to find somthing you dropped in a dimly lit area. I hate dark and crowded areas because the whole time I have to work really hard to not run over people, trip, etc. RP isn't preventable. It is a genetic disease. My Mom and brother are also effected with this disease. Not all of the DNA patterns for RP causing mutations have been found. This could help more than just people with retinitis pigmentosa. It could also help people with macular degeneration, stargarts, or age related macular degeneration. AMD (the blindness, not the processor company) is the leading cause of retinal blindness. Retinal diseases in most cases are not related to you acuitive vison. I have pretty bad vision, but with correction I see 20/20, yet there are quite a few areas in my pariphial vision that are impared. My brother sees 20/20 with no correction, he has an about 5% field of vision. Let me put it this way: if somting pops up on his 17inch moniter, unless he is looking at it, he won't see it at all. Plus we get to look forward to cataracts which will have to be removed, my Mom has had them. I hope this works out, I'd like to be able to use a 17 inch moniter in 14 years... --Josh
  • Actually, brains are remarkably flexible, but it's also equally interesting where they are not flexible.

    A fascinating book on the subject is called Why Michael Couldn't Hit (and Other Tales from the Neurology of Sports) [amazon.com]. The author, a Neurologist, talks about the brain's role in becoming a world-class athlete. The title is in reference to asking the question of why Michael Jordan, possibly the best basketball player in history, utterly failed to be a competent baseball player.

    It turns out that to be a world-class athlete, there are certain critical neurological growth periods where you have to play the sport or you will never be world-class in the sport. What's interesting is that the age seems to vary based on the sport. Most critical periods seem to be in adolescence, but he also talks about the fact that world-class violinists have to start at a very early age (like 5 or something) or it's simply too late.

    You don't have to be into sports to enjoy the book. I found it extremely interesting because rarely do you see information about what the brain can't do.


    --

  • been dere, dun dat. don't have the ref handy but one of the other other artificial retina projects is doing with laser, just like you suggest.
  • The point is, seeing as most of the worlds blindness can be prevented or cured at low cost, maybe resources would be better spent striving for this rather than pursuing newsworthy but extremely limited solutions such as these implants.

    Seeing as how most of the world's ignorance can be cured by providing free in-house tutoring to the underprivileged, maybe your time would be better spent in the ghetto educating the young?

    Seeing as how we have plenty of problems to deal with on the ground, perhaps we should never have developed a space program? Oh wait, that gave us incredible leaps in technology. Or as NASA's website puts it, "Orbiting spacecraft transmit information like phone calls and television signals around the globe with extreme speed and precision. Other satellites monitor the weather and the health of the atmosphere, the dynamics of the oceans and the vitality of the land. Satellite-based navigation systems aboard airplanes and boats enable people to determine their geographic position and heading with greater accuracy than ever before. This improves safety and makes travel more efficient."

    Now, I know this article isn't about space travel, but there is a parallel here. NASA's site continues, "Technology created to prepare systems and people to operate in the harsh conditions of space contributes to advances in composite materials, electronics, robotics, medicine, energy production, manufacturing, transportation and many other areas of human activity." And then points out the thing I really want you to notice: "In many cases, these advances would occur much more slowly or not at all without the challenge of space exploration."

    This research is just the same deal. The things we learn in this kind of research may give us insight both into curing other kinds of blindness, as well as detecting them more easily and preventing them. Furthermore, however, it may also give us insight into other bits of science which are not related to blindness, or even unrelated to vision.

  • I recall a story in one of the Oliver Sacks [amazon.com] books about someone who had "motion blindness". There are parts of the brain that process motion, and the patient could see things that were still, but could see them in motion. It wasn't a tracking problem, it was a perception problem. The patient literally couldn't perceive objects in motion.

    By the way, anyone who is interested in how the brain works and the nature of perception, concousness and reality should pick up some of his books. They are absolutely fascinating. Any of them will do. Sometimes the best way to see how the brain works is looking at the various ways it can malfunction.

    One last story: he had a patient how could only percieve things on the right side of her, but not on the left. She was perfectly rational. Her vision was perfect. She simply couldn't percieve it. When she ate, she would have to eat from the right side of her plate, then turn the plate around. Then eat half of that. Then turn it around again, etc until there was nothing left.


    --

  • Babies also haven't talked, but don't usually have trouble learning. However, take a fifteen-year-old who has never been exposed to language and teach him how to talk. Good luck.... The same goes for almost any basic activity, whether is be talking or seeing.
  • Sure, we may never be able to find the answer. Try asking one of these patients what color a flower is. If it wasn't instilled in their mind, they wouldn't know.

    If you'd read up on RP, however, you'd know that the people this will help are people who once could see.

  • The beauty of this, is that as we improve our miniaturization technologies, we can pack more photosensors on the same bit of silicon. Eventually, if we can refine the techniques enough, it might get to the point where the resolution could be nearly as good as the human eye. Plus, since we are dealing with something digital, we could allow for the modification of the image based upon active filtering. Just think: you're playing a game of hide and go seek, and you order the controller to search the image for all pixels that match the color of your prey's shirt.
  • Just interesting to note that this page is not readable by machines that help the blind surf the web. They have not added any extra code to help their audience receive this information.

    Really? It seems to me that all the text images on the site have ALT attributes. What else should they be doing? Not to mention the fact that there is, in fact, a text-only site.

  • Thanks for replying.

    What I meant was that the whole thing is one big friggin' table. If you do go in the text-only site, though, speech based and braille based browsers will do fine.

    If a blind slashdot user clicked on the above link, though, he'd be screwed. If he could read Slashdot at all.
  • Don't forget that much of what we see is through our brains. Our eyes simply capture "bitmaps" of the world and our brains make sense of what we see i.e., columns of neurons in our brains parses these bitmaps into lines, contours, shapes, depth, etc. The problem with people who have been blind for a period of time is that these neuronal columns do not get stimulation. Neurons that do not get stimulated shrink and die off. The eyes may be able to send pictures to the brain but the brain won't be able to make sense of it.

    The brain is known to be able to mallable and it has been known shift functions from damage areas to other areas. However, current literature suggests that recovery will be minimal given the complexity of the visual system.

    These type of restoration will probably only help those who have recently become blind.
  • Eventually, if we can refine the techniques enough, it might get to the point where the resolution could be nearly as good as the human eye. Plus, since we are dealing with something digital, we could allow for the modification of the image based upon active filtering.

    Being as good as the human eye may not be strictly necessary. Your vision system is pretty sophisticated and if you have (for example) solder burns on the surface of your eye, it will wander independently of the other to get the information that would otherwise be obscured by the burn.

    Also, it doesn't sound like this is digital technology at all; It sounds more like they're using small, hyperefficient photovoltaic cells directly attached to electrodes which get stuffed into the existing (damaged) retina; It's basically a synthetic analogue for the analog retina. Backing this up is something I found on Optobionics [optobionics.com]' website which states "The area of the retina that receives and processes the detailed images--and then sends them via the optic nerve to the brain--is referred to as the macula. The macula is of significant importance in that this area provides the highest resolution for the images we see. The macula is comprised of multiple layers of cells which process the initial "analog" light energy entering the eye into "digital" electro-chemical impulses." The site says that the ASR is made up of an array of "microphotodiodes".

    This page [centrovision.com] is a primer on photodiode technology.

    It states that "Silicon photodiodes are most useful as current generators although a voltage is also generated by illumination. Most of the data supplied in this manual refers to the short circuit current characteristics of the photodiodes. The short circuit current is a linear function of the irradiance over a very wide range of at least seven orders of magnitude. The Isc is only slightly affected by temperature, varying less than 0.2% per degree C for visible wavelengths. A recently published independent laboratory study has shown Thermo Centro Vision photodiodes to have Isc stability better than +/-0.25% per year."

    In other words - I was right. Yay!

  • You could superimpose images of really hot nude women on anyone you're talking to!

  • I see. So, as it is, it interfaces directly with the optical nerve. That doesn't nessecarily mean you have to keep it that way. You could have an intermediate computer that received the charges from the photosensors and processed and passed the info to the optical nerve.
  • Oooo! Night vision IR!

    This page [centrovision.com] (a primer on photodiodes) has a chart of Photodiode Responsivity. You start to get reasonable response out of them around 600nm, which is actually before the infrared range, which begins at 750nm [dictionary.com]. Interestingly enough, this page also have a chart which compares their Series E photodiode to that of the Human Eye [centrovision.com].

    In any case, you could almost certainly tune one of these suckers to let you see into the IR range. I'm not sure you'd want to, if you had ever had normal eyesight, but it is an interesting idea. Certainly if you could embed them as seperate entities, AND turn them on and off, then you could selectively see into the infrared range in a selective manner without seriously compromising your natural vision.

  • When prosthetic eyes are better than the standard eye, people will be ripping out their good eyes to get 'enhanced' eyes.

    This would also lead to the manufacturer putting non-ignorable advertisements in your vision!

    Imagine the type of virtual billboards you could have!

  • Oliver Sacks wrote about a man whose sight was restored but who was left nothing but confused. It wasn't the experience you'd expect. It wasn't even a net positive for him, as it destroyed his adaptive behavior and gave him nothing to replace it with.
    --
  • Did the book say anything about the age when someone would start playing to become a world class guitarist?

    The book is packed away in a box somewhere, but I don't recall anything specific to guitarists. The book is mostly about sports where there is a fair amount of empirical evidence (by looking at current and historical players and when they began). Violinists have fairly formalized training, so he had some knowledge to draw from there. I don't know if anyone has studied guitarists.


    --

  • Of course, the optobionics device will be out of focus since the eye focusses light on the retina and not on the silicon chip.

    Why wouldn't it focus on the array? I know nothing about occular biology but I believe that the eye's focus system is a closed-loop system. i.e. you know what you want to focus on and control the lens such that what you desire to see is in focus. How else could you look at your hands and then at the wall and focus on both if the lens was a fixed-focus "device"?

  • thats good to hear , as I have hope that if the retinitis pigmentosa I have every starts to degrade my vision I can look forward to this technology

    So my guess would be that you're preaching to the converted :).

    I hope this works out...having RP must really suck. Well, I thought needing glasses sucked, but I guess I should count my blessings.

  • There's a crucial period in which the brain must be exposed to light and visual stimuli. As it gets exposed, neural pathways are trained to pave the way for visual attention and visual capability in general. The crucial period, IIRC, is the first several weeks to months after the child is born. Children who are unable to see during that period for whatever reason never seem to be able to, even if there is no damage to their optical "stuff" (to use the technical term).
    --
  • by the eric conspiracy ( 20178 ) on Wednesday October 25, 2000 @04:18PM (#675710)
    Unfortunately this posting describes retenitis pigmentosa, a relatively rare from of blindness. By far the most common is macular degeneration which occurs mostly in those 55 and older. The numbers of people affected by this disease are staggering; one in six in this age range experience the affects. The fact that this technology may be useful in cases of AMD is exciting news indeed - it has been estimated that as many as 10 million 'boomers' may go blind due to AMD.

  • by Plasmic ( 26063 ) on Wednesday October 25, 2000 @04:40PM (#675711)
    I'm curious about something and I think the follow-up discussion will be interesting:

    How do people that have been blind their entire life visualize things?

    I don't mean to imply that they can't visualize, only that I'm wondering about the extent of their ability to create mental images and how they differ from my own (FYI, I am not blind). That is, it seems as thought they could feel an object and create some sort of wireframe-like thing in their head. Maybe a more appropriate question would have been directed at what they visualize. Most my visualization consist of a combination of things I've perceived with my eyes, not to mention issues associated with color.

    Well, there's my potentially ignorant question that's probably only answerable by either blind people or someone who has close contact with them.

    Educate us.
  • While true, it unfortunately is not good enough to map an entire sense from scratch after a certain age. Sight, and all the coordination that goes with it, is just way too complex to learn after a certain point. Think about it- when people talk about the brains amazing ability to remap new sense, we're usually talking about very simple things like motor switches- on/off- open closed. And even the brain's ability to adapt to serve these new functions is still limited- its never good as new. Sight, however, is immensely complex- it requires the coordination of millions of neurons and effects countless different parts of the brain. The person Oliver Sacks tested on wasn't even a good example- because he WENT blind early in his life- he at least had early experiences to start forming the pathways. And he couldn't make it.
  • by JabberWokky ( 19442 ) <slashdot.com@timewarp.org> on Wednesday October 25, 2000 @05:16PM (#675713) Homepage Journal
    I can see at 1600x1200 what about you?

    Actaully, you can only see at something less than 200x200, with horribly lossy images. Your brain interpolates everything you see. Interesting factoid: your optic nerve carries more information to the retina than it carries to the brain.

    When you get into real neurology 101, things get really interesting (even if you're auditing for amusement as an armchair scientist).

    Has anybody else noticed morie effects in real life? There is a stretch of I-95 in Palm Beach Country, as you pass over Lake Worth Road... heading north, you can see the side of the water treatment plant. The side has close horizontal slats, all painted an off-white color. As you drive towards it on a bright day, it comes alive with "dancing bugs", similar to two morie patterns overlaid and rotating. The distance at which this occurs is different for different individuals. Some people can't see it, but that may be because they didn't know what to look for.

    --
    Evan

  • I've been blind in one eye (left) since birth. My sight in the other one is okay, but as you can imagine my depth-perception is not what most people are used to. I've adapted quite well i think, and can estimate distance pretty well...but what really attracts me is the possiblity of having a more powerful eye implanted where my left one is doing nothing now.

    Maybe i can get one so i can see infrared!

    i'd want to be able to turn that off occasionally tho....

    hey, something is better than nothing!

  • How is it controllable??
  • Okay, this subject touches a nerve with me, because my best friend has RP. She's only 20 now, and is almost totally blind. She is also the nicest person I know.
    "People need to take genetic self responsibiility by not injecting their defective DNA into the genepool!"
    Well...sorry....but sometimes, a disability makes for a better person. I, personally, wouldn't mind if the whole world were infected with her DNA. Sure, we might not be able to see, but it would be a hell of a lot better place than it is now!
    She's in a regular college right now, taking regular classes. She doesn't want to be treated different than anyone else. She works much harder than a normal person to do the same things. I, for one, hope she has lots of kids just like her--even if they have RP, like i said, the world will be just a bit better.
    Moral of the story: usually people with something that doesn't make them 'normal' perform better personally, sociably, and at work. Most assholes are just 'normal' people.
  • > Well...sorry....but sometimes, a disability
    > makes for a better person.

    You wont get any argument here. A very good friend of mine has a genetic disorder - I forget the name but his body muscle mass is severely decreased.

    Nicest guy I ever met. Very intelligent.

    However - I do think that it is wise for people with such disorders to not breed. I don't mean to say that a person who has had offspring is bad for having done it - its a personal choice, but -you get good people without genetic diseases too.

    Personally, I have reservations about breeding myself (my father and I were both born epileptic - its treatable and mine went away around age 15 - but his never did). I don't know that I would feel comfortable having a child, knowing that there is a pretty good chance that they would have to live with that (even if it goes away - it means an entire childhood on drugs like dilantin and tegretol)

    If other people can do it thats fine with me. I just don't feel right about forcing a person into a life like that.

    Of course - I would unilatterally encourage everyone to stop breeding anyway. Theres plenty of humans now. We can cut back on production now.

    -Steve
    -Steve
  • It works pretty good, but it gave me a horrible case of red-eye [primenet.com].

    --Joe
    --
    Program Intellivision! [schells.com]
  • And this story is different from what we heard in July [slashdot.org] how? Oh, except for 5 months passing an no substantive update as to how the people with these devices have turned out.
  • Boo fucking hoo. Another grammer and spelling Nazi on Slashdot, what a surprise.
  • If it's so, I want to move to Silicone Valley NOW ! :)

    --
  • Nah ... You'll be better with IDEYES ! [segfault.org]

    --
  • Marginally off-topic, but losing your sight through cataracts makes you worry about retinal detachment. I should know, I have two such implants.

    Anyway, did you know Harold Ridley came up with the idea for implantable lenses after pulling bits of cockpit plastic from the eyes of Royal Air Force Spitfire pilots, and noticing that the plastic didn't irritate?

  • by Anonymous Coward
    I haven't seen this effect myself

    But the eye is as prone to aliasing artifacts as any other point sampling device. The only reason you dont see massive jaggies on everything is that the distribution of receptor cells is something approximating a poisson disk distribution, rather than a regular grid.

    It just does the standard graphics trick of hiding aliasing behind "noise".
  • Oh yeah, definitely. Infrared vision, zoom, freeze frame, split screen (well, not exactly screen) ... and other nifty features would be schweet. Ohh, and a linkup to a storage device so you can record what you see or take still snapshots.

    Sadly I can't see this kind of technology coming along in any of our lifetimes :(

  • Optical display is preferred. Visual cortex stimulation is very complicated and will probably
    not be good enough for text-information transfer.
    Early tests on cats showed that a computing intensive system could read neuro-signals
    and interprete them into a blurry picture.
    The brain can handle a blurry picture and figure out what it's supposed to look like.
    But what do you do if you have blurry text?
    Information gets lost...

    I'm like "good RAM, bad CPU"
  • This gives me some hope. Maybe within a few years they'll have something I cann attach to my brain so that I can tell the fucking difference between green and yellow.
  • Retinal replacement or transplantation does not address one big issue: the visual pathways in the brain. Contrary to some people's beliefs you are not born with the ability to see, you learn to see and differentiate between objects and surfaces through EXPERIENCE. The brain essentially has a Darwinian approach to sight where connections that are active are retained and those that are inactive degenerate. People blind since birth haven't gone through this process and so there visual cortex is mainly a random mess (there would be some organization to help them visualize spaces and surfaces). If you suddenly give these people sight it would be like walking around with keliedoscope glasses on at the circus - a confusing mess. Indeed patients who had a monochromatic form of color-blindness that was repairable surgically found that the colours would simply float in space and not be contained within the objects to which they belong! Note that many of the patients requested that the process be REVERSED. Just remember that retinal transplants are not a panacea.

    -ShieldWolf
  • Not every genetic aberration is apparent before a someone injects their defective DNA into the genepool. Who are you to judge their "defects"? Some people might question how defective your DNA is.
  • by Anonymous Coward
    There is an artist from Venezuela (Jesus Soto) who speicalizes in sculptures and paintings based on these and other similar optical effects. Most of his art has lots of lines and wires running around. It's interesting, a black square a feet wide, placed a few inches in front of a wall with narrow vertical black stripes. When you move towards or across, the square seems to vibrate. There are all sorts of moire patterns, color mixings and so on.

    If you are ever in Ciudad Bolivar, Venezuela, stop by the museum that bears his name.
  • Salon had an article a while back about the deaf community's ambivalence toward cochlear implants. Basically the argument was whether implants would give kids who were deaf a sort of half-real entry into the hearing world -- and whether the community, or culture, of deaf people would be damaged as a result. Supposedly, hearing parents who got cochlear implants for their deaf kids were "stealing" their kids from the deaf culture, which would lose a whole generation of kids as a result. And no, some deaf people don't care to be thought of as "defective" so that hearing people can "fix" them. It was a really surprising article, or it was for me anyway...

    So what's the analogous dispute here? Rallies of deaf folks complaining that blind kids shouldn't be given the specious "gift" of sight? People protesting that braille shouldn't die as a language? From the perspective of someone who isn't deaf or blind, it's hard to imagine...

  • "Now even blind people can get a feast of Pamela Anderson's amazing breastesses with our latest Silicone Eye Implants - a pair of fake boobs in each eye!"

    (sorry I just had to =)
  • by haaz ( 3346 ) on Thursday October 26, 2000 @06:20AM (#675733) Homepage
    Could this help people with detached retinas?

    Back in March, April, and May, I had sugery to reattach my retina after I got hit by that drunk driver. (I had surgery two or three times to do that!) What I'm wondering is, if it gets really bad, and they can't do anything for the retina, will one of these help? And would it help me ride a motorcylce again? ;-)

    -- jason, who's so looking forward to riding again.

    Haaz: Co-founder, LinuxPPC Inc., making Linux for PowerPC since 1996.
  • Good questions. This really comes down to an issue of epistemology (the philosophy of knowledge, or how it is that we can know things).

    A quick answer is that blind people can visualize some things that exist in the world. For example, they could visualize what a cube looks like if they have touched it and felt the edges. Blind people can visualize reality because they exist in it and participate in it. For example, they can (and must) be able to visualize the layout of their houses because they will be walking around in them.

    What they can not do is visualize the less empirical things, for example the color blue. "Blue" is defined to be the range of colors whose wavelengths are slightly above the ultraviolet spectrum. If you tell a blind person that a cube is blue, they will catch the cube part but not understand what you *really* mean by blue because they have never experienced blue. A blind scientist would know that electromagnetic radiation with a certain wavelength is considered to be "blue", but wouldn't really know what blue is because it is something that really isn't understood until it is seen. When I visualize blue, I get a little bit of red, a little bit of green, and alot of blue. For a blind person who has never seen blue, they get a schematic of wavelengths.

    It would be interesting if we had the ability to give someone who was blind from birth the ability to see. How they perceive reality would change dramatically! They would have to learn to associate the words we have given to colors as well as quite a few other things.

  • by hawkfish ( 8978 ) on Thursday October 26, 2000 @06:59AM (#675735) Homepage
    Good question. One of Oliver Sacks' books has an essay on this. _An Anthropologist on Mars_ maybe?

    The simple answer is that they can't. The first experiments to restore sight in the late 1700s with cataract replacement surgery were a failure because there is a small window of opportunity in the development of the visual cortex. Even people who are not born blind but have been blind a long time have a lot of trouble becoming visual again and many don't succeed. Blind people seem to have significantly different models of the world (e.g. they generally conceptualize distance in terms of time, not spacial referents) and changing back is often more than most can manage.

    By the same token, people who are sighted often have a lot of trouble adapting to being blind because they are not wired correctly either.

  • by Bozinbali ( 89017 ) on Thursday October 26, 2000 @07:15AM (#675736) Homepage
    I've been legally blind since birth, and just had corrective surgery to "fix" my vision. IMO, the problems one will encounter doing this kind of procedure are not medical in nature, they're psychological. Before my surgery, my uncorrected vision was 20/200 in my right eye, and 20/1000 in my left. With correction, I could get down to 20/80 in my right eye and 20/200 in my left; a marked improvement. With special adaptation, I was even able to get my right eye to 20/30 at distance so that I could get and maintain an unrestricted driver's license. I still walked with the aid of a white cane due to my lack of depth perception (since the vision in my eyes was so unbalanced) and peripheral vision. All in all, I was a pretty well adapted, employed, and productive person. The problems I encountered were primarily social. I found that the sighted public in general wants very little to do with anyone who is obviously disabled. Even if someone would initiate a conversation in a social setting, the only thing they'd want to discuss is my vision. Now, maybe I'm at fault here, but after 25 years of talking about my vision with every Tom, Dick, and Harry; I just didn't want to do it any more. So I talked to an opthomologist and scheduled lens implant surgery to try and correct my vision. Although the surgery was deemed a success in medical terms, my useful vision is substantially less than before. The difficulty that I encountered wasn't medical. The medical procedure was perfect. The problem I'm encountering has to do with my perception of the images I see. Having worn thick glasses my entire life, my brain was used to a greatly magnified image of the world. After surgery, that image was no longer magnified at all, and everything seems small and distant. As a result, I'm not able to pick out much detail in the images that I see, which effects my useful vision. Some of the side effects are quite disturbing. For instance, I can no longer read a magazine, or street signs. This has severely impeded my independence as I have a great deal of difficulty even driving myself to work. These types of problems appear to be common in people who had significant vision impairments for most of their lives. The exact same surgery I had has been performed on countless people who had normal vision for most of their lives, but who developed cataracts later in life with no ill effects whatsoever. In fact, most people return to 20/20 vision or better within days. I had the surgery nearly a month ago, and even with glasses I can not see as well as I did before. This type of medical advance is great, and medically it's a quantum leap in the field. The problem is that there is no rehabilitation available to people in situations similar to mine. There must be a way to teach the brain how to deal with "normal" vision when it isn't used to coping with it. This same phenonenon is what causes the "confusion" in people who have been given sight after being blind for most of their lives. A great physical improvement does not always result in a higher quality of life. It certainly hasn't in my case, and I don't believe it will in others who weren't sighted before the procedure.
  • The end of the article mentions that the researchers are thinking about implanting a chip in the tissue of the visual cortex. Imagine, a Geordi LaForge-like sensor/visor prosthesis that can be removed, upgraded, customized, etc., because it sends its information to implanted receivers that are hard-wired to the brain. This would bypass the nerves that connect the retina to the visual cortex, possibly opening up this technology for use with a much wider range of degenerative diseases. As long as the visual cortex is intact, the technology could be applied.

    Or, for the more paranoid among you, it could also be something The Man would implant into navy SEALs and Mossad agents... sure, they look like normal humans, but when they put on their special visors, they get UV, IR, RF vision, and with the built-in wireless WAN, what Sgt. Smith sees, everybody in the unit (and back at the base) sees in a little popup window.
  • Val was a lucky SOB to see Mira Sorvino nude in that movie. Lucky bastard. That's what I want to see if I ever got blind and make a recovery.....P.
  • My father used to be part-owner of a company that manufactured telecommunications devices for the deaf (TDD), so I got a first-hand look at the dynamics of the 'deaf community'. Lessons that I believe would carry over into the 'blind community'. Many of the people who suffer a profound disability define their very identity by this fact. I was astounded to find that, when one company announced a device that may have allowed many if not most deaf people some degree of hearing, some in the community began to say that it would be a mistake to use it! They were concerned that the community would be eroded if large numbers of the afflicted were to be able to hear sound again. I was absolutely flabbergasted that anyone would want to perpetuate their deafness, yet there it was.

    I think this carries a larger message: large-scale change - even for the better - is terrifying to people and to those who wield authority or power under the old regime. Even though it seems farfetched, I would not be at all surprised to find out that the blind will be exhorted to remain so by some of their leaders and self-appointed advocates. All in the name of group identity.

  • Using tables for formatting pages rarely causes them to be unreadable via speech readers. The speech reader just ignores the tables and reads the content in the order that it is in the HTML. There's no reason that the use of tables on that page should cause readability issues.

    The main problem with tables is when they're used to group content in a manner where the context is important and for tabular data. Speech readers will generally just read the info as listed in the HTML and if the order comes out wrong it will be confusing. This is not the case on this article because the order comes out just fine if you ignore the table.
  • Ever go to a hardware store and proclaim loudly that you really need black caulk? Its hilarious... Then we go to the compressor supplies department, and insist on buying a pair of 3/4" nipples. We nearly got kicked out of the store...

    The sad thing is that we actually needed these things.
  • It is highly unlikely that prosthetic eyes will ever be better than real eyes. I'm in grad school for visual neurophysiology, and when you start to learn what the visual system can actually do, you realize there is no man-made device that even comes close. Photoreceptor cells can reliably detect the presence of one photon, and an individual rhodopsin molecule falsely registers a photon approximately once per 500 years at physiological temperatures (I forget the numbers for a whole cell, but it's still on the order of hours, if not days). The eye has a dynamic range orders of magnitude greater than any electronic camera I'm aware of in addition to motor tracking that is very difficult to implement in hardware. The retina also has mechanisms to compensate for motion of rapidly moving objects, which would also be difficult to implement in hardware. But the real challenge would be implementing the feedback mechanisms that your brain uses to tell your eyes exactly where to look, to focus and filter differently, etc. Not to mention depth and motion perception by circuits that integrate things like feedback from head movement with changes in binocular disparity (how different what your two eyes see is), differential movement of objects across the visual field, etc. Even if you could make something small enough that would be optically better than an eye, it would still be lagging far behind the eye in real vision because of the problems of interfacing it with everything else already there. Prosthetic eyes better than natural ones are unlikely to exist in the lifetimes of our grandchildren.
  • Stimulation of visual cortex for a visual prosthesis for the blind is not a new idea. It was first done back in the 60's (I think) by Brindley and Lewin. There even used to be a neural prosthetics division working on stuff like that over at the NIH, but I guess the consensus was that there needed to be more animal testing done first. Stimulating primary visual cortex is going to be a lot trickier than the retina, though. First of all, it's huge--you would have to get a large portion of it in order to have any real sight, plus it's subdivided on a microscopic level into cells that get input from one eye, ones that get input from both, ones that see certain colors, ones that are tuned for orientation of a contrast boundary, ones tuned for temporal and spatial frequencies, ones for spatial phase, etc. etc. etc. It's not as easy as the retina, where the optics make things a lot more obvious. I'm guessing that within our lifetime there will be prostheses for primary visual cortex that will allow people to see the same way cochlear implants allows people to hear; that is, well enough to function, but not as well as a normal person.
  • Flamebait? It was HUMOR, asshole.
  • It really isn't. Tiny blood vessels begin growing in the back of the eye, in front of the retina. They are not terribly strong, and, aside from obscuring vision (they're in *front* of the retina now), tend to break off and float around in the eye. Eventually, the 'floaters' obscure vision entirely in the affected eye. Laser treatment can destroy some of these new growths, which can delay blindness.

    The *other* mainfestation of retinopathy in diabetics, where the existing blood vessels break open and leak blood into the vitreous humour, is also treatable with laser surgery.

    Laser surgery in both cases is little more than triage, preventing blindness temporarily. Both conditions can be temporarily reversed through a surgical process called vitrectomy, where the vitreous humour is extracted and replaced with clear fluid (saline? I can't remember...). The root cause of the blindness is *not* corrected by vitrectomy, however.

    The DCCT (diabetes complications and control test) showed that a pattern of low glycosylated hemoglobin (sp?) results (in th 5.5-6.5 range) can delay complications for a significant period of time. But in the end, if the other complications of diabetes don't kill the diabetic first, blindness will probably come a' knockin'.

  • wasnt it selfish of your mom not to have one but 2 kids with this genetic disease?

    Well, no. I'm glad to be here. So is my brother. With this disease, you get more quackery than anything. Everytime I see an opthamoligist, they ALWAYS want a photo of my retina, they ALWAYS want to look in there. It's so exciting for them to see a case of it. One guy sugested that I wear some kind of device to shrink the field of vision in front of me, then look around it when I want to see somthing.

    I think you asume that all people have a good understanding of genetics, while you do not. Before my mom there is no family history of it. None. I've talked to leading reasearchers in retinal degeneration about the genitics of it. It's kind of bafeling of why I got it. The disease looks to be X linked recessive. If that is the case, none of my children would be effected with it. Any daughters I that may have would be a carrier. Any sons that I may have would be un-effected. In that case my mom should not be effected. If it is just recesive, then my mom's first husband (my brother's father) and my dad would have to both have the recesive trait. The odds of that with this disease are nill.

    I think that the RP has helped me in some ways. There is no way for me to play sports effectivly. I was already intrested in science, and for about a decade, computers. I've probibly devoted more time to computers than I would have. I'd say that it is time well spent, I think that it's fun. I also had some learning disabilities when I was younger, should I not put my children through that? I have an above average inteligence level, and just had trouble learning that I learned to cope with. It becomes a matter of learning to cope. For RP, that means that I look around a lot, rely less on sight to navigate than most people do, and trying to avoid dark situations. I don't think that saying "don't breed" is a good thing. Isn't that what the Nazi's goal was? A master race with no genetic flaws. It'll never work.

    I am glad to be here, losing site or not so don't call my mom selfish because I have trouble seeing.

    --Josh
  • According to Jim Knipfel, an excellent writer and author of "Slackjaw" a book about his own case of "Classic RP," most blind people can see to an extent, just not enough to get around. The only people who are truly blind (according to Knipfel) are those whose eyes are completely destroyed (for example, in an industrial accident). The vast majority of blind people are not "in the dark" as I always imagined things would look with my eyes closed. Also, RP primarily affects the cones of the eyes, the larger cells responsible for peripheral and night vision. I'd like to know how close they are to reproducing the much smaller rods, required for central vision and reading. Read Slackjaw. It's a great book.
  • it has been estimated that as many as 10 million 'boomers' may go blind due to AMD.

    So how many will go blind due to Intel?

Byte your tongue.

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