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Medicine

Researchers Successfully Cut HIV DNA Out of Human Cells 24

Posted by Soulskill
from the uses-for-your-trusty-nanoknife dept.
mrspoonsi sends word that researchers from Temple University have managed to eliminate the HIV-1 virus from human cells for the first time. "When deployed, a combination of a DNA-snipping enzyme called a nuclease and a targeting strand of RNA called a guide RNA (gRNA) hunt down the viral genome and excise the HIV-1 DNA (abstract). From there, the cell's gene repair machinery takes over, soldering the loose ends of the genome back together – resulting in virus-free cells." While antiretroviral therapy can treat people who are infected with HIV, the immune system is incapable of actually removing the virus, so this is an important step in fighting it. The researchers still have to overcome the problem of delivering the the genetic "toolkit" to each affected cell in a patient's body, and also HIV's high mutation rate.
Medicine

Why Are the World's Scientists Continuing To Take Chances With Smallpox? 131

Posted by Soulskill
from the what-could-possibly-go-wrong dept.
Lasrick writes: MIT's Jeanne Guillemin looks at the recent blunders with smallpox and H5N1 at the Centers for Disease Control and the National Institutes of Health to chronicle the fascinating history of smallpox eradication efforts and the attempts (thwarted by Western scientists) to destroy lab collections of the virus in order to make it truly extinct. "In 1986, with no new smallpox cases reported, the World Health Assembly, the decision-making body of the WHO, resolved to destroy the strain collections and make the virus extinct. But there was resistance to this; American scientists in particular wanted to continue their research." Within a few years, secret biological warfare programs were discovered in Moscow and in Iraq, and a new flurry of defensive research was funded. Nevertheless, Guillemin and others believe that changes in research methods, which no longer require the use of live viruses, mean that stocks of the live smallpox virus can and should finally be destroyed.
Bug

Researchers Test Developer Biometrics To Predict Buggy Code 72

Posted by Soulskill
from the subject-was-asleep-when-this-code-was-checked-in dept.
rjmarvin writes: Microsoft Research is testing a new method for predicting errors and bugs while developers write code: biometrics. By measuring a developer's eye movements, physical and mental characteristics as they code, the researchers tracked alertness and stress levels to predict the difficulty of a given task with respect to the coder's abilities. In a paper entitled "Using Psycho-Physiological Measures to Assess Task Difficulty in Software Development," the researchers summarized how they strapped an eye tracker, an electrodermal sensor and an EEG sensor to 15 developers as they programmed for various tasks. Biometrics predicted task difficulty for a new developer 64.99% of the time. For a subsequent tasks with the same developer, the researchers found biometrics to be 84.38% accurate. They suggest using the information to mark places in code that developers find particularly difficult, and then reviewing or refactoring those sections later.
Science

Experiment Shows People Exposed To East German Socialism Cheat More 482

Posted by Unknown Lamer
from the roll-high-or-be-sent-to-siberia dept.
An anonymous reader writes The Economist reports, "'UNDER capitalism', ran the old Soviet-era joke, 'man exploits man. Under communism it is just the opposite.' In fact new research suggests that the Soviet system inspired not just sarcasm but cheating too: in East Germany, at least, communism appears to have inculcated moral laxity. Lars Hornuf of the University of Munich and Dan Ariely, Ximena García-Rada and Heather Mann of Duke University ran an experiment last year to test Germans' willingness to lie for personal gain. Some 250 Berliners were randomly selected to take part in a game where they could win up to €6 ($8). ... The authors found that, on average, those who had East German roots cheated twice as much as those who had grown up in West Germany under capitalism. They also looked at how much time people had spent in East Germany before the fall of the Berlin Wall. The longer the participants had been exposed to socialism, the greater the likelihood that they would claim improbable numbers ... when it comes to ethics, a capitalist upbringing appears to trump a socialist one."
Medicine

Mimicking Vesicle Fusion To Make Gold Nanoparticles Easily Penetrate Cells 19

Posted by Unknown Lamer
from the golden-hypospray dept.
rtoz (2530056) writes A special class of tiny gold particles can easily slip through cell membranes, making them good candidates to deliver drugs directly to target cells. A new study from MIT materials scientists reveals that these nanoparticles enter cells by taking advantage of a route normally used in vesicle-vesicle fusion, a crucial process that allows signal transmission between neurons. MIT engineers created simulations of how a gold nanoparticle coated with special molecules can penetrate a membrane. Paper (abstract; full text paywalled).
NASA

NASA Names Building For Neil Armstrong 52

Posted by samzenpus
from the new-name dept.
An anonymous reader writes A building at NASA's Kennedy Space Center in Florida, where Apollo astronauts once trained, was named in honor of astronaut Neil Armstrong. Armstrong, who died in 2012, was remembered at a ceremony as not only an astronaut, but also as an aerospace engineer, test pilot, and university professor. NASA renamed the Operations and Checkout building, also known as the O&C, which is on the National Register of Historic Places. It has been the last stop for astronauts before their flights since 1965. It was also used to test and process Apollo spacecraft. Currently, it's where the Orion spacecraft is being assembled to send astronauts to an asteroid and later to Mars.
EU

UEA Research Shows Oceans Vital For Possibility of Alien Life 83

Posted by samzenpus
from the everything-is-wet dept.
An anonymous reader writes New research at the University of East Anglia finds that oceans are vital in the search for alien life. So far, computer simulations of habitable climates on other planets have focused on their atmospheres. But oceans play an equally vital role in moderating climates on planets and bringing stability to the climate, according to the study. From the press release: "The research team from UEA's schools of Mathematics and Environmental Sciences created a computer simulated pattern of ocean circulation on a hypothetical ocean-covered Earth-like planet. They looked at how different planetary rotation rates would impact heat transport with the presence of oceans taken into account. Prof David Stevens from UEA's school of Mathematics said: 'The number of planets being discovered outside our solar system is rapidly increasing. This research will help answer whether or not these planets could sustain alien life. We know that many planets are completely uninhabitable because they are either too close or too far from their sun. A planet's habitable zone is based on its distance from the sun and temperatures at which it is possible for the planet to have liquid water. But until now, most habitability models have neglected the impact of oceans on climate.'"
Science

Method Rapidly Reconstructs Animal's Development Cell By Cell 39

Posted by samzenpus
from the best-baby-pictures dept.
An anonymous reader writes Researchers at the Howard Hughes Medical Institute's Janelia Research Campus have developed software that can track each and every cell in a developing embryo. The software will allow a researcher to pick out a single cell at any point in development and trace its life backward and forward during the embryo's growth. Philipp Keller, a group leader at Janelia says: "We want to reconstruct the elemental building plan of animals, tracking each cell from very early development until late stages, so that we know everything that has happened in terms of cell movement and cell division. In particular, we want to understand how the nervous system forms. Ultimately, we would like to collect the developmental history of every cell in the nervous system and link that information to the cell's final function. For this purpose, we need to be able to follow individual cells on a fairly large scale and over a long period of time."
Robotics

Researchers Create Origami Wheels That Can Change Size 51

Posted by samzenpus
from the power-of-the-fold dept.
rtoz writes Researchers from Seoul National University have designed a robotic wheel based on the origami "magic ball pattern," which is a traditional technique used to create folded paper spheres. This robotic wheel can change its radius to create larger wheels to climb over things, and shrink back to a smaller size to squeeze under obstacles. The diameter of the wheels changes automatically to enable the robot to either be strong or speedy. The scientists think their innovation could one day be used for interplanetary rovers as the wheel can be folded up and "inflate" itself.
Space

A Look At NASA's Orion Project 108

Posted by samzenpus
from the bruce-willis-approved dept.
An anonymous reader writes "People in north Iowa got a first-hand look at NASA's Orion Project. Contractors with NASA were in Forest City to talk about the new project and show off a model of the new spaceship. NASA has big plans to send humans to an asteroid by 2025. The mission, however, will not be possible without several important components that include yet-to-be-developed technologies, as well as the Space Launch System (SLS) and the Orion spacecraft to fly astronauts beyond low-Earth orbit. In fact, Orion's first flight test later this year will provide NASA with vital data that will be used to design future missions."
United States

Apollo 11 Moon Landing Turns 45 203

Posted by samzenpus
from the we're-here dept.
An anonymous reader writes On July 20, 1969, U.S. astronauts Neil Armstrong and Buzz Aldrin became the first humans to walk on the moon. Neil Armstrong would say later he thought the crew had a 90% chance of getting home from the moon, and only a 50% chance of landing safely. The scope of NASA's Apollo program seems staggering today. President Kennedy announced his moon goal just four years into the Space Age, but the United States had not even launched a human into orbit yet. Amazingly, just eight years later, Armstrong and Aldrin were walking on the moon.
Space

Can the Multiverse Be Tested Scientifically? 145

Posted by Soulskill
from the signs-point-to-no dept.
astroengine writes: Physicists aren't afraid of thinking big, but what happens when you think too big? This philosophical question overlaps with real physics when hypothesizing what lies beyond the boundary of our observable universe. The problem with trying to apply science to something that may or may not exist beyond our physical realm is that it gets a little foggy as to how we could scientifically test it. A leading hypothesis to come from cosmic inflation theory and advanced theoretical studies — centering around the superstring hypothesis — is that of the "multiverse," an idea that scientists have had a hard time in testing. But now, scientists at the Perimeter Institute for Theoretical Physics, in Ontario, Canada have, for the first time, created a computer model of colliding universes in the multiverse in an attempt to seek out observational evidence of its existence.
Biotech

Genetically Modifying an Entire Ecosystem 52

Posted by Soulskill
from the evolve-big-or-evolve-home dept.
New submitter structural_biologist writes: Genes normally have a 50-50 chance of being passed from parent to offspring, but scientists may have figured out a way to create genes that show up in offspring with a much higher frequency. "One type of gene drive influences inheritance by copying itself onto chromosomes that previously lacked it. When an organism inherits such a gene drive from only one parent, it makes a cut in the chromosome from the other parent, forcing the cell to copy the inheritance-biasing gene drive—and any adjacent genes—when it repairs the damage." When introduced into the wild, organisms containing gene drives would breed with the population, quickly spreading the modified genes throughout the ecosystem. While the technology could help prevent the spread of malaria and manage invasive species, many scientists worry about the wide-ranging effects of such a technology and are calling for its regulation.
Moon

NASA: Lunar Pits and Caves Could House Astronauts 154

Posted by Soulskill
from the assuming-we-ever-go-back dept.
An anonymous reader writes: Astronomers have documented hundreds of holes on the lunar surface. These aren't simply craters, but actual pits ranging from 5 to 900 meters across. Scientists suspects many of these will lead to underground cave systems, which NASA says would be great spots for an astronaut habitat once we get back to the Moon. "A habitat placed in a pit — ideally several dozen meters back under an overhang — would provide a very safe location for astronauts: no radiation, no micrometeorites, possibly very little dust, and no wild day-night temperature swings," said Robert Wagner of Arizona State University. He says it's time to send probes into a few of these pits to see what they're like: "Pits, by their nature, cannot be explored very well from orbit — the lower walls and any floor-level caves simply cannot be seen from a good angle. Even a few pictures from ground-level would answer a lot of the outstanding questions about the nature of the voids that the pits collapsed into. We're currently in the very early design phases of a mission concept to do exactly this, exploring one of the largest mare pits."
Crime

World Health Organization Calls For Decriminalization of Drug Use 469

Posted by Soulskill
from the WHO-already-dismissed-by-old-people-as-being-a-bunch-of-potheads dept.
An anonymous reader writes: We've known for a while: the War on Drugs isn't working. Scientists, journalists, economists, and politicians have all argued against continuing the expensive and ineffective fight. Now, the World Health Organization has said flat out that nations should work to decriminalize the use of drugs. The recommendations came as part of a report released this month focusing on the prevention and treatment of HIV. "The WHO's unambiguous recommendation is clearly grounded in concerns for public health and human rights. Whilst the call is made in the context of the policy response to HIV specifically, it clearly has broader ramifications, specifically including drug use other than injecting. In the report, the WHO says: 'Countries should work toward developing policies and laws that decriminalize injection and other use of drugs and, thereby, reduce incarceration. ...Countries should ban compulsory treatment for people who use and/or inject drugs." The bottom line is that the criminalization of drug use comes with substantial costs, while providing no substantial benefit.
Medicine

Gene Therapy Converts Heart Cells Into "Biological Pacemakers" 26

Posted by Unknown Lamer
from the tick-tock dept.
Zothecula (1870348) writes Pacemakers serve an invaluable purpose, by electrically stimulating a recipient's heart in order to keep it beating at a steady rate. The implantation of a pacemaker is a major surgical procedure, however, plus its presence in the body can lead to complications such as infections. Now, for the first time, scientists have instead injected genes into the defective hearts of pigs, converting unspecialized heart cells into "biological pacemakers." Research Paper (abstract, full text paywalled).
Programming

Math, Programming, and Language Learning 238

Posted by Soulskill
from the i-before-e-except-SyntaxError: dept.
An anonymous reader writes: There's often debate amongst modern programmers about how much math a professional developer should know, and to what extent programming is math. Learning to program is often viewed as being on a spectrum between learning math and learning spoken/written languages. But in a new article, Jeremy Kun argues that the spectrum should be formulated another way: Human language -> Mathematics -> Programming. "Having studied all three subjects, I'd argue that mathematics falls between language and programming on the hierarchy of rigor. ... [T]he hierarchy of abstraction is the exact reverse, with programming being the most concrete and language being the most abstract. Perhaps this is why people consider mathematics a bridge between human language and programming. Because it allows you to express more formal ideas in a more concrete language, without making you worry about such specific hardware details like whether your integers are capped at 32 bits or 64. Indeed, if you think that the core of programming is expressing abstract ideas in a concrete language, then this makes a lot of sense. This is precisely why learning mathematics is 'better' at helping you learn the kind of abstract thinking you want for programming than language. Because mathematics is closer to programming on the hierarchy. It helps even more that mathematics and programming readily share topics."
Science

The New Science of Evolutionary Forecasting 63

Posted by Soulskill
from the partly-hairy-with-a-chance-of-eyeballs dept.
An anonymous reader writes "Scientists may not be able to predict what life will be like 100 million years from now, but they may be able to make short-term forecasts for the next few months or years. And if they're making predictions about viruses or other health threats, they might be able to save some lives in the process. "Biologists have found cases in which evolution has, in effect, run the same experiment several times over. And in some cases the results of those natural experiments have turned out very similar each time. In other words, evolution has been predictable. One of the most striking cases of repeated evolution has occurred in the Caribbean. ... Each time lizards colonized an island, they evolved into many of the same forms. On each island, some lizards adapted to living high in trees, evolving pads on their feet for gripping surfaces, along with long legs and a stocky body. Other lizards adapted to life among the thin branches lower down on the trees, evolving short legs that help them hug their narrow perches. Still other lizards adapted to living in grass and shrubs, evolving long tails and slender trunks. On island after island, the same kinds of lizards have evolved."
Space

Preparing For Satellite Defense 114

Posted by Soulskill
from the road-to-kessler-syndrome dept.
Taco Cowboy sends a report into China's development of anti-satellite technology, and efforts by the U.S. and Japan to build defenses for this new potential battleground. Last year, China launched what they said was a science space mission, but they did so at night and with a truck-based launch system, which are not generally used for science projects. Experts believe this was actually a missile test for targets in geostationary orbit. U.S. and Japanese analysts say China has the most aggressive satellite attack program in the world. It has staged at least six ASAT missile tests over the past nine years, including the destruction of a defunct Chinese weather satellite in 2007. ... Besides testing missiles that can intercept and destroy satellites, the Chinese have developed jamming techniques to disrupt satellite communications. In addition, ... the Chinese have studied ground-based lasers that could take down a satellite's solar panels, and satellites equipped with grappling arms that could co-orbit and then disable expensive U.S. hardware. To defend themselves against China, the U.S. and Japan are in the early stages of integrating their space programs as part of negotiations to update their defense policy guidelines. ... Both countries have sunk billions of dollars into a sophisticated missile defense system that relies in part on data from U.S. spy satellites. That's why strategists working for China's People's Liberation Army have published numerous articles in defense journals about the strategic value of chipping away at U.S. domination in space.
Medicine

New Treatment Stops Type II Diabetes 253

Posted by samzenpus
from the one-shot-and-your-done dept.
multicsfan writes Researchers have found that an injection of protein FGF1 stops weight induced diabetes in mice, with no apparent side effects. However, the cure only lasts 2 days at a time. Future research and human trials are needed to better understand and create a working drug. From the story: "The team found that sustained treatment with the protein doesn't merely keep blood sugar under control, but also reverses insulin insensitivity, the underlying physiological cause of diabetes. Equally exciting, the newly developed treatment doesn't result in side effects common to most current diabetes treatments."

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