Biotech

Tiny 'Micro-Robots' in your Bloodstream Could Deliver Drugs with Greater Precision (msn.com) 30

The Washington Post reports: Scientists in Switzerland have created a robot the size of a grain of sand that is controlled by magnets and can deliver drugs to a precise location in the human body, a breakthrough aimed at reducing the severe side effects that stop many medicines from advancing in clinical trials... "I think surgeons are going to look at this," [said Bradley J. Nelson, an author of the paper in Science describing the discovery and a professor of robotics and intelligent systems at ETH Zurich]. I'm sure they're going to have a lot of ideas on how to use" the microrobot. The capsule, which is steered by magnets, might also be useful in treating aneurysms, very aggressive brain cancers, and abnormal connections between arteries and veins known as arteriovenous malformations, Nelson said. The capsules have been tested successfully in pigs, which have similar vasculature to humans, and in silicone models of the blood vessels in humans and animals... Nelson said drug-ferrying microrobots of this kind may be three to five years from being tested in clinical trials. The problem faced by many drugs under development is that they spread throughout the body instead of going only to the area in need... A major cause of side effects in patients is medications traveling to parts of the body that don't need them. The capsules developed in Switzerland, however, can be maneuvered into precise locations by a surgeon using a tool not that different from a PlayStation controller. The navigation system involves six electromagnetic coils positioned around the patient, each about 8 to 10 inches in diameter... The capsules are made of materials that have been found safe for people in other medical tools...

When the capsule reaches its destination in the body, "we can trigger the capsule to dissolve," Nelson said.

Science

CERN Can Now Produce Antihydrogen Atoms Eight Times Faster Than Before (phys.org) 41

fahrbot-bot shares a report from Phys.org: Physicists from Swansea University have played the leading role in a scientific breakthrough at CERN, developing an innovative technique that increases the antihydrogen trapping rate by a factor of ten. The advancement, achieved as part of the international Antihydrogen Laser Physics Apparatus (ALPHA) collaboration, has been published in Nature Communications and could help answer one of the biggest questions in physics: Why is there such a large imbalance between matter and antimatter? According to the Big Bang theory, equal amounts were created at the beginning of the universe, so why is the world around us made almost entirely of matter?

Antihydrogen is the "mirror version" of hydrogen, made from an antiproton and a positron. Trapping and studying it helps scientists explore how antimatter behaves, and whether it follows the same rules as matter. Producing and trapping antihydrogen is an extremely complicated process. Previous methods took 24 hours to trap just 2,000 atoms, limiting the scope of experiments at ALPHA. The Swansea-led team has changed that. Using laser-cooled beryllium ions, the team has demonstrated that it is possible to cool positrons to less than 10 Kelvin (below -263C), significantly colder than the previous threshold of about 15 Kelvin. These cooler positrons dramatically boost the efficiency of antihydrogen production and trapping -- allowing a record 15,000 atoms to be trapped in less than seven hours.

ISS

Moss Spores Survive 9 Months Outside ISS (phys.org) 34

alternative_right shares a report from Phys.org: Inspired by moss's resilience, researchers sent moss sporophytes -- reproductive structures that encase spores -- to the most extreme environment yet: space. Their results, published in the journal iScience on November 20, show that more than 80% of the spores survived nine months outside of the International Space Station (ISS) and made it back to Earth still capable of reproducing, demonstrating for the first time that an early land plant can survive long-term exposure to the elements of space.

[Lead author Tomomichi Fujita of Hokkaido University and his team] subjected Physcomitrium patens, a well-studied moss commonly known as spreading earthmoss, to a simulated a space environment, including high levels of UV radiation, extreme high and low temperatures, and vacuum conditions. They tested three different structures from the moss -- protenemata, or juvenile moss; brood cells, or specialized stem cells that emerge under stress conditions; and sporophytes, or encapsulated spores -- to find out which had the best chance of surviving in space.

The researchers found that UV radiation was the toughest element to survive, and the sporophytes were by far the most resilient of the three moss parts. None of the juvenile moss survived high UV levels or extreme temperatures. The brood cells had a higher rate of survival, but the encased spores exhibited ~1,000x more tolerance to UV radiation. The spores were also able to survive and germinate after being exposed to 196C for over a week, as well as after living in 55C heat for a month.

Medicine

CDC Changes Webpage To Say Vaccines May Cause Autism, Revising Prior Language (msn.com) 317

A Centers for Disease Control and Prevention webpage that previously made the case that vaccines don't cause autism now says they might. WSJ: The contents of the webpage came up during Health Secretary Robert F. Kennedy Jr. Senate confirmation process. Sen. Bill Cassidy (R., La.) in February said Kennedy had assured him that, if he was confirmed, the CDC would "not remove statements on their website pointing out that vaccines do not cause autism."

The revised webpage says: "The claim 'vaccines do not cause autism' is not an evidence-based claim because studies have not ruled out the possibility that infant vaccines cause autism. Studies supporting a link have been ignored by health authorities." The new text posted Wednesday also notes that the Department of Health and Human Services has launched "a comprehensive assessment" to probe the causes of autism.

Math

American Kids Can't Do Math Anymore (theatlantic.com) 259

An anonymous reader shares a report: For the past several years, America has been using its young people as lab rats in a sweeping, if not exactly thought-out, education experiment. Schools across the country have been lowering standards and removing penalties for failure. The results are coming into focus.

Five years ago, about 30 incoming freshmen at UC San Diego arrived with math skills below high-school level. Now, according to a recent report from UC San Diego faculty and administrators, that number is more than 900 -- and most of those students don't fully meet middle-school math standards. Many students struggle with fractions and simple algebra problems. Last year, the university, which admits fewer than 30 percent of undergraduate applicants, launched a remedial-math course that focuses entirely on concepts taught in elementary and middle school. (According to the report, more than 60 percent of students who took the previous version of the course couldn't divide a fraction by two.) One of the course's tutors noted that students faced more issues with "logical thinking" than with math facts per se. They didn't know how to begin solving word problems.

The university's problems are extreme, but they are not unique. Over the past five years, all of the other University of California campuses, including UC Berkeley and UCLA, have seen the number of first-years who are unprepared for precalculus double or triple. George Mason University, in Virginia, revamped its remedial-math summer program in 2023 after students began arriving at their calculus course unable to do algebra, the math-department chair, Maria Emelianenko, told me.

"We call it quantitative literacy, just knowing which fraction is larger or smaller, that the slope is positive when it is going up," Janine Wilson, the chair of the undergraduate economics program at UC Davis, told me. "Things like that are just kind of in our bones when we are college ready. We are just seeing many folks without that capability."

Part of what's happening here is that as more students choose STEM majors, more of them are being funneled into introductory math courses during their freshman year. But the national trend is very clear: America's students are getting much worse at math. The decline started about a decade ago and sharply accelerated during the coronavirus pandemic. The average eighth grader's math skills, which rose steadily from 1990 to 2013, are now a full school year behind where they were in 2013, according to the National Assessment of Educational Progress, the gold standard for tracking academic achievement. Students in the bottom tenth percentile have fallen even further behind. Only the top 10 percent have recovered to 2013 levels.

The Internet

Quantum Teleportation Between Photons From Two Distant Light Sources Achieved (phys.org) 41

Researchers in Germany achieved a major milestone for the future quantum internet by successfully teleporting quantum information between photons generated by two different, physically separated quantum dots -- something never accomplished before due to the difficulty of producing indistinguishable photons from remote sources. Phys.org reports: At the University of Stuttgart, the team succeeded in teleporting the polarization state of a photon originating from one quantum dot to another photon from a second quantum dot. One quantum dot generates a single photon, the other an entangled photon pair. Entangled means that the two particles constitute a single quantum entity, even when they are physically separated. One of the two particles travels to the second quantum dot and interferes with its light particle. The two overlap. Because of this superposition, the information of the single photon is transferred to the distant partner of the pair.

Instrumental for the success of the experiment were quantum frequency converters, which compensate for residual frequency differences between the photons. These converters were developed by a team led by Prof. Christoph Becher, an expert in quantum optics at Saarland University. [...] In the Stuttgart experiment, the quantum dots were separated only by an optical fiber of about 10 m length. "But we are working on achieving considerably greater distances," says Strobel. In earlier work, the team had shown that the entanglement of the quantum dot photons remains intact even after a 36-kilometer transmission through the city center of Stuttgart. Another aim is to increase the current success rate of teleportation, which currently stands at just over 70%. Fluctuations in the quantum dot still lead to slight differences in the photons.
The findings have been published in the journal Nature Communications.
Medicine

New Antibiotic Could Be a Breakthrough in Treatment for Killer TB, Trial Suggests (theguardian.com) 15

A new treatment for tuberculosis could boost cure rates and shorten the time needed to treat the disease by months, trial results suggest. The Guardian: Globally, an estimated 10.7 million people fell ill with TB last year and 1.23 million died from it. In its annual report on tuberculosis, launched last week, the World Health Organization said it remained a "major global public-health problem" and the leading infectious cause of death. [...] Sorfequiline, a new antibiotic, showed stronger action against the deadly bacteria than existing treatments, with a comparable safety profile, researchers from the TB Alliance told the Union Conference on Lung Health in Copenhagen on Wednesday.

The trial involved 309 people across 22 sites in South Africa, the Philippines, Georgia, Tanzania and Uganda, with different dose regimens. All participants had "drug-sensitive" tuberculosis, meaning a standard cocktail of drugs can safely treat them but researchers believe TB infections that are resistant to standard treatment could also be helped. The trial suggested a sorfequiline-based regimen could be used for anyone testing positive, said Dr Maria Beumont, vice-president of TB Alliance.

Science

Ultra-Processed Food is Global Health Threat, Researchers Warn (bbc.com) 84

Action is needed now to reduce ultra-processed food (UPF) in diets worldwide because of their threat to health, say international experts in a global review of research. From a report: They say the way we eat is changing - with a move away from fresh, whole foods to cheap, highly-processed meals - which is increasing our risk of a range of chronic diseases, including obesity and depression. Writing in The Lancet, the researchers say governments need "to step up" and introduce warnings and higher taxes on UPF products, to help fund access to more nutritious foods.

[...] This review of evidence on the impact of UPFs on health, carried out by 43 global experts and based on 104 long-term studies, suggests these foods are linked to a greater risk of 12 health conditions. These include type 2 diabetes, cardiovascular disease, kidney disease, depression and dying prematurely from any cause.

Medicine

CDC Data Confirms US is 2 Months Away From Losing Measles Elimination Status 297

An anonymous reader shares a report: Federal health officials have linked two massive US measles outbreaks, confirming that the country is about two months away from losing its measles elimination status, according to a report by The New York Times. The Times obtained a recording of a call during which officials from the Centers for Disease Control and Prevention confirmed to state health departments that the ongoing measles outbreak at the border of Arizona and Utah is a continuation of the explosive outbreak in West Texas that began in mid- to late-January. That is, the two massive outbreaks are being caused by the same subtype of measles virus.

This is a significant link that hasn't previously been reported despite persistent questions from journalists and concerns from health experts, particularly in light of Canada losing its elimination status last week. The loss of an elimination status means that measles will once again be considered endemic to the US, an embarrassing public health backslide for a vaccine-preventable disease.
Biotech

Man Who Cryogenically Froze Late Wife Sparks Debate By Dating New Partner (bbc.com) 87

A Chinese man who cryogenically preserved his wife after her death has sparked a heated online debate after it emerged he began dating a new partner in 2020. Some argue it's natural for him to move on, while others say he's being selfish or disrespectful to both his late wife and his current partner. The BBC reports: As a sign of his devotion, Gui Junmin decided to freeze his wife Zhan Wenlian's body after she died from lung cancer in 2017, aged 49, making her China's first cryogenically preserved person. But after a November interview revealed he had been dating a different partner since 2020, Chinese social media has been torn on Mr Junmin's predicament. Whilst some asked why the 57-year-old didn't just "let go" another commenter remarked he appeared to be "most devoted to himself."

After Zhan Wenlian was given months to live by doctors, Gui Junmin decided to use cryonics - which is scientifically unproven - to preserve her body once she died. Following her death, he signed a 30-year agreement to preserve his wife's frozen body with the Shandong Yinfeng Life Science Research Institute. Since then, Zhan's body has been stored in a 2,000-litre container at the institute in a vat of -190C liquid nitrogen.

Chinese newspaper Southern Weekly revealed that although Mr Junmin lived alone for two years after the procedure, in 2020 he began dating again, despite his wife remaining in cryopreservation. He told the newspaper that a severe gout attack which left him unable to move for two days began to change his mind about the benefits of living alone. Soon after, he started seeing his current partner Wang Chunxia, although Mr Junmin suggested to the paper the love was only "utilitarian" and that she hadn't "entered" his heart.

Science

UC Berkeley Scientists Hail Breakthrough In Decoding Whale Communication (sfgate.com) 35

UC Berkeley researchers working with Project CETI discovered that sperm whales produce vowel-like sounds embedded in their click codas, suggesting a far more complex communication system than previously understood. "It was striking just how structured the system was. I've never seen anything like that before with other animals," Begus, a UC Berkeley linguistics professor and the linguistics lead at Project CETI, told SFGATE. "We're showing the world that there's more than meets the eye in sperm whales and that, if one cares to look closely, they're not as alien. We're much more similar to each other than we used to think." SFGATE reports: With the help of a machine-learning model to identify patterns, Begus and his team combed through recordings collected from social units of sperm whales off the coast of the island of Dominica between 2005 and 2018. When they sped up the audio, removing the silences between clicks, they heard new patterns. They found acoustic properties that share similarities with two vowels -- a and i -- and several vowel combinations.

"Before, people were looking just at the timing and the number of clicks exchanged between sperm whales, but now we have to look at the frequencies, too. A whole new set of patterns have appeared," Begus said. "Now, it's one of the most complex non-human communication systems we have observed." [...] Begus said the research only shows how much more we have to learn about whales' style of communicating. He is particularly interested in exploring how the system may differ for whales between regions and how whale babies learn to communicate in this way. Most importantly, he wants to understand the meaning behind the sounds, as a "window into whale thoughts and lives."
The research was published in the journal Open Mind.
Bug

We Can Now Track Individual Monarch Butterflies (nytimes.com) 48

An anonymous reader quotes a report from the New York Times: For the first time, scientists are tracking the migration of monarch butterflies across much of North America, actively monitoring individual insects on journeys from as far away as Ontario all the way to their overwintering colonies in central Mexico. This long-sought achievement could provide crucial insights into the poorly understood life cycles of hundreds of species of butterflies, bees and other flying insects at a time when many are in steep decline.

The breakthrough is the result of a tiny solar-powered radio tag that weighs just 60 milligrams and sells for $200. Researchers have tagged more than 400 monarchs this year and are now following their journeys on a cellphone app created by the New Jersey-based company that makes the tags, Cellular Tracking Technologies. Most monarchs weigh 500 to 600 milligrams, so each tag-bearing migrator making the transcontinental journey is, by weight, equivalent to a half-raisin carrying three uncooked grains of rice.

Researchers are tracking more than 400 tagged monarch butterflies as they fly toward winter colonies in central Mexico. The maps [in the article] follow six butterflies. [...] Tracking the world's most famous insect migration may also have a big social impact, with monarch lovers able to follow the progress of individual butterflies on the free app, called Project Monarch Science. Many of the butterflies are flying over cities and suburbs where pollinator gardens are increasingly popular. Some tracks could even lead to the discovery of new winter hideaways.
"There's nothing that's not amazing about this," said Cheryl Schultz, a butterfly scientist at Washington State University and the senior author of a recent study documenting a 22 percent drop in butterfly abundance in North America over a recent 20-year period. "Now we will have answers that could help us turn the tide for these bugs."
Science

Some People Never Forget a Face, and Now We Know Their Secret (sciencealert.com) 30

alternative_right shares a report from ScienceAlert: A new study from researchers in Australia reveals that the people who never forget faces look "smarter, not harder." In other words, they naturally focus on a person's most distinguishing facial features. "Their skill isn't something you can learn like a trick," explains lead author James Dunn, a psychology researcher at the University of New South Wales (UNSW) Sydney. "It's an automatic, dynamic way of picking up what makes each face unique."

To see what super-recognizers see, Dunn and his colleagues used eye-tracking technology to reconstruct how people surveyed new faces. They did this with 37 super-recognizers and 68 people with ordinary facial recognition skills, noting where and for how long participants looked at pictures of faces displayed on a computer screen. The researchers then fed the data into machine learning algorithms trained to recognize faces. The algorithms, a type known as deep neural networks, were tasked with deciding if two faces belonged to the same person.
"These findings suggest that the perceptual foundations of individual differences in face recognition ability may originate at the earliest stages of visual processing -- at the level of retinal encoding," Dunn and colleagues write in their paper.

The findings have been published in the journal Proceedings of the Royal Society B: Biological Sciences.
AI

More Tech Moguls Want to Build Data Centers in Outer Space (msn.com) 90

"To be clear, the current economics of space-based data centers don't make sense," writes the Wall Street Journal.

"But they could in the future, perhaps as soon as a decade or so from now, according to an analysis by Phil Metzger, a research professor at the University of Central Florida and formerly of the National Aeronautics and Space Administration." "Space enthusiasts (comme moi) have long sought a business case to enable human migration beyond our home world," he posted on X amid the new hype. "I think AI servers in space is the first real business case that will lead to many more...."

The argument essentially boils down to the belief that AI's needs are eventually going to grow so great that we need to move to outer space. There the sun's power can be more efficiently harvested. In space, the sun's rays can be direct and constant for solar panels to collect — no clouds, no rainstorms, no nighttime. Demands for cooling could also be cut because of the vacuum of space. Plus, there aren't those pesky regulations that executives like to complain about, slowing construction of new power plants to meet the data-center needs. In space, no one can hear the Nimbys scream. "We will be able to beat the cost of terrestrial data centers in space in the next couple of decades," Bezos said at a tech conference last month. "Space will end up being one of the places that keeps making Earth better."

It's still early days. At Alphabet, Google's plans sound almost conservative. The search-engine company in recent days announced Project Suncatcher, which it describes as a moonshot project to scale machine learning in space. It plans to launch two prototype satellites by early 2027 to test its hardware in orbit. "Like any moonshot, it's going to require us to solve a lot of complex engineering challenges," Pichai posted on social media. Nvidia, too, has announced a partnership with startup Starcloud to work on space-based data centers. Not to be outdone, Elon Musk has been painting his own updated vision for the heavens... in recent weeks he has been talking more about how he can use his spaceships to deploy new versions of his solar-powered Starlink satellites equipped with high-speed lasers to build out in-space data centers.

On Friday, Musk further reiterated how those AI satellites would be able to generate 100 gigawatts of annual solar power — or, what he said, would be roughly a quarter of what the U.S. consumes on average in a year. "We have a plan mapped out to do it," he told investor Ron Baron during an event. "It gets crazy." Previously, he has suggested he was four to five years away from that ability. He's also touted even wilder ideas, saying on X that 100 terawatts a year "is possible from a lunar base producing solar-powered AI satellites locally and accelerating them to escape velocity with a mass driver." Simply put, he's suggesting a moon base will crank out satellites and throw them into orbit with a catapult. And those satellites' solar panels would generate 100,000 gigawatts a year. "I think we'll see intelligence continue to scale all the way up to where...most of the power of the sun is harnessed for compute," Musk told a tech conference in September.

China

Chinese Astronauts Return From Their Space Station After Delay Blamed on Space Debris Damage (apnews.com) 29

"Three Chinese astronauts returned from their nation's space station Friday," reports the Associated Press, "after more than a week's delay because the return capsule they had planned to use was damaged, likely from being hit by space debris." The team left their Shenzhou-20 spacecraft in orbit and came back using the recently arrived Shenzhou-21, which had ferried a three-person replacement crew to the station, China's Manned Space Agency said. The original return plan was scrapped because a window in the Shenzhou-20 capsule had tiny cracks, most likely caused by impact from space debris, the space agency said Friday... Their return was delayed for nine days, and their 204-day stay in space was the longest for any astronaut at China's space station...

China developed the Tiangong space station after the country was excluded from the International Space Station over U.S. national security concerns. China's space program is controlled by its military.

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