pigrabbitbear writes "The active ingredient in OxyContin, oxycodone, isn't a new compound. It was originally synthesized in Germany in 1916. The patent on the medication had expired well before Purdue Pharma, a Stamford, Connecticut-based pharmaceutical company and the industry leader in pain medication, released it under the brand name in 1996. The genius of Purdue's continued foray into pain-management medication – they had already produced versions of hydromorphone, oxycodone, fentanyl, codeine, and hydrocodone – was twofold. They not only created a drug from an already readily available compound, but they were able to essentially re-patent the active ingredient by introducing a time-release element. Prior to the 1990s, strong opioid medications were not routinely given for miscellaneous or chronic, moderately painful conditions; the strongest classes of drugs were often reserved for the dying. But Purdue parlayed their time-release system not only into the patent for OxyContin. They also went on a PR blitz, claiming their drug was unique because of the time-release element and implied that it was so difficult to abuse that the risk of addiction was 'under 1%.'"

bdking writes "A recent study by a Louisiana State University psychology professor adds more evidence to the argument that the human brain is incapable of performing numerous tasks without memory and productivity loss. 'In four separate experiments, both local second-graders and LSU psychology students were shown words on a computer screen and instructed to remember them in the correct sequence. As the participants read the words, they also sometimes heard unrelated words in the headphones all were wearing. Adults in the LSU study showed a word recall performance drop of 10% on average, while the second-graders’ performance diminished by up to 30% on average.'"

An anonymous reader writes "An achievement that would have extraordinary energy and defense implications might be near at Sandia National Laboratories. The lab is testing a concept called MagLIF (Magnetized Liner Inertial Fusion), which uses magnetic fields and laser pre-heating in the quest for energetic fusion. A paper by Sandia researchers that was accepted for publication states that the Z-pinch driven MagLIF fusion could reach 'high-gain' fusion conditions, where the fusion energy released greatly exceeds (by more than 1,000 times) the energy supplied to the fuel."

ananyo writes "Climate scientist Michael Mann reported Monday that he and the University of Virginia in Charlottesville have prevailed in a court case against the conservative American Tradition Institute (ATI), which had sought access to emails he wrote while serving as a professor at the school from 1999-2005. Now at the Pennsylvania State University, University Park, Mann says the ruling supports the University of Virginia's argument than an exemption to the state's freedom-of-information law 'applies to faculty communications in furtherance of their work.' The Prince William County Circuit Court ruling came directly from the bench in and was not immediately available online. The Virgina Supreme Court tossed out a case against Mann in March. The state's conservative attorney general, Ken Cuccinelli, had, among other things, demanded access to the climatologist's emails, arguing that Mann might have manipulated data and thus defrauded the government in applying for scientific grants."

An anonymous reader writes "Nature has advance word on the first science results from GRAIL, NASA's twin probes launched a year ago which are mapping the gravity of the Moon from lunar orbit. This is coming out in advance of any official publication or NASA release, so the data isn't available, but the story trails what the PI Maria Zuber told a Harvard CFA colloquium last week are some of the team's key scientific findings: including that the Moon's crust is substantially thinner than once thought; and some of the more speculative impact basins haven't been confirmed."

`puddingebola writes "A report in the journal Nature Neuroscience (paywalled) says scientists have observed epigenetic markers in bees that correspond to their roles in the society. From the article, 'Honeybees are born into their place in society. Those fed royal jelly as larvae emerge as queens and do little but lay eggs. The rest become worker bees and divvy up the jobs that need doing around the hive. While some worker bees remain at home, others take flight in search of nectar, pollen and other hive essentials. The entire honeybee workforce are genetically identical sisters. But analysis of the worker bees' DNA revealed that foragers had one pattern of chemical tags on their genes, while those that stayed home had another. When bees swapped one job for the other, their genetic tags changed accordingly.'"

runner_one writes "Harold 'Sonny' White of NASA's Johnson Space Center said Friday (Sept. 14) at the 100 Year Starship Symposium that warp drive might be easier to achieve than earlier thought. The first concept for a real-life warp drive was suggested in 1994 by Mexican physicist Miguel Alcubierre, however subsequent calculations found that such a device would require prohibitive amounts of energy, studies estimated the warp drive would require a minimum amount of energy about equal to the mass-energy of the planet Jupiter. But recent calculations showed that if the shape of the ring encircling the spacecraft was adjusted into more of a rounded donut, as opposed to a flat ring the warp drive could be powered by the energy of a mass as small as 500 kg. Furthermore, if the intensity of the space warps can be oscillated over time, the energy required is reduced even more."

Amiga Trombone writes "Christopher Stringer is one of the world's foremost paleoanthropologists. He is a founder and most powerful advocate of the leading theory concerning our evolution: Recent African Origin or 'Out of Africa.' He now calls the theory into question: 'I'm thinking a lot about species concepts as applied to humans, about the "Out of Africa" model, and also looking back into Africa itself. I think the idea that modern humans originated in Africa is still a sound concept. Behaviorally and physically, we began our story there, but I've come around to thinking that it wasn't a simple origin. Twenty years ago, I would have argued that our species evolved in one place, maybe in East Africa or South Africa. There was a period of time in just one place where a small population of humans became modern, physically and behaviourally. Isolated and perhaps stressed by climate change, this drove a rapid and punctuational origin for our species. Now I don't think it was that simple, either within or outside of Africa.'"

First time accepted submitter nerdyalien writes "In the academic world, it's publish or perish; getting papers accepted by the right journals can make or break a researcher's career. But beyond a cushy tenured position, it's difficult to measure success. In 2005, physicist Jorge Hurst suggested the h-index, a quantitative way to measure the success of scientists via their publication record. This score takes into account both the number and the quality of papers a researcher has published, with quality measured as the number of times each paper has been cited in peer-reviewed journals. H-indices are commonly considered in tenure decisions, making this measure an important one, especially for scientists early in their career. However, this index only measures the success a researcher achieved so far; it doesn't predict their future career trajectory. Some scientists stall out after a few big papers; others become breakthrough stars after a slow start. So how we estimate what a scientist's career will look like several years down the road? A recent article in Nature suggests that we can predict scientific success, but that we need to take into account several attributes of the researcher (such as the breadth of their research)."

cylonlover writes "In mankind's attempts to gain some understanding of this marvelous place in which we live, we have slowly come to accept some principles to help guide our search. One such principle is that the Universe, on a large enough scale, is homogeneous, meaning that one part looks pretty much like another. Recent studies by a group of Australian researchers have established that, on sizes greater than about 250 million light years (Mly), the Universe is indeed statistically homogeneous, thereby reinforcing this cosmological principle."

SchrodingerZ writes "Though solar eclipses are fairly common on Earth (much more in the southern hemisphere), yesterday the Mars Curiosity Rover caught sight of a partial solar eclipse in Gale Crater on the Red planet. The martian moon Phobos took a small bite out of the sun on the 37th day (Sol 37) of the rover's martian mission. The Curiosity Rover was able to take a picture of the rare event through a 'neutral density filter that reduced the sunlight to a thousandth of its natural intensity.' This protects the camera from the intense light rays seen during an eclipse or looking directly at the sun. It is possible a short movie of the event could be compiled from the data in the near future. More solar transits of Mars's moon (including the second moon Deimos) are predicted to happen in the days to come."

Hugh Pickens writes "Oil-field service companies lower radioactive units into wells to let workers identify places to break apart rock for a drilling process known as hydraulic fracturing, or fracking, which frees oil and natural gas. Now Bloomberg reports that Halliburton workers have discovered that a lock on the container used to transport one such device has gone missing, along with the unit, after employees drove a truck from a site near Peco to a well south of Odessa and while the loss of radioactive rods occurs from time to time, it has been years since a device with americium-241/beryllium, the material in Halliburton's device, was misplaced in Texas. NRC spokeswoman Maureen Conley says the material would have to be in someone's physical possession for several hours for it to be considered harmful as teams comb the route between the two wellsites searching for the seven-inch tube, which is clearly marked with the words 'DANGER RADIOACTIVE' as well as a radiation warning symbol, "Halliburton strongly cautions members of the public that if they locate this source, they should not touch or handle it, stay a minimum of 25 feet away," and contact local law enforcement or the company's emergency hotline if they find the cylinder, says the company which is also offering a reward for information about the tube's whereabouts."

MarkWhittington writes "A recent story in The Atlantic reminds us that the Apollo program, so fondly remembered in the 21st Century, was opposed by a great many people while it was ongoing, on the theory that the money spent going to the moon would have been better spent on poverty programs. The problem with this view was that spending for Lyndon Johnson's Great Society dwarfed the Apollo program, that the programs in the Great Society largely failed to address poverty and other social ills, and that the Apollo program actually had a stimulative effect on the economy that fostered economic growth and created jobs by driving the development of technology,"

Endeavour will be the second of NASA's space shuttles to leave the Kennedy Space Center. The ship will piggyback on top of a specially modified 747 and head to a Los Angeles museum this week. From the article: "Endeavour's lifespan was relatively short by shuttle standards - 25 missions over 20 years, totaling 299 days in space. But those flights ran the gamut of orbital odysseys, including the sheer moxie of its May 1992 debut when three astronauts made an impromptu and unprecedented spacewalk to rescue a stranded Intelsat communications satellite."

DevotedSkeptic writes in with a story about the lack of usable microwave technology to come from 50 years of military research. "For some Pentagon officials, the demonstration in October 2007 must have seemed like a dream come true — an opportunity to blast reporters with a beam of energy that causes searing pain. The event in Quantico, Virginia, was to be a rare public showing for the US Air Force's Active Denial System: a prototype non-lethal crowd-control weapon that emits a beam of microwaves at 95 gigahertz. Radiation at that frequency penetrates less than half a millimetre into the skin, so the beam was supposed to deliver an intense burning sensation to anyone in its path, forcing them to move away, but without, in theory, causing permanent damage. However, the day of the test was cold and rainy. The water droplets in the air did what moisture always does: they absorbed the microwaves. And when some of the reporters volunteered to expose themselves to the attenuated beam, they found that on such a raw day, the warmth was very pleasant. The story is much the same in other areas of HPM weapons development, which began as an East–West technology race nearly 50 years ago. In the United States, where spending on electromagnetic weapons is down from cold-war levels, but remains at some US$47 million per year, progress is elusive. 'There's lots of smoke and mirrors,' says Peter Zimmerman, an emeritus nuclear physicist at King's College London and former chief scientist of the US Arms Control and Disarmament Agency in Washington DC. Although future research may yield scientific progress, he adds, 'I cannot see they will build a useful, deployable weapon.'"

littlesparkvt writes "A budget forecast that was released on Friday shows that the defense department isn't the only department getting hammered: NASA is as well, if the automatic budget cuts happen. According to Nature magazine, NASA will lose '$417 million from its science budget, $346 for space operations, $309 for exploration, $246 for cross agency support, among other cuts.'"

Techmeology writes "A team from IBM in Zurich has published images of molecules that are detailed enough to show the lengths of atomic bonds. 'The IBM team's innovation to create the first single molecule picture, of a molecule called pentacene, was to use the tip to pick up a single, small molecule made up of a carbon and an oxygen atom. This carbon monoxide molecule effectively acts as a record needle, probing with unprecedented accuracy the very surfaces of atoms. It is difficult to overstate what precision measurements these are. The experiments must be isolated from any kind of vibration coming from within the laboratory or even its surroundings. They are carried out at a scale so small that room temperature induces wigglings of the AFM's constituent molecules that would blur the images, so the apparatus is kept at a cool -268C.' This allows an analysis of imperfections in the molecular structure (abstract). The team plans to use the method to examine molecules of graphene."

An anonymous reader writes with news of research from MIT, where engineers have found a better way to use ultrasound waves to boost the permeability of skin for the delivery of drugs. "Ultrasound — sound waves with frequencies greater than the upper limit of human hearing — can increase skin permeability by lightly wearing away the top layer of the skin, an effect that is transient and pain-free. ... When ultrasound waves travel through a fluid, they create tiny bubbles that move chaotically. Once the bubbles reach a certain size, they become unstable and implode. Surrounding fluid rushes into the empty space, generating high-speed 'microjets' of fluid that create microscopic abrasions on the skin. In this case, the fluid could be water or a liquid containing the drug to be delivered. In recent years, researchers working to enhance transdermal drug delivery have focused on low-frequency ultrasound, because the high-frequency waves don’t have enough energy to make the bubbles pop. However, those systems usually produce abrasions in scattered, random spots across the treated area. In the new study (abstract), the MIT team found that combining high and low frequencies offers better results. The high-frequency ultrasound waves generate additional bubbles, which are popped by the low-frequency waves."

DevotedSkeptic writes with this excerpt pulled from the San Francisco Chronicle:"A seemingly ordinary day at the Transbay Transit Center construction site became a mammoth day of discovery Monday when a mild-mannered crane operator reached deep into the earth and pulled out a tooth. This was no ordinary tooth. The 10-inch-long brown, black and beige chomper, broken in two and missing a chunk, once belonged to a woolly mammoth, an elephantine creature that roamed the grassy valley that's now San Francisco Bay 10 to 15 thousand years ago in the Pleistocene epoch."

An anonymous reader writes "Scientists have successfully restored and, in some cases, enhanced decision-making ability in brain-damaged monkeys on cocaine by connecting a prosthetic device to their brains. 'In the study, the scientists trained five monkeys to match multiple images on a computer screen until they were correct 70 to 75 percent of the time. First, an image appeared on the screen, which the animals were trained to select using a hand-controlled cursor. The screen then went blank for up to two minutes, followed by the reappearance of two to eight images, including the initial one, on the same screen. When the monkeys correctly chose the image they were shown first, the electronic prosthetic device recorded the pattern of neural pulses associated with their decision by employing a multi-input multi-output nonlinear (MIMO) mathematical model, developed by researchers at the University of Southern California. In the next phase of the study, a drug known to disrupt cognitive activity, cocaine, was administered to the animals to simulate brain injury. When the animals repeated the image-selection task, their decision-making ability decreased 13 percent from normal. However, during these "drug sessions," the MIMO prosthesis detected when the animals were likely to choose the wrong image and played back the previously recorded "correct" neural patterns for the task. According to the study findings, the MIMO device was exceedingly effective in restoring the cocaine-impaired decision-making ability to an improved level of 10 percent above normal, even when the drug was still present and active.'"