Culberson wants to save NASA and the space program from his fellow politicians and return it to its true glory. He favors sending American astronauts back to the moon and a robotic space probe to Jupiter's moon Europa. He would like to enact budget reforms that take funding decisions away from the Office of Management and Budget and gives them solely to Congress. He favors a steady increase in NASA funding to pay for a proper program of space exploration. To say the least, he has his work cut out for him.
The results support the idea that the Deccan Traps played a role in the K-Pg extinction, and challenge the dominant theory that a meteorite impact near present-day Chicxulub, Mexico, was the sole cause of the extinction. The researchers suggest that the Deccan Traps eruptions and the Chicxulub impact need to be considered together when studying and modeling the K-Pg extinction event."
For example, researchers can use the model to predict what will happen to a protein when there’s a mistake in part of the regulatory code. Mutations in splicing instructions have already been linked to diseases such as spinal muscular atrophy, a leading cause of infant death, and some forms of colorectal cancer. In the new study, researchers used the trained model to analyze genetic data from people afflicted with some of those diseases. The scientists identified some known mutations linked to these maladies, verifying that the model works. They picked out some new candidate mutations as well, most notably for autism.
One of the benefits of the model, Frey said, is that it wasn’t trained using disease data, so it should work on any disease or trait of interest. The researchers plan to make the system publicly available, which means that scientists will be able to apply it to many more diseases.
In a process known as DNA methylation, clusters of atoms, called methyl groups, attach to the outside of a gene like microscopic mollusks and make the gene more or less able to receive and respond to biochemical signals from the body. In the exercised portions of the bodies, many of the methylation changes were on portions of the genome known as enhancers that can amplify the expression of proteins by genes. And gene expression was noticeably increased or changed in thousands of the muscle-cell genes that the researchers studied. Most of the genes in question are known to play a role in energy metabolism, insulin response and inflammation within muscles. In other words, they affect how healthy and fit our muscles — and bodies — become. Many mysteries still remain but the message of the study is unambiguous. "Through endurance training — a lifestyle change that is easily available for most people and doesn't cost much money," says Sara Lindholm, "we can induce changes that affect how we use our genes and, through that, get healthier and more functional muscles that ultimately improve our quality of life."