alternative_right shares a report from ScienceAlert: The colossal black hole lurking at the center of the Milky Way galaxy is spinning almost as fast as its maximum rotation rate. That's just one thing astrophysicists have discovered after developing and applying a new method to tease apart the secrets still hidden in supermassive black hole observations collected by the Event Horizon Telescope (EHT). The unprecedented global collaboration spent years working to give us the first direct images of the shadows of black holes, first with M87* in a galaxy 55 million light-years away, then with Sgr A*, the supermassive black hole at the heart of our own galaxy. [...]

Their results show, among other things, that Sgr A* is not only spinning at close to its maximum speed, but that its rotational axis is pointed in Earth's direction, and that the glow around it is generated by hot electrons. Perhaps the most interesting thing is that the magnetic field in the material around Sgr A* doesn't appear to be behaving in a way that's predicted by theory. M87*, they discovered, is also rotating rapidly, although not as fast as Sgr A*. However, it is rotating in the opposite direction to the material swirling in a disk around it -- possibly because of a past merger with another supermassive black hole. The findings have been detailed in three papers published in the journal Astronomy & Astrophysics. They can be found here, here, and here.

An anonymous reader quotes a report from the BBC: The Earth could be doomed to breach the symbolic 1.5C warming limit in as little as three years at current levels of carbon dioxide emissions. That's the stark warning from more than 60 of the world's leading climate scientists in the most up-to-date assessment of the state of global warming. [...] At the beginning of 2020, scientists estimated that humanity could only emit 500 billion more tonnes of carbon dioxide (CO2) -- the most important planet-warming gas -- for a 50% chance of keeping warming to 1.5C. But by the start of 2025 this so-called "carbon budget" had shrunk to 130 billion tonnes, according to the new study.

That reduction is largely due to continued record emissions of CO2 and other planet-warming greenhouse gases like methane, but also improvements in the scientific estimates. If global CO2 emissions stay at their current highs of about 40 billion tonnes a year, 130 billion tonnes gives the world roughly three years until that carbon budget is exhausted. This could commit the world to breaching the target set by the Paris agreement, the researchers say, though the planet would probably not pass 1.5C of human-caused warming until a few years later.

Last year was the first on record when global average air temperatures were more than 1.5C above those of the late 1800s. A single 12-month period isn't considered a breach of the Paris agreement, however, with the record heat of 2024 given an extra boost by natural weather patterns. But human-caused warming was by far the main reason for last year's high temperatures, reaching 1.36C above pre-industrial levels, the researchers estimate. This current rate of warming is about 0.27C per decade -- much faster than anything in the geological record. And if emissions stay high, the planet is on track to reach 1.5C of warming on that metric around the year 2030. After this point, long-term warming could, in theory, be brought back down by sucking large quantities of CO2 back out of the atmosphere. But the authors urge caution on relying on these ambitious technologies serving as a get-out-of-jail card. "For larger exceedance [of 1.5C], it becomes less likely that removals [of CO2] will perfectly reverse the warming caused by today's emissions," warned Joeri Rogelj, professor of climate science and policy at Imperial College London.

"Reductions in emissions over the next decade can critically change the rate of warming," he added. "Every fraction of warming that we can avoid will result in less harm and less suffering of particularly poor and vulnerable populations and less challenges for our societies to live the lives that we desire."

alternative_right shares a report from ScienceAlert: A team of biologists from Northeastern University and the University of Kentucky has found one of the key molecules involved in axolotl regeneration. It's a crucial component in ensuring the body grows back the right parts in the right spot: for instance, growing a hand, from the wrist. "The cells can interpret this cue to say, 'I'm at the elbow, and then I'm going to grow back the hand' or 'I'm at the shoulder... so I'm going to then enable those cells to grow back the entire limb'," biologist James Monaghan explains.

That molecule, retinoic acid, is arranged through the axolotl body in a gradient, signaling to regenerative cells how far down the limb has been severed. Closer to the shoulder, axolotls have higher levels of retinoic acid, and lower levels of the enzyme that breaks it down. This ratio changes the further the limb extends from the body. The team found this balance between retinoic acid and the enzyme that breaks it down plays a crucial role in 'programming' the cluster of regenerative cells that form at an injury site. When they added surplus retinoic acid to the hand of an axolotl in the process of regenerating, it grew an entire arm instead.

In theory, the human body has the right molecules and cells to do this too, but our cells respond to the signals very differently, instead forming collagen-based scars at injury sites. Next, Monaghan is keen to find out what's going on inside cells -- the axolotl's, and our own -- when those retinoic acid signals are received. The research is published in Nature Communications.

Longtime Slashdot reader fahrbot-bot shares a report from the Cool Down: A team of chemical engineers at the Massachusetts Institute of Technology has invented a new process to separate crude oil components, potentially bringing forward a replacement that can cut its harmful carbon pollution by 90%. The original technique, which uses heat to separate crude oil into gasoline, diesel, and heating oil, accounts for roughly 1% of all global energy consumption and 6% of dirty energy pollution from the carbon dioxide it releases.

"Instead of boiling mixtures to purify them, why not separate components based on shape and size?" said Zachary P. Smith, associate professor of chemical engineering at MIT and senior author of the study, as previously reported in Interesting Engineering. The team invented a polymer membrane that divides crude oil into its various uses like a sieve. The new process follows a similar strategy used by the water industry for desalination, which uses reverse osmosis membranes and has been around since the 1970s. [The membrane excelled in lab tests. It increased the toluene concentration by 20 times in a mixture with triisopropylbenzene. It also effectively separated real industrial oil samples containing naphtha, kerosene, and diesel.]

SpaceX's Starship exploded on its test stand in South Texas ahead of an engine test, marking the fourth loss of a Starship this year. "In three previous test flights, the vehicle came apart or detonated during its flight," notes the Washington Post. No injuries were reported but the incident highlights ongoing technical challenges as SpaceX races to prove Starship's readiness for deep-space travel. From the report: In a post on the social media site X, SpaceX said that the explosion on the test stand, which could be seen for miles, happened at about 11 p.m. Central time. For safety reasons, the company had cleared personnel from around the site, and "all personnel are safe and accounted for," it said. The company is "actively working to safe the test site and the immediate surrounding area in conjunction with local officials," the post continued. "There are no hazards to residents in surrounding communities, and we ask that individuals do not attempt to approach the area while safing operations continue."

Starship comprises two stages -- the Super Heavy booster, which has 33 engines, and the Starship spacecraft itself, which has six. Before Wednesday's explosion, the spacecraft was standing alone on the test stand, and not mounted on top of the booster, when it blew up. The engines are test-fired on the Starship before it's mounted on the booster. SpaceX had been hoping to launch within the coming weeks had the engine test been successful. [...] In a post on X, Musk said that preliminary data pointed to a pressure vessel that failed at the top of the rocket. You can watch a recording of the explosion on YouTube.

SpaceX called the incident a "rapid unscheduled disassembly," which caught the attention of Slashdot reader hambone142. In a story submitted to the Firehose, they commented: "I worked for a major computer company whose power supplies caught on fire. We were instructed to cease saying that and instead say the power supply underwent a 'thermal event.' Gotta love it."

ChatGPT-assisted writing dampened brain activity and recall in a controlled MIT study [PDF] of 54 college volunteers divided into AI-only, search-engine, and no-tool groups. Electroencephalography recorded during three essay-writing sessions found the AI group consistently showed the weakest neural connectivity across all measured frequency bands; the tool-free group showed the strongest, with search users in between.

In the first session 83% of ChatGPT users could not quote any line they had just written and none produced a correct quote. Only nine of the 18 claimed full authorship of their work, compared with 16 of 18 in the brain-only cohort. Neural coupling in the AI group declined further over repeated use. When these participants were later asked to write without assistance, frontal-parietal networks remained subdued and 78% again failed to recall a single sentence accurately.

The pattern reversed for students who first wrote unaided: introducing ChatGPT in a crossover session produced the highest connectivity sums in alpha, theta, beta and delta bands, indicating intense integration of AI suggestions with prior knowledge. The MIT authors warn that habitual reliance on large language models "accumulates cognitive debt," trading immediate fluency for weaker memory, reduced self-monitoring, and narrowed neural engagement.

Nature will automatically publish peer review reports and author responses alongside all newly submitted research papers starting this week. The flagship scientific journal previously offered transparent peer review as an optional service since 2020, while Nature Communications has required it since 2016.

All exchanges between authors and anonymous reviewers will become publicly accessible (reviewer identities remain confidential unless they choose disclosure). Nature aims to open what it calls the "black box" of science by revealing the months-long conversations that shape research papers before publication.

Honda has successfully conducted a surprise launch and landing test of its prototype reusable rocket as part of its plan to achieve suborbital spaceflight by 2029. Reuters reports: Honda R&D, the research arm of Japan's second-biggest carmaker, successfully landed its 6.3-meter (20.6-foot) experimental reusable launch vehicle after reaching an altitude of 271 meters (889 feet) at its test facility in northern Japan's space town Taiki, according to the company. While "no decisions have been made regarding commercialization of these rocket technologies, Honda will continue making progress in the fundamental research with a technology development goal of realizing technological capability to enable a suborbital launch by 2029," it said in a statement.

Honda in 2021 said it was studying space technologies such as reusable rockets, but it has not previously announced the details of the launch test. A suborbital launch may touch the verge of outer space but does not enter orbit. Studying launch vehicles "has the potential to contribute more to people's daily lives by launching satellites with its own rockets, that could lead to various services that are also compatible with other Honda business," the company added.

sciencehabit shares a report from Science.org: The newly discovered microbe provisionally known as Sukunaarchaeum isn't a virus. But like viruses, it seemingly has one purpose: to make more of itself. As far as scientists can tell from its genome -- the only evidence of its existence so far -- it's a parasite that provides nothing to the single-celled creature it calls home. Most of Sukunaarchaeum's mere 189 protein-coding genes are focused on replicating its own genome; it must steal everything else it needs from its host Citharistes regius, a dinoflagellate that lives in ocean waters all over the world. Adding to the mystery of the microbe, some of its sequences identify it as archaeon, a lineage of simple cellular organisms more closely related to complex organisms like us than to bacteria like Escherichia coli.

The discovery of Sukunaarchaeum's bizarrely viruslike way of living, reported last month in a bioRxiv preprint, "challenges the boundaries between cellular life and viruses," says Kate Adamala, a synthetic biologist at the University of Minnesota Twin Cities who was not involved in the work. "This organism might be a fascinating living fossil -- an evolutionary waypoint that managed to hang on." Adamala adds that if Sukunaarchaeum really does represent a microbe on its way to becoming a virus, it could teach scientists about how viruses evolved in the first place. "Most of the greatest transitions in evolution didn't leave a fossil record, making it very difficult to figure out what were the exact steps," she says. "We can poke at existing biochemistry to try to reconstitute the ancestral forms -- or sometimes we get a gift from nature, in the form of a surviving evolutionary intermediate."

What's already clear: Sukunaarchaeum is not alone. When team leader Takuro Nakayama, an evolutionary microbiologist at Tsukuba, and his colleagues sifted through publicly available DNA sequences extracted from seawater all over the world, they found many sequences similar to those of Sukunaarchaeum. "That's when we realized that we had not just found a single strange organism, but had uncovered the first complete genome of a large, previously unknown archaeal lineage," Nakayama says.

alternative_right shares a report from ScienceDaily: When the brain is under pressure, certain neural signals begin to move in sync -- much like a well-rehearsed orchestra. A new study from Johannes Gutenberg University Mainz (JGU) is the first to show how flexibly this neural synchrony adjusts to different situations and that this dynamic coordination is closely linked to cognitive abilities. "Specific signals in the midfrontal brain region are better synchronized in people with higher cognitive ability -- especially during demanding phases of reasoning," explained Professor Anna-Lena Schubert from JGU's Institute of Psychology, lead author of the study recently published in the Journal of Experimental Psychology: General.

The researchers focused on the midfrontal area of the brain and the measurable coordination of the so-called theta waves. These brainwaves oscillate between four and eight hertz and belong to the group of slower neural frequencies. "They tend to appear when the brain is particularly challenged such as during focused thinking or when we need to consciously control our behavior," said Schubert, who heads the Analysis and Modeling of Complex Data Lab at JGU. The 148 participants in the study, aged between 18 and 60, first completed tests assessing memory and intelligence before their brain activity was recorded using electroencephalography (EEG). [...]

As a result, individuals with higher cognitive abilities showed especially strong synchronization of theta waves during crucial moments, particularly when making decisions. Their brains were better at sustaining purposeful thought when it mattered most. "People with stronger midfrontal theta connectivity are often better at maintaining focus and tuning out distractions, be it that your phone buzzes while you're working or that you intend to read a book in a busy train station," explained Schubert. The findings have been published in the Journal of Experimental Psychology.

Researchers have built a breakthrough random number generator that solves a critical problem: for the first time, every step of creating random numbers can be independently verified and audited, with quantum physics guaranteeing the numbers were truly unpredictable.

Random numbers are essential for everything from online banking encryption to fair lottery drawings, but current systems have serious limitations. Computer-based generators follow predictable algorithms -- if someone discovers the starting conditions, they can predict all future outputs. Hardware generators that measure physical processes like electronic noise can't prove their randomness wasn't somehow predetermined or tampered with.

The new system, developed by teams at the University of Colorado Boulder and the National Institute of Standards and Technology, uses quantum entanglement -- Einstein's "spooky action at a distance" -- to guarantee unpredictability. The setup creates pairs of photons that share quantum properties, then sends them to measurement stations 110 meters apart. When researchers measure each photon's properties, quantum mechanics ensures the results are fundamentally random and cannot be influenced by any classical communication between the stations.

The team created a system called "Twine" that distributes the random number generation process across multiple independent parties, with each step recorded in tamper-proof digital ledgers called hash chains. This means no single organization controls the entire process, and anyone can verify that proper procedures were followed. During a 40-day demonstration, the system successfully generated random numbers in 7,434 of 7,454 attempts -- a 99.7% success rate. Each successful run produced 512 random bits with mathematical certainty of randomness bounded by an error rate of 2^-64, an extraordinarily high level of confidence.

Pharmaceutical giant Novo Nordisk forfeited patent protection for semaglutide -- the active ingredient in blockbuster diabetes and weight loss drugs Ozempic and Wegovy -- in Canada after failing to pay a $450 maintenance fee in 2019. The company had paid maintenance fees through 2018 but requested a refund for the 2017 fee, apparently seeking more time to decide whether to continue protecting the patent.

When the 2019 fee came due at $450 with late penalties, Novo never paid despite having a one-year grace period. Canadian patent authorities confirmed the patent "cannot be revived" once lapsed. The oversight is particularly costly given Canada represents the world's second-largest semaglutide market, worth billions annually. Generic drugmaker Sandoz plans to launch a competing version in early 2026, while Novo's U.S. patent protection extends until at least 2032.

Space may be the perfect place to study cancer — and someday even treat it," writes Space.com: On Earth, gravity slows the development of cancer because cells normally need to be attached to a surface in order to function and grow. But in space, cancer cell clusters can expand in all directions as bubbles, like budding yeast or grapes, said Shay Soker, chief science program officer at Wake Forest's Institute for Regenerative Medicine. Since bubbles grow larger and more quickly in space, researchers can more easily test substances clinging to the edge of the larger bubbles, too. Scientists at the University of Notre Dame are taking advantage of this quirk to develop an in-space cancer test that needs just a single drop of blood. The work builds on a series of bubble-formation experiments that have already been conducted on the ISS. "If cancer screening using our bubble technology in space is democratized and made inexpensive, many more cancers can be screened, and everyone can benefit," said Tengfei Luo, a Notre Dame researcher who pioneered the technology, speaking to the ISS' magazine, Upward. "It's something we may be able to integrate into annual exams. It sounds far-fetched, but it's achievable...."

Chemotherapy patients could save precious time, too. In normal gravity, they typically have to spend a half-hour hooked up to a needle before the medicine begins to take effect, because most drugs don't dissolve easily in water. But scientists at Merck have discovered that, in space, their widely used cancer drug pembrolizumab, or Keytruda, can be administered through a simple injection, because large crystalline molecules that would normally clump together are suspended in microgravity... Someday, microgravity could even help patients recovering from surgery heal faster than they would on Earth, Soker added. "Wound healing in high pressure is faster. That's the hyperbaric treatment for wounds...."

For the Wake Forest experiment, which is scheduled to launch next spring, scientists will cut out two sections of a cancer tumor from around 20 patients. One sample will stay on Earth while the other heads to the ISS, with scientists observing the difference. The testing will be completed within a week, to avoid any interference from cosmic radiation. If successful, Soker said, it could set the stage for diagnostic cancer tests in space available to the general population — perhaps on a biomedical space station that could launch after the planned demise of the ISS. "Can we actually design a special cancer space station that will be dedicated to cancer and maybe other diseases?" Shoker asked, answering his question in the affirmative. "Pharmaceutical companies that have deep pockets would certainly support that program."

In a world first, a research team used 2D materials — only an atom thick — to develop a computer. The team (led by researchers at Pennsylvania State University) says it's a major step toward thinner, faster and more energy-efficient electronics.

From the University's announcement: They created a complementary metal-oxide semiconductor (CMOS) computer — technology at the heart of nearly every modern electronic device — without relying on silicon. Instead, they used two different 2D materials to develop both types of transistors needed to control the electric current flow in CMOS computers: molybdenum disulfide for n-type transistors and tungsten diselenide for p-type transistors... "[A]s silicon devices shrink, their performance begins to degrade," [said lead researcher/engineering professor Saptarshi Das]. "Two-dimensional materials, by contrast, maintain their exceptional electronic properties at atomic thickness, offering a promising path forward...."

The team used metal-organic chemical vapor deposition (MOCVD) — a fabrication process that involves vaporizing ingredients, forcing a chemical reaction and depositing the products onto a substrate — to grow large sheets of molybdenum disulfide and tungsten diselenide and fabricate over 1,000 of each type of transistor. By carefully tuning the device fabrication and post-processing steps, they were able to adjust the threshold voltages of both n- and p-type transistors, enabling the construction of fully functional CMOS logic circuits.

"Our 2D CMOS computer operates at low-supply voltages with minimal power consumption and can perform simple logic operations at frequencies up to 25 kilohertz," said first author Subir Ghosh, a doctoral student pursuing a degree in engineering science and mechanics under Das's mentorship. Ghosh noted that the operating frequency is low compared to conventional silicon CMOS circuits, but their computer — known as a one instruction set computer — can still perform simple logic operations.

NASA and Axiom Space have indefinitely delayed the Axiom-4 launch to the International Space Station due to concerns about a persistent air leak in the Russian PrK vestibule of the aging Zvezda module. "The PrK serves as a passageway between the station's Zvezda module and spacecraft docked at its aft port," notes CBS News. From the report: In a blog post, NASA said cosmonauts aboard the station "recently performed inspections of the pressurized module's interior surfaces, sealed some additional areas of interest, and measured the current leak rate. Following this effort, the segment now is holding pressure." The post went on to say the Axiom-4 delay will provide "additional time for NASA and (the Russian space agency) Roscosmos to evaluate the situation and determine whether any additional troubleshooting is necessary."

Launched in July 2000 atop a Russian Proton rocket, Zvezda was the third module to join the growing space station, providing a command center for Russian cosmonauts, crew quarters, the aft docking port and two additional ports now occupied by airlock and research modules. The leakage was first noticed in 2019, and has been openly discussed ever since by NASA during periodic reviews and space station news briefings. The leak rate has varied, but has stayed in the neighborhood of around 1-to-2 pounds per day. "The station is not young," astronaut Mike Barratt said last November during a post flight news conference. "It's been up there for quite a while, and you expect some wear and tear, and we're seeing that in the form of some cracks that have formed." The Russians have made a variety of attempts to patch a suspect crack and other possible sources of leakage, but air has continued to escape into space.

In November, Bob Cabana, a former astronaut and NASA manager who chaired the agency's ISS Advisory Committee, said U.S. and Russian engineers "don't have a common understanding of what the likely root cause is, or the severity of the consequences of these leaks." "The Russian position is that the most probable cause of the PrK cracks is high cyclic fatigue caused by micro vibrations," Cabana said. "NASA believes the PrK cracks are likely multi-causal including pressure and mechanical stress, residual stress, material properties and environmental exposures. "The Russians believe that continued operations are safe, but they can't prove to our satisfaction that they are, and the US believes that it's not safe, but we can't prove that to the Russian satisfaction that that's the case."

As an interim step, the hatch leading to the PrK and the station's aft docking compartment is closed during daily operations and only opened when the Russians need to unload a visiting Progress cargo ship. And as an added precaution on NASA's part, whenever the hatch to the PrK and docking compartment is open, a hatch between the Russian and U.S. segments of the station is closed. "We've taken a very conservative approach to close a hatch between the US side and the Russian side during those time periods," Barratt said. "It's not a comfortable thing, but it is the best agreement between all the smart people on both sides. And it's something that we crew live with and enact." Cabana said last year that the Russians do not believe "catastrophic disintegration of the PrK is realistic (but) NASA has expressed concerns about the structural integrity of the PrK and the possibility of a catastrophic failure."