An anonymous reader shared this report from ScienceAlert: The Fermi Paradox is the discrepancy between the apparent high likelihood of advanced civilizations existing and the total lack of evidence that they do exist. Many solutions have been proposed for why the discrepancy exists. One of the ideas is the 'Great Filter.' The Great Filter is a hypothesized event or situation that prevents intelligent life from becoming interplanetary and interstellar and even leads to its demise....

[H]ow about the rapid development of AI?

A new paper in Acta Astronautica explores the idea that Artificial Intelligence becomes Artificial Super Intelligence (ASI) and that ASI is the Great Filter. The paper's title is "Is Artificial Intelligence the Great Filter that makes advanced technical civilizations rare in the universe?"
"Upon reaching a technological singularity, ASI systems will quickly surpass biological intelligence and evolve at a pace that completely outstrips traditional oversight mechanisms, leading to unforeseen and unintended consequences that are unlikely to be aligned with biological interests or ethics," the paper explains... The author says their projects "underscore the critical need to quickly establish regulatory frameworks for AI development on Earth and the advancement of a multiplanetary society to mitigate against such existential threats."

"The persistence of intelligent and conscious life in the universe could hinge on the timely and effective implementation of such international regulatory measures and

Popular Science reports that early last week, researchers at the U.S. Energy Department's Princeton Plasma Physics Laboratory revealed their new "MUSE" stellarator — "a unique fusion reactor that uses off-the-shelf and 3D-printed materials to contain its superheated plasma."

The researchers' announcement says the technique suggests "a simple way to build future devices for less cost and allow researchers to test new concepts for future fusion power plants." Stellarators typically rely on complicated electromagnets that have complex shapes and create their magnetic fields through the flow of electricity. Those electromagnets must be built precisely with very little room for error, increasing their cost. However, permanent magnets, like the magnets that hold art to refrigerator doors, do not need electric currents to create their fields. They can also be ordered off the shelf from industrial suppliers and then embedded in a 3D-printed shell around the device's vacuum vessel, which holds the plasma.

"MUSE is largely constructed with commercially available parts," said Michael Zarnstorff, a senior research physicist at PPPL. "By working with 3D-printing companies and magnet suppliers, we can shop around and buy the precision we need instead of making it ourselves." The original insight that permanent magnets could be the foundation for a new, more affordable stellarator variety came to Zarnstorff in 2014. "I realized that even if they were situated alongside other magnets, rare-earth permanent magnets could generate and maintain the magnetic fields necessary to confine the plasma so fusion reactions can occur," Zarnstorff said, "and that's the property that makes this technique work." [...]

In addition to being an engineering breakthrough, MUSE also exhibits a theoretical property known as quasisymmetry to a higher degree than any other stellarator has before. It is also the first device completed anywhere in the world that was designed specifically to have a type of quasisymmetry known as quasiaxisymmetry. Conceived by physicist Allen Boozer at PPPL in the early 1980s, quasisymmetry means that although the shape of the magnetic field inside the stellarator may not be the same around the physical shape of the stellarator, the magnetic field's strength is uniform around the device, leading to good plasma confinement and higher likelihood that fusion reactions will occur. "In fact, MUSE's quasisymmetry optimization is at least 100 times better than any existing stellarator," Zarnstorff said.

"The fact that we were able to design and build this stellarator is a real achievement," said Tony Qian, a graduate student in the Princeton Program in Plasma Physics, which is based at PPPL.
Also covered by Gizmodo. Thanks to Slashdot reader christoban for sharing the news.

O'Reilly's "Tech Trends" newsletter included an interesting item this month: Want your own Klein Bottle? Made by Cliff Stoll, author of the cybersecurity classic The Cuckoo's Egg, who will autograph your bottle for you (and may include other surprises).
First described in 1882 by the mathematician Felix Klein, a Klein bottle (like a Mobius strip) has a one-side surface. ("Need a zero-volume bottle...?" asks Stoll's web site. "Want the ultimate in non-orientability...? A mathematician's delight, handcrafted in glass.")

But how the legendary cyberbreach detective started the company is explained in this 2016 article from a U.C. Berkeley alumni magazine. Its headline? "How a Berkeley Eccentric Beat the Russians — and Then Made Useless, Wondrous Objects." The reward for his cloak-and-dagger wizardry? A certificate of appreciation from the CIA, which is stashed somewhere in his attic... Stoll published a best-selling book, The Cuckoo's Egg, about his investigation. PBS followed it with a NOVA episode entitled "The KGB, the Computer, and Me," a docudrama starring Stoll playing himself and stepping through the "fourth wall" to double as narrator. Stoll had stepped through another wall, as well, into the numinous realm of fame, as the burgeoning tech world went wild with adulation... He was more famous than he ever could have dreamed, and he hated it. "After a few months, you realize how thin fame is, and how shallow. I'm not a software jockey; I'm an astronomer. But all people cared about was my computing."

Stoll's disenchantment also arose from what he perceived as the false religion of the Internet... Stoll articulated his disenchantment in his next book, Silicon Snake Oil, published in 1995, which urged readers to get out from behind their computer screens and get a life. "I was asking what I thought were reasonable questions: Is the electronic classroom an improvement? Does a computer help a student learn? Yes, but what it teaches you is to go to the computer whenever you have a question, rather than relying on yourself. Suppose I was an evil person and wanted to eliminate the curiosity of children. Give the kid a diet of Google, and pretty soon the child learns that every question he has is answered instantly. The coolest thing about being human is to learn, but you don't learn things by looking it up; you learn by figuring it out." It was not a popular message in the rise of the dot-com era, as Stoll soon learned...

Being a Voice in the Wilderness doesn't pay well, however, and by this time Stoll had taken his own advice and gotten a life; namely, marrying and having two children. So he looked around for a way to make some money. That ushered in his third — and current — career as President and Chief Bottle Washer of the aforementioned Acme Klein Bottle company... At first, Stoll had a hard time finding someone to make Klein bottles. He tried a bong peddler on Telegraph Avenue, but the guy took Cliff's money and disappeared. "I realized that the trouble with bong makers is that they're also bong users."

Then in 1994, two friends of his, Tom Adams and George Chittenden, opened a shop in West Berkeley that made glassware for science labs. "They needed help with their computer program and wanted to pay me," Stoll recalls. "I said, 'Nah, let's make Klein bottles instead.' And that's how Acme Klein Bottles was born."
UPDATE: Turns out Stoll is also a long-time Slashdot reader, and shared comments this weekend on everything from watching the eclipse to his VIP parking pass for CIA headquarters and "this CIA guy's rubber-stamp collection."

"I am honored by the attention and kindness of fellow nerds and online friends," Stoll added Saturday. "When I first started on that chase in 1986, I had no idea wrhere it would lead me... To all my friends: May you burdens be light and your purpose high. Stay curious!"

Under a new agreement between the U.S. and Japan, the first non-American on the Moon as part of the Artemis lunar exploration campaign will be a Japanese astronaut. SpaceNews reports: At an event in Washington, NASA Administrator Bill Nelson and Japanese Minister of Education, Culture, Sports, Science and Technology (MEXT) Masahito Moriyama signed an agreement regarding an additional Japanese contribution to Artemis, a pressurized lunar rover called Lunar Cruiser. NASA will deliver the rover to the moon, which the agencies said should take place ahead of the Artemis 7 mission scheduled for no earlier than 2031. NASA will also provide two seats on future Artemis lunar landing missions to astronauts from the Japanese space agency JAXA, the first agency other than NASA to secure spots on landing missions.

The Japanese rover will support extended expeditions from Artemis landing sites that are beyond the range of the Lunar Terrain Vehicle that three American companies are developing for NASA under contracts announced April 3. The rover is designed to accommodate two astronauts for up to 30 days, with an overall lifetime of 10 years. The announcement, though, offered no details about when the Japanese astronauts would fly to the moon. "It depends," Nelson said at an April 10 briefing when asked about schedules, noting that the two countries "announced a shared goal for a Japanese national to land on the moon on a future NASA mission assuming benchmarks are achieved."

"No mission has been currently assigned to a Japanese astronaut," added Lara Kearney, manager of NASA's extravehicular activity and human surface mobility program, at the briefing. The implementing agreement (PDF) said several factors will go into crew assignments, including progress on the pressurized rover, or PR: "The timing of the flight opportunities will be determined by NASA in line with existing flight manifesting and crew assignment processes and will take into account program progress and constraints, MEXT's request for the earliest possible assignment of the Japanese astronauts to lunar surface missions, and major PR milestones such as when the PR is first deployed on the lunar surface." The assumption among many in the industry, though, is that at least one of the astronauts will fly before the rover is delivered, and possibly as soon as the Artemis 4 mission, the second crewed landing, in the late 2020s.

Andrew Jones reports via IEEE Spectrum: The European Space Agency will launch a mission late this year to demonstrate precision formation flying in orbit to create artificial solar eclipses. In a press conference last week, the agency announced details of the mission and the technology the orbiters will use to pull off its exquisitely-choreographed maneuvers. ESA's Proba-3 (PRoject for On-Board Autonomy) consists of a pair of spacecraft: a 300-kilogram Coronagraph spacecraft and a 250-kilogram Occulter. The pair are now slated to launch on an Indian PSLV rocket in September and ultimately enter a highly elliptical, 600-by-60,530-kilometer orbit. The aim, the agency says, is to move the separate spacecraft to some 144 meters apart, with the Occulter, as a disc, blocking out the sun.

Achieving this formation will allow the Coronagraph to study our star's highly ionized, extremely hot atmosphere -- but also demonstrate the technology as a precursor for more ambitious, future, formation-flying endeavors. [...] ESA has science objectives for Proba-3, using observations made in space to study solar astrophysics without any intervention of the Earth's atmosphere. The agency's Association of Spacecraft for Polarimetric and Imaging Investigation of the Corona of the Sun (ASPIICS) coronagraph will help to discern why the solar corona is significantly hotter than the Sun itself. This could further our understanding of the Sun and assist solar weather predictions. However, it is the precision formation flying that Proba-3 aims to demonstrate which could help unlock future breakthroughs. [...]

Precisely-controlled Occulter spacecraft could be used with space telescopes to block light from a star in order to directly detect potential orbiting planets, while a constellation of spacecraft can, through interferometry, create large-scale observatories, achieving large apertures and long focal lengths than possible with large solo satellites. Further applications include Earth observation, space-based gravitational wave detection, and a range of missions in which two or more spacecraft need to interact, such as rendezvous, docking, and in-orbit servicing.

In two recent papers, an international team of scientists describes the first known nitrogen-fixing organelle within a eukaryotic cell, which the researchers are calling a nitroplast. Phys.Org reports: The discovery of the organelle involved a bit of luck and decades of work. In 1998, Jonathan Zehr, a UC Santa Cruz distinguished professor of marine sciences, found a short DNA sequence of what appeared to be from an unknown nitrogen-fixing cyanobacterium in Pacific Ocean seawater. Zehr and colleagues spent years studying the mystery organism, which they called UCYN-A. At the same time, Kyoko Hagino, a paleontologist at Kochi University in Japan, was painstakingly trying to culture a marine alga. It turned out to be the host organism for UCYN-A. It took her over 300 sampling expeditions and more than a decade, but Hagino eventually successfully grew the alga in culture, allowing other researchers to begin studying UCYN-A and its marine alga host together in the lab. For years, the scientists considered UCYN-A an endosymbiont that was closely associated with an alga. But the two recent papers suggest that UCYN-A has co-evolved with its host past symbiosis and now fits criteria for an organelle.

In a paper published in Cell in March 2024, Zehr and colleagues from the Massachusetts Institute of Technology, Institut de Ciencies del Mar in Barcelona and the University of Rhode Island show that the size ratio between UCYN-A and their algal hosts is similar across different species of the marine haptophyte algae Braarudosphaera bigelowii. The researchers use a model to demonstrate that the growth of the host cell and UCYN-A are controlled by the exchange of nutrients. Their metabolisms are linked. This synchronization in growth rates led the researchers to call UCYN-A "organelle-like." "That's exactly what happens with organelles," said Zehr. "If you look at the mitochondria and the chloroplast, it's the same thing: they scale with the cell."

But the scientists did not confidently call UCYN-A an organelle until confirming other lines of evidence. In the cover article of the journal Science, published today, Zehr, Coale, Kendra Turk-Kubo and Wing Kwan Esther Mak from UC Santa Cruz, and collaborators from the University of California, San Francisco, the Lawrence Berkeley National Laboratory, National Taiwan Ocean University, and Kochi University in Japan show that UCYN-A imports proteins from its host cells. "That's one of the hallmarks of something moving from an endosymbiont to an organelle," said Zehr. "They start throwing away pieces of DNA, and their genomes get smaller and smaller, and they start depending on the mother cell for those gene products -- or the protein itself -- to be transported into the cell."

Coale worked on the proteomics for the study. He compared the proteins found within isolated UCYN-A with those found in the entire algal host cell. He found that the host cell makes proteins and labels them with a specific amino acid sequence, which tells the cell to send them to the nitroplast. The nitroplast then imports the proteins and uses them. Coale identified the function of some of the proteins, and they fill gaps in certain pathways within UCYN-A. "It's kind of like this magical jigsaw puzzle that actually fits together and works," said Zehr. In the same paper, researchers from UCSF show that UCYN-A replicates in synchrony with the alga cell and is inherited like other organelles.

China is rapidly advancing its space capabilities to challenge the United States' dominance in space, as evidenced by its significant increase in on-orbit intelligence and reconnaissance satellites and the development of sophisticated counterspace weapons. Space.com reports: "Frankly, China is moving at a breathtaking speed. Since 2018, China has more than tripled their on-orbit intelligence, surveillance and reconnaissance satellites," Gen. Stephen Whiting, commander of U.S. Space Command, said here on Tuesday, during a talk at the 39th Space Symposium. "And with these systems, they've built a kill web over the Pacific Ocean to find, fix, track and, yes, target United States and allied military capabilities," he added. And that's not all. China has also "built a range of counterspace weapons, from reversible jamming all the way up to kinetic hit-to-kill direct-ascent and co-orbital ASATs," Whiting said.

Indeed, China demonstrated direct-ascent ASAT, or anti-satellite, weapon technology back in January 2007, when it destroyed one of its defunct weather satellites with a missile. That test was widely decried as irresponsible, for it generated thousands of pieces of debris, many of which are still cluttering up Earth orbit. Such activities show that China is now treating space as a war-fighting domain, Whiting said. And so, he added, is Russia, which has also conducted ASAT tests recently, including a destructive one in November 2021. Russia has also been aggressively building out its orbital architecture; since 2018, the nation has more than doubled its total number of active satellites, according to Whiting. The U.S. government has taken notice of these trends.

"We are at a pivotal moment in history," Troy Meink, principal deputy director of the National Reconnaissance Office, which builds and operates the United States' fleet of spy satellites, said during a different talk on Tuesday here at the symposium. "For the first time in decades, U.S. leadership in space and space technology is being challenged," Meink added. "Our competitors are actively seeking ways to threaten our capabilities, and we see this every day." The U.S. must act if it wishes to beat back this challenge, Meink and Whiting stressed; it cannot rely on the inertia of past success to do the job. For example, Meink highlighted the need to innovate with the nation's reconnaissance satellites, to make them more numerous, more agile and more resilient. U.S. Under Secretary of Defense for Research and Engineering Heidi Shyu also emphasized the importance of increasing resilience, a goal that she said could be achieved by diversifying the nation's space capabilities. "We must assess ways to incorporate radiation-hardened electronics, novel orbits, varied communication pathways, advancements in propulsion technologies and increased cooperation with our allies," Shyu said in another talk on Tuesday at the symposium.

Computational scientist and mathematician Avi Wigderson of the Institute for Advanced Study (IAS) in Princeton has won the 2023 A.M. Turing Award. From a report: The prize, which is given annually by the Association for Computing Machinery (ACM) to a computer scientist for their contributions to the field, comes with $1 million thanks to Google. It is named in honor of the British mathematician Alan Turing, who helped develop a theoretical foundation for understanding machine computation. Wigderson is being honored "for foundational contributions to the theory of computation, including reshaping our understanding of the role of randomness in computation and for his decades of intellectual leadership in theoretical computer science." He also won the prestigious Abel Prize in 2021 for his work in theoretical computer science -- the first person to be so doubly honored.

Sierra Space CEO Tom Vice told Yahoo Finance it plans to go public within the next 18 months at a valuation of $5.3 billion. Since being spun out of defense contractor Sierra Nevada Corporation in 2021, the company has "placed its bets on building out the growing space economy, from developing rocket propulsion technology to a commercial space station with Blue Origin." From the report: Its ambitions have fueled the development of its cargo space plane, the Dream Chaser, set to have its inaugural mission to the International Space Station (ISS) in the second half of this year. Built to land on any commercial runway, the plane will lower the barrier to entry into low-earth orbit and open up business opportunities, Vice said. "Since the 1960s, every science experiment or human being that's come back to earth from space, even today, is still landing in a capsule in the ocean," he said. "We think changing and revolutionizing the way that we bring things back from space, both humans and cargo, and landing [the spacecraft] back at a commercial runway will completely accelerate the new space economy."

"We believe that the next big breakthrough products in oncology, longevity, and industrialized components like glass will be produced in low Earth orbit," Vice said, noting that many of those opportunities are likely to come from the development of commercial space stations to replace the decades-old ISS. Sierra Space has partnered with Blue Origin to build out the Orbital Reef, a commercially owned and operated space station, though recent reports have hinted at tension between the corporate partners. "We're transitioning from decades of government-run space stations with just a handful of government-trained astronauts to the full commercialization of low Earth orbit," Vice said. "We think that's going to create, we believe, probably the most profound industrial revolution and grow that space economy well over a trillion dollars by 2040."

A brain implant startup called Synchron is preparing to recruit patients for a large-scale clinical trial to seek commercial approval for its device. Reuters reports: Synchron on Monday plans to launch an online registry for patients interested in joining the trial meant to include dozens of participants, and has received interest from about 120 clinical trial centers to help run the study, CEO Thomas Oxley said in an interview. "Part of this registry is to start to enable local physicians to speak to patients with motor impairment," he said. "There's a lot of interest so we don't want it to come in a big bottleneck right before the study we'll be doing."

Synchron received U.S. authorization for preliminary testing in July 2021 and has implanted its device in six patients. Prior testing in four patients in Australia showed no serious adverse side effects, the company has reported. Synchron will be analyzing the U.S. data to prepare for the larger study, while awaiting authorization from the U.S. Food and Drug Administration to proceed, Oxley said. Synchron and the FDA declined to comment on the expected timing of that decision. The company aims to include patients who are paralyzed due to the neurodegenerative disease ALS (amyotrophic lateral sclerosis), stroke and multiple sclerosis, Oxley said. [...]

Synchron's device is delivered to the brain via the large vein that sits next to the motor cortex in the brain instead of being surgically implanted into the brain cortex like Neuralink's. The FDA has asked Synchron to screen stroke patients using a non-invasive test to determine whether they would respond to an implant, Oxley said. "They want to expand the market to people who have had a stroke severe enough to cause paralysis because if limited to quadriplegia, the market is way too small to be sustainable," Kip Ludwig, former program director for neural engineering at the U.S. National Institutes of Health, said of Synchron. In 2020, Synchron reported that patients, opens new tab in its Australian study could use its first-generation device to type an average of 16 characters per minute. That's better than non-invasive devices that sit atop the head and record the electrical activity of the brain, which have helped people type up to eight characters per minute, but not the leap forward that is hoped for with an implant, Ludwig said. Oxley would not say whether typing has gotten faster or offer any other details from the ongoing U.S. trial. Reuters notes that Synchron's investors include billionaires Jeff Bezos and Bill Gates. It's competing with Elon Musk's Neuralink brain implant startup and claims it's farther along in the process of testing its device.

Earlier this year, Neuralink said it implanted a chip in its first human patient. It later said the patient fully recovered and was able to control a computer mouse using their thoughts.

After 64 years of service, ULA on Tuesday launched its last-ever Delta rocket carrying a classified payload for the U.S. National Reconnaissance Office (NRO). "The powerful booster departed Space Launch Complex-37 (SLC-37) at Cape Canaveral Space Force Station in Florida at 12:53 p.m. EDT (1653 GMT), literally setting itself on fire for the 16th and final time," reports Space.com. From the report: That spectacle, which was unique to the Delta IV in its heaviest configuration, was the result of hydrogen building up in the flame trench and then rising up alongside the rocket after it was used to cool down the three RS-68A engines to cryogenic temperatures. When the engines fired, the hydrogen ignited and flames lapped at the orange insulation covering the core stage and its two side-mounted boosters. The two boosters were jettisoned about four minutes into the flight, followed by the core, or first stage, separating one minute and 45 seconds later. A single RL10C-2-1 engine on the Delta cryogenic second stage then took over, propelling the NROL-70 payload into space. Due to national security concerns, coverage of the launch ceased following fairing jettison at about 6 minutes and 40 seconds into the flight.

ULA is retiring the Delta IV, and eventually its other legacy rocket, the Atlas V, in favor of its newly introduced Vulcan, which flew a near-perfect first mission in January. The Vulcan was developed to replace both long-flying rockets in all of their configurations. "This is a great mission to think about that transition, because national security space missions is our core and the unique set of missions there require a high-energy launch vehicle. We designed Vulcan specifically for that," said [Tory Bruno, chief executive officer of United Launch Alliance]. In addition to being the 16th Delta IV Heavy, Tuesday's launch was also the 45th liftoff of a Delta IV, the 35th Delta IV to fly from Florida and the 389th Delta launch of any kind since 1960 (of which 294 were sent skyward from Cape Canaveral). Half of the Delta IV Heavy launches were devoted to sending NRO payloads into orbit. The rocket and its less powerful configurations were also used in support of NASA, NOAA (the U.S. National Oceanic and Atmospheric Administration), U.S. Air Force and commercial payloads.

jd shares a report: Peter Higgs, the Nobel prize-winning physicist who discovered a new particle known as the Higgs boson, has died. Higgs, 94, who was awarded the Nobel prize for physics in 2013 for his work in 1964 showing how the boson helped bind the universe together by giving particles their mass, died at home in Edinburgh on Monday. After a series of experiments, which began in earnest in 2008, his theory was proven by physicists working at the Large Hadron Collider at Cern in Switzerland in 2012; the Nobel prize was shared with Francois Englert, a Belgian theoretical physicist whose work in 1964 also contributed directly to the discovery. A member of the Royal Society and a Companion of Honour, Higgs spent the bulk of his professional life at Edinburgh University, which set up the Higgs centre for theoretical physics in his honour in 2012.

Prof Peter Mathieson, the university's principal, said: "Peter Higgs was a remarkable individual -- a truly gifted scientist whose vision and imagination have enriched our knowledge of the world that surrounds us. "His pioneering work has motivated thousands of scientists, and his legacy will continue to inspire many more for generations to come." Prof Fabiola Gianotti, the director general at Cern and former leader of the Atlas experiment, which helped discover the Higgs particle in 2012, said: "Besides his outstanding contributions to particle physics, Peter was a very special person, a man of rare modesty, a great teacher and someone who explained physics in a very simple and profound way. "An important piece of Cern's history and accomplishments is linked to him. I am very saddened, and I will miss him sorely." Jon Butterworth, a member of the Atlas collaboration, said Higgs was "a hero to the particle physics community." Further reading: Higgs: No University Would Employ Me Today (2013);
How the Higgs Boson Particle Ruined Peter Higgs's Life (2022).

"Varda Space Industries has closed a massive tranche of funding," reports TechCrunch, "just weeks after its first drug manufacturing capsule returned from orbit."

Varda has now raised $145 million to date, the article points out, and the $90 million in new Series B funding "marks an inflection point for the company, which is now gearing up to scale from the initial demonstration mission to a regular set of missions carrying customer payloads, Varda founder Delian Asparouhov told TechCrunch." El Segundo-based Varda was founded in 2021 by Asparouhov, who is also a partner at Founders Fund, and Will Bruey, a spacecraft engineer who cut his teeth at SpaceX. The pair had an audacious goal to commercialize what until very recently was promising but ultimately small-scale research into the effects of microgravity on pharmaceutical crystals... Astronauts have been conducting protein crystallization experiments in space for decades on the International Space Station and before that, the Space Shuttle. But the business case for expanding this research has never materialized — until now...

Part of the reason Varda is possible today is due to the availability of regular, low-cost rideshare launches from SpaceX and Rocket Lab's innovations in satellite bus manufacturing. Even beyond these external partnerships, the startup has made significant headway in its own right, as the success of the first mission showed: Their reentry capsule appears to have performed flawlessly and the experiment to reformulate the HIV medicine ritonavir was executed without a hitch, it says. Varda has also started publishing the results of its internal R&D efforts, including a scientific paper on its hyper-gravity (as opposed to microgravity) crystallization platform, which the startup developed as a sort of screening method prior to sending drugs to space. [The paper is titled "Gravity as a Knob for Tuning Particle Size Distributions of Small Molecules."] It's an entirely new field of research that takes advantage of the ability to truly unlock gravity as a variable in scientific experiments. "Over time, we will be able to generate data sets between both hyper-gravity and microgravity and start to show correlations," he said....

In a recent podcast appearance, he specified that the all-in initial mission cost around $12 million, which will drop to $5-6 million by mission 4 and $2.5 million or less by mission 10.) Larger capsules are also in the longer-term pipeline, though also not until the 2027 time frame. Asparouhov also confirmed that pharmaceuticals will be Varda's sole focus for the next 10-20 (or more) years, based on the company's conviction that pharmaceutical products will generate more economic value compared to other materials. A lot of that comes down to the fact that there are a significant set of drugs that require only a "seed" of the material that can only be made in microgravity, and the rest of the drug formulation can be completed here on Earth...

The company is also aiming to improve the processing capabilities of the on-board pharmaceutical reactor. The first mission carried just one drug protein, but in the future the company hopes to process multiple drug products that could be run through different processing regimes. In the future, other missions could carry larger reactors for drugs that do need more than the "seed" crystal, and those mission profiles would be closer to something like mass manufacturing.
Varda already has "a handful" of signed contracts with biotech companies, according to the article — and Varda's next manufacturing mission "will launch later this year."

CNN revisits 2003's disastrous landing of the Space Shuttle Columbia tonight with two "immersive" specials co-produced by BBC and Mindhouse Productions "featuring exclusive interviews and revealing never-before-broadcast footage," according to an announcement — with two more specials airing next week.

You can watch a trailer here. Across four episodes, the story of the ticking-clock of Columbia's final mission is told in dramatic detail, beginning months before the troubled launch, unfolding across the sixteen days in orbit, and concluding with the investigation into the tragic loss of the seven astronauts' lives. Weaving together intimate footage shot by the astronauts themselves inside the orbiter, exclusive first-hand testimony from family members of the Shuttle's crew, key players at NASA — some of whom have never spoken before — and journalists who covered the story on the ground, the series paints an intimate portrait of the women and men onboard and uncovers in forensic detail the trail of events and missed opportunities that ultimately led to disaster.
CNN says the first two episodes will livestream tonight at 9 p.m. EST (time-delayed on the west coast until 9 p.m.PST) — and then be available on-demand starting Monday — "for pay TV subscribers via CNN.com, CNN connected TV and mobile apps." CNN's web site offers a "preview" of its live TV offerings here.

They're promising "the inside story of one America's most iconic institutions, uncovering how financial pressures and a culture of complacency may have contributed to the events of February 1, 2003. The series also reflects on the legacy of the Space Shuttle era, serving as a timely exploration of the challenges and inherent dangers that remain relevant to space travel today."

On its web site CNN has also published two companion articles — one by Rice history professor Douglas Brinkley arguing that NASA "was America's crown jewel. After the Columbia disaster it was never quite the same." Because other shuttle missions had returned safely with "shredded" surface tiles — and because the stalwart Columbia had brought astronauts home from 27 previous flights — many NASA officials were lulled into complacency. They went so far as to assure the pilot and commander via email that "there is no concern ... We have seen the same phenomenon on several other flights and there is absolutely no concern for entry."

NASA officials also decided against enlisting spy satellite photography to examine the shuttle damage more thoroughly. If they had, it's possible that the astronauts could have repaired the spaceplane or at least abandoned it for refuge on the International Space Station...

As the Columbia Accident Investigation Board (CAIB) noted in its final report, "the NASA organizational culture had as much to do with this accident as the foam." All of NASA's launches were suspended for two years. While the shuttles eventually flew again, post-Columbia, the program was stunted and curtailed.
The article notes that since then SpaceX, Blue Origin, and the United Launch Alliance (Lockheed Martin and Boeing) "are thriving today in the space industry," along with Virgin Galactic and Axiom Space. "NASA, far from feeling threatened, has encouraged many of the private companies with massive contracts. The agency already had a long history of dealing with sub-contractors, using its pocketbook to steer aerospace development; that tradition has adjusted seamlessly to the current space economy."

In the other article CNN Space & Science writer Jackie Wattles notes that when America later retired its Space Shuttle program in 2011, "no U.S. astronaut would travel to space on an American-made rocket for nearly a decade."

Slashdot reader sciencehabit shares this report from Science magazine: Fifty years ago, famed physicist Stephen Hawking wrote down an equation that predicts that a black hole has entropy, an attribute typically associated with the disordered jumbling of atoms and molecules in materials.

The arguments for black hole entropy were indirect, however, and no one had derived the famous equation from the fundamental definition of entropy — at least not for realistic black holes. Now, one team of theorists claims to have done so, although some experts are skeptical.

Reported in a paper in press at Physical Review Letters, the work would solve a homework problem that some theorists have labored over for decades. "It's good to have it done," says Don Marolf, a gravitational theorist at the University of California, Santa Barbara who was not involved in the research. It "shows us how to move forward, that's great."